Clinical Trials

19 enrolled 10 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma

NCT03165721 2026-02-18

A Phase II Trial of the DNA Methyl Transferase Inhibitor, Guadecitabine (SGI-110), in Children and Adults With Wild Type GIST,Pheochromocytoma and Paraganglioma Associated With Succinate Dehydrogenase Deficiency and HLRCC-associated Kidney Cancer

CNSEndocrineGastrointestinalGenitourinarySarcoma

9 enrolled 11 charts

Carcinoma, Renal Cell, Kidney Neoplasms, Paraganglioma, Pheochromocytoma, Gastrointestinal Stromal Tumors

NCT05746481 2026-01-22

Tiragolumab and Atezolizumab in Patients With Non-squamous Non-small Cell Lung Cancer (NSCLC) and Untreated Brain Metastases

3 enrolled 12 charts

CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT05267106 2025-12-30

FIGHT-209

83 enrolled 18 charts

Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms

NCT06359379 2025-12-18

Ropidoxuridine as a Radiosensitizer in Newly Diagnosed IDH-Wildtype Glioblastoma With Unmethylated MGMT Promoter

30 enrolled

Glioblastoma

NCT04955743 2025-11-24

Pembrolizumab and Lenvatinib in Patients With Brain Metastases From Melanoma or Renal Cell Carcinoma

CNSDermatologicGenitourinary

18 enrolled

Brain Neoplasms, Carcinoma, Renal Cell, Melanoma

NCT04964960 2025-10-31

Pembro+Chemo in Brain Mets

3 enrolled 7 charts

CNSThoracic

Brain Neoplasms, Lung Neoplasms, Neoplasms

NCT04402073 2025-10-23

PersoMed-I

20 enrolled

Medulloblastoma

NCT03868943 2025-10-21

JAZZ

2 enrolled 5 charts

Glioblastoma, Glioma

NCT04985604 2025-10-02

Tovorafenib (DAY101) Monotherapy for Patients With Melanoma and Other Solid Tumors

CNSDermatologicEndocrineGastrointestinalGenitourinaryHead & NeckThoracic

23 enrolled 15 charts

Thyroid Cancer, Papillary, Astrocytoma, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Pancreatic Neoplasms, Colorectal Neoplasms

NCT03347617 2025-09-09

Ferumoxytol MRI in Assessing Response to Pembrolizumab in Patients With Glioblastoma

52 enrolled 15 charts

Glioblastoma

NCT03018288 2025-08-08

Radiation Therapy Plus Temozolomide and Pembrolizumab With and Without HSPPC-96 in Newly Diagnosed Glioblastoma (GBM)

90 enrolled 24 charts

Glioblastoma, Glioma

NCT03295396 2025-07-28

ONC201 in Adults With Recurrent H3 K27M-mutant Glioma

73 enrolled 13 charts 1 FDA

Glioma

NCT04729348 2025-07-25

Pembrolizumab And Lenvatinib In Leptomeningeal Metastases

10 enrolled

Meningeal Carcinomatosis

NCT05563272 2025-07-10

STARBURST

CNSGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmSarcomaThoracic

11 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Ovarian Epithelial, Nasopharyngeal Carcinoma, Mesothelioma, Malignant, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Esophageal Neoplasms, Glioblastoma, Carcinoma, Hepatocellular, Sarcoma, Stomach Neoplasms, Colorectal Neoplasms, Cholangiocarcinoma, Small Cell Lung Carcinoma

NCT04530487 2025-06-29

Donor Stem Cell Transplant After Chemotherapy for the Treatment of Recurrent or Refractory High-Risk Solid Tumors in Pediatric and Adolescent-Young Adults

1 enrolled 7 charts

Neuroblastoma, Rhabdomyosarcoma, Neuroectodermal Tumors, Primitive, Peripheral, Neurofibrosarcoma, Desmoplastic Small Round Cell Tumor

NCT04461418 2025-06-27

ACT-FAST

2 enrolled

Brain Neoplasms

NCT00538343 2025-05-29

RTA 744 in Breast Cancer Patients With Progression of Previously Irradiated Brain Metastases

14 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT05297864 2025-05-23

OU-SCC-PI-4G

15 enrolled 13 charts

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma

NCT03095248 2025-04-22

SEL-TH-1601

10 enrolled 9 charts

Ependymoma, Glioma, Meningioma, Neuroma, Acoustic, Neurofibromatosis 2

NCT02100891 2025-03-19

STIR

15 enrolled 11 charts

Brain Neoplasms, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Central Nervous System Neoplasms

