Clinical Trials

BreastCNSDermatologicOther hematologic neoplasmThoracic

Diffuse Intrinsic Pontine Glioma, Glioma

NCT04789668 2026-03-18

Bintrafusp Alfa and Pimasertib for the Treatment of Patients With Brain Metastases

Phase 1/2 Terminated

8 enrolled 13 charts

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Hematologic Neoplasms, Triple Negative Breast Neoplasms

NCT05286684 2026-03-18

Exo-LCR

Phase NA Completed

7 enrolled

BreastCNS

Breast Neoplasms, Meningeal Carcinomatosis

NCT05500391 2026-03-18

SUR-CAN

CNSEndocrineGastrointestinalNETSarcoma

88 enrolled

Carcinosarcoma, Glioma, Seminoma, Adenocarcinoma, Clear Cell, Carcinoma, Small Cell, Sex Cord-Gonadal Stromal Tumors, Neuroendocrine Tumors, Gastrointestinal Stromal Tumors

NCT07479446 2026-03-18

Oliceridine Versus Sufentanil for Postoperative Nausea in Cerebellopontine Angle Surgery

174 enrolled

Phase NA Active not recruiting

Neuroma, Acoustic, Postoperative Nausea and Vomiting

NCT02429570 2026-03-17

Meclofenamate in Subjects With Recurrent or Progressive Brain Metastasis From Solid Tumor Primary

30 enrolled

Brain Neoplasms

NCT04119024 2026-03-17

Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors

BreastCNSDermatologicEndocrineHead & NeckNETThoracic

18 enrolled

Adenocarcinoma of Lung, Squamous Cell Carcinoma of Head and Neck, Uveal Melanoma, Breast Neoplasms, Adenoma, Islet Cell, Melanoma, Neoplasm Metastasis, Paraganglioma, Pheochromocytoma, Thyroid Neoplasms, Adrenocortical Carcinoma, Neuroendocrine Tumors

NCT04732065 2026-03-17

PNOC023

208 enrolled

Ependymoma, Glioblastoma, Central Nervous System Neoplasms

NCT05393258 2026-03-17

Temporally-modulated Pulsed Radiation Therapy (TMPRT) After Prior EBRT for Recurrent IDH-mutant Gliomas

Phase NA Completed

13 enrolled

Astrocytoma, Glioma, Oligodendroglioma

NCT06934889 2026-03-17

Study of ABBV-637 or ABBV-155 With ERAS-801 for People With Glioblastoma

Phase NA Active not recruiting

60 enrolled

CNSSarcoma

Glioblastoma, Gliosarcoma

NCT07475390 2026-03-17

99mTc-1-thio-D-glucose SPECT/CT Versus 18F-Fluoroethyl-l-tyrosine PET/CT in Brain Tumor Imaging

40 enrolled

Glioma

NCT07476794 2026-03-17

TEMPO

118 enrolled

Glioblastoma

NCT01165333 2026-03-16

CILENT

Phase 1 Completed

32 enrolled

Diffuse Intrinsic Pontine Glioma, Glioma

NCT02565433 2026-03-16

PRAMECE

Phase NA Terminated

52 enrolled

Brain Neoplasms, Neoplasm Metastasis

NCT04485559 2026-03-16

Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)

50 enrolled

Glioma

NCT05057702 2026-03-16

PNOC027

74 enrolled

Ependymoma, Medulloblastoma

NCT05753007 2026-03-16

A Clinical Trial of a Hemp-Derived, High Cannabidiol Product for Anxiety in Glioblastoma Patients

Phase 2 Terminated

2 enrolled 13 charts

Glioblastoma

NCT06186401 2026-03-16

Anti-EGFRvIII synNotch Receptor Induced Anti-EphA2/IL-13Ralpha2 CAR (E-SYNC) T Cells

20 enrolled

Glioblastoma

NCT07472387 2026-03-16

Andro-iGlio

40 enrolled

Glioblastoma

NCT00107289 2026-03-13

Iodine I 131 Metaiodobenzylguanidine in Treating Patients With Recurrent, Progressive, or Refractory Neuroblastoma or Malignant Pheochromocytoma or Paraganglioma

200 enrolled

CNSEndocrine

Neuroblastoma, Pheochromocytoma

NCT01804634 2026-03-13

Reduced Intensity Haploidentical BMT for High Risk Solid Tumors

CNSGastrointestinalSarcoma

60 enrolled

Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma

NCT03475186 2026-03-13

Testing Ramipril to Prevent Memory Loss in People With Glioblastoma

Phase 2 Completed

75 enrolled 47 charts

Phase 1 Active not recruiting

Brain Neoplasms, Glioblastoma, Cognitive Dysfunction

NCT03749187 2026-03-13

PNOC017

78 enrolled

Glioblastoma, Glioma

NCT04936529 2026-03-13

A Study of a Vaccine in Combination With β-glucan and GM-CSF in People With Neuroblastoma

