Clinical Trials Browser

Adenocarcinoma, Brain Neoplasms, Bronchial Neoplasms, Carcinoma, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Lung Diseases, Lung Neoplasms, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Thoracic Neoplasms

NCT05324501 2025-02-10

MAGIC-G1

Phase 1 Terminated

4 enrolled

CNS

Glioblastoma

NCT01121588 2025-01-23

Studying An Investigational Drug Crizotinib (PF-02341066) In Non Non-Small Cell Lung Cancer Tumors That Are Positive For Anaplastic Lymphoma Kinase (ALK)

Phase 1 Terminated

44 enrolled 22 charts 1 FDA

CNSLymphoid

Lymphoma, Neoplasms, Neuroblastoma

NCT04397679 2025-01-15

Partial Brain RT, Temozolomide, Chloroquine, and TTF Therapy for the Treatment of Newly Diagnosed Glioblastoma

Phase 1 Terminated

2 enrolled

CNSSarcoma

Glioblastoma, Gliosarcoma

NCT04404569 2024-12-20

ETERNITI

Phase 1 Terminated

5 enrolled

CNS

Glioblastoma, Glioma, Neoplasms

NCT04771897 2024-12-20

KONQUER

Phase 1 Terminated

10 enrolled

CNS

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Glioma

NCT05831995 2024-12-06

Safety and Effectiveness of ABM-168 in Adults with Advanced Solid Tumors.

Phase 1 Terminated

12 enrolled

CNSDermatologicGastrointestinalThoracic

Brain Neoplasms, Glioblastoma, Lung Neoplasms, Melanoma, Pancreatic Neoplasms, Colorectal Neoplasms

NCT04525014 2024-10-31

PIRATE

Phase 1 Terminated

2 enrolled

CNS

Brain Neoplasms, Neoplasms, Spinal Cord Neoplasms, Central Nervous System Neoplasms

NCT04800822 2024-10-22

PF-07284892 in Participants With Advanced Solid Tumors

Phase 1 Terminated

53 enrolled

CNSGastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Neurofibromatosis 1, Hereditary Sensory and Autonomic Neuropathies, Colorectal Neoplasms

NCT01246869 2024-10-01

Assessment of Primary and Metastatic Brain Tumor Hypoxia With Fluoromisonidazole, FDG and Water

Phase 1 Terminated

2 enrolled

CNS

Brain Neoplasms, Glioblastoma, Glioma, Meningioma, Neoplasms

NCT03539731 2024-08-12

[18F]DASA-23 and PET Scan in Evaluating Pyruvate Kinase M2 Expression in Patients With Intracranial Tumors or Recurrent Glioblastoma and Healthy Volunteers

Phase 1 Terminated

27 enrolled

CNS

Brain Neoplasms, Glioblastoma

NCT02630043 2024-08-06

Trial of Tolcapone With Oxaliplatin for Neuroblastoma

Phase 1 Terminated

5 enrolled

CNS

Neuroblastoma

NCT04047303 2024-07-05

CNS Penetration, PK and PD of Preoperative CC-90010 in Progressive/Recurrent Diffuse Astrocytoma, Anaplastic Astrocytoma and Glioblastoma

Phase 1 Terminated

20 enrolled

CNS

Astrocytoma, Glioblastoma, Recurrence

NCT03250299 2024-06-24

Microtubule-Targeted Agent BAL101553 and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma

Phase 1 Terminated

26 enrolled 17 charts

CNS

Brain Neoplasms, Glioblastoma

NCT03451825 2024-06-24

Phase I/II Study of Avelumab in Pediatric Cancer Participants

Phase 1 Terminated

21 enrolled 21 charts

CNSLymphoid

Lymphoma, Central Nervous System Neoplasms

NCT02924038 2024-06-14

A Study of Varlilumab and IMA950 Vaccine Plus Poly-ICLC in Patients With WHO Grade II Low-Grade Glioma (LGG)

Phase 1 Terminated

14 enrolled 10 charts

CNSLymphoid

Astrocytoma, Glioma, Lymphoma, Follicular, Oligodendroglioma

NCT04190628 2024-05-21

Safety and Tolerability of ABM-1310 in Patients With Advanced Solid Tumors

Phase 1 Terminated

53 enrolled

CNSDermatologicGastrointestinalGynecologicHead & NeckThoracic

Carcinoma, Non-Small-Cell Lung, Glioblastoma, Melanoma, Ovarian Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms, Cholangiocarcinoma

NCT02880410 2024-04-12

FLAG

Phase 1 Terminated

3 enrolled

CNS

Glioblastoma

NCT02133183 2024-04-04

Sapanisertib Before and After Surgery in Treating Patients With Recurrent Glioblastoma

Phase 1 Terminated

40 enrolled

CNSSarcoma

Glioblastoma, Gliosarcoma

NCT04901806 2024-03-28

Study of PBI-200 in Subjects With NTRK-Fusion-Positive Solid Tumors

Phase 1 Terminated

29 enrolled

CNS

Brain Neoplasms, Desmoplastic Small Round Cell Tumor

NCT03705351 2024-03-04

Tumor Treating Fields With Chemoradiation in Newly Diagnosed GBM

Phase 1 Terminated

7 enrolled 12 charts

CNS

Brain Neoplasms, Glioblastoma

NCT04341311 2024-02-15

DIPG

Phase 1 Terminated

4 enrolled

CNS

Diffuse Intrinsic Pontine Glioma, Neoplasms, Recurrence

NCT04187872 2023-12-27

TORCH

Phase 1 Terminated

10 enrolled

CNSDermatologicGastrointestinalGenitourinaryGynecologicThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Carcinoma, Hepatocellular, Melanoma, Stomach Neoplasms, Carcinoma, Merkel Cell, Small Cell Lung Carcinoma

