Clinical Trials

29 enrolled

Phase 1/2 Active not recruiting

Glioma, Recurrence, Central Nervous System Neoplasms

NCT02650401 2025-12-24

STARTRK-NG

69 enrolled 1 FDA

CNSEndocrineGenitourinaryHead & NeckSarcoma

Thyroid Cancer, Papillary, Brain Neoplasms, Glioma, Medulloblastoma, Neoplasm Metastasis, Wilms Tumor, Neuroblastoma, Recurrence, Salivary Gland Neoplasms, Sarcoma, Sarcoma, Ewing, Central Nervous System Neoplasms, Nephroma, Mesoblastic

NCT05429502 2025-10-10

Study of Efficacy and Safety of Ribociclib (LEE011) in Combination With Topotecan and Temozolomide (TOTEM) in Pediatric Patients With Relapsed or Refractory Neuroblastoma and Other Solid Tumors

Phase 1 Terminated

12 enrolled

CNSGastrointestinalSarcoma

Glioma, Medulloblastoma, Neuroblastoma, Recurrence, Rhabdomyosarcoma

NCT04337177 2025-09-23

Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors

Phase 1 Recruiting

20 enrolled

Medulloblastoma, Neuroblastoma, Recurrence, Rhabdomyosarcoma, Sarcoma, Ewing, Hepatoblastoma

NCT02986178 2025-07-11

Lerapolturev in Recurrent Malignant Glioma

121 enrolled 15 charts

Brain Neoplasms, Glioblastoma, Glioma, Recurrence

NCT02766699 2025-06-03

CerebralEDV

9 enrolled

Brain Neoplasms, Glioblastoma, Neoplasms, Neoplasms by Site, Recurrence, Disease Progression

NCT05900908 2025-04-10

PATHWAyS

Phase 4 Withdrawn

Glioblastoma, Neoplasm Metastasis, Neoplasms, Recurrence

NCT06674265 2025-04-09

Safety and Efficacy of Systemic Allogenic NK Cells in R/R Neuroblastoma

Phase 1 Recruiting

10 enrolled

Neuroblastoma, Recurrence

NCT03690869 2025-04-08

REGN2810 in Pediatric Patients With Relapsed, Refractory Solid, or Central Nervous System (CNS) Tumors and Safety and Efficacy of REGN2810 in Combination With Radiotherapy in Pediatric Patients With Newly Diagnosed or Recurrent Glioma

57 enrolled 31 charts

Diffuse Intrinsic Pontine Glioma, Glioma, Recurrence, Central Nervous System Neoplasms

NCT04908176 2024-12-13

A Drug-drug Interaction Study of Avapritinib and Midazolam

CNSGastrointestinalSarcoma

10 enrolled

Glioblastoma, Neoplasms, Recurrence, Gastrointestinal Stromal Tumors

NCT05592743 2024-11-05

Vorasidenib Expanded Access Program

Approved for marketing

Astrocytoma, Glioma, Neoplasms, Neoplasms by Histologic Type, Neoplasms, Germ Cell and Embryonal, Neoplasms, Glandular and Epithelial, Neoplasms, Nerve Tissue, Oligodendroglioma, Pathologic Processes, Recurrence, Neuroectodermal Tumors, Neoplasms, Neuroepithelial, Disease Attributes

NCT04047303 2024-07-05

CNS Penetration, PK and PD of Preoperative CC-90010 in Progressive/Recurrent Diffuse Astrocytoma, Anaplastic Astrocytoma and Glioblastoma

Phase 1 Terminated

20 enrolled

Astrocytoma, Glioblastoma, Recurrence

NCT03458728 2023-12-04

Safety, Tolerability, Efficacy and Pharmacokinetics of Copanlisib in Pediatric Patients

31 enrolled 17 charts

CNSLymphoidSarcoma

Lymphoma, Neuroblastoma, Recurrence, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma

NCT03245151 2023-08-30

Study of Lenvatinib in Combination With Everolimus in Recurrent and Refractory Pediatric Solid Tumors, Including Central Nervous System Tumors

64 enrolled 29 charts

Glioma, Recurrence, Rhabdomyosarcoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral

NCT03236857 2023-05-22

A Study of the Safety and Pharmacokinetics of Venetoclax in Pediatric and Young Adult Patients With Relapsed or Refractory Malignancies

CNSLymphoidOther hematologic neoplasm

143 enrolled

Lymphoma, Non-Hodgkin, Neoplasms, Neuroblastoma, Recurrence, Leukemia, Myeloid, Acute, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT04730349 2023-03-24

PIVOT IO 020

CNSDermatologicLymphoidOther hematologic neoplasmSarcoma

15 enrolled 14 charts

Ependymoma, Glioma, Leukemia, Lymphoma, Lymphoma, Non-Hodgkin, Medulloblastoma, Melanoma, Neoplasms, Neuroblastoma, Recurrence, Rhabdomyosarcoma, Sarcoma, Ewing, Leukemia, B-Cell

