Clinical Trials

Brain Neoplasms, Communication, Glioblastoma

NCT04189172 2026-03-18

MiDura

Active not recruiting

328 enrolled

BreastCNSDermatologicOther hematologic neoplasmThoracic

Arnold-Chiari Malformation, Brain Neoplasms, Hydrocephalus, Meningioma, Spinal Cord Injuries, Vascular Malformations

NCT04789668 2026-03-18

Bintrafusp Alfa and Pimasertib for the Treatment of Patients With Brain Metastases

Phase 1/2 Terminated

8 enrolled 13 charts

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Hematologic Neoplasms, Triple Negative Breast Neoplasms

NCT04817254 2026-03-18

Association of Peripheral Blood Immunologic Response to Therapeutic Response to Adjuvant Treatment With Immune Checkpoint Inhibition (ICI) in Patients With Newly Diagnosed Glioblastoma or Gliosarcoma

Phase 1/2 Not yet recruiting

47 enrolled

CNSSarcoma

Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT07416188 2026-03-18

Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma

40 enrolled

Phase NA Active not recruiting

Brain Neoplasms, Glioblastoma, Glioma, Neoplasms, Neoplasms by Histologic Type, Neoplasms, Nerve Tissue, Recurrence, Central Nervous System Neoplasms

NCT02429570 2026-03-17

Meclofenamate in Subjects With Recurrent or Progressive Brain Metastasis From Solid Tumor Primary

30 enrolled

Brain Neoplasms

NCT02971501 2026-03-17

Osimertinib With or Without Bevacizumab in Treating Patients With EGFR Positive Non-small Cell Lung Cancer and Brain Metastases

7 enrolled 9 charts

CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT06161519 2026-03-17

PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications

Phase 1/2 Recruiting

146 enrolled

Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Recurrence

NCT02565433 2026-03-16

PRAMECE

Phase NA Terminated

52 enrolled

Brain Neoplasms, Neoplasm Metastasis

NCT03475186 2026-03-13

Testing Ramipril to Prevent Memory Loss in People With Glioblastoma

75 enrolled 47 charts

Brain Neoplasms, Glioblastoma, Cognitive Dysfunction

NCT05588141 2026-03-13

A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations

Phase 1/2 Recruiting

96 enrolled

Brain Neoplasms, Glioma, Neoplasms, Recurrence

NCT06946680 2026-03-13

IMPACT

18 enrolled

Brain Neoplasms, Glioblastoma, Glioma

NCT02896335 2026-03-12

Palbociclib and Pembrolizumab In Central Nervous System Metastases

Phase 2 Recruiting

45 enrolled

Brain Neoplasms

NCT05865990 2026-03-12

TUXEDO-3

63 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms, Meningeal Neoplasms

NCT07100730 2026-03-12

IPAX BrIGHT

Phase 3 Recruiting

50 enrolled

Brain Neoplasms, Glioblastoma, Neoplasm Recurrence, Local, Neoplasms, Central Nervous System Neoplasms

NCT07297212 2026-03-12

A Clinical Trial Testing the Safety of the Investigational Drug Pumitamig (BNT327) and How Well it Works in Patients With Recurrent Glioblastoma

Phase 2 Recruiting

75 enrolled

Brain Neoplasms, Glioblastoma

NCT07464470 2026-03-12

GENCONCOR-2

30 enrolled

CNSGastrointestinal

Brain Neoplasms, Esophageal Neoplasms, Stomach Neoplasms

NCT07467109 2026-03-12

A Study to Evaluate the Safety and Efficacy of Intracranial Venous Blood Sampling for Liquid Biopsy in the Diagnosis of Brain Cancers

Not yet recruiting

20 enrolled

Brain Neoplasms

NCT02639325 2026-03-11

Tumor Related Epilepsy

100 enrolled

Brain Neoplasms, Epilepsy, Neoplasms, Seizures

NCT02851706 2026-03-11

Natural History of and Specimen Banking for People With Tumors of the Central Nervous System

Completed

1,214 enrolled

Astrocytoma, Brain Neoplasms, Glioma, Neoplasms, Spinal Cord Neoplasms

NCT04044937 2026-03-11

UC-GlioFET

143 enrolled

Brain Neoplasms, Glioblastoma

NCT04301089 2026-03-11

Immersive Virtual Reality (VR) at the Time of Clinical Evaluation to Improve Psychological Distress and Anxiety in Primary Brain Tumor (PBT) Patients

61 enrolled 20 charts

Anxiety Disorders, Brain Neoplasms

NCT05086497 2026-03-11

WBSI Guided Personalized Delivery of TTFields

Phase NA Recruiting

155 enrolled

Brain Neoplasms, Glioblastoma

NCT06914479 2026-03-11

Virus-Based Gene Therapy (AdV-HSV1-TK and AdV-Flt3L) in Combination With Valacyclovir for the Treatment of Pediatric and Young Adult Patients With Resectable, Recurrent Primary Malignant Brain Tumors

