Clinical Trials

CNSDermatologicHead & NeckThoracic

124 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Glioma, Melanoma, Neoplasms, Thyroid Neoplasms

NCT04238819 2026-03-02

A Study of Abemaciclib (LY2835219) in Combination With Other Anti-Cancer Treatments in Children and Young Adult Participants With Solid Tumors, Including Neuroblastoma

Phase 1/2 Completed

47 enrolled 36 charts

CNSSarcoma

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Rhabdoid Tumor

NCT06047379 2026-03-02

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

CNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

134 enrolled

Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Astrocytoma, Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Squamous Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Glioblastoma, Melanoma, Stomach Neoplasms, Colorectal Neoplasms, Carcinoma, Merkel Cell, Central Nervous System Neoplasms, Small Cell Lung Carcinoma

NCT01068782 2026-02-25

Multiple Doses and Regimens of Cabozantinib in Subjects With Grade IV Astrocytic Tumors in First or Second Relapse

Phase 2 Terminated

19 enrolled 10 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma

NCT05593094 2026-02-25

A Phase 1 Trial of ZN-A-1041 Enteric Capsules or Combination in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Advanced Solid Tumors

210 enrolled

Phase 2 Not yet recruiting

Brain Neoplasms

NCT07428616 2026-02-24

A Study of Zanzalintinib in Participants With Recurrent or Progressive Meningioma

100 enrolled

Brain Neoplasms, Meningioma

NCT05124912 2026-02-20

REMASTer: REcurrent Brain Metastases After SRS Trial

Phase NA Recruiting

261 enrolled

Brain Neoplasms, Neoplasm Metastasis, Recurrence

NCT07238322 2026-02-20

[18F]FET PET for Characterization of Progressive or Recurrent Glioma From Treatment Related Changes

Active not recruiting

400 enrolled

Brain Neoplasms, Glioma

NCT04427384 2026-02-13

Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)

Recruiting

600 enrolled

Phase 3 Active not recruiting

Brain Neoplasms, Meningioma

NCT04739761 2026-02-11

DESTINY-B12

506 enrolled 27 charts

Brain Neoplasms, Breast Neoplasms

NCT04478279 2026-02-09

A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors

BreastCNSDermatologicGenitourinary

125 enrolled

Brain Neoplasms, Breast Neoplasms, Glioblastoma, Melanoma, Prostatic Neoplasms

NCT05386108 2026-02-05

ELECTRA

73 enrolled

Brain Diseases, Brain Neoplasms, Breast Diseases, Breast Neoplasms, Central Nervous System Diseases, Neoplasms, Neoplasms by Site, Central Nervous System Neoplasms

NCT06253871 2026-02-03

A Phase 1/1b Study of IAM1363 in HER2 Cancers

BreastCNSGastrointestinalThoracic

243 enrolled

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Neoplasms, Stomach Neoplasms

NCT06810544 2026-02-02

Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

191 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Glioblastoma, Glioma, Lung Neoplasms

NCT06057168 2026-01-29

GDX-44-016

Phase 3 Completed

138 enrolled 7 charts

BreastCNSGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther hematologic neoplasmPlasma cellSarcomaThoracic

Brain Neoplasms

NCT05366881 2026-01-20

CAMPERR

Recruiting

7,000 enrolled

Urinary Bladder Neoplasms, Brain Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Leukemia, Lung Neoplasms, Lymphoma, Multiple Myeloma, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Sarcoma, Stomach Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms

NCT06458712 2026-01-16

Study to Assess Safety, Tolerability and Activity of DSB2455 in Participants With Advanced Malignancies

90 enrolled

Kenny-Caffey syndrome, Type 1, Brain Neoplasms

NCT06322342 2025-12-26

Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent

Phase 2 Completed

18 enrolled

Neuroinflammatory Diseases, Brain Neoplasms, Glioma, Meningioma, Multiple Sclerosis, Neoplasms, Neurilemmoma, Neurofibroma, Neuroma, Acoustic, Central Nervous System Neoplasms

NCT02650401 2025-12-24

STARTRK-NG

CNSEndocrineGenitourinaryHead & NeckSarcoma

69 enrolled 1 FDA

Thyroid Cancer, Papillary, Brain Neoplasms, Glioma, Medulloblastoma, Neoplasm Metastasis, Wilms Tumor, Neuroblastoma, Recurrence, Salivary Gland Neoplasms, Sarcoma, Sarcoma, Ewing, Central Nervous System Neoplasms, Nephroma, Mesoblastic

NCT03423628 2025-12-22

A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer

180 enrolled

Brain Neoplasms, Glioblastoma, Inhibition, Psychological, Meningeal Neoplasms, Hereditary Sensory and Autonomic Neuropathies

NCT06098248 2025-12-15

cCeLLExvivo

Phase NA Terminated

285 enrolled 5 charts

Brain Neoplasms

NCT05317858 2025-12-10

LIMITLESS

Phase 3 Recruiting

30 enrolled

Phase NA Not yet recruiting

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT07274397 2025-12-10

EARLYBRAINPET

15 enrolled

Brain Neoplasms, Glioblastoma

NCT04538742 2025-12-08

DB-07

245 enrolled

Brain Neoplasms, Breast Neoplasms

NCT07206498 2025-11-28

WAYWIN103

48 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT06777433 2025-11-24

RAD101

Phase 2 Recruiting

30 enrolled

Brain Neoplasms

NCT02831959 2025-10-31

Pivotal, Open-label, Randomized Study of Radiosurgery With or Without Tumor Treating Fields (TTFields) for 1-10 Brain Metastases From Non-small Cell Lung Cancer (NSCLC).

