Clinical Trials

58 enrolled

Astrocytoma, Glioblastoma, Glioma

NCT05099003 2026-03-18

A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

Phase 1/2 Recruiting

132 enrolled

Glioma

NCT03528642 2026-03-17

Telaglenastat With Radiation Therapy and Temozolomide in Treating Patients With IDH-Mutated Diffuse Astrocytoma or Anaplastic Astrocytoma

40 enrolled

CNSLymphoid

Astrocytoma, Lymphoma, Follicular

NCT04732065 2026-03-17

PNOC023

208 enrolled

Ependymoma, Glioblastoma, Central Nervous System Neoplasms

NCT06344130 2026-03-17

Hypofractionation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma

28 enrolled

Astrocytoma, Glioblastoma, Glioma

NCT06934889 2026-03-17

Study of ABBV-637 or ABBV-155 With ERAS-801 for People With Glioblastoma

Glioblastoma, Gliosarcoma

NCT05109728 2026-03-16

A Dose Finding Study of [177Lu]Lu-DOTA-TATE in Newly Diagnosed Glioblastoma in Combination With Standard of Care and in Recurrent Glioblastoma as a Single Agent.

65 enrolled

Glioblastoma

NCT02287428 2026-03-12

Personalized NeoAntigen Cancer Vaccine w RT Plus Pembrolizumab for Patients With Newly Diagnosed GBM

56 enrolled

Glioblastoma

NCT06504381 2026-03-11

DB107-RRV, DB107-FC, and Radiation Therapy With or Without Temozolomide (TMZ) for High Grade Glioma

Phase 1/2 Recruiting

70 enrolled

Phase EARLY_PHASE1 Active not recruiting

Glioma

NCT05076513 2026-03-09

Trial of Niraparib in Participants With Newly-diagnosed Glioblastoma and Recurrent Glioma

42 enrolled

Phase 1 Not yet recruiting

Glioblastoma, Glioma

NCT07457307 2026-03-09

INSIGHT MRL

20 enrolled

Glioma

NCT03028337 2026-03-05

Single Versus Multifraction Salvage Spine Stereotactic Radiosurgery for Previously Irradiated Spinal Metastases

Phase 3 Not yet recruiting

80 enrolled

CNSOther neoplasm

Malignant Neoplasms of Eye Brain and Other Parts of Central Nervous System

NCT07452458 2026-03-05

Temporally-Modulated Pulsed Radiation Therapy Versus Standard Radiation Therapy for the Treatment of Newly Diagnosed, IDH Wildtype, MGMT-Unmethylated Glioblastoma

398 enrolled

Glioblastoma

NCT06719440 2026-02-27

BELGICA

Phase NA Recruiting

347 enrolled

Glioblastoma, Radiation Injuries

NCT05382338 2026-02-24

A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

225 enrolled

Medulloblastoma

NCT05124912 2026-02-20

REMASTer: REcurrent Brain Metastases After SRS Trial

Phase NA Recruiting

261 enrolled

Phase 3 Not yet recruiting

Brain Neoplasms, Neoplasm Metastasis, Recurrence

NCT06448286 2026-02-19

PH Weighted Chemical Exchange Saturation Transfer MRI-Based Surgical Resection to Improve Survival in Patients With Glioblastoma

Glioblastoma

NCT03529448 2026-02-12

GEINOCANN

Phase 1/2 Completed

33 enrolled

Glioblastoma

NCT05535166 2026-02-12

Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed Medulloblastoma

130 enrolled

Brain Neoplasms, Medulloblastoma

NCT05476939 2026-02-05

BIOMEDE 2

433 enrolled

Diffuse Intrinsic Pontine Glioma

NCT05331521 2026-02-03

ImproveCodel

406 enrolled

Oligodendroglioma

NCT05781321 2026-02-03

Short Course Radiotherapy for the Treatment of Patients With Glioblastoma, SAGA Study

170 enrolled

Glioblastoma

NCT04702581 2026-01-29

POLO

280 enrolled

Phase 1/2 Active not recruiting

Oligodendroglioma

NCT03491683 2026-01-28

INO-5401 and INO-9012 Delivered by Electroporation (EP) in Combination With Cemiplimab (REGN2810) in Newly-Diagnosed Glioblastoma (GBM)

52 enrolled

Phase 3 Active not recruiting

Glioblastoma

NCT00887146 2026-01-22

Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma

305 enrolled

Astrocytoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms

NCT04623931 2026-01-14

Chemotherapy and Radiation Therapy for the Treatment of IDH Wildtype Gliomas or Non-histological (Molecular) Glioblastomas

