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NCT03794349 2026-02-18

Irinotecan Hydrochloride, Temozolomide, and Dinutuximab With or Without Eflornithine in Treating Patients With Relapsed or Refractory Neuroblastoma

Phase 2 Active not recruiting

94 enrolled 14 charts

Neuroblastoma

NCT00336024 2026-01-23

Combination Chemotherapy Followed By Peripheral Stem Cell Transplant in Treating Young Patients With Newly Diagnosed Supratentorial Primitive Neuroectodermal Tumors or High-Risk Medulloblastoma

Phase 3 Completed

91 enrolled 24 charts

Medulloblastoma

NCT01175356 2026-01-23

Induction Therapy Including 131 I-MIBG and Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant, Radiation Therapy, and Maintenance Therapy With Isotretinoin

Phase 1 Completed

99 enrolled 11 charts

Neuroblastoma, Ganglioneuroblastoma

NCT01503086 2025-12-05

Computer Training Program for Younger Patients With a Brain Tumor Who Underwent Radiation Therapy

Phase NA Active not recruiting

45 enrolled 10 charts

Brain Neoplasms

NCT03834961 2025-12-02

Larotrectinib in Treating Patients With Previously Untreated TRK Fusion Solid Tumors and TRK Fusion Relapsed Acute Leukemia

Phase 2 Active not recruiting

33 enrolled 18 charts

Central Nervous System Neoplasms

NCT03224104 2025-11-26

STEAM

Phase 1 Completed

71 enrolled 18 charts

Astrocytoma, Glioblastoma

NCT01602666 2025-11-20

Chemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors

Phase 2 Completed

262 enrolled 17 charts

Central Nervous System Nongerminomatous Germ Cell Tumor

NCT02234050 2025-07-10

Trabectedin for Recurrent Grade II/III Meningioma

Phase 2 Completed

90 enrolled 18 charts

Recurrent High Grade Meningioma

NCT03345095 2025-07-01

MIRAGE

Phase 3 Completed

749 enrolled 15 charts

Glioblastoma

NCT00392327 2025-06-13

Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma/PNET

Phase 3 Active not recruiting

379 enrolled 29 charts

Medulloblastoma

NCT00085735 2025-01-14

Comparison of Radiation Therapy Regimens in Combination With Chemotherapy in Treating Young Patients With Newly Diagnosed Standard-Risk Medulloblastoma

Phase 3 Completed

549 enrolled 32 charts

Medulloblastoma

NCT02323880 2025-01-14

Selinexor in Treating Younger Patients With Recurrent or Refractory Solid Tumors or High-Grade Gliomas

Phase 1 Completed

59 enrolled 20 charts

Astrocytoma, Brain Neoplasms, Glioma, Lymphoma, Central Nervous System Neoplasms

NCT02975882 2025-01-14

Nanoparticle Albumin-Bound Rapamycin, Temozolomide, and Irinotecan Hydrochloride in Treating Pediatric Patients With Recurrent or Refractory Solid Tumors

Phase 1 Completed

33 enrolled 15 charts

Central Nervous System Neoplasms

NCT01798004 2024-07-15

Busulfan, Melphalan, and Stem Cell Transplant After Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma

Phase 1 Completed

150 enrolled 9 charts

Neuroblastoma, Ganglioneuroblastoma

NCT00114140 2024-07-08

Temozolomide and Radiation Therapy in Treating Patients With Gliomas

Phase 2 Completed

136 enrolled 9 charts

Astrocytoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms

NCT01606878 2024-01-05

Crizotinib and Combination Chemotherapy in Treating Younger Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma

Phase 1 Completed

46 enrolled 24 charts

Neuroblastoma, Lymphoma, Large-Cell, Anaplastic

NCT02808650 2023-12-20

Prexasertib in Treating Pediatric Patients With Recurrent or Refractory Solid Tumors

Phase 1 Completed

30 enrolled 16 charts

Central Nervous System Neoplasms

NCT00626990 2023-09-11

CATNON

Phase 3 Active not recruiting

751 enrolled 18 charts

Astrocytoma, Oligodendroglioma, Central Nervous System Neoplasms

NCT00895622 2023-09-08

Observation or Radiation Therapy in Treating Patients With Grade I, Grade II, or Grade III Meningioma

