Clinical Trials

42 enrolled 13 charts

Uveal Melanoma

NCT03070392 2026-03-17

Safety and Efficacy of IMCgp100 Versus Investigator Choice in Advanced Uveal Melanoma

378 enrolled 15 charts 1 FDA

Uveal Melanoma, Melanoma

NCT04119024 2026-03-17

Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors

BreastCNSDermatologicEndocrineHead & NeckNETThoracic

18 enrolled

Adenocarcinoma of Lung, Squamous Cell Carcinoma of Head and Neck, Uveal Melanoma, Breast Neoplasms, Adenoma, Islet Cell, Melanoma, Neoplasm Metastasis, Paraganglioma, Pheochromocytoma, Thyroid Neoplasms, Adrenocortical Carcinoma, Neuroendocrine Tumors

NCT02068586 2026-03-16

Sunitinib Malate or Valproic Acid in Preventing Metastasis in Patients With High-Risk Uveal Melanoma

210 enrolled

Uveal Melanoma

NCT05907954 2026-03-16

(Neo)Adjuvant IDE196 (Darovasertib) in Patients With Localized Ocular Melanoma

160 enrolled

Uveal Melanoma, Plaque, Amyloid

NCT07076550 2026-03-16

A Phase 1-1b Study to Evaluate the Safety, Efficacy and Dosimetry of Study Drug A9-3408 in Subjects With Metastatic Melanoma

50 enrolled

DermatologicGastrointestinalSarcoma

Uveal Melanoma, Melanoma, Neoplasm Metastasis

NCT01046487 2026-03-13

PALANGI3

Phase 1 Completed

26 enrolled

Uveal Melanoma, Chordoma, Carcinoma, Adenoid Cystic, Neoplasms, Desmoid Tumors, Dermatofibrosarcoma, Gastrointestinal Stromal Tumors

NCT07364474 2026-03-11

Immune Response to Percutaneous Hepatic Perfusion With Melphalan for Ocular Melanoma Metastatic to the Liver

Phase NA Recruiting

10 enrolled

DermatologicGastrointestinalGenitourinaryOther solid neoplasmThoracic

Uveal Melanoma, Neoplasm Metastasis

NCT02858869 2026-03-09

Pembrolizumab and Stereotactic Radiosurgery for Melanoma or Non-Small Cell Lung Cancer Brain Metastases

Phase 1 Completed

25 enrolled 14 charts

CNSDermatologicThoracic

Uveal Melanoma, Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma

NCT04792463 2026-03-09

Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome

Recruiting

500 enrolled

Uveal Melanoma, Carcinoma, Renal Cell, Carcinoma, Hepatocellular, Melanoma, Mesothelioma, Cholangiocarcinoma

NCT05199584 2026-03-05

A Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function Mutations

CNSDermatologicEndocrineHead & NeckOther solid neoplasmSarcomaThoracic

20 enrolled

Uveal Melanoma, Glioma, Adenoma, Islet Cell, Laryngeal Diseases, Medulloblastoma, Melanoma, Mesothelioma, Neuroblastoma, Pituitary Diseases, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Osteosarcoma

NCT06246149 2026-03-04

ATOM

Phase 3 Recruiting

290 enrolled

Uveal Melanoma

NCT06414590 2026-03-03

Neoadjuvant Tebentafusp for Uveal Melanoma

19 enrolled

Uveal Melanoma

NCT04855435 2026-03-02

Safety and Preliminary Efficacy of MBS8(1V270) in Cancer Patients With Advanced Solid Tumours

106 enrolled

Uveal Melanoma, Melanoma, Neoplasm Metastasis

NCT06007690 2026-03-02

CoMpass

Phase 3 Recruiting

100 enrolled

Uveal Melanoma, Eye Neoplasms

NCT04336241 2026-02-27

Study of RP2 Monotherapy and RP2 in Combination With Nivolumab in Patients With Solid Tumors

BreastDermatologicGastrointestinalThoracic

36 enrolled

Uveal Melanoma, Breast Neoplasms, Gastrointestinal Neoplasms, Lung Neoplasms, Neoplasms

NCT06070012 2026-02-27

Tebentafusp in HLA-A*0201 Positive Previously Untreated Metastatic Uveal Melanoma

44 enrolled

Uveal Melanoma

NCT03417739 2026-02-25

A Phase II Study of BVD-523 in Metastatic Uveal Melanoma

Phase 2 Terminated

13 enrolled 9 charts

Uveal Melanoma

NCT07421739 2026-02-19

Choroidal Melanoma Patient-Reported Outcome Study (CM-PRO) in a Subset of AU-011-301 (CoMpass) Subjects