Phase 3 Completed

298 enrolled

Phase EARLY_PHASE1 Terminated

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT04543188 2025-10-23

A FIH Study of PF-07284890 in Participants With BRAF V600 Mutant Solid Tumors With and Without Brain Involvement

Phase 1 Terminated

65 enrolled 52 charts

CNSDermatologicThoracic

Brain Diseases, Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Neoplasms, Central Nervous System Neoplasms

NCT04712721 2025-10-10

Study of [68Ga]-FF58 in Patients With Selected Solid Tumors Expected to Overexpress αvβ3 and αvβ5 Integrins.

14 enrolled

Phase 3 Active not recruiting

Brain Neoplasms, Breast Neoplasms, Glioblastoma

NCT04365374 2025-10-07

Post-Surgical Stereotactic Radiotherapy (SRT) Versus GammaTile-ROADS (Radiation One and Done Study)

230 enrolled

Brain Neoplasms, Neoplasm Metastasis, Neoplasms

NCT05630209 2025-10-02

Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric Diffuse Intrinsic Pontine Gliomas (DIPG)

10 enrolled

BreastCNSGastrointestinalGenitourinaryGynecologicLymphoidSarcoma

Brain Neoplasms

NCT05974410 2025-10-02

Expanded Access to Immunomodulatory AVM0703 for Solid Tumor and Blood Cancer Patients

Available

Brain Neoplasms, Breast Neoplasms, Carcinoma, Squamous Cell, Glioblastoma, Hodgkin Disease, Lymphoma, Non-Hodgkin, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Sarcoma, Stomach Neoplasms

NCT06136884 2025-10-01

A First-In-Human, Phase 1 Study Evaluating Oral TACC3 PPI Inhibitor, AO-252, in Advanced Solid Tumors With or Without Brain Metastases

86 enrolled

Phase 3 Active not recruiting

Brain Neoplasms

NCT04674683 2025-09-24

Study Comparing Investigational Drug HBI-8000 + Nivolumab vs. Placebo + Nivolumab in Patients With Advanced Melanoma

450 enrolled

CNSDermatologic

Brain Neoplasms, Melanoma

NCT05270707 2025-09-24

HyperArc Registry Study

Completed

968 enrolled

Phase EARLY_PHASE1 Active not recruiting

Brain Diseases, Brain Neoplasms, Central Nervous System Neoplasms

NCT05023551 2025-09-16

Study of DSP-0390 in Patients With Recurrent High-Grade Glioma

39 enrolled

Brain Neoplasms, Glioblastoma, Glioma

NCT03653546 2025-09-10

BM

Phase 2/3 Completed

492 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasms, Respiratory Tract Diseases

NCT03050736 2025-09-04

Safety Study of VAL-083 and Radiotherapy in Patients With Newly Diagnosed GBM Having Unmethylated MGMT Expression

Phase 2 Completed

29 enrolled

Brain Neoplasms, Glioblastoma, Glioma

NCT03149575 2025-09-04

STAR-3

Phase 3 Terminated

2 enrolled

Brain Neoplasms, Glioblastoma, Glioma

NCT06309251 2025-09-03

Effectiveness and Impact on the Quality of Life of Ketogenic Diet in Pediatric Patients

Recruiting

100 enrolled

Autism Spectrum Disorder, Drug Resistant Epilepsy, Brain Neoplasms

NCT01478178 2025-08-29

Safety Study of VAL-083 in Patients With Recurrent Malignant Glioma

Phase 1/2 Completed

55 enrolled

Brain Neoplasms, Glioblastoma, Glioma

NCT02717962 2025-08-29

Study of VAL-083 in Patients With MGMT Unmethylated, Bevacizumab-naive Glioblastoma in the Adjuvant or Recurrent Setting

Phase 2 Completed

118 enrolled

Brain Neoplasms, Glioblastoma, Glioma

NCT04410133 2025-08-28

REVELATE

Phase 3 Completed

151 enrolled 29 charts

Brain Neoplasms, Disease

NCT06907043 2025-08-19

EIK1004-001

130 enrolled

Brain Neoplasms

NCT04487236 2025-08-11

Trial of ZN-A-1041 Enteric Capsules in Patients With HER2-Positive Advanced Solid Tumors

Phase 1 Completed

61 enrolled

Brain Neoplasms

NCT06727032 2025-08-03

BrainMets AI

Enrolling by invitation

12 enrolled