Clinical Trials

19 enrolled 10 charts

Phase 2 Active not recruiting

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma

NCT04711135 2026-02-12

NETTER-P

11 enrolled 14 charts 1 FDA

CNSEndocrineGastrointestinalNET

Gastro-enteropancreatic neuroendocrine tumor, Paraganglioma, Pheochromocytoma

NCT04739761 2026-02-11

DESTINY-B12

Phase 3 Active not recruiting

506 enrolled 27 charts

BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT04187404 2026-01-30

Spencer

70 enrolled 20 charts

CNSEndocrine

Paraganglioma, Pheochromocytoma, Adrenocortical Carcinoma

NCT06057168 2026-01-29

GDX-44-016

138 enrolled 7 charts

Phase 1/2 Active not recruiting

Brain Neoplasms

NCT04544995 2026-01-21

Dose Escalation and Cohort Expansion Study of Niraparib and Dostarlimab in Paediatric Participants With Solid Tumors (SCOOP)

Phase 1 Terminated

47 enrolled 43 charts

CNSSarcoma

Neoplasms, Neuroblastoma, Osteosarcoma

NCT02586857 2026-01-12

A Phase 1b/2, Multicenter, Open-label Study of ACP-196 in Subjects With Recurrent Glioblastoma Multiforme (GBM)

24 enrolled 10 charts

CNSLymphoidOther hematologic neoplasm

Glioblastoma, Leukemia, Lymphocytic, Chronic, B-Cell

NCT04924608 2026-01-12

KOMET

Phase 3 Active not recruiting

145 enrolled 17 charts 1 FDA

Phase 1/2 Active not recruiting

Neurofibromatosis 1, Neurofibroma, Plexiform

NCT03899792 2026-01-06

LIBRETTO-121

36 enrolled 13 charts 2 FDA

BreastCNSEndocrineGastrointestinalHead & NeckSarcomaThoracic

Thyroid Cancer, Papillary, Breast Neoplasms, Bronchial Neoplasms, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Endocrine System Diseases, Endocrine Gland Neoplasms, Head and Neck Neoplasms, Lung Diseases, Lung Neoplasms, Neoplasms, Neoplasms by Site, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Sarcoma, Thoracic Neoplasms, Thyroid Diseases, Thyroid Neoplasms, Central Nervous System Neoplasms, Myofibromatosis, Carcinoma, Medullary

NCT05267106 2025-12-30

FIGHT-209

83 enrolled 18 charts

Phase 1/2 Active not recruiting

Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms

NCT05309668 2025-12-18

SPRINKLE

36 enrolled 37 charts

Neurofibromatosis 1

NCT06098248 2025-12-15

cCeLLExvivo

Phase NA Terminated

285 enrolled 5 charts

Brain Neoplasms

NCT03797326 2025-11-17

LEAP-005

BreastCNSGastrointestinalGynecologic

611 enrolled 27 charts

Parkinson Disease 4, Autosomal Dominant Lewy Body, Biliary Tract Neoplasms, Glioblastoma, Ovarian Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Triple Negative Breast Neoplasms

NCT04543188 2025-10-23

A FIH Study of PF-07284890 in Participants With BRAF V600 Mutant Solid Tumors With and Without Brain Involvement

Phase 1 Terminated

65 enrolled 52 charts

CNSDermatologicThoracic

Brain Diseases, Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Neoplasms, Central Nervous System Neoplasms

NCT02711137 2025-10-21

Open-Label Safety and Tolerability Study of INCB057643 in Subjects With Advanced Malignancies

BreastCNSGastrointestinalGenitourinaryGynecologicLymphoidMyeloidOther hematologic neoplasmPlasma cellThoracic

137 enrolled 31 charts

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Glioblastoma, Leukemia, Lymphoma, Lymphoma, Non-Hodgkin, Multiple Myeloma, Myelodysplastic Syndromes, Myeloproliferative Disorders, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Colorectal Neoplasms, Lymphoma, Large B-Cell, Diffuse, Primary Myelofibrosis

NCT00807027 2025-10-10

Clinical Trial to Assess the Efficacy and Safety of 'Immuncell-LC' With Temozolomide in Newly Diagnosed Glioblastoma of Korea

180 enrolled 8 charts

Glioblastoma

NCT04985604 2025-10-02

Tovorafenib (DAY101) Monotherapy for Patients With Melanoma and Other Solid Tumors

CNSDermatologicEndocrineGastrointestinalGenitourinaryHead & NeckThoracic

23 enrolled 15 charts

Thyroid Cancer, Papillary, Astrocytoma, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Pancreatic Neoplasms, Colorectal Neoplasms

NCT03679754 2025-08-28

Evaluation of Ad-RTS-hIL-12 + Veledimex in Subjects With Recurrent or Progressive Glioblastoma, a Substudy to ATI001-102

36 enrolled 21 charts

Glioblastoma

NCT04410133 2025-08-28

REVELATE

151 enrolled 29 charts

Brain Neoplasms, Disease

NCT02327078 2025-08-14

A Study of the Safety, Tolerability, and Efficacy of Epacadostat Administered in Combination With Nivolumab in Select Advanced Cancers (ECHO-204)