Phase 2 Completed

244 enrolled 15 charts

Brain Neoplasms, Meningioma, Central Nervous System Neoplasms

NCT00482677 2023-08-22

Radiation Therapy With or Without Temozolomide in Treating Older Patients With Newly Diagnosed Glioblastoma Multiforme

Phase 3 Completed

562 enrolled 11 charts

Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT01259869 2023-08-22

A Study of PX-866 in Patients With Glioblastoma Multiforme at Time of First Relapse or Progression

Phase 2 Completed

34 enrolled 7 charts

Glioblastoma

NCT00080938 2023-06-29

Temozolomide and Radiation Therapy in Treating Patients With Brain Metastasis Secondary to Non-Small Cell Lung Cancer

Phase 2 Completed

26 enrolled 8 charts

Adenocarcinoma of Lung, Brain Neoplasms, Adenocarcinoma, Bronchiolo-Alveolar, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasm Metastasis

NCT00033293 2023-04-18

Cyclophosphamide and Prednisone With or Without Immunoglobulin in Treating Abnormal Muscle Movement in Children With Neuroblastoma

Phase 3 Completed

53 enrolled 14 charts

Neuroblastoma

NCT00100802 2023-02-15

Radiation Therapy, Temozolomide, and Lomustine in Treating Young Patients With Newly Diagnosed Gliomas

Phase 2 Completed

118 enrolled 8 charts

Astrocytoma, Glioblastoma, Spinal Cord Neoplasms, Central Nervous System Neoplasms, Gliosarcoma

NCT02017964 2023-01-09

Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed, Non-metastatic Desmoplastic Medulloblastoma

Phase 2 Completed

26 enrolled 14 charts

CNSDermatologic

Basal Cell Nevus Syndrome, Medulloblastoma

NCT01730950 2022-12-29

Bevacizumab With or Without Radiation Therapy in Treating Patients With Recurrent Glioblastoma

Phase 2 Completed

182 enrolled 19 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT01062399 2022-06-09

RTOG 0913

Phase 1/2 Completed

279 enrolled 14 charts

Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00567567 2022-04-28

Comparing Two Different Myeloablation Therapies in Treating Young Patients Who Are Undergoing a Stem Cell Transplant for High-Risk Neuroblastoma

Phase 3 Completed

665 enrolled 26 charts

Neuroblastoma

NCT02452554 2022-01-13

Lorvotuzumab Mertansine in Treating Younger Patients With Relapsed or Refractory Wilms Tumor, Rhabdomyosarcoma, Neuroblastoma, Pleuropulmonary Blastoma, Malignant Peripheral Nerve Sheath Tumor, or Synovial Sarcoma

Phase 2 Completed

62 enrolled 15 charts

CNSGenitourinarySarcoma

Pleuropulmonary blastoma, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Synovial, Neurofibrosarcoma

NCT03387020 2021-08-27

Ribociclib and Everolimus in Treating Children With Recurrent or Refractory Malignant Brain Tumors

Phase 1 Completed

22 enrolled 16 charts

Familial ependymoma, Diffuse Intrinsic Pontine Glioma, Glioma, Medulloblastoma, Rhabdoid Tumor

NCT02974803 2021-08-20

Concurrent Dabrafenib + Trametinib With Sterotactic Radiation in BRAF Mutation-Positive Malignant Melanoma and Brain Metastases

Phase 2 Terminated

6 enrolled 3 charts

CNSDermatologic

Brain Neoplasms, Melanoma

NCT00499616 2021-07-06

Combination Chemotherapy and Surgery With or Without Isotretinoin in Treating Young Patients With Neuroblastoma

Phase 3 Completed

464 enrolled 25 charts

Neuroblastoma

NCT02255461 2021-03-02

Palbociclib Isethionate in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors

Phase 1 Terminated

35 enrolled 28 charts

Astrocytoma, Glioblastoma, Medulloblastoma, Oligodendroglioma, Choroid Plexus Neoplasms, Neoplasms, Neuroepithelial

NCT00006916 2020-10-26

Radiation Therapy Followed by Bleomycin in Treating Adult Patients With Newly Diagnosed Supratentorial Glioblastoma Multiforme

Phase 2 Terminated

19 enrolled 4 charts

Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00939770 2020-06-09

Crizotinib in Treating Younger Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma

Phase 1/2 Completed

122 enrolled 24 charts 2 FDA

Neuroblastoma, Lymphoma, Large-Cell, Anaplastic

NCT01154816 2020-05-13

Alisertib in Treating Young Patients With Recurrent or Refractory Solid Tumors or Leukemia