NCT00479765 2022-06-22

A Phase 1 / 2 Dose Escalation Study of Locally-Administered OncoGel™ in Subjects With Recurrent Glioma

4 enrolled 5 charts

Brain Neoplasms, Glioblastoma, Glioma, Neoplasms, Recurrence

NCT02564198 2021-08-17

A Study of Ramucirumab (LY3009806) in Children With Refractory Solid Tumors

29 enrolled 12 charts

Neoplasms, Recurrence, Central Nervous System Neoplasms

NCT02765165 2021-07-23

Phase 1/2 Study of USL311 +/- Lomustine in Advanced Solid Tumors or Relapsed/Recurrent Glioblastoma Multiforme (GBM)

26 enrolled 20 charts

Brain Neoplasms, Glioblastoma, Neoplasms, Recurrence

NCT02748135 2021-01-13

A Study of TB-403 in Pediatric Subjects With Relapsed or Refractory Medulloblastoma

18 enrolled

Medulloblastoma, Neuroblastoma, Recurrence, Sarcoma, Ewing, Rhabdomyosarcoma, Alveolar

NCT01967810 2020-02-25

ANG1005 in Patients With Recurrent High-Grade Glioma

73 enrolled

Brain Neoplasms, Glioblastoma, Glioma, Recurrence

NCT01498328 2020-02-17

ReACT

127 enrolled

Brain Neoplasms, Glioblastoma, Neoplasms, Recurrence, Gliosarcoma

NCT02414165 2020-02-07

Toca5

Phase 2/3 Terminated

403 enrolled

Astrocytoma, Glioblastoma, Recurrence

NCT01708174 2017-08-11

A Phase II Study of Oral LDE225 in Patients With Hedge-Hog (Hh)-Pathway Activated Relapsed Medulloblastoma (MB)

22 enrolled 12 charts

Medulloblastoma, Recurrence

NCT02919046 2017-03-14

Study Evaluating the Efficacy and Safety With CAR-T for Relapsed or Refractory Neuroblastoma in Children

Phase NA Unknown

22 enrolled

Neuroblastoma, Recurrence

NCT02060955 2016-06-06

Randomized Phase 2 Study to Investigate Efficacy of ALECSAT in Patients With GBM Measured Compared to Avastin/Irinotecan

Phase 2 Terminated

25 enrolled

Glioblastoma, Recurrence

NCT01756729 2016-03-02

Post-approval Study of NovoTTF-100A in Recurrent GBM Patients

Phase 4 Terminated

13 enrolled

Brain Neoplasms, Glioblastoma, Recurrence

NCT00116376 2015-11-10

Study of AEE788 in Patients With Recurrent/Relapse Glioblastoma Multiforme (GBM)

64 enrolled

Glioblastoma, Recurrence

NCT00024570 2014-11-14

Interstitial Infusion of IL13-PE38QQR Cytotoxin in Recurrent Malignant Glioma

60 enrolled

Astrocytoma, Glioblastoma, Glioma, Recurrence

NCT00378235 2014-11-13

Phase I/II Trial of Intracerebral IL13-PE38QQR Infusions in Pediatric Patients With Recurrent Malignant Glioma

Phase 1/2 Withdrawn

Glioma, Recurrence

NCT00539344 2014-07-31

A Phase 1, Open-Label, Dose Escalation Study of ANG1005 in Patients With Malignant Glioma

63 enrolled

Astrocytoma, Glioblastoma, Oligodendroglioma, Recurrence

NCT00004212 2012-05-16

DX-8951f in Treating Children With Advanced Solid Tumors or Lymphomas

CNSLymphoidSarcoma

Familial ependymoma, Astrocytoma, Burkitt Lymphoma, Lymphoma, Medulloblastoma, Oligodendroglioma, Recurrence, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Optic Nerve Glioma, Dendritic Cell Sarcoma, Interdigitating

NCT00379470 2012-05-01

Effect of NovoTTF-100A in Recurrent Glioblastoma Multiforme (GBM)

Phase 3 Completed

236 enrolled

Brain Neoplasms, Glioblastoma, Recurrence

NCT00024557 2011-06-06

Histologic Effect/Safety of Pre/Post-Operative IL13-PE38QQR in Recurrent Resectable Supratentorial Malignant Glioma Patients

40 enrolled

Astrocytoma, Glioblastoma, Glioma, Recurrence

NCT00635557 2011-03-25

Phase 1 Study of MPC-6827 and Carboplatin in Recurrent/Relapsed Glioblastoma Multiforme

Phase 1/2 Unknown

30 enrolled

Glioblastoma, Recurrence

NCT00120939 2009-04-03

Study of Motexafin Gadolinium and Docetaxel for Advanced Cancer