Clinical Trials Browser

Terminated × Gliosarcoma × CNS × Clear all

NCT02942264 2026-02-23

Zotiraciclib (TG02) Plus Dose-Dense or Metronomic Temozolomide Followed by Randomized Phase II Trial of Zotiraciclib (TG02) Plus Temozolomide Versus Temozolomide Alone in Adults With Recurrent Anaplastic Astrocytoma and Glioblastoma

Phase 1/2 Terminated

53 enrolled 22 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Recurrence, Gliosarcoma

NCT03107780 2025-11-13

Testing the Ability of AMG 232 (KRT 232) to Get Into the Tumor in Patients With Brain Cancer

Phase 1 Terminated

Glioblastoma, Gliosarcoma

NCT01430351 2025-05-07

Temozolomide, Memantine Hydrochloride, Mefloquine, and Metformin Hydrochloride in Treating Patients With Glioblastoma Multiforme After Radiation Therapy

Phase 1 Terminated

Glioblastoma, Gliosarcoma

NCT01814813 2025-01-24

Vaccine Therapy With Bevacizumab Versus Bevacizumab Alone in Treating Patients With Recurrent Glioblastoma Multiforme That Can Be Removed by Surgery

Phase 2 Terminated

90 enrolled 13 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT04397679 2025-01-15

Partial Brain RT, Temozolomide, Chloroquine, and TTF Therapy for the Treatment of Newly Diagnosed Glioblastoma

Phase 1 Terminated

Glioblastoma, Gliosarcoma

NCT03973918 2024-10-31

BRAF

Phase 2 Terminated

5 enrolled 15 charts

Astrocytoma, Glioblastoma, Glioma, Gliosarcoma

NCT02133183 2024-04-04

Sapanisertib Before and After Surgery in Treating Patients With Recurrent Glioblastoma

Phase 1 Terminated

Glioblastoma, Gliosarcoma

NCT02168270 2023-11-24

Temozolomide and Ascorbic Acid in Treating Patients With Recurrent High-Grade Glioma

Phase 1 Terminated

4 enrolled 6 charts

Astrocytoma, Glioblastoma, Oligodendroglioma, Gliosarcoma

NCT01721577 2023-05-22

AXL1717

Phase 1/2 Terminated

10 enrolled 8 charts

Astrocytoma, Ependymoma, Glioblastoma, Oligodendroglioma, Gliosarcoma

NCT02664363 2023-02-17

ExCeL

Phase 1 Terminated

3 enrolled 8 charts

Glioblastoma, Gliosarcoma

NCT00014443 2023-01-09

Topotecan and Thalidomide in Treating Patients With Recurrent or Refractory Malignant Glioma

Phase 2 Terminated

Astrocytoma, Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT03641326 2022-04-19

Sunitinib in Sarcomas of the Central Nervous System

Phase 2 Terminated

5 enrolled 14 charts

Brain Neoplasms, Gliosarcoma

NCT01110876 2021-08-25

Phase I / II Vorinostat, Erlotinib and Temozolomide for Recurrent Glioblastoma Multiforme (GBM)

Phase 1/2 Terminated

21 enrolled 8 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT02743078 2021-06-02

Optune® Plus Bevacizumab in Bevacizumab-Refractory Recurrent Glioblastoma

Phase 2 Terminated

3 enrolled 10 charts

Glioblastoma, Glioma, Gliosarcoma

NCT03283631 2021-04-05

INTERCEPT

Phase 1 Terminated

Glioblastoma, Glioma, Gliosarcoma

NCT00006916 2020-10-26

Radiation Therapy Followed by Bleomycin in Treating Adult Patients With Newly Diagnosed Supratentorial Glioblastoma Multiforme

Phase 2 Terminated

19 enrolled 4 charts

Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00756106 2020-05-13

MRI Scans in Evaluating the Effects of Radiation Therapy and Chemotherapy in Patients With Newly Diagnosed Glioblastoma Multiforme or Anaplastic Glioma

Phase NA Terminated

15 enrolled 6 charts

Astrocytoma, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT03843814 2019-11-26

Pilot Study Using Amide Proton Transfer Magnetic Resonance Imaging Distinguishing Glioma

Phase NA Terminated

Glioma, Gliosarcoma

NCT00035373 2019-11-07

Eligibility Screening of Patients With Central Nervous System Tumors for the National Cancer Institute s (NCI) Clinical Research Protocols

Astrocytoma, Neoplasms, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT01582152 2019-06-05

Phase I/II Bevacizumab Versus Bevacizumab Plus TPI 287 for Recurrent Glioblastoma

Phase 1/2 Terminated

12 enrolled 7 charts

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00915694 2019-04-23

Nelfinavir Mesylate, Radiation Therapy, and Temozolomide in Treating Patients With Glioblastoma Multiforme

Phase 1 Terminated

Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT01186406 2019-02-15

Gliadel, XRT, Temodar, Avastin Followed by Avastin, Temodar for Newly Diagnosed Glioblastoma Multiforme (GBM)

Phase 2 Terminated

41 enrolled 9 charts

Glioblastoma, Glioma, Gliosarcoma

NCT00671801 2018-11-13

Irinotecan Plus Lenalidomide in Adult Patients With Recurrent Glioblastoma Multiforme: Phase I

Phase 1 Terminated

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT00734526 2018-11-09

Phase I Portion of Phase I/II Sorafenib With Radiation and Temozolomide in Newly Diagnosed Glioblastoma or Gliosarcoma