Phase 2 Completed

118 enrolled 24 charts

CNSGastrointestinalLymphoidOther hematologic neoplasmSarcoma

Neuroblastoma, Osteosarcoma, Hepatoblastoma, Neuroectodermal Tumors, Primitive, Peripheral, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT01334515 2019-10-21

Biological Therapy, Sargramostim, and Isotretinoin in Treating Patients With Relapsed or Refractory Neuroblastoma

Phase 2 Completed

52 enrolled 11 charts

Neuroblastoma

NCT00004259 2019-09-12

Radiation Therapy Combined With Chemotherapy in Treating Patients With Anaplastic Astrocytoma or Mixed Gliomas

Phase 3 Completed

230 enrolled 14 charts

Astrocytoma, Glioma, Central Nervous System Neoplasms

NCT00027846 2019-08-07

Observation or Radiation Therapy and/or Chemotherapy and Second Surgery in Treating Children Who Have Undergone Surgery for Ependymoma

Phase 2 Completed

378 enrolled 16 charts

Brain Neoplasms, Central Nervous System Neoplasms

NCT00238264 2019-08-07

Radiation Therapy in Treating Young Patients With Gliomas

Phase 2 Completed

92 enrolled 12 charts

Astrocytoma, Brain Neoplasms, Oligodendroglioma, Central Nervous System Neoplasms, Optic Nerve Glioma

NCT00436852 2019-07-17

ABT-751 in Treating Children With Neuroblastoma That Has Relapsed or Not Responded to Previous Treatment

Phase 2 Completed

92 enrolled 17 charts

Neuroblastoma

NCT00085098 2018-09-07

Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Primary Central Nervous System (CNS) Germ Cell Tumor

Phase 3 Completed

24 enrolled 9 charts

Brain Neoplasms, Central Nervous System Neoplasms

NCT01836549 2018-07-20

Imetelstat Sodium in Treating Younger Patients With Recurrent or Refractory Brain Tumors

Phase 2 Terminated

43 enrolled 14 charts

Astrocytoma, Ependymoma, Glioblastoma, Oligodendroglioma, Gliosarcoma, Brain Stem Neoplasms

NCT00077207 2018-05-16

Carboplatin, Vincristine, and Temozolomide in Treating Children With Progressive and/or Symptomatic Low-Grade Glioma

Phase NA Completed

66 enrolled 13 charts

Brain Neoplasms, Oligodendroglioma, Spinal Cord Neoplasms, Central Nervous System Neoplasms

NCT00047320 2018-02-14

Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors

Phase 2 Completed

104 enrolled 12 charts

Brain Neoplasms, Teratoma, Central Nervous System Neoplasms

NCT00068250 2018-02-07

Combination Chemotherapy, Monoclonal Antibody, and Radiation Therapy in Treating Patients With Primary Central Nervous System Lymphoma

Phase 1/2 Completed

60 enrolled 10 charts

Lymphoma, Central Nervous System Neoplasms

NCT00309907 2017-09-29

Etanercept in Treating Young Patients With Idiopathic Pneumonia Syndrome After Undergoing a Donor Stem Cell Transplant

Phase 2 Completed

39 enrolled 12 charts

CNSGenitourinaryLymphoidOther hematologic neoplasmSarcoma

Blast Crisis, Burkitt Lymphoma, Wilms Tumor, Neuroblastoma, Recurrence, Leukemia, Myeloid, Accelerated Phase, Leukemia, Myeloid, Chronic-Phase, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myelomonocytic, Juvenile, Dendritic Cell Sarcoma, Interdigitating

NCT01227954 2017-09-27

Avoiding the Hippocampus During Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases

Phase 2 Completed

113 enrolled 12 charts

Brain Neoplasms, Neoplasm Metastasis

NCT00566852 2017-08-21

Memantine in Preventing Side Effects in Patients Undergoing Whole-Brain Radiation Therapy for Brain Metastases From Solid Tumors

Phase 3 Completed

554 enrolled 12 charts

Brain Neoplasms, Neoplasm Metastasis, Neurotoxicity Syndromes

NCT01026493 2017-07-02

Veliparib and Temozolomide in Treating Patients With Recurrent Glioblastoma

Phase 1/2 Completed

257 enrolled 16 charts

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma