Clinical Trials

Neuroblastoma

NCT03210714 2026-03-18

Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial)

CNSGastrointestinalGenitourinaryLymphoidMyeloid

20 enrolled 10 charts

Familial ependymoma, Ependymoma, Glioma, Histiocytosis, Langerhans-Cell, Lymphoma, Non-Hodgkin, Medulloblastoma, Wilms Tumor, Neuroblastoma, Central Nervous System Neoplasms, Hepatoblastoma, Neuroectodermal Tumors, Primitive, Peripheral, Rhabdoid Tumor

NCT03213652 2026-03-18

Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With ALK or ROS1 Genomic Alterations (A Pediatric MATCH Treatment Trial)

CNSGastrointestinalGenitourinaryLymphoidMyeloidSarcoma

13 enrolled

Ependymoma, Glioma, Histiocytosis, Langerhans-Cell, Lymphoma, Non-Hodgkin, Medulloblastoma, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Osteosarcoma, Central Nervous System Neoplasms, Hepatoblastoma, Neuroectodermal Tumors, Primitive, Peripheral, Rhabdoid Tumor

NCT03478462 2026-03-18

CLOVER-2

Phase 1 Active not recruiting

30 enrolled

CNSGenitourinaryLymphoidSarcoma

Diffuse Intrinsic Pontine Glioma, Ependymoma, Glioblastoma, Glioma, Hodgkin Disease, Lymphoma, Lymphoma, Non-Hodgkin, Medulloblastoma, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Sarcoma, Synovial, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Gliosarcoma, Rhabdoid Tumor, Desmoplastic Small Round Cell Tumor

NCT07437963 2026-03-18

Testing the Addition of Iberdomide to Therapy in People With Neuroblastoma That Has Come Back, Not Responded to Treatment, or Gotten Worse

Phase 1/2 Not yet recruiting

76 enrolled

Neuroblastoma, Ganglioneuroblastoma

NCT00107289 2026-03-13

Iodine I 131 Metaiodobenzylguanidine in Treating Patients With Recurrent, Progressive, or Refractory Neuroblastoma or Malignant Pheochromocytoma or Paraganglioma

200 enrolled

CNSEndocrine

Neuroblastoma, Pheochromocytoma

NCT01804634 2026-03-13

Reduced Intensity Haploidentical BMT for High Risk Solid Tumors

CNSGastrointestinalSarcoma

60 enrolled

Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma

NCT04936529 2026-03-13

A Study of a Vaccine in Combination With β-glucan and GM-CSF in People With Neuroblastoma

286 enrolled

CNSGenitourinaryOther solid neoplasmSarcoma

Neuroblastoma

NCT01109394 2026-03-11

Comprehensive Omics Analysis of Pediatric and Adult Solid Tumors and Establishment of a Repository for Related Biological Studies

Recruiting

6,035 enrolled

Kidney Neoplasms, Neoplasms, Neuroblastoma, Retinoblastoma, Sarcoma

NCT06395103 2026-03-11

MK-9999-01A

90 enrolled

CNSLymphoidSarcoma

Burkitt Lymphoma, Neuroblastoma, Sarcoma, Ewing, Lymphoma, Large B-Cell, Diffuse

NCT06625190 2026-03-11

Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors

27 enrolled

Chordoma, Myoepithelioma, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Sarcoma, Synovial, Sarcoma, Clear Cell, Sarcoma, Alveolar Soft Part, Nerve Sheath Neoplasms, Rhabdoid Tumor, Desmoplastic Small Round Cell Tumor

NCT02780128 2026-03-10

NEPENTHE

Phase 1 Terminated

66 enrolled

Phase 1 Active not recruiting

Neoplasms, Neuroblastoma

NCT04837547 2026-03-09

PEACH

24 enrolled

Diffuse Intrinsic Pontine Glioma, Neuroblastoma

NCT06057948 2026-03-06

A Study of a Vaccine in Combination With Beta-glucan in People With Neuroblastoma

94 enrolled

Neuroblastoma

NCT00026312 2026-03-05

Isotretinoin With or Without Dinutuximab, Aldesleukin, and Sargramostim Following Stem Cell Transplant in Treating Patients With Neuroblastoma

Phase 3 Completed

1,449 enrolled 17 charts

CNSDermatologicEndocrineHead & NeckOther solid neoplasmSarcomaThoracic

Neuroblastoma

NCT05199584 2026-03-05

A Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function Mutations

Phase 2 Completed

20 enrolled

Uveal Melanoma, Glioma, Adenoma, Islet Cell, Laryngeal Diseases, Medulloblastoma, Melanoma, Mesothelioma, Neuroblastoma, Pituitary Diseases, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Osteosarcoma

NCT02574728 2026-03-02

AflacST1502

46 enrolled

CNSMyeloidSarcoma

Brain Neoplasms, Carcinoma, Ependymoma, Histiocytosis, Langerhans-Cell, Medulloblastoma, Neoplasms, Neoplasms, Germ Cell and Embryonal, Neuroblastoma, Pinealoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Rhabdoid Tumor

NCT04238819 2026-03-02

A Study of Abemaciclib (LY2835219) in Combination With Other Anti-Cancer Treatments in Children and Young Adult Participants With Solid Tumors, Including Neuroblastoma

Phase 1/2 Completed

47 enrolled 36 charts

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Rhabdoid Tumor

NCT06540963 2026-03-02

Tipifarnib and Naxitamab for Relapsed/Refractory Neuroblastoma

98 enrolled

Neuroblastoma

NCT06541262 2026-03-02

Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors

104 enrolled

Liposarcoma, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma

NCT03126916 2026-02-27

Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

Phase 3 Recruiting

750 enrolled

Neuroblastoma, Ganglioneuroblastoma

NCT06104488 2026-02-25

A Study of Avutometinib for People With Solid Tumor Cancers

Phase 1 Recruiting

23 enrolled

Brain Neoplasms, Neoplasms, Neuroblastoma, Central Nervous System Neoplasms, Neurofibroma, Plexiform

NCT04851119 2026-02-24

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

CNSDermatologicGastrointestinalGenitourinaryGynecologicLymphoidSarcoma

147 enrolled

Carcinoma, Hepatocellular, Lymphoma, Non-Hodgkin, Melanoma, Wilms Tumor, Neuroblastoma, Ovarian Neoplasms, Sarcoma, Ewing, Osteosarcoma, Colorectal Neoplasms, Endometrial Neoplasms, Hepatoblastoma, Desmoid Tumors

NCT02559778 2026-02-20

PEDS-PLAN

500 enrolled

Neuroblastoma

NCT03581240 2026-02-20

An Intermediate Expanded Use Trial of DFMO

Available

Typical Teratoid Rhabdoid Tumor, Medulloblastoma, Neuroblastoma, Neuroectodermal Tumors, Primitive

NCT03363373 2026-02-19

Naxitamab for High-Risk Neuroblastoma Patients With Primary Refractory Disease or Incomplete Response to Salvage Treatment in Bone and/or Bone Marrow

122 enrolled 2 FDA

Neuroblastoma

NCT03794349 2026-02-18

Irinotecan Hydrochloride, Temozolomide, and Dinutuximab With or Without Eflornithine in Treating Patients With Relapsed or Refractory Neuroblastoma

94 enrolled 14 charts

Neuroblastoma

NCT06995872 2026-02-17

Phase I Trial of rhIL-15 Plus Dinutuximab Plus Irinotecan/Temozolomide for Children and Young Adults With Relapsed/Refractory Neuroblastoma

Phase 1 Recruiting

34 enrolled

Phase 4 Active not recruiting

Neuroblastoma

NCT03975829 2026-02-13

Pediatric Long-Term Follow-up and Rollover Study

163 enrolled

CNSMyeloid

Astrocytoma, Ganglioneuroma, Glioblastoma, Glioma, Histiocytosis, Langerhans-Cell, Neuroblastoma, Neurofibromatosis 1, Oligodendroglioma, Ganglioglioma, Neurocytoma, Neurofibroma, Plexiform

NCT02909777 2026-02-11

Trial of CUDC-907 in Children and Young Adults With Relapsed or Refractory Solid Tumors, CNS Tumors, or Lymphoma

Phase 1 Completed

26 enrolled

CNSLymphoid

Brain Neoplasms, Lymphoma, Neuroblastoma

NCT03155620 2026-02-10

Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

CNSGastrointestinalGenitourinaryLymphoidMyeloidSarcoma

1,376 enrolled

Ependymoma, Glioma, Histiocytosis, Langerhans-Cell, Lymphoma, Non-Hodgkin, Medulloblastoma, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Xanthogranuloma, Juvenile, Central Nervous System Neoplasms, Hepatoblastoma, Neuroectodermal Tumors, Primitive, Peripheral, Rhabdoid Tumor, Histiocytic Sarcoma

NCT06528496 2026-02-10

N10: A Study of Reduced Chemotherapy and Monoclonal Antibody (mAb)-Based Therapy in Children With Neuroblastoma

45 enrolled

Neuroblastoma

NCT06831552 2026-02-10

RISE in HR NBL

Phase NA Recruiting

84 enrolled

Neuroblastoma

NCT07399821 2026-02-10

GLOW-FISH

22 enrolled

BreastCNSClassical hematologyDermatologicEndocrineGastrointestinalGynecologicLymphoidOther solid neoplasmSarcoma

Neuroblastoma

NCT03050268 2026-02-09

SJFAMILY

Recruiting

1,500 enrolled

Turcot syndrome, Juvenile polyposis syndrome, Choroid Plexus Carcinoma, GATA2 Deficiency, Basal Cell Nevus Syndrome, Colorectal Neoplasms, Hereditary Nonpolyposis, Fanconi Anemia, Hamartoma Syndrome, Multiple, von Hippel-Lindau Disease, Hodgkin Disease, Lymphoma, Non-Hodgkin, Melanoma, Neuroblastoma, Neurofibromatosis 1, Noonan Syndrome, Pancreatic Neoplasms, Paraganglioma, Peutz-Jeghers Syndrome, Pheochromocytoma, Rothmund-Thomson Syndrome, Adenomatous Polyposis Coli, Retinoblastoma, Rhabdomyosarcoma, Tuberous Sclerosis, Neurofibromatosis 2, Li-Fraumeni Syndrome, Adrenocortical Carcinoma, Multiple Endocrine Neoplasia Type 1, Multiple Endocrine Neoplasia Type 2a, Dyskeratosis Congenita, Genetic Predisposition to Disease, Anemia, Diamond-Blackfan, Carney Complex, Hereditary Breast and Ovarian Cancer Syndrome

NCT04706910 2026-02-09

18F-DOPA II - PET Imaging Optimization

Phase 3 Recruiting

800 enrolled

CNSEndocrineNET

Brain Neoplasms, Neuroblastoma, Parkinson Disease, Neuroendocrine Tumors, Lewy Body Disease, Congenital Hyperinsulinism

NCT04901702 2026-02-09

Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma

CNSGastrointestinalGenitourinarySarcoma

90 enrolled

Neoplasms, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma, Neuroectodermal Tumors, Primitive, Peripheral, Rhabdoid Tumor

NCT05642455 2026-02-09

SPEARHEAD-3 Pediatric Study

20 enrolled

CNSDermatologicGastrointestinalGenitourinaryLymphoidSarcoma

Neuroblastoma, Osteosarcoma, Sarcoma, Synovial, Neurofibrosarcoma

NCT01625351 2026-02-06

A Study of CD45RA+ Depleted Haploidentical Stem Cell Transplantation in Children With Relapsed or Refractory Solid Tumors and Lymphomas

Phase 1 Completed

23 enrolled

Carcinoma, Renal Cell, Digestive System Neoplasms, Carcinoma, Hepatocellular, Lymphoma, Melanoma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Adenocarcinoma, Clear Cell, Rhabdoid Tumor

NCT07211737 2026-02-06

NKG2D.Zeta-NK Cell Conditioning With C7R.GD2.CAR-T Cells for Patients With Relapsed or Refractory Osteosarcoma or Neuroblastoma

Phase 1 Not yet recruiting

27 enrolled

Neuroblastoma, Osteosarcoma

NCT05027386 2026-02-05

Apatinib Mesylate Combined With IT Regimen for the Treatment of Recurrent or Refractory Pediatric Neuroblastoma: A Single-arm, Phase I/II，Multi-center, Clinical Study.

125 enrolled

Neuroblastoma

NCT04301843 2026-02-03

Eflornithine (DFMO) and Etoposide for Relapsed/Refractory Neuroblastoma

131 enrolled

Neuroblastoma

NCT05489887 2026-02-03

Naxitamab Added to Induction for Newly Diagnosed High-Risk Neuroblastoma

93 enrolled

Neuroblastoma

NCT04195555 2026-01-29

Ivosidenib in Treating Patients With Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With IDH1 Mutations (A Pediatric MATCH Treatment Trial)