CNSDermatologicGastrointestinalGynecologicHead & NeckLymphoidThoracic

307 enrolled 27 charts

Glioblastoma, Head and Neck Neoplasms, Lung Neoplasms, Lymphoma, Melanoma, Ovarian Neoplasms, Colorectal Neoplasms

NCT03330197 2025-08-12

A Study of Ad-RTS-hIL-12 + Veledimex in Pediatric Subjects With Brain Tumors Including DIPG

6 enrolled 14 charts

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Glioblastoma, Glioma

NCT03636477 2025-08-12

A Study of Ad-RTS-hIL-12 With Veledimex in Combination With Nivolumab in Subjects With Glioblastoma; a Substudy to ATI001-102

21 enrolled 36 charts

Phase 2 Active not recruiting

Glioblastoma

NCT03962543 2025-08-07

ReNeu

114 enrolled 25 charts 1 FDA

Neurofibroma, Neurofibromatosis 1, Neurofibromatoses, Neurofibroma, Plexiform

NCT03295396 2025-07-28

ONC201 in Adults With Recurrent H3 K27M-mutant Glioma

73 enrolled 13 charts 1 FDA

Glioma

NCT04410367 2025-07-20

PURSUE

23 enrolled 10 charts

Brain Neoplasms, Disease

NCT02986178 2025-07-11

Lerapolturev in Recurrent Malignant Glioma

121 enrolled 15 charts

Brain Neoplasms, Glioblastoma, Glioma, Recurrence

NCT02667587 2025-06-18

CheckMate548

716 enrolled 15 charts

Brain Neoplasms

NCT04971733 2025-06-10

A Study to Assess Safety and Target Engagement of E2814 in Participants With Mild to Moderate Cognitive Impairment Due to Dominantly Inherited Alzheimer's Disease

8 enrolled 21 charts

CNSLymphoid

Alzheimer Disease, Central Nervous System Diseases, Lymphoma, Follicular

NCT02655601 2025-06-08

BMX-HGG

177 enrolled 34 charts

Astrocytoma, Glioblastoma, Glioma

NCT04479241 2025-06-05

LUMINOS-101: Lerapolturev (PVSRIPO) and Pembrolizumab in Patients With Recurrent Glioblastoma

25 enrolled 12 charts

Brain Neoplasms, Glioblastoma

NCT02392078 2025-04-24

LAANTERN

Completed

1,153 enrolled 15 charts

Brain Neoplasms, Epilepsy, Movement Disorders, Disease Progression

NCT04006119 2025-04-18

Study of Ad-RTS-hIL-12 + Veledimex in Combination With Cemiplimab in Subjects With Recurrent or Progressive Glioblastoma

40 enrolled 14 charts

Glioblastoma

NCT04704154 2025-04-18

A Trial to Learn Whether Regorafenib in Combination With Nivolumab Can Improve Tumor Responses and How Safe it is for Participants With Solid Tumors

CNSGastrointestinalHead & Neck

175 enrolled 20 charts

Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Astrocytoma, Glioblastoma

NCT02026271 2025-04-16

A Study of Ad-RTS-hIL-12 With Veledimex in Subjects With Glioblastoma or Malignant Glioma

40 enrolled 22 charts

Glioblastoma

NCT03632135 2025-04-15

CSCRGBM

78 enrolled 10 charts

Brain Neoplasms, Glioblastoma

NCT03690869 2025-04-08

REGN2810 in Pediatric Patients With Relapsed, Refractory Solid, or Central Nervous System (CNS) Tumors and Safety and Efficacy of REGN2810 in Combination With Radiotherapy in Pediatric Patients With Newly Diagnosed or Recurrent Glioma

57 enrolled 31 charts

Phase 3 Active not recruiting

Diffuse Intrinsic Pontine Glioma, Glioma, Recurrence, Central Nervous System Neoplasms

NCT04164901 2025-04-03

Study of Vorasidenib (AG-881) in Participants With Residual or Recurrent Grade 2 Glioma With an IDH1 or IDH2 Mutation (INDIGO)

331 enrolled 25 charts 1 FDA

Glioma

NCT03522298 2025-03-24

Safety, Pharmacokinetics and Efficacy of Paxalisib (GDC-0084) in Newly-diagnosed Glioblastoma

30 enrolled 27 charts

Glioblastoma

NCT03150862 2025-02-04

A Study Assessing Pamiparib With Radiation and/or Temozolomide (TMZ) in Participants With Newly Diagnosed or Recurrent Glioblastoma

116 enrolled 31 charts

CNSSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Nervous System Diseases, Central Nervous System Neoplasms, Neuroectodermal Tumors, Gliosarcoma

NCT02078648 2025-02-03

Safety and Efficacy Study of SL-701, a Glioma-Associated Antigen Vaccine To Treat Recurrent Glioblastoma Multiforme

74 enrolled 19 charts

Glioblastoma

NCT06469138 2025-01-29

8479217