Phase 1 Terminated

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00895960 2018-11-08

Dasatinib Plus Radiation Therapy/Temozolomide in Newly-Diagnosed Glioblastoma

Phase 1 Terminated

Brain Diseases, Central Nervous System Diseases, Glioblastoma, Gliosarcoma

NCT00631137 2018-08-27

Testosterone Gel in Preventing Weakness Caused by Steroid Therapy in Men With Glioma

Phase NA Terminated

1 enrolled 2 charts

Astrocytoma, Glioblastoma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT01575275 2018-07-31

Aminolevulinic Acid in Visualizing a Tumor During Surgery in Patients With Glioblastoma Multiforme

Phase 2 Terminated

8 enrolled 7 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT01836549 2018-07-20

Imetelstat Sodium in Treating Younger Patients With Recurrent or Refractory Brain Tumors

Phase 2 Terminated

43 enrolled 14 charts

Astrocytoma, Ependymoma, Glioblastoma, Oligodendroglioma, Gliosarcoma, Brain Stem Neoplasms

NCT00052715 2018-07-18

Poly-ICLC

Phase 2 Terminated

31 enrolled 8 charts

Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00471653 2018-07-09

Pharmacokinetics in Patients With Newly Diagnosed High-Grade Glioma Receiving Temozolomide and Radiation Therapy

CNSClassical hematologySarcoma

Astrocytoma, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Thrombocytopenia, Central Nervous System Neoplasms, Gliosarcoma

NCT01086345 2018-07-03

Radiosurgery Plus Bevacizumab in Glioblastoma

Phase EARLY_PHASE1 Terminated

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT01234805 2018-07-03

Yoga Therapy in Treating Patients With Malignant Brain Tumors

Phase NA Terminated

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Oligodendroglioma, Pinealoma, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Gliosarcoma

NCT00238277 2018-06-27

Temozolomide During and After Radiation Therapy in Treating Patients Who Have Undergone Previous Surgery and Placement of Gliadel Wafers for Newly Diagnosed Glioblastoma Multiforme

Phase 2 Terminated

Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT01870726 2018-05-30

Safety and Efficacy of INC280 and Buparlisib (BKM120) in Patients With Recurrent Glioblastoma

Phase 1/2 Terminated

43 enrolled 22 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00112866 2017-06-14

Cilengitide in Treating Patients Who Are Undergoing Surgery for Recurrent or Progressive Glioblastoma Multiforme

Phase 2 Terminated

30 enrolled 10 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT01310855 2017-05-31

Cediranib Maleate With or Without Gefitinib in Treating Patients With Recurrent or Progressive Glioblastoma

Phase 2 Terminated

38 enrolled 8 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT01122901 2017-05-03

Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Recurrent or Progressive Glioblastoma

Phase 2 Terminated

47 enrolled 9 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT01996527 2017-04-17

3T MRI Biomarkers of Glioma Treatment Response

Phase EARLY_PHASE1 Terminated

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Oligodendroglioma, Gliosarcoma

NCT00436436 2017-03-28

O(6)-Benzylguanine and Temozolomide in Treating Patients With Glioblastoma Multiforme That Did Not Respond to Previous Temozolomide and Radiation Therapy

Phase 2 Terminated

12 enrolled 10 charts

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT02967380 2017-03-27

Gadobutrol Versus Gadopentetate Dimeglumine or Gadobenate Dimeglumine Before DCE-MRI in Diagnosing Patients With Multiple Sclerosis, Grade II-IV Glioma, or Brain Metastases

Phase NA Terminated

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Multiple Sclerosis, Oligodendroglioma, Pinealoma, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Gliosarcoma

NCT01148966 2017-02-15

Aminolevulinic Acid During Surgery in Treating Patients With Malignant Brain Tumors

Phase 1 Terminated

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT02394665 2017-01-05

Dose Escalated MRSI Guided Radiation Therapy in Glioblastoma

Phase 2 Terminated

1 enrolled 3 charts

Glioblastoma, Gliosarcoma

NCT01189240 2015-12-14

RO4929097and Bevacizumab in Treating Patients With Progressive or Recurrent Malignant Glioma

Phase 1/2 Terminated

13 enrolled 13 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Oligodendroglioma, Gliosarcoma

NCT01122888 2015-04-28

Cilengitide and Sunitinib Malate in Treating Patients With Advanced Solid Tumors or Glioblastoma Multiforme

Phase 1 Terminated

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00068770 2015-03-18

Celecoxib in Patients With Newly Diagnosed GBM Who Are Receiving Anticonvulsant Drugs and Undergoing RT

Phase 2 Terminated

35 enrolled 12 charts

Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT01233492 2013-10-08

Boron Phenylalanine With or Without Mannitol in Treating Patients With Glioblastoma Multiforme

Phase 1 Terminated

Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT01017653 2013-09-04

Panitumumab and Irinotecan for Malignant Gliomas

Phase 2 Terminated

16 enrolled 9 charts

Glioblastoma, Glioma, Gliosarcoma

NCT01095094 2013-06-10

Ritonavir and Lopinavir in Treating Patients With Progressive or Recurrent High-Grade Glioma

Phase 2 Terminated

19 enrolled 9 charts

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT00387894 2013-06-04

Erlotinib in Treating Patients With Recurrent Glioblastoma Multiforme or Gliosarcoma

Phase 2 Terminated

6 enrolled 10 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00735436 2013-02-11

A Study of Gliadel Followed by Avastin + Irinotecan for Glioblastoma Multiforme (GBM)

Phase 2 Terminated

18 enrolled 11 charts

Glioblastoma, Glioma, Gliosarcoma