Clinical Trials Browser

Active not recruiting × Diffuse Intrinsic Pontine Glioma × CNS × Clear all

NCT02359565 2026-03-18

Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma

Familial ependymoma, Turcot syndrome, Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Ependymoma, Glioma, Medulloblastoma

NCT03478462 2026-03-18

CLOVER-2

Phase 1 Active not recruiting

30 enrolled

CNSGenitourinaryLymphoidSarcoma

Diffuse Intrinsic Pontine Glioma, Ependymoma, Glioblastoma, Glioma, Hodgkin Disease, Lymphoma, Lymphoma, Non-Hodgkin, Medulloblastoma, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Sarcoma, Synovial, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Gliosarcoma, Rhabdoid Tumor, Desmoplastic Small Round Cell Tumor

NCT04837547 2026-03-09

PEACH

Phase 1 Active not recruiting

24 enrolled

CNS

Diffuse Intrinsic Pontine Glioma, Neuroblastoma

NCT03033992 2026-03-05

Optune for Children With High-Grade Glioma or Ependymoma, and Optune With Radiation Therapy for Children With DIPG

Phase NA Active not recruiting

80 enrolled

CNS

Diffuse Intrinsic Pontine Glioma, Ependymoma, Glioma

NCT04978727 2026-03-05

A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma

Phase 1 Active not recruiting

35 enrolled

CNS

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Ependymoma, Glioblastoma, Medulloblastoma, Oligodendroglioma

NCT04049669 2026-01-08

Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG

Phase 2 Active not recruiting

130 enrolled

CNS

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Ependymoma, Glioblastoma, Medulloblastoma

NCT05768880 2025-11-20

Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors

Phase 1 Active not recruiting

72 enrolled

CNS

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Recurrence, Central Nervous System Neoplasms

NCT06521567 2025-11-12

A Study of Cobolimab Plus Dostarlimab in Pediatric and Young Adult Participants With Cancer

Phase 1/2 Active not recruiting

83 enrolled

CNSDermatologicGastrointestinalLymphoidSarcoma

Fibrolamellar hepatocellular carcinoma, Diffuse Intrinsic Pontine Glioma, Ependymoma, Glioblastoma, Carcinoma, Hepatocellular, Hodgkin Disease, Melanoma, Rhabdomyosarcoma, Osteosarcoma, Hepatoblastoma

NCT03893487 2025-07-11

PNOC016

Phase EARLY_PHASE1 Active not recruiting

30 enrolled

CNS

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Glioblastoma, Glioma, Medulloblastoma

NCT03605550 2025-02-24

A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma

Phase 1 Active not recruiting

64 enrolled

CNS

Diffuse Intrinsic Pontine Glioma, Glioma

NCT03709680 2025-01-14

Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors

Phase 2 Active not recruiting

128 enrolled

CNSSarcoma

Diffuse Intrinsic Pontine Glioma, Bone Neoplasms, Medulloblastoma, Neoplasms, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Rhabdoid Tumor

NCT04758533 2024-12-27

AloCELYVIR

Phase 1/2 Active not recruiting

13 enrolled

CNS

Diffuse Intrinsic Pontine Glioma, Medulloblastoma, Recurrence

NCT04911621 2024-05-08

ADDICT-pedGLIO

Phase 1/2 Active not recruiting

10 enrolled

CNS

Diffuse Intrinsic Pontine Glioma, Glioma