Clinical Trials

70 enrolled

Glioma

NCT06625190 2026-03-11

Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors

Phase 1/2 Not yet recruiting

27 enrolled

CNSSarcoma

Chordoma, Myoepithelioma, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Sarcoma, Synovial, Sarcoma, Clear Cell, Sarcoma, Alveolar Soft Part, Nerve Sheath Neoplasms, Rhabdoid Tumor, Desmoplastic Small Round Cell Tumor

NCT06639607 2026-03-10

PRiME II

68 enrolled

Diffuse Intrinsic Pontine Glioma, Ependymoma, Medulloblastoma, Recurrence

NCT05660408 2026-03-09

RNA PRIME

36 enrolled

Brain Neoplasms, Glioma

NCT05987644 2026-03-09

DURABLE

56 enrolled

CNSThoracic

Brain Neoplasms, Lung Neoplasms

NCT05789589 2026-03-04

ADORATION

46 enrolled

Brain Neoplasms, Neoplasm Metastasis, Neoplasms

NCT06541262 2026-03-02

Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors

104 enrolled

CNSSarcoma

Liposarcoma, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma

NCT06672575 2026-02-27

A Phase I/II Study of IVONESCIMAB in Recurrent Glioblastoma

45 enrolled

Glioblastoma

NCT06622434 2026-02-20

NAVIG-1

35 enrolled

Glioblastoma

NCT07410494 2026-02-18

SELECT-CAR-NK

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicLymphoidOther hematologic neoplasmPlasma cellThoracic

85 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Glioblastoma, Carcinoma, Hepatocellular, Liver Neoplasms, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Melanoma, Multiple Myeloma, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms, Colorectal Neoplasms, Leukemia, Myeloid, Acute

NCT07410676 2026-02-18

EBNK-ST-001

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicOther hematologic neoplasmSarcomaThoracic

83 enrolled

Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Bronchogenic, Disease, Esophageal Neoplasms, Glioblastoma, Kidney Neoplasms, Leukemia, Liver Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Sarcoma, Stomach Neoplasms, Colorectal Neoplasms

NCT03529448 2026-02-12

GEINOCANN

Phase 1/2 Completed

33 enrolled

Glioblastoma

NCT07399821 2026-02-10

GLOW-FISH

22 enrolled

Neuroblastoma

NCT03510208 2026-02-09

Panitumumab-IRDye800 in Diagnosing Participants With Malignant Glioma Undergoing Surgery

46 enrolled

Brain Neoplasms, Glioma

NCT04901702 2026-02-09

Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma

CNSGastrointestinalGenitourinarySarcoma

90 enrolled

Neoplasms, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma, Neuroectodermal Tumors, Primitive, Peripheral, Rhabdoid Tumor

NCT04923542 2026-02-06

Stereotactic Radiation & Abemaciclib in the Management of HR+/HER2- Breast Cancer Brain Metastases

31 enrolled

Phase 1/2 Not yet recruiting

Brain Neoplasms

NCT07392957 2026-02-06

Safety and Efficacy of CTX-009 With or Without CTX-471 for Recurrent Glioblastoma

54 enrolled

Glioblastoma

NCT05027386 2026-02-05

Apatinib Mesylate Combined With IT Regimen for the Treatment of Recurrent or Refractory Pediatric Neuroblastoma: A Single-arm, Phase I/II，Multi-center, Clinical Study.

125 enrolled

Neuroblastoma

NCT07391215 2026-02-05

5G-PEARL

64 enrolled

Glioblastoma

NCT06208657 2026-01-28

Optimal Precision TherapIes to CustoMISE Care in Childhood and Adolescent Cancer

90 enrolled

CNSLymphoid

Lymphoma, Neoplasms, Recurrence, Central Nervous System Neoplasms

NCT06630260 2026-01-21

5G-RUBY

182 enrolled

Phase 1/2 Not yet recruiting

Glioblastoma

NCT07346157 2026-01-16

PNOC044

69 enrolled

Medulloblastoma

NCT05588453 2026-01-12

Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to the Brain

30 enrolled

CNSDermatologic

Brain Neoplasms, Melanoma

NCT03277638 2026-01-08

Laser Interstitial Thermotherapy (LITT) Combined With Checkpoint Inhibitor for Recurrent GBM (RGBM)

32 enrolled

Brain Neoplasms, Glioblastoma

NCT01757626 2026-01-07

Combination Therapy of Antibody Hu3F8 With Granulocyte- Macrophage Colony Stimulating Factor (GM-CSF) in Patients With Relapsed/Refractory High-Risk Neuroblastoma

