Clinical Trials Browser

Interventional × Busulfan × CNS × Clear all

NCT03126916 2026-02-27

Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

Phase 3 Recruiting

750 enrolled

CNS

Neuroblastoma, Ganglioneuroblastoma

NCT01625351 2026-02-06

A Study of CD45RA+ Depleted Haploidentical Stem Cell Transplantation in Children With Relapsed or Refractory Solid Tumors and Lymphomas

Phase 1 Completed

23 enrolled

CNSDermatologicGastrointestinalGenitourinaryLymphoidSarcoma

Carcinoma, Renal Cell, Digestive System Neoplasms, Carcinoma, Hepatocellular, Lymphoma, Melanoma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Adenocarcinoma, Clear Cell, Rhabdoid Tumor

NCT01175356 2026-01-23

Induction Therapy Including 131 I-MIBG and Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant, Radiation Therapy, and Maintenance Therapy With Isotretinoin

Phase 1 Completed

99 enrolled 11 charts

CNS

Neuroblastoma, Ganglioneuroblastoma

NCT05735717 2025-07-24

MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies

Phase 2 Recruiting

70 enrolled

CNSClassical hematologyLymphoidOther hematologic neoplasm

Chromosome 7, monosomy, Anemia, Refractory, with Excess of Blasts, Chromosome Aberrations, Influenza, Human, Neurofibromatosis 1, Leukemia, Myeloid, Acute, beta-Thalassemia, Neoplasm, Residual, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myelomonocytic, Juvenile

NCT00638898 2025-03-20

Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor

Phase 1 Completed

25 enrolled

CNSGenitourinarySarcoma

Familial ependymoma, Astrocytoma, Brain Neoplasms, Medulloblastoma, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Testicular Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Optic Nerve Glioma

NCT01798004 2024-07-15

Busulfan, Melphalan, and Stem Cell Transplant After Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma

Phase 1 Completed

150 enrolled 9 charts

CNS

Neuroblastoma, Ganglioneuroblastoma

NCT01505569 2024-02-26

Auto Transplant for High Risk or Relapsed Solid or CNS Tumors

Phase NA Completed

44 enrolled

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

Brain Neoplasms, Carcinoma, Renal Cell, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Central Nervous System Neoplasms, Hepatoblastoma, Rhabdoid Tumor

NCT00588523 2023-10-27

Intensive Chemotherapy and Autotransplantation for Patients With Newly Diagnosed Anaplastic Oligodendroglioma

Phase 2 Completed

60 enrolled 9 charts

CNS

Central Nervous System Neoplasms

NCT05303727 2022-07-01

Allogeneic Hematopoietic Stem Cell Transplantation for 4/M Neuroblastoma

Phase 2 Not yet recruiting

64 enrolled

CNS

Neuroblastoma

NCT01704716 2020-10-23

High Risk Neuroblastoma Study 1.8 of SIOP-Europe (SIOPEN)

Phase 3 Recruiting

3,300 enrolled

CNS

Neuroblastoma

NCT00836628 2020-08-05

Study of Busulfan for Refractory Central Nervous System (CNS) Tumors

Phase 1 Withdrawn

CNS

Brain Neoplasms

NCT00801931 2019-03-27

Double Cord Blood Transplant for Patients With Malignant and Non-malignant Disorders

Phase 1/2 Terminated

1 enrolled 8 charts

CNSClassical hematologyLymphoidOther hematologic neoplasm

Anemia, Immunologic Deficiency Syndromes, Leukemia, Lymphoma, Neuroblastoma

NCT02130869 2017-12-22

A Pilot Study of Immunotherapy Including Haploidentical NK Cell Infusion Following CD133+ Positively-Selected Autologous Hematopoietic Stem Cells in Children With High Risk Solid Tumors or Lymphomas

Phase 1 Completed

8 enrolled

CNSLymphoid

Lymphoma, Neuroblastoma

NCT00623077 2017-12-05

MT2004-30: Tomotherapy for Solid Tumors

Phase 1 Terminated

23 enrolled

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

Familial ependymoma, Astrocytoma, Carcinoma, Renal Cell, Carcinoma, Hepatocellular, Kidney Neoplasms, Liver Neoplasms, Medulloblastoma, Wilms Tumor, Retinoblastoma, Sarcoma, Central Nervous System Neoplasms, Hepatoblastoma, Neuroectodermal Tumors, Primitive, Peripheral, Rhabdoid Tumor, Optic Nerve Glioma

NCT00003926 2017-11-29

Amifostine to Protect From Side Effects of PSCT in Treating Patients With Solid Tumors