NCT04469699 2025-03-11

NOA11

30 enrolled

Glioblastoma

NCT04897880 2025-02-24

NORTH

25 enrolled

Brain Neoplasms, Rhabdoid Tumor

NCT03016091 2025-02-18

A Trial of Pembrolizumab for Refractory Atypical and Anaplastic Meningioma

18 enrolled 9 charts

Hemangiopericytoma, Meningioma

NCT01814813 2025-01-24

Vaccine Therapy With Bevacizumab Versus Bevacizumab Alone in Treating Patients With Recurrent Glioblastoma Multiforme That Can Be Removed by Surgery

90 enrolled 13 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT01743950 2025-01-08

A Phase II Study of Pulse Reduced Dose Rate Radiation Therapy With Bevacizumab

49 enrolled

Glioblastoma, Glioma

NCT02525692 2024-12-24

Oral ONC201 in Adult Recurrent Glioblastoma

84 enrolled 14 charts 1 FDA

Glioblastoma

NCT02372409 2024-11-01

Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Treatment of Pediatric Brain Tumors

6 enrolled 10 charts

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma, Optic Nerve Glioma

NCT03973918 2024-10-31

BRAF

5 enrolled 15 charts

Astrocytoma, Glioblastoma, Glioma, Gliosarcoma

NCT04952571 2024-10-15

Combined Treatment of Camrelizumab and Bevacizumab for Adult Patients with Recurrent Glioblastoma (GBM)

3 enrolled

Glioblastoma

NCT03363659 2024-10-03

Disulfiram and Copper Gluconate With Temozolomide in Unmethylated Glioblastoma Multiforme

15 enrolled 9 charts

Glioblastoma

NCT02621515 2024-05-06

CA209-322

7 enrolled

CNSDermatologic

Brain Neoplasms, Melanoma

NCT02624388 2024-05-06

UVA-Gen001

CNSGenitourinaryLymphoidSarcoma

4 enrolled 16 charts

Brain Neoplasms, Hodgkin Disease, Lymphoma, Lymphoma, Non-Hodgkin, Medulloblastoma, Neoplasms, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Neuroectodermal Tumors, Primitive

NCT04681677 2024-04-26

IORT

12 enrolled

Glioblastoma

NCT03474614 2024-04-19

Effect of Oral Propranolol on mRNA Expresssion in Symptomatic Cavernous Malformation

4 enrolled

Hemangioma, Cavernous, Central Nervous System

NCT03927222 2024-04-08

I-ATTAC

6 enrolled 7 charts

Glioblastoma, Tetanus

NCT04610684 2024-03-13

Chemotherapy and Atezolizumab for Patients With Extensive Stage Small Cell Lung Cancer (SCLC) With Untreated, Asymptomatic Brain Metastases

3 enrolled 13 charts

CNSThoracic

Brain Neoplasms, Small Cell Lung Carcinoma

NCT01345136 2024-02-13

Study of RAD001 for Treatment of NF2-related Vestibular Schwannoma

4 enrolled

Neuroma, Acoustic, Neurofibromatosis 2

NCT01894633 2024-01-24

CLQ

73 enrolled

Brain Neoplasms, Neoplasm Metastasis

NCT03504501 2023-11-30

SynCoRAS

16 enrolled

Cognition Disorders, Neurofibromatosis 1, Noonan Syndrome

NCT03430947 2023-09-14

RadioCoBRIM

20 enrolled

CNSDermatologic

Brain Neoplasms, Melanoma

NCT00659126 2023-09-07

Ferumoxytol- and Gadolinium-Labeled MRI in Measuring Tumors Before or After Treatment in Patients With Primary or Metastatic Brain Tumors

40 enrolled 8 charts

Brain Neoplasms

NCT00074165 2023-07-06

Treating Patients With Recurrent PCNSL With Carboplatin/BBBD and Adding Rituxan To The Treatment Regimen

CNSClassical hematologyLymphoid

17 enrolled 7 charts

Lymphoma, Thrombocytopenia, Central Nervous System Neoplasms, Intraocular Lymphoma, Drug-Related Side Effects and Adverse Reactions

NCT03911869 2023-05-31

POLARIS

13 enrolled 55 charts

CNSDermatologic

Brain Neoplasms, Melanoma

NCT03436433 2023-04-13

Seizure Prophylaxis in Patients With Glioma or Brain Metastasis

4 enrolled 8 charts

Brain Neoplasms, Glioma

NCT02490878 2023-03-23

Corticosteroids + Bevacizumab vs. Corticosteroids + Placebo (BEST) for Radionecrosis After Radiosurgery for Brain Metastases

19 enrolled 15 charts

Brain Neoplasms

NCT03430791 2023-02-02

Trial of Combination Tumor Treating Fields (TTF; Optune), Nivolumab Plus/Minus Ipilimumab for Recurrent Glioblastoma

5 enrolled 10 charts

Glioblastoma

NCT01986348 2023-01-26

KING

76 enrolled 16 charts