Clinical Trials

Phase 2 Active not recruiting

Colonic Neoplasms, Digestive System Diseases, Colorectal Neoplasms

NCT05063565 2026-03-02

ROWAN

100 enrolled

Adenocarcinoma, Carcinoma, Digestive System Diseases, Digestive System Neoplasms, Carcinoma, Hepatocellular, Liver Diseases, Liver Neoplasms, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Glandular and Epithelial

NCT07377487 2026-02-20

INDIGO

EndocrineGastrointestinalNET

51 enrolled

Carcinoma, Colonic Diseases, Digestive System Diseases, Digestive System Neoplasms, Carcinoma, Hepatocellular, Liver Diseases, Liver Neoplasms, Neoplasm Metastasis, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Glandular and Epithelial, Colorectal Neoplasms, Carcinoma, Neuroendocrine, Neuroendocrine Tumors

NCT07222800 2026-01-30

A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer

Phase 3 Recruiting

800 enrolled

Colonic Diseases, Colonic Neoplasms, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Neoplasm Metastasis, Neoplasms by Site, Rectal Diseases, Colorectal Neoplasms

NCT04457297 2026-01-21

ALTAIR

243 enrolled 13 charts

Digestive System Diseases, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Colorectal Neoplasms

NCT07335042 2026-01-12

Prediction Model for MINS After Major Hepatobiliary Surgery

Recruiting

1,800 enrolled

Digestive System Diseases, Liver Neoplasms, Postoperative Complications

NCT05066139 2026-01-05

EPODIG-G

144 enrolled

Digestive System Diseases, Gastrointestinal Neoplasms, Neoplasms

NCT05874726 2025-12-02

Biological Sample Repository for Gastrointestinal Disorders

Active not recruiting

500 enrolled

GastrointestinalOther

Collagen Diseases, Diabetes Mellitus, Diabetes Mellitus, Type 2, Digestive System Diseases, Gastroesophageal Reflux, Hyperlipidemias, Hypertension, Neoplasms, Obesity, Obesity, Morbid, Sleep Apnea Syndromes, Weight Loss, Overweight

NCT05489237 2025-11-17

First-in-human Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors

Phase 1 Recruiting

278 enrolled

GastrointestinalSarcoma

Digestive System Diseases, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Neoplasm Metastasis, Gastrointestinal Stromal Tumors

NCT05612347 2025-09-23

COOP

8,946 enrolled

Digestive System Diseases, Colorectal Neoplasms

NCT06929845 2025-09-15

Organoid Models of Hepatocellular Carcinoma

150 enrolled

Digestive System Diseases, Carcinoma, Hepatocellular

NCT02246725 2025-09-12

ALLAN

108 enrolled

Phase 3 Active not recruiting

Depression, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Colorectal Neoplasms

NCT04607421 2025-08-14

A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal Cancer

831 enrolled 2 FDA

590 enrolled 58 charts 5 FDA

Colonic Diseases, Colonic Neoplasms, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Neoplasms, Rectal Diseases, Rectal Neoplasms, Colorectal Neoplasms

NCT03037385 2025-05-31

ARROW

Phase 1/2 Completed

EndocrineGastrointestinalHead & NeckNETThoracic

Thyroid Cancer, Papillary, Adenocarcinoma, Adenocarcinoma, Papillary, Bronchial Neoplasms, Carcinoma, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Colonic Diseases, Colonic Neoplasms, Digestive System Diseases, Digestive System Neoplasms, Endocrine System Diseases, Endocrine Gland Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Lung Diseases, Lung Neoplasms, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Glandular and Epithelial, Neoplasms, Nerve Tissue, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Thoracic Neoplasms, Thyroid Diseases, Thyroid Neoplasms, Colorectal Neoplasms, Neuroectodermal Tumors, Carcinoma, Medullary, Carcinoma, Neuroendocrine, Neuroendocrine Tumors, Multiple Endocrine Neoplasia Type 2a

NCT01550510 2025-05-06

Research Study of IV Vitamin C in Combination With Irinotecan vs Irinotecan Alone for Advanced Colorectal CA

Phase 1/2 Terminated

4 enrolled 5 charts

Colonic Diseases, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Neoplasms, Neoplasms by Site, Rectal Diseases, Colorectal Neoplasms

NCT01555489 2025-05-04

Assessing the Efficacy and Safety of IV Vitamin C in Combination With Standard Chemotherapy for Pancreatic Ca

Phase 2 Terminated

11 enrolled 8 charts

Digestive System Diseases, Digestive System Neoplasms, Endocrine System Diseases, Endocrine Gland Neoplasms, Neoplasms, Neoplasms by Site, Pancreatic Diseases, Pancreatic Neoplasms

NCT04774952 2025-04-15

Dose Escalation of RMC-5552 Monotherapy in Relapsed/Refractory Solid Tumors

DermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

58 enrolled

Urinary Bladder Neoplasms, Bronchial Neoplasms, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Uterine Cervical Neoplasms, Digestive System Diseases, Digestive System Neoplasms, Esophageal Diseases, Esophageal Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Lung Diseases, Lung Neoplasms, Melanoma, Neoplasms, Neoplasms by Site, Neoplasms, Glandular and Epithelial, Hereditary Sensory and Autonomic Neuropathies, Ovarian Neoplasms, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Skin Neoplasms, Thoracic Neoplasms, Uterine Neoplasms, Neoplasms, Squamous Cell

NCT05233098 2025-03-06

TheraSphere Post-Approval Study to Calculate the Radiation-absorbed Dose of Tc-99m MAA.

