Clinical Trials Browser

NCT05376878 2026-02-23

An Investigational Scan (64Cu-DOTA-Trastuzumab PET/MRI) in Imaging Patients With HER2+ Breast Cancer With Brain Metastasis

Phase 4 Recruiting

10 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT04588545 2026-02-09

Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease

Phase 1/2 Recruiting

39 enrolled

CNS

Meningeal Neoplasms, Meningeal Carcinomatosis

NCT05553522 2025-12-31

Tucatinib, Trastuzumab, and Capecitabine With SRS for Brain Metastases From HER-2 Positive Breast Cancer

Phase 1 Terminated

1 enrolled

CNS

Brain Neoplasms

NCT01373710 2025-11-24

HIT

Phase 1/2 Completed

34 enrolled

BreastCNS

Breast Neoplasms, Meningeal Carcinomatosis

NCT05800275 2025-11-18

ETIC-LM

Phase 2 Recruiting

30 enrolled

CNS

Meningeal Neoplasms, Meningeal Carcinomatosis

NCT03417544 2025-04-02

Atezolizumab + Pertuzumab + Trastuzumab In CNS Mets In BC

Phase 2 Active not recruiting

19 enrolled 26 charts

BreastCNS

HER2-positive Metastatic Breast Cancer

NCT04512261 2022-07-01

TOPAZ

Phase 1/2 Withdrawn

BreastCNS

Brain Neoplasms, Breast Neoplasms, Central Nervous System Diseases

NCT04334330 2022-05-02

Palbociclib, Trastuzumab,Pyrotinib and Fulvestrant Treatment in Patients With Brain Metastasis From ER/PR Positive, HER-2 Positive Breast Cancer: A Multi-center, Prospective Study in China

Phase 2 Unknown

34 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT04760431 2021-06-02

TKIs vs. Pertuzumab in HER2+ Breast Cancer Patients With Active Brain Metastases (HER2BRAIN)

Phase 2 Unknown

120 enrolled

CNS

Brain Neoplasms

NCT02260531 2021-05-20

Cabozantinib +/- Trastuzumab In Breast Cancer Patients w/ Brain Metastases

Phase 2 Completed

36 enrolled 19 charts

BreastCNS

Brain Neoplasms, Breast Neoplasms, Triple Negative Breast Neoplasms

NCT01305941 2018-12-17

A Study Of Everolimus, Trastuzumab And Vinorelbine In HER2-Positive Breast Cancer Brain Metastases

Phase 2 Completed

32 enrolled 19 charts

BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT02598427 2018-02-28

Intrathecal Pertuzumab and Trastuzumab in Patients With New Untreated Asymptomatic or Low Symptomatic Brain Metastasis in HER2 Positive Breast Cancer

Phase 1 Terminated

1 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT02735798 2017-05-04

64-Cu Labeled Brain PET/MRI for MM-302 in Advanced HER2+ Cancers With Brain Mets

Phase EARLY_PHASE1 Withdrawn

CNS

Brain Neoplasms

NCT00397501 2017-04-21

BBBD Followed By Methotrexate and Carboplatin With or Without Trastuzumab in Treating Women With Breast Cancer That Has Spread to the Brain

Phase 1/2 Withdrawn

BreastCNS

Brain Neoplasms, Breast Neoplasms, Central Nervous System Neoplasms, Drug-Related Side Effects and Adverse Reactions