Phase 1 Recruiting

11 enrolled

Phase EARLY_PHASE1 Not yet recruiting

Brain Neoplasms

NCT07039760 2026-03-11

Asciminib With or Without Sildenafil for Brain Tumors

12 enrolled

Brain Neoplasms

NCT05378633 2026-03-10

CyberChallenge

Phase NA Recruiting

190 enrolled

CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasm Metastasis

NCT06048718 2026-03-10

TUXEDO-4

28 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT07063693 2026-03-10

ABY-029 Glioma Trial

Phase 1 Recruiting

33 enrolled

Phase 2 Not yet recruiting

Brain Neoplasms

NCT07462507 2026-03-10

Inflammation in Primary and Secondary Malignancies of the Central Nervous System Using [C-11]-CS1P1

104 enrolled

Phase 3 Active not recruiting

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms

NCT01592968 2026-03-09

Stereotactic Radiosurgery or Whole Brain Radiation Therapy in Treating Patients With Newly Diagnosed Non-melanoma Brain Metastases

88 enrolled

Brain Neoplasms, Neoplasm Metastasis

NCT02153957 2026-03-09

Trial Evaluating an Enhanced Physical Activity Intervention to Improve Cognitive Late Effects in Children Treated With Cranial Radiation for Brain Tumors

36 enrolled

Brain Neoplasms, Motor Activity

NCT02389309 2026-03-09

Dasatinib, Temsirolimus, and Cyclophosphamide in Treating Patients With Advanced, Recurrent, or Refractory Solid Tumors

14 enrolled

Brain Neoplasms

NCT02858869 2026-03-09

Pembrolizumab and Stereotactic Radiosurgery for Melanoma or Non-Small Cell Lung Cancer Brain Metastases

Phase 1 Completed

25 enrolled 14 charts

CNSDermatologicThoracic

Uveal Melanoma, Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma

NCT04573140 2026-03-09

PNOC020

28 enrolled

CNSLymphoid

Brain Neoplasms, Glioblastoma, Glioma, Lymphoma, Follicular

NCT05353530 2026-03-09

IMPACT

39 enrolled

Phase 1/2 Active not recruiting

Brain Neoplasms, Glioblastoma

NCT05660408 2026-03-09

RNA PRIME

36 enrolled

Brain Neoplasms, Glioma

NCT05859659 2026-03-09

Clinical, patHOlogical and Imaging Project of nEuro-oncology (HOPE)

70,000 enrolled

Brain Neoplasms, Glioma, Neoplasms, Neurologic Manifestations

NCT05987644 2026-03-09

DURABLE

Phase 1/2 Recruiting

56 enrolled

CNSThoracic

Brain Neoplasms, Lung Neoplasms

NCT06254326 2026-03-09

ADAGiO

12 enrolled

Brain Neoplasms, Oligodendroglioma

NCT06389591 2026-03-09

RNA-Lipid Particle (RNA-LP) Vaccines for Recurrent Adult Glioblastoma (GBM)

24 enrolled

Brain Neoplasms, Glioblastoma

NCT07053033 2026-03-09

Laser Interstitial Thermal Therapy (LITT) or Surgery and Adjuvant Reirradiation for Recurrent Brain Metastases (LaSAR BeaM)

Phase 2 Recruiting

155 enrolled

Phase 2 Not yet recruiting

Brain Neoplasms

NCT07458113 2026-03-09

BERLIN

20 enrolled

BreastCNS

Brain Neoplasms, Triple Negative Breast Neoplasms

NCT01445483 2026-03-06

Neuropsychological Changes in Patients Receiving Radiation Therapy for Brain Metastases

Completed

35 enrolled

Brain Neoplasms, Neoplasm Metastasis, Neoplasms

NCT02303678 2026-03-06

D2C7 for Adult Patients With Recurrent Malignant Glioma

Phase 1 Completed

81 enrolled

Brain Neoplasms, Glioma

NCT02568267 2026-03-06

STARTRK-2

BreastCNSDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidNETSarcomaThoracic

534 enrolled 1 FDA

Thyroid Cancer, Papillary, Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Head and Neck Neoplasms, Melanoma, Ovarian Neoplasms, Pancreatic Neoplasms, Salivary Gland Neoplasms, Sarcoma, Colorectal Neoplasms, Lymphoma, Large-Cell, Anaplastic, Cholangiocarcinoma, Neuroendocrine Tumors

NCT03606421 2026-03-06

CBF and NCF Changes With Brain Radiation

Active not recruiting

110 enrolled

Brain Neoplasms, Cognition Disorders

NCT05559853 2026-03-06

Developing a New MRI Technique to Understand Changes in Brain Tumors After Treatment

119 enrolled

Brain Neoplasms

NCT07446842 2026-03-06

Construction of AI Model for Precision Imaging Diagnosis of Cranial Diseases

1,000 enrolled