186 enrolled 2 FDA

Neuroblastoma

NCT04677049 2026-01-02

Study of Niacin in Glioblastoma

Phase 1/2 Suspended

59 enrolled

Glioblastoma

NCT04711824 2025-12-23

SOLARA

41 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT07150806 2025-12-22

RYZ101 for the Treatment of Progressive or Recurrent Intracranial Meningioma

30 enrolled

Meningioma

NCT05039281 2025-12-19

Atezolizumab and Cabozantinib for the Treatment of Recurrent Glioblastoma

6 enrolled

CNSSarcoma

Glioblastoma, Gliosarcoma

NCT07145047 2025-12-19

Clinical Study of Oncolytic Virus in Glioblastoma

20 enrolled

Glioblastoma

NCT05521048 2025-12-08

Doxycycline in Cutaneous Schwannoma (NF2)

19 enrolled

Neurofibromatosis 2

NCT05956821 2025-12-08

Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age

20 enrolled

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Glioblastoma, Oligodendroglioma

NCT02932280 2025-12-05

Safety and Dose Finding Study of Neratinib in Children and Young Adults With Cancer That Has Returned or Not Responded to Treatment

CNSLymphoidOther hematologic neoplasm

14 enrolled

Disease, Leukemia, Lymphoma, Recurrence, Central Nervous System Neoplasms

NCT03212742 2025-12-04

OLA-TMZ-RTE-01

91 enrolled

Glioma

NCT06194929 2025-12-03

DETERMINE

33 enrolled

CNSDermatologic

Brain Neoplasms, Melanoma

NCT03687957 2025-11-25

rhIL-7-hyFc on Increasing Lymphocyte Counts in Patients With Newly Diagnosed Non-severe Lymphopenic Gliomas Following Radiation and Temozolomide

42 enrolled 19 charts

Glioma

NCT01373710 2025-11-24

HIT

Phase 1/2 Completed

34 enrolled

BreastCNS

Breast Neoplasms, Meningeal Carcinomatosis

NCT03233152 2025-11-21

GlitIpNi

110 enrolled

Glioblastoma, Recurrence

NCT04085887 2025-11-18

Panitumumab-IRDye800 to Detect Pediatric Neoplasms During Neurosurgical Procedures

12 enrolled

Brain Neoplasms

NCT06970145 2025-11-18

Safety and Efficacy of Anlotinib in the Treatment of Recurrent Craniopharyngioma

57 enrolled

Craniopharyngioma

NCT02696993 2025-11-10

Nivolumab and Radiation Therapy With or Without Ipilimumab in Treating Patients With Brain Metastases From Non-small Cell Lung Cancer

80 enrolled

CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT05278208 2025-10-20

Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors

65 enrolled

Diffuse Intrinsic Pontine Glioma, Ependymoma, Glioma, Medulloblastoma, Meningioma, Neoplasms, Germ Cell and Embryonal, Central Nervous System Neoplasms

NCT06814496 2025-10-09

RABBIT

CNSDermatologicGenitourinaryGynecologicThoracic

30 enrolled

Sinonasal undifferentiated carcinoma, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Glioblastoma, Melanoma, Testicular Neoplasms, Carcinoma, Merkel Cell, Carcinoma, Medullary, Esthesioneuroblastoma, Olfactory

NCT06059690 2025-10-08

Biologic Association Between Metabolic Magnetic Resonance-positron Emission Tomograph (MR-PET) and Tissue Measures of Glycolysis in Brain Tumors of Infiltrating Glioblastoma Cells

50 enrolled

Glioblastoma

NCT02285439 2025-10-07

Study of MEK162 for Children With Low-Grade Gliomas

Phase 1/2 Completed

105 enrolled 17 charts

Brain Neoplasms, Soft Tissue Neoplasms

NCT05734560 2025-10-06

D2C7-IT and 2141-V11 in Newly Diagnosed GBM Patients

50 enrolled

Glioblastoma

NCT05296564 2025-10-02

Anti-NY-ESO-1 TCR-Gene Engineered Lymphocytes Given by Infusion to Patients With NY-ESO-1 -Expressing Metastatic Cancers

BreastCNSDermatologicGynecologicSarcomaThoracic

3 enrolled

Carcinoma, Non-Small-Cell Lung, Melanoma, Neoplasm Metastasis, Neuroblastoma, Ovarian Neoplasms, Sarcoma, Sarcoma, Synovial, Triple Negative Breast Neoplasms

NCT06462092 2025-09-29

Sacituzumab Govitecan and Intrathecal Chemotherapy for Treating Leptomeningeal Metastases From Her2-negative Breast Cancer

34 enrolled

BreastCNS

Breast Neoplasms, Meningeal Carcinomatosis

NCT06462222 2025-09-29

Immune Checkpoint Inhibitor Combined With Pemetrexed Intrathecal Injection for Leptomeningeal Metastasis From Solid Tumors

45 enrolled