Clinical Trials

Phase 2 Not yet recruiting

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT07365410 2026-01-26

Furmonertinib 160mg vs 80mg + Chemotherapy in EGFR-Mutated NSCLC With Brain Metastases: Efficacy and Safety Study

60 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT05746481 2026-01-22

Tiragolumab and Atezolizumab in Patients With Non-squamous Non-small Cell Lung Cancer (NSCLC) and Untreated Brain Metastases

Phase 2 Terminated

3 enrolled 12 charts

Phase 2 Active not recruiting

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT01878617 2025-11-13

A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma

660 enrolled

Brain Neoplasms, Medulloblastoma, Infratentorial Neoplasms, Neuroectodermal Tumors, Primitive

NCT04964960 2025-10-31

Pembro+Chemo in Brain Mets

Phase 2 Terminated

3 enrolled 7 charts

Phase 2 Active not recruiting

Brain Neoplasms, Lung Neoplasms, Neoplasms

NCT05012254 2025-04-09

NIVIPI-Brain

71 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Diseases, Lung Neoplasms

NCT06812871 2025-02-06

High-dose Furmonertinib Combined With Bevacizumab and Intrathecal Pemetrexed Chemotherapy in Patients With EGFR-mutated Non-small Cell Lung Cancer and Meningeal Metastasis

Phase 2 Recruiting

30 enrolled

Phase 2 Not yet recruiting

Meningeal Carcinomatosis

NCT05805631 2024-05-01

Intrathecal Pemetrexed for Leptomeningeal Metastasis in EGFR-Mutant NSCLC

23 enrolled

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT04507217 2023-05-25

Tislelizumab Combined With Pemetrexed/ Carboplatin in Patients With Brain Metastases of Non-squamous NSCLC

Phase 2 Completed

36 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT05810350 2023-04-13

Aumolertinib Combined Intrathecal Chemotherapy for Leptomeningeal Metastasis From EGFR-Mutated NSCLC and Prognostic Value of Dynamic Changes in cfDNA Profiles

40 enrolled

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT04211090 2022-11-16

CAP-BRAIN

45 enrolled

Brain Neoplasms

NCT00276783 2020-03-05

Pemetrexed Disodium in Treating Patients With Recurrent Malignant Gliomas, Primary CNS Lymphoma, or Brain Metastases

31 enrolled

CNSLymphoidSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Lymphoma, Neoplasm Metastasis, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00280748 2017-06-23

NRR

Phase 2 Terminated

10 enrolled 14 charts

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasm Metastasis

NCT01578668 2015-01-26

Erlotinib Plus Pemetrexed to Treat Lung Adenocarcinoma With Brain Metastases

Phase 2 Completed

69 enrolled

Adenocarcinoma of Lung, Brain Neoplasms

NCT02284490 2014-11-06

High-dose Pemetrexed to Treat Lung Adenocarcinoma With Brain Metastases

25 enrolled