6 enrolled 15 charts

Adenocarcinoma, Carcinoma, Digestive System Diseases, Digestive System Neoplasms, Carcinoma, Hepatocellular, Liver Diseases, Liver Neoplasms, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Glandular and Epithelial

NCT05786482 2025-01-06

EMPOwer

Phase NA Completed

825 enrolled

Anxiety Disorders, Depression, Digestive System Diseases, Heart Failure, Liver Cirrhosis, Liver Cirrhosis, Biliary, Neoplasms, Renal Insufficiency, Chronic

NCT02112656 2024-08-20

OPTIMA

554 enrolled 9 charts

Phase NA Active not recruiting

Adenocarcinoma, Carcinoma, Digestive System Diseases, Digestive System Neoplasms, Carcinoma, Hepatocellular, Liver Diseases, Liver Neoplasms, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Glandular and Epithelial

NCT04084249 2024-07-09

ctDNA-guided Surveillance for Stage III CRC, a Randomized Intervention Trial

359 enrolled

Colonic Diseases, Colonic Neoplasms, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Neoplasms, Rectal Diseases, Rectal Neoplasms, Colorectal Neoplasms

NCT03077685 2024-06-24

Trial of NanoPac® in Subjects With Locally Advanced Pancreatic Adenocarcinoma

54 enrolled 17 charts

Digestive System Diseases, Digestive System Neoplasms, Pancreatic Diseases, Pancreatic Neoplasms

NCT05160168 2024-06-05

A Study of THE-630 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)

Phase 1/2 Terminated

32 enrolled 20 charts

GastrointestinalSarcoma

Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Neoplasms, Neoplasms by Histologic Type, Neoplasms, Connective Tissue, Neoplasms, Connective and Soft Tissue, Gastrointestinal Stromal Tumors

NCT02831556 2024-05-21

Point of Care 3D Ultrasound for Various Applications: A Pilot Study

GastrointestinalGenitourinaryGynecologic

174 enrolled

Abdominal Injuries, Aortic Aneurysm, Appendicitis, Digestive System Diseases, Diverticulitis, Gastrointestinal Diseases, Intestinal Diseases, Kidney Calculi, Leiomyoma, Neoplasms, Ovarian Cysts, Pancreatitis, Polyps, Pregnancy, Ectopic, Vascular Diseases, Gallstones, Intraabdominal Infections

NCT01832116 2024-05-03

MMOT

GastrointestinalGynecologic

11 enrolled

Adnexal Diseases, Digestive System Diseases, Digestive System Neoplasms, Ovarian Diseases, Ovarian Neoplasms, Pancreatic Diseases, Pancreatic Neoplasms

NCT04493632 2024-04-30

OSPREY

Recruiting

500 enrolled

Digestive System Diseases, Digestive System Neoplasms, Endocrine System Diseases, Endocrine Gland Neoplasms, Neoplasm Metastasis, Neoplasms, Neoplasms by Site, Pancreatic Diseases, Pancreatic Neoplasms

NCT00838578 2024-04-26

Phase I/II Study of KRN330 Plus Irinotecan in Patients With Metastatic Colorectal Cancer

Phase 1/2 Terminated

65 enrolled 7 charts

Colonic Diseases, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Neoplasms, Neoplasms by Site, Rectal Diseases, Colorectal Neoplasms

NCT06365866 2024-04-15

Evaluate the Efficacy of Adding Intraluminal Brachytherapy After CCRT for Local-regional Thoracic Esophageal Cancer.

GastrointestinalHead & Neck

20 enrolled

Digestive System Diseases, Digestive System Neoplasms, Esophageal Diseases, Esophageal Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Neoplasms, Neoplasms by Site

NCT03464305 2024-03-19

ASPIRIN

Phase 3 Active not recruiting

148 enrolled

Colonic Diseases, Colonic Neoplasms, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Neoplasms, Neoplasms by Site, Pathologic Processes, Recurrence, Colorectal Neoplasms, Disease Attributes

NCT03549494 2024-02-07

Evaluation of Ocoxin®-Viusid® in Advanced Stomach Cancer and Gastric Esophagogastric Junction

GastrointestinalHead & