Clinical Trials

Phase 2 Active not recruiting

Brain Neoplasms

NCT02574728 2026-03-02

AflacST1502

46 enrolled

CNSMyeloidSarcoma

Brain Neoplasms, Carcinoma, Ependymoma, Histiocytosis, Langerhans-Cell, Medulloblastoma, Neoplasms, Neoplasms, Germ Cell and Embryonal, Neuroblastoma, Pinealoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Rhabdoid Tumor

NCT01625351 2026-02-06

A Study of CD45RA+ Depleted Haploidentical Stem Cell Transplantation in Children With Relapsed or Refractory Solid Tumors and Lymphomas

CNSDermatologicGastrointestinalGenitourinaryLymphoidSarcoma

23 enrolled

Carcinoma, Renal Cell, Digestive System Neoplasms, Carcinoma, Hepatocellular, Lymphoma, Melanoma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Adenocarcinoma, Clear Cell, Rhabdoid Tumor

NCT01552434 2025-10-14

Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease

Phase 1 Active not recruiting

155 enrolled

BreastCNSGenitourinaryHead & NeckLymphoidMyeloidSarcoma

Breast Neoplasms, Carcinoma, Transitional Cell, Endocrine Gland Neoplasms, Castleman Disease, Mouth Neoplasms, Neoplasm Metastasis, Neoplasms, Pharyngeal Neoplasms, Recurrence, Sarcoma, Soft Tissue Neoplasms, Thyroid Neoplasms, Urologic Neoplasms, Neurofibromatosis 2, Lymphangioleiomyomatosis, Neoplasms, Mesothelial, Erdheim-Chester Disease

NCT02420613 2025-04-02

Vorinostat and Temsirolimus With or Without Radiation Therapy in Treating Younger Patients With Newly Diagnosed or Progressive Diffuse Intrinsic Pontine Glioma

18 enrolled

Diffuse Intrinsic Pontine Glioma

NCT03433183 2023-12-26

SARC031: MEK Inhibitor Selumetinib (AZD6244) in Combination With the mTOR Inhibitor Sirolimus for Patients With Malignant Peripheral Nerve Sheath Tumors

21 enrolled

Neurofibromatosis 1, Neurofibrosarcoma

NCT01767194 2022-10-24

Irinotecan Hydrochloride and Temozolomide With Temsirolimus or Dinutuximab in Treating Younger Patients With Refractory or Relapsed Neuroblastoma

73 enrolled 12 charts

Neuroblastoma, Ganglioneuroblastoma

NCT01467986 2020-10-06

RIST-rNB-2011

130 enrolled

Neuroblastoma

NCT00047073 2020-08-03

Sirolimus in Treating Patients With Glioblastoma Multiforme

Phase 1/2 Completed

13 enrolled

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00509431 2020-07-31

Erlotinib and Sirolimus in Treating Patients With Recurrent Malignant Glioma

19 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT01331135 2020-05-29

Aflac ST0901

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

18 enrolled

Astrocytoma, Carcinoma, Renal Cell, Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Recurrence, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma, Sarcoma, Clear Cell, Rhabdoid Tumor

NCT01135563 2019-09-20

Study of Vinblastine and Sirolimus in Children With Recurrent/Refractory Solid Tumours Including CNS Tumours

14 enrolled

Recurrence, Central Nervous System Neoplasms

NCT00335764 2018-07-02

Sorafenib Combined With Erlotinib, Tipifarnib, or Temsirolimus in Treating Patients With Recurrent Glioblastoma Multiforme or Gliosarcoma

Phase 1/2 Completed

92 enrolled 24 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00634270 2017-11-17

Protocol 102

58 enrolled 19 charts

Neurofibromatosis 1

NCT01490476 2017-05-23

AFINF2

10 enrolled

Vestibulocochlear Nerve Diseases, Neuroma, Acoustic, Otorhinolaryngologic Diseases, Peripheral Nervous System Diseases, Neurofibromatosis 2

NCT01155258 2016-06-13

Temsirolimus and Vinorelbine Ditartrate in Treating Patients With Unresectable or Metastatic Solid Tumors