40 enrolled

Astrocytoma, Glioblastoma, Oligodendroglioma

NCT05236036 2026-01-14

Mycophenolate Mofetil in Combination With Standard of Care for the Treatment of Glioblastoma

Astrocytoma, Glioblastoma

NCT03550391 2026-01-13

Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

206 enrolled

Brain Neoplasms

NCT05083754 2026-01-09

Carmustine Wafer in Combination With Retifanlimab and Radiation With/Without Temozolomide in Subjects With Glioblastoma

50 enrolled

Glioblastoma

NCT04959500 2026-01-02

Newly Diagnosed Glioblastoma

150 enrolled

Phase EARLY_PHASE1 Recruiting

Glioblastoma

NCT06829173 2026-01-02

Concurrent XRD-0394 With Radiation Therapy for High Grade Gliomas

39 enrolled

Glioma

NCT03423628 2025-12-22

A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer

180 enrolled

Brain Neoplasms, Glioblastoma, Inhibition, Psychological, Meningeal Neoplasms, Hereditary Sensory and Autonomic Neuropathies

NCT05009992 2025-12-17

PNOC022

360 enrolled

Diffuse Intrinsic Pontine Glioma

NCT02344355 2025-12-12

A Phase 2 Trial of High-Dose Ascorbate in Glioblastoma Multiforme

90 enrolled

Glioblastoma

NCT04900792 2025-12-03

XACT-Fe-GBM-01

17 enrolled

Glioblastoma

NCT03224104 2025-11-26

STEAM

Phase 1 Completed

71 enrolled 18 charts

Phase 1/2 Active not recruiting

Astrocytoma, Glioblastoma

NCT03687957 2025-11-25

rhIL-7-hyFc on Increasing Lymphocyte Counts in Patients With Newly Diagnosed Non-severe Lymphopenic Gliomas Following Radiation and Temozolomide

42 enrolled 19 charts

Glioma

NCT03532295 2025-11-21

Retifanlimab and Epacadostat in Combination With Radiation and Bevacizumab in Patients With Recurrent Gliomas

Phase 2 Completed

51 enrolled 16 charts

Glioblastoma, Glioma

NCT05030298 2025-11-21

Preoperative Radiosurgery for the Treatment of High Grade Glioma, NeoGlioma Trial

28 enrolled

Glioma

NCT03746080 2025-11-14

Whole Brain Radiation Therapy With Standard Temozolomide Chemo-Radiotherapy and Plerixafor in Treating Patients With Glioblastoma

Phase 2 Completed

21 enrolled 12 charts

Glioblastoma, Glioma, Gliosarcoma

NCT01878617 2025-11-13

A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma

660 enrolled

Brain Neoplasms, Medulloblastoma, Infratentorial Neoplasms, Neuroectodermal Tumors, Primitive

NCT03107780 2025-11-13

Testing the Ability of AMG 232 (KRT 232) to Get Into the Tumor in Patients With Brain Cancer

Phase 1 Terminated

32 enrolled

Glioblastoma, Gliosarcoma

NCT02792582 2025-11-12

A Phase II Trial of Intensity-Modulated Proton Therapy for Incompletely Resected Craniopharyngioma and Observation for Craniopharyngioma After Radical Resection

160 enrolled

Phase EARLY_PHASE1 Recruiting

Brain Neoplasms, Craniopharyngioma

NCT06831526 2025-11-12

Neoadjuvant Chemoradiotherapy With or Without Concurrent Azeliragon in Patients With Newly Diagnosed Glioblastoma

12 enrolled

Glioblastoma

NCT04555577 2025-10-29

Peposertib and Radiation Therapy, Followed by Temozolomide for the Treatment of Patients With Newly Diagnosed MGMT Unmethylated Glioblastoma or Gliosarcoma

29 enrolled

Glioblastoma, Gliosarcoma

NCT04402073 2025-10-23

PersoMed-I

Phase 2 Terminated

20 enrolled

Phase 1/2 Not yet recruiting

Medulloblastoma

NCT04373785 2025-10-21

NG101m Adjuvant Therapy in Glioblastoma Patients

52 enrolled

Glioblastoma

NCT03426891 2025-10-06

Pembrolizumab and Vorinostat Combined With Temozolomide for Newly Diagnosed Glioblastoma

Phase 1 Completed

21 enrolled 12 charts

Brain Neoplasms, Glioblastoma

NCT06649851 2025-09-25

G-CSF After Chemo-radiation in Patients With Glioblastoma

Glioblastoma

NCT03174197 2025-09-24

Atezolizumab in Combination With Temozolomide and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma

Phase 1/2 Completed