Recruiting

15 enrolled

Uveal Melanoma, Eye Neoplasms

NCT03686124 2026-02-18

ACTengine

375 enrolled

DermatologicGynecologic

Uveal Melanoma, Melanoma, Neoplasms, Ovarian Neoplasms, Recurrence

NCT06581406 2026-02-18

A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma

Phase 2/3 Recruiting

280 enrolled

Uveal Melanoma, Melanoma, Neoplasm Metastasis

NCT07015190 2026-02-18

Neoadjuvant Darovasertib in Primary Uveal Melanoma

Phase 3 Recruiting

520 enrolled

Uveal Melanoma, Melanoma

NCT02517736 2026-02-17

O-Mel-Sora

32 enrolled

Uveal Melanoma

NCT04552223 2026-02-11

Nivolumab Plus Relatlimab in Patients With Metastatic Uveal Melanoma

27 enrolled 9 charts

Uveal Melanoma

NCT06432660 2026-02-06

PROMPT

Active not recruiting

42 enrolled

Uveal Melanoma

NCT04645680 2026-01-30

DIET

50 enrolled

Uveal Melanoma, Melanoma

NCT03865212 2026-01-28

Modified Virus VSV-IFNbetaTYRP1 in Treating Patients With Stage III-IV Melanoma

Phase 1 Terminated

12 enrolled

Uveal Melanoma, Melanoma

NCT03947385 2026-01-27

Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions

DermatologicGastrointestinal

336 enrolled

Uveal Melanoma, Melanoma, Colorectal Neoplasms

NCT06717126 2026-01-16

OCULE-01

85 enrolled

Phase NA Active not recruiting

Uveal Melanoma, Melanoma

NCT06075589 2026-01-15

Psychoeducation for Uveal Melanoma

108 enrolled

Uveal Melanoma

NCT07338968 2026-01-14

CoMpass

Not yet recruiting

100 enrolled

Uveal Melanoma

NCT03025256 2026-01-08

Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Disease

71 enrolled

DermatologicThoracic

Uveal Melanoma, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Melanoma, Meningeal Neoplasms, Nevus

NCT05524935 2026-01-08

Olaparib in Combination With Pembrolizumab for Advanced Uveal Melanoma

37 enrolled

BreastDermatologicEndocrineGynecologicHead & Neck

Uveal Melanoma

NCT03746431 2026-01-07

A Phase 1 Study of [225Ac]-FPI-1434 Injection

Phase 1 Terminated

78 enrolled

Squamous Cell Carcinoma of Head and Neck, Uveal Melanoma, Breast Neoplasms, Uterine Cervical Neoplasms, Ovarian Neoplasms, Endometrial Neoplasms, Adrenocortical Carcinoma, Triple Negative Breast Neoplasms

NCT05628883 2026-01-07

Proof of Concept of TBio-4101, Lymphodepleting Chemo, IL-2 for Relapsed/Refractory Melanoma

17 enrolled

Uveal Melanoma, Melanoma

NCT05075993 2025-12-26

Study of LVGN3616 and LVGN6051±LVGN7409 in Combination With Nab-Paclitaxel or Bevacizumab and Cyclophosphamide in Metastatic Solid Tumors

DermatologicGastrointestinalGynecologicSarcoma

352 enrolled

Uveal Melanoma, Carcinoma, Hepatocellular, Ovarian Neoplasms, Sarcoma, Stomach Neoplasms

NCT06022029 2025-12-24

ON-5001

BreastDermatologicGenitourinaryGynecologicHead & NeckLymphoid

168 enrolled

Squamous Cell Carcinoma of Head and Neck, Uveal Melanoma, Bites and Stings, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma in Situ, Uterine Cervical Neoplasms, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Melanoma, Neoplasm Metastasis, Neoplasms, Recurrence, Skin Neoplasms, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Mantle-Cell, Triple Negative Breast Neoplasms

NCT04130516 2025-12-18

Study Assessing MTD, Safety, Tolerability, PK and Anti-tumor Effects of LNS8801alone and With Pembrolizumab

DermatologicGastrointestinalThoracic

200 enrolled

Uveal Melanoma, Carcinoma, Non-Small-Cell Lung, Melanoma, Stomach Neoplasms

NCT07276386 2025-12-11

Phase 2 Combination of Melphalan/HDS Via PHP + Tebentafusp in Treating Metastatic Uveal Melanoma

18 enrolled

Uveal Melanoma

NCT06121180 2025-12-04

Study of Cemiplimab Plus Ziv-Aflibercept for Subjects With Metastatic Uveal Melanoma

32 enrolled

Uveal Melanoma

NCT06940739 2025-12-03

A Study to Investigate the Safety and Efficacy of IOV-3001 in Adults With Advanced Melanoma Who Will Receive Lifileucel

42 enrolled

Uveal Melanoma, Melanoma

NCT06961357 2025-12-03

Clinical Trial of CD40L-augmented TIL for Patients With Advanced Melanoma

36 enrolled

Uveal Melanoma, Melanoma

NCT06626516 2025-11-28

Tebentafusp-tebn With LDT in Metastatic UM

109 enrolled

Uveal Melanoma, Melanoma

NCT07136181 2025-11-28

NBM-BMX-UM

36 enrolled

Uveal Melanoma, Eye Neoplasms, Neoplasm Metastasis, Recurrence

NCT01334008 2025-11-24

Study of Circulating Tumoral DNA in Metastatic Choroidal Melanoma

Phase NA Completed

40 enrolled

Uveal Melanoma

NCT05282901 2025-11-24

PLUME

51 enrolled

Phase 1/2 Active not recruiting

Uveal Melanoma, Melanoma, Neoplasm Metastasis

NCT06784648 2025-11-19

Different Doses of BI-1607 in Combination With Pembrolizumab and Ipilimumab, in Participants With Unresectable or Metastatic Melanoma

35 enrolled

DermatologicGynecologicHead & NeckSarcomaThoracic

Uveal Melanoma, Melanoma, Neoplasm Metastasis

NCT05812027 2025-11-17

A Screening Study to Collect Samples for TAA, HLA & HLA Loss of Heterozygosity in Patients With Metastatic Solid Tumors

Active not recruiting

1,150 enrolled

Uveal Melanoma, Adenocarcinoma, Carcinoma, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Sarcoma

NCT01473004 2025-11-14

SIR-Spheres® 90Y Microspheres Treatment of Uveal Melanoma Metastasized to Liver

48 enrolled 10 charts