286 enrolled

Neuroblastoma

NCT05940493 2026-03-13

Abemaciclib in Newly Diagnosed Meningioma Patients

72 enrolled

Phase 1 Active not recruiting

Meningioma

NCT06946680 2026-03-13

IMPACT

18 enrolled

Brain Neoplasms, Glioblastoma, Glioma

NCT07469735 2026-03-13

VANGUARD

10 enrolled

Glioma

NCT07471100 2026-03-13

Neuromodulation-Induced Cortical Prehabilitation in High Grade Glioma Near the Motor Pathway: Cortical Plasticity Assessed by Navigated Transcranial Magnetic Stimulation (nTMS)

63 enrolled

Glioma

NCT02287428 2026-03-12

Personalized NeoAntigen Cancer Vaccine w RT Plus Pembrolizumab for Patients With Newly Diagnosed GBM

56 enrolled

Glioblastoma

NCT02896335 2026-03-12

Palbociclib and Pembrolizumab In Central Nervous System Metastases

45 enrolled

Brain Neoplasms

NCT03257618 2026-03-12

TEMOIN

Phase NA Completed

26 enrolled

Phase 2 Active not recruiting

Glioma

NCT05865990 2026-03-12

TUXEDO-3

63 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms, Meningeal Neoplasms

NCT06188741 2026-03-12

NF114

200 enrolled

Phase EARLY_PHASE1 Recruiting

Neurofibromatosis 1, Neurofibroma, Plexiform

NCT06333899 2026-03-12

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

15 enrolled

Phase 1 Not yet recruiting

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Glioblastoma, Glioma

NCT06502171 2026-03-12

NF113

30 enrolled

Phase 2 Active not recruiting

Neurofibromatosis 1, Neurofibroma, Plexiform

NCT03971461 2026-03-11

Phase II Study of 177Lu-DOTATATE Radionuclide in Adults With Progressive or High-risk Meningioma

32 enrolled

Meningioma

NCT04044937 2026-03-11

UC-GlioFET

Phase 2 Completed

143 enrolled

Brain Neoplasms, Glioblastoma

NCT05086497 2026-03-11

WBSI Guided Personalized Delivery of TTFields

155 enrolled

Phase 1 Active not recruiting

Brain Neoplasms, Glioblastoma

NCT05743595 2026-03-11

Neoantigen-based Personalized DNA Vaccine With Retifanlimab PD-1 Blockade Therapy in Patients With Newly Diagnosed, Unmethylated Glioblastoma

27 enrolled

Glioblastoma

NCT06504381 2026-03-11

DB107-RRV, DB107-FC, and Radiation Therapy With or Without Temozolomide (TMZ) for High Grade Glioma

Phase 1/2 Recruiting

70 enrolled

Glioma

NCT06625190 2026-03-11

Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors

Phase 1/2 Recruiting

27 enrolled

CNSSarcoma

Chordoma, Myoepithelioma, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Sarcoma, Synovial, Sarcoma, Clear Cell, Sarcoma, Alveolar Soft Part, Nerve Sheath Neoplasms, Rhabdoid Tumor, Desmoplastic Small Round Cell Tumor

NCT06914479 2026-03-11

Virus-Based Gene Therapy (AdV-HSV1-TK and AdV-Flt3L) in Combination With Valacyclovir for the Treatment of Pediatric and Young Adult Patients With Resectable, Recurrent Primary Malignant Brain Tumors

11 enrolled

Phase EARLY_PHASE1 Not yet recruiting

Brain Neoplasms

NCT07039760 2026-03-11

Asciminib With or Without Sildenafil for Brain Tumors

12 enrolled

Brain Neoplasms

NCT02780128 2026-03-10

NEPENTHE

Phase 1 Terminated

66 enrolled

Neoplasms, Neuroblastoma

NCT04752280 2026-03-10

GRIPS

326 enrolled

Glioblastoma

NCT05378633 2026-03-10

CyberChallenge

Phase 2 Active not recruiting

190 enrolled

CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasm Metastasis

NCT06048718 2026-03-10

TUXEDO-4

28 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT06104930 2026-03-10

MOLI

60 enrolled

Phase 1/2 Not yet recruiting

Meningioma

NCT06639607 2026-03-10

PRiME II

68 enrolled