Phase 1 Terminated

13 enrolled

CNSGastrointestinalGenitourinaryGynecologicOther solid neoplasmSarcoma

Ovarian Germ Cell Cancer, Astrocytoma, Brain Neoplasms, Chordoma, Ependymoma, Glioma, Kidney Neoplasms, Liver Neoplasms, Medulloblastoma, Wilms Tumor, Neuroblastoma, Ovarian Neoplasms, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Teratoma, Testicular Neoplasms, Central Nervous System Neoplasms, Neuroectodermal Tumors, Hepatoblastoma, Desmoplastic Small Round Cell Tumor

NCT00670410 2016-06-24

Autologous Transplant Followed by Allogeneic Transplant for High Risk Neuroblastoma

Phase 1 Terminated

15 enrolled

CNS

Neuroblastoma

NCT00874315 2015-10-16

Allogeneic Hematopoietic Stem Cell Transplantation for Relapsed or Refractory High-Risk NBL.

Phase 2 Withdrawn

CNS

Neuroblastoma, Recurrence

NCT00084695 2014-01-10

Umbilical Cord Blood for Stem Cell Transplantation in Treating Young Patients With Malignant or Nonmalignant Diseases

Phase 2 Unknown

25 enrolled

CNSClassical hematologyLymphoidMyeloidOther hematologic neoplasmSarcoma

Burkitt Lymphoma, Fanconi Anemia, Leukemia, Lymphoma, Myelodysplastic Syndromes, Neuroblastoma, Recurrence, Sarcoma, Leukemia, Myeloid, Chronic-Phase, Neuroectodermal Tumors, Primitive, Peripheral, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myelomonocytic, Juvenile, Dendritic Cell Sarcoma, Interdigitating

NCT00253487 2014-01-06

Combination Chemotherapy and Radiation Therapy in Treating Younger Patients Who Are Undergoing an Autologous Stem Cell Transplant for Newly Diagnosed Gliomas

Phase NA Completed

CNSSarcoma

Astrocytoma, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00024193 2013-08-07

Chemotherapy and Surgery Followed by Peripheral Stem Cell Transplantation in Treating Patients With Metastatic Neuroblastoma

Phase 2 Unknown

CNS

Neuroblastoma

NCT00417053 2013-08-02

Combination Chemotherapy in Treating Infants With Newly Diagnosed Neuroblastoma Who Are Undergoing Surgery With or Without Autologous Bone Marrow or Peripheral Stem Cell Transplant

Phase 3 Unknown

CNS

Neuroblastoma

NCT00112645 2013-07-18

Donor Stem Cell Transplant in Treating Young Patients With Relapsed or Refractory Solid Tumors

Phase 1 Completed

10 enrolled

CNSSarcoma

Neuroblastoma, Sarcoma, Neuroectodermal Tumors, Primitive, Peripheral

NCT00003101 2013-06-25

Combination Chemotherapy and Bone Marrow Transplantation or Peripheral Stem Cell Transplantation in Treating Patients With Oligodendroglioma

Phase 2 Completed

60 enrolled

CNS

Oligodendroglioma, Central Nervous System Neoplasms

NCT00003462 2013-02-20

Intrathecal Busulfan in Treating Patients With Recurrent, Refractory, or Metastatic Leptomeningeal Tumors

Phase 1 Completed

20 enrolled

CNS

Central Nervous System Neoplasms, Meningeal Carcinomatosis

NCT00003661 2011-03-07

Chemotherapy, Radiation Therapy, and Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer

Phase 2 Completed

3 enrolled

CNSClassical hematologyLymphoidMyeloidOther hematologic neoplasmSarcoma

Anemia, Refractory, with Excess of Blasts, Burkitt Lymphoma, Graft vs Host Disease, Leukemia, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Myelodysplastic Syndromes, Neuroblastoma, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myeloid, Accelerated Phase, Leukemia, Myeloid, Chronic-Phase, Leukemia, Myelomonocytic, Chronic, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Dendritic Cell Sarcoma, Interdigitating

NCT00006246 2009-10-07

Busulfan in Treating Children and Adolescents With Refractory CNS Cancer

Phase 1 Completed

28 enrolled

CNSLymphoidOther hematologic neoplasmOther solid neoplasmSarcoma

Familial ependymoma, Astrocytoma, Leukemia, Lymphoma, Medulloblastoma, Neoplasm Metastasis, Oligodendroglioma, Recurrence, Retinoblastoma, Sarcoma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Optic Nerve Glioma, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Dendritic Cell Sarcoma, Interdigitating, Meningeal Carcinomatosis

NCT00152126 2009-02-13

Chemotherapy With CD133+ Select Autologous Hematopoietic Stem Cells for Children With Solid Tumors and Lymphomas

Phase NA Completed

26 enrolled

CNSGenitourinaryLymphoid

Lymphoma, Wilms Tumor, Neuroblastoma, Central Nervous System Neoplasms