Clinical Trials

Phase 1 Active not recruiting

41 enrolled

CNSSarcoma

Neurofibromatosis 1, Sarcoma, Neurofibrosarcoma

NCT04590235 2026-01-30

A Study of Selumetinib in Chinese Paediatric and Adult Subjects With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas (PN)

32 enrolled

Phase 1 Active not recruiting

Neurofibromatosis 1, Neurofibroma, Plexiform

NCT05363267 2026-01-13

NF-1, Nutraceutical Intervention

23 enrolled

Phase 3 Active not recruiting

Neurofibromatosis 1

NCT04924608 2026-01-12

KOMET

145 enrolled 17 charts 1 FDA

Neurofibromatosis 1, Neurofibroma, Plexiform

NCT03406208 2025-12-24

Resiliency Training for Adults With Neurofibromatosis Via Live Videoconferencing

228 enrolled

Phase 1/2 Active not recruiting

Schwannomatosis, Behavior, Neurofibromatosis 1, Neurofibromatosis 2, Neurofibromatoses

NCT05309668 2025-12-18

SPRINKLE

36 enrolled 37 charts

Neurofibromatosis 1

NCT06961565 2025-12-04

PAS-004 in Adults Who Have Neurofibromatosis Type 1 With Plexiform Neurofibromas

Phase 1 Recruiting

56 enrolled

Neurofibromatosis 1, Neurofibromatoses, Neurofibroma, Plexiform

NCT06132165 2025-11-21

Efficacy of Skin Cooling in Reducing Pain Associated With Non-invasive Treatments of Neurofibromatosis Type 1 Cutaneous Neurofibromas

13 enrolled

Neurofibromatosis 1

NCT06541847 2025-11-21

INSPIRE-NF1

Phase 2 Recruiting

25 enrolled

Phase 1 Enrolling by invitation

Neurofibromatosis 1, Neurofibroma, Plexiform

NCT06300502 2025-11-20

Assessing the Efficacy of Repeat, Monthly Treatments of Deoxycholate for NF1 Associated Cutaneous Neurofibromas (cNFs)

15 enrolled

Neurofibroma, Neurofibromatosis 1

NCT06262113 2025-10-03

A Decentralized Clinical Trial to Promote Evidence-Based Care for Underserved Patients With Neurofibromatosis 1

Phase NA Recruiting

294 enrolled

Neurofibromatosis 1, Neurofibromatoses

NCT04763109 2025-09-09

Identification of Pre-Malignant Lesions In Pediatric Patients With Neurofibromatosis Type 1 Using Novel Magnetic Resonance Imaging Techniques Paired With Artificial Intelligence

Phase NA Recruiting

15 enrolled

Phase 2 Active not recruiting

Neurofibromatosis 1

NCT03962543 2025-08-07

ReNeu

114 enrolled 25 charts 1 FDA

Neurofibroma, Neurofibromatosis 1, Neurofibromatoses, Neurofibroma, Plexiform

NCT04481035 2025-07-31

NF1NAC

Phase 2 Completed

5 enrolled 10 charts

CNSClassical hematologyLymphoidOther hematologic neoplasm

Neurofibromatosis 1

NCT05735717 2025-07-24

MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies

Phase 2 Recruiting

70 enrolled

Chromosome 7, monosomy, Anemia, Refractory, with Excess of Blasts, Chromosome Aberrations, Influenza, Human, Neurofibromatosis 1, Leukemia, Myeloid, Acute, beta-Thalassemia, Neoplasm, Residual, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myelomonocytic, Juvenile

NCT07077408 2025-07-22

iCanCope With NF: Innovating an Efficacious Digital Self-management and Transitional Care Program for Adolescents With Neurofibromatosis

Phase NA Not yet recruiting

60 enrolled

Neurofibromatosis 1

NCT00624234 2025-07-08

Neurobiology and Treatment of Reading Disability in NF-1

184 enrolled 10 charts

Phase 1/2 Not yet recruiting

Dyslexia, Learning Disabilities, Neurofibromatosis 1

NCT06735820 2025-07-03

MEKMDM2

45 enrolled

CNSSarcoma

Neurofibromatosis 1, Neurofibrosarcoma

NCT02964884 2025-06-24

Interventions for Reading Disabilities in NF1

Phase 2 Active not recruiting

120 enrolled

Phase 1/2 Not yet recruiting

Dyslexia, Learning Disabilities, Neurofibromatosis 1

NCT07024394 2025-06-17

Follow-up Study to Evaluate the Safety and Efficacy of FCN-159 in Pediatric Participants With Neurofibromatosis Type 1

65 enrolled

Neurofibromatosis 1, Neurofibroma, Plexiform

NCT02728388 2025-05-08

Photodynamic Therapy for Benign Dermal Neurofibromas- Phase II

Phase 2 Recruiting

30 enrolled

Neurofibroma, Neurofibromatosis 1

NCT03231306 2025-05-02

NF108-BINI

Phase 2 Completed

45 enrolled 8 charts

Neurofibroma, Neurofibromatosis 1, Peripheral Nervous System Neoplasms, Neurofibromatoses, Neurofibroma, Plexiform

NCT04561765 2025-03-30

Innovation in the Treatment of Persistent Pain in Adults With NF1: Implementation of the iCanCope Mobile Application- Clinical Trial

122 enrolled 21 charts

Neurofibromatosis 1, Chronic Pain

NCT05196854 2025-02-24

Clinical Hypnosis and Home Blood Pressure Monitoring in Children With Neurofibromatosis Type 1

54 enrolled

Hypertension, Neurofibromatosis 1, Neurofibromatoses

NCT04730583 2025-02-21

Tolerability of Device Based Therapies for Neurofibromatosis Type 1 Cutaneous Neurofibromas

34 enrolled

Neurofibromatosis 1

NCT06120036 2025-02-21

Dosing and Tolerability of Deoxycholic Acid vs. Polidocanol in the Treatment of Neurofibromatosis Type 1 Cutaneous Neurofibromas

20 enrolled

Neurofibromatosis 1

NCT06763315 2025-01-08

LS-NF1PNs

50 enrolled

Neurofibromatosis 1, Neurofibroma, Plexiform

NCT01553149 2025-01-07

Low-Dose or High-Dose Lenalidomide in Treating Younger Patients With Recurrent, Refractory, or Progressive Pilocytic Astrocytoma or Optic Pathway Glioma

Phase 2 Completed

75 enrolled 17 charts

Phase 1/2 Active not recruiting

Astrocytoma, Neurofibromatosis 1, Optic Nerve Glioma

NCT04954001 2024-11-12

Study to Evaluate the Safety, Tolerability, PK Characteristics and Anti-tumor Activity of FCN-159 in Adult and Pediatric Participants With Neurofibromatosis Type 1

160 enrolled

CNSOther hematologic neoplasm

Neurofibromatosis 1, Neurofibroma, Plexiform

NCT05849662 2024-11-12

A Phase I/II Study of Trametinib and Azacitidine for Patients With Newly Diagnosed Juvenile Myelomonocytic Leukemia

Phase 1/2 Recruiting

58 enrolled

Neurofibromatosis 1, Leukemia, Myelomonocytic, Juvenile

NCT04800822 2024-10-22

PF-07284892 in Participants With Advanced Solid Tumors

Phase 1 Terminated

53 enrolled

CNSGastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Neurofibromatosis 1, Hereditary Sensory and Autonomic Neuropathies, Colorectal Neoplasms

NCT04481048 2024-10-09

DoDNAC

Phase 2 Active not recruiting

58 enrolled

Neurofibromatosis 1

NCT06620354 2024-10-01

Clinical Study on the Treatment of Type I Neurofibromatosis With Smeitinib Hydrosulfate Capsule

33 enrolled

Neurofibromatosis 1

NCT06621082 2024-10-01

The Clinical Study of the Treatment of Patients With Type I Neurofibromatosis With Smetinib Hydrosulfate Capsule

19 enrolled

Neurofibromatosis 1

NCT02700230 2024-09-27

Vaccine Therapy in Treating Patients with Malignant Peripheral Nerve Sheath Tumor That is Recurrent or Cannot Be Removed by Surgery

9 enrolled

CNSSarcoma

Neurofibromatosis 1, Neurofibrosarcoma

NCT05438290 2024-05-06

DPCP to Treat Cutaneous Neurofibromas Associated With NF1

17 enrolled