NCT04096716 2023-12-21

Mapping Draining Lymph Nodes in CNS Malignancies

Phase 1 Terminated

14 enrolled

CNS

Central Nervous System Neoplasms

NCT02168270 2023-11-24

Temozolomide and Ascorbic Acid in Treating Patients With Recurrent High-Grade Glioma

Phase 1 Terminated

4 enrolled 6 charts

CNSSarcoma

Astrocytoma, Glioblastoma, Oligodendroglioma, Gliosarcoma

Clinical Trials

NEPENTHE

DFF332 as a Single Agent and in Combination With Everolimus & Immuno-Oncology Agents in Advanced/Relapsed Renal Cancer & Other Malignancies

ACTION

Re-Administration of C134 in Patients With Recurrent GBM (C134-HSV-1)

Dose Escalation and Cohort Expansion Study of Niraparib and Dostarlimab in Paediatric Participants With Solid Tumors (SCOOP)

Tucatinib, Trastuzumab, and Capecitabine With SRS for Brain Metastases From HER-2 Positive Breast Cancer

Testing the Ability of AMG 232 (KRT 232) to Get Into the Tumor in Patients With Brain Cancer

BRAVO

A FIH Study of PF-07284890 in Participants With BRAF V600 Mutant Solid Tumors With and Without Brain Involvement

A Study of TAS2940 in Participants With Locally Advanced or Metastatic Solid Tumor Cancer

Study of Efficacy and Safety of Ribociclib (LEE011) in Combination With Topotecan and Temozolomide (TOTEM) in Pediatric Patients With Relapsed or Refractory Neuroblastoma and Other Solid Tumors

Study of IK-595 in RAS- or RAF-altered Advanced Tumors

A Study of HMPL-306 in Advanced Solid Tumors With IDH Mutations

E6201 and Dabrafenib for the Treatment of Central Nervous System Metastases From BRAF V600 Mutated Metastatic Melanoma

Tovorafenib (DAY101) or in Combination With Pimasertib for Participants With Melanoma and Other Solid Tumors

RENEW: Feasibility of CMV RNA-Pulsed Dendritic Cells Vaccines for the Treatment of Newly Diagnosed Glioblastoma Patients.

9-ING-41 in Pediatric Patients With Refractory Malignancies.

Non-Invasive Focused Ultrasound (FUS) With Oral Panobinostat in Children With Progressive Diffuse Midline Glioma (DMG)

LMD

Temozolomide, Memantine Hydrochloride, Mefloquine, and Metformin Hydrochloride in Treating Patients With Glioblastoma Multiforme After Radiation Therapy

Panobinostat and Stereotactic Radiation Therapy in Treating Patients With Brain Tumors

GVAX Plus Checkpoint Blockade in Neuroblastoma

Trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine

ONC201 in Pediatric H3 K27M Gliomas

RAPIBE

(Concerto) Study of BLU-451 in Advanced Cancers With EGFR Exon 20 Insertion Mutations

MAGIC-G1

Studying An Investigational Drug Crizotinib (PF-02341066) In Non Non-Small Cell Lung Cancer Tumors That Are Positive For Anaplastic Lymphoma Kinase (ALK)

Partial Brain RT, Temozolomide, Chloroquine, and TTF Therapy for the Treatment of Newly Diagnosed Glioblastoma

ETERNITI

KONQUER

Safety and Effectiveness of ABM-168 in Adults with Advanced Solid Tumors.

PIRATE

PF-07284892 in Participants With Advanced Solid Tumors

Assessment of Primary and Metastatic Brain Tumor Hypoxia With Fluoromisonidazole, FDG and Water

[18F]DASA-23 and PET Scan in Evaluating Pyruvate Kinase M2 Expression in Patients With Intracranial Tumors or Recurrent Glioblastoma and Healthy Volunteers

Trial of Tolcapone With Oxaliplatin for Neuroblastoma

CNS Penetration, PK and PD of Preoperative CC-90010 in Progressive/Recurrent Diffuse Astrocytoma, Anaplastic Astrocytoma and Glioblastoma

Microtubule-Targeted Agent BAL101553 and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma

Phase I/II Study of Avelumab in Pediatric Cancer Participants

A Study of Varlilumab and IMA950 Vaccine Plus Poly-ICLC in Patients With WHO Grade II Low-Grade Glioma (LGG)

Safety and Tolerability of ABM-1310 in Patients With Advanced Solid Tumors

FLAG

Sapanisertib Before and After Surgery in Treating Patients With Recurrent Glioblastoma

Study of PBI-200 in Subjects With NTRK-Fusion-Positive Solid Tumors

Tumor Treating Fields With Chemoradiation in Newly Diagnosed GBM

DIPG

TORCH

Mapping Draining Lymph Nodes in CNS Malignancies

Temozolomide and Ascorbic Acid in Treating Patients With Recurrent High-Grade Glioma