Clinical Trials

608 enrolled 17 charts

Breast Neoplasms

NCT02158507 2026-01-22

Pilot Study of Veliparib (ABT-888) and Lapatinib (Tykerb) in Patients With Metastatic, Triple Negative Breast Cancer

Phase NA Completed

20 enrolled 10 charts

Triple Negative Breast Neoplasms

NCT00770809 2025-08-15

Paclitaxel and Trastuzumab With or Without Lapatinib in Treating Patients With Stage II or Stage III Breast Cancer That Can Be Removed by Surgery

305 enrolled 10 charts

Phase 2 Active not recruiting

Breast Neoplasms, Breast Neoplasms, Male

NCT01273610 2025-06-10

Tolerability of the Combination of Lapatinib and Trastuzumab in Adults Age 60 or Older With HER2 Positive Locally Advanced or Metastatic Breast Cancer

40 enrolled 15 charts

Breast Neoplasms, Patient Compliance

NCT00490139 2025-03-21

ALTTO

8,381 enrolled 22 charts

Breast Neoplasms

NCT00667251 2025-03-21

Chemotherapy and Lapatinib or Trastuzumab in Treating Women With HER2/Neu-Positive Metastatic Breast Cancer

652 enrolled 50 charts

Breast Neoplasms

NCT01160211 2025-03-07

A Study to Compare the Safety and Efficacy of an Aromatase Inhibitor in Combination With Lapatinib, Trastuzumab or Both for the Treatment of Hormone Receptor Positive, HER2+ Metastatic Breast Cancer

369 enrolled 19 charts

Breast Neoplasms

NCT00470704 2024-12-19

Lapatinib in Combination With Trastuzumab in Patients With HER2-Positive, Metastatic Breast Cancer

87 enrolled 23 charts

Breast Neoplasms

NCT00963547 2024-06-04

MK-2206-015

Phase 1 Terminated

33 enrolled 13 charts

Breast Neoplasms

NCT01622868 2023-10-17

Whole-Brain Radiation Therapy or Stereotactic Radiosurgery With or Without Lapatinib Ditosylate in Treating Patients With Brain Metastasis From HER2-Positive Breast Cancer

143 enrolled 24 charts

BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT00272987 2023-04-28

ErbB2 Over-expressing Metastatic Breast Cancer Study Using Paclitaxel, Trastuzumab, and Lapatinib

Phase 3 Terminated

63 enrolled 22 charts

Breast Neoplasms

NCT00841828 2023-03-31

Trastuzumab Versus Lapatinib as Neoadjuvant Treatment for Her2+ Patients

102 enrolled 10 charts

Breast Neoplasms

NCT00436566 2022-08-05

Doxorubicin and Cyclophosphamide Followed By Trastuzumab, Paclitaxel, and Lapatinib in Treating Patients With Early-Stage HER2-Positive Breast Cancer That Has Been Removed By Surgery

122 enrolled 22 charts

Breast Neoplasms, Breast Neoplasms, Male, Cardiotoxicity

NCT01499160 2022-02-11

Letrozole and Lapatinib Followed by Everolimus in Women With Advanced Breast Cancer

7 enrolled 6 charts

Breast Diseases, Breast Neoplasms, Neoplasm Metastasis

NCT00952692 2021-12-20

Study to Assess dHER2+AS15 Cancer Vaccine Given in Combination With Lapatinib to Patients With Metastatic Breast Cancer

Phase 1/2 Completed

12 enrolled 9 charts

Breast Neoplasms

NCT00444535 2021-10-25

Lapatinib and Bevacizumab for Metastatic Breast Cancer

52 enrolled 13 charts

Breast Neoplasms, Osteitis Deformans

NCT00206427 2021-09-29

GW

49 enrolled 7 charts

Breast Neoplasms, Neoplasms

NCT00508274 2021-09-21

Lapatinib +Capecitabine Treatment for Advanced Metastatic Breast Cancer in Women From China

Phase 3 Terminated

52 enrolled 12 charts

Breast Neoplasms

NCT00553358 2021-09-21

Neo ALTTO

455 enrolled 34 charts

Breast Neoplasms, Osteitis Deformans

NCT01808573 2021-06-11

NALA

621 enrolled 21 charts 2 FDA

HER2+ Metastatic Breast Cancer (MBC)

NCT00073528 2021-02-24

Study Comparing Lapatinib (GW572016) And Letrozole Versus Letrozole In Subjects With Advanced Or Metastatic Breast Cancer

1,286 enrolled 41 charts

Breast Neoplasms

NCT00684983 2020-03-24

Capecitabine and Lapatinib Ditosylate With or Without Cixutumumab in Treating Patients With Previously Treated HER2-Positive Stage IIIB-IV Breast Cancer

64 enrolled 13 charts

Phase EARLY_PHASE1 Completed

Insulin-Like Growth Factor I, Resistance To, Breast Neoplasms

NCT00331630 2020-03-06

Abraxane and Lapatinib in Treating Patients With Stage I, Stage II, or Stage III Breast Cancer

30 enrolled 13 charts

Breast Neoplasms

NCT00390455 2019-12-20

Fulvestrant With or Without Lapatinib in Treating Postmenopausal Women With Stage III or Stage IV Breast Cancer That is Hormone Receptor-Positive

295 enrolled 18 charts

Breast Neoplasms

NCT00263588 2019-12-12

Lapatinib for Brain Metastases In ErbB2-Positive Breast Cancer

242 enrolled 19 charts

BreastCNS

Brain Neoplasms, Breast Neoplasms, Neoplasms

NCT01118975 2019-11-13

GCC 0845:Vorinostat and Lapatinib in Advanced Solid Tumors and Advanced Breast Cancer to Evaluate Response and Biomarkers

Phase 1/2 Terminated

12 enrolled 6 charts

Breast Neoplasms, Neoplasm Metastasis

NCT00820872 2019-10-21

Docetaxel, Carboplatin, Trastuzumab, and Lapatinib in Treating Patients With Early Stage Breast Cancer

30 enrolled 6 charts

Breast Neoplasms, Breast Neoplasms, Male

NCT01891357 2019-09-17

Phase II Trial to Validate Markers for a Response Evaluation of a Combined Therapy in Patients With HER2+ Breast Cancer

64 enrolled 7 charts

Carcinoma, Ductal, Breast

NCT02294786 2019-07-15

Study of Prophylactic Octreotide to Prevent or Reduce the Frequency and Severity of Diarrhoea in Subjects Receiving Lapatinib With Capecitabine for the Treatment of Metastatic Breast Cancer

62 enrolled 25 charts

Breast Neoplasms, Diarrhea, Neoplasms

NCT00759642 2019-07-01

Lapatinib in Women With Metastatic Breast Cancer Who Have Failed Prior Antihormone Therapy

33 enrolled 7 charts

Breast Neoplasms

NCT00820222 2019-04-02

Lapatinib Plus Capecitabine Versus Trastuzumab Plus Capecitabine in ErbB2 (HER2) Positive Metastatic Breast Cancer

540 enrolled 18 charts

BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT00320411 2019-01-31

GW572016 In Patients With ErbB2 Over - Expressing Advanced Or Metastatic Breast Cancer

62 enrolled 24 charts

Breast Neoplasms

NCT00477464 2018-09-17

Lapatinib in Combination With Capecitabine in Japanese Patients With Metastatic Breast Cancer

51 enrolled 25 charts

Breast Neoplasms

NCT00777101 2018-08-09

Study Evaluating Neratinib Versus Lapatinib Plus Capecitabine For ErbB2 Positive Advanced Breast Cancer

233 enrolled 16 charts

Breast Neoplasms, Neoplasm Metastasis

NCT00225758 2018-07-27

Lapatinib in Metastatic Breast Cancer Resistant to Hormone Therapy

27 enrolled 5 charts

Breast Neoplasms

NCT00555152 2018-04-20

Lapatinib Ditosylate in Treating Patients With Ductal Breast Carcinoma In Situ

Phase NA Completed

22 enrolled 9 charts

Carcinoma, Intraductal, Noninfiltrating

NCT00118157 2017-12-04

Lapatinib and Tamoxifen in Treating Patients With Locally Advanced or Metastatic Breast Cancer That Did Not Respond to Previous Tamoxifen

19 enrolled 6 charts

Breast Neoplasms, Breast Neoplasms, Male

NCT01688609 2017-09-11

Lapatinib Ditosylate, Trastuzumab, Paclitaxel, and Surgery in Treating Patients With Breast Cancer

18 enrolled 7 charts

Breast Neoplasms

NCT00721630 2017-08-15

Novel Capecitabine Dosing Schedule in Combination With Lapatinib, Based on the Norton-Simon Mathematical Method in Patients With HER2 Overexpressed/Amplified, Trastuzumab (Herceptin) -Refractory, Metastatic Breast Cancer

24 enrolled 8 charts

Breast Neoplasms

NCT01934894 2017-07-02

Cabazitaxel Plus Lapatinib as Therapy for HER2-Positive Metastatic Breast Cancer Patients With Intracranial Metastases

11 enrolled 7 charts

Metastatic Breast Cancer With Intracranial Metastases

NCT01868503 2017-06-26

Lapatinib Ditosylate and Radiation Therapy in Treating Patients With Locally Advanced or Locally Recurrent Breast Cancer

7 enrolled 8 charts

Breast Neoplasms, Breast Neoplasms, Male

NCT01013740 2017-05-31

VITAL

112 enrolled 15 charts

Breast Neoplasms, Neoplasms

NCT00482391 2017-05-12

Doxorubicin and Cyclophosphamide Followed by Paclitaxel, Trastuzumab, and Lapatinib in Treating Patients With HER2/Neu-Overexpressed Breast Cancer

95 enrolled 7 charts

Breast Neoplasms, Breast Neoplasms, Male

NCT00496366 2017-03-21

Capecitabine (Xeloda) and Lapatinib (Tykerb) as First-line Therapy in HER2/Neu-positive Breast Cancer

11 enrolled 8 charts

Breast Neoplasms

NCT00089999 2017-02-28

Lapatinib In Chemotherapy-Naive Or Metastatic Breast Cancer

138 enrolled 16 charts

Breast Neoplasms

NCT00524303 2016-11-11

Lapatinib +/- Trastuzumab In Addition To Standard Neoadjuvant Breast Cancer Therapy.

100 enrolled 14 charts

Breast Neoplasms

NCT00829166 2016-10-31

EMILIA

991 enrolled 26 charts

Breast Neoplasms

NCT00422903 2016-05-12

Letrozole In Combination With Lapatinib In Neoadjuvant Treatment Of Early Breast Cancer

92 enrolled 14 charts

Breast Neoplasms

NCT00429299 2016-03-22

CHERLOB

121 enrolled 16 charts

Breast Neoplasms

NCT00634088 2016-03-10

Phase I Study of Ixabepilone Plus Lapatinib With or Without Capecitabine in the Treatment of Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer

Phase 1 Terminated

13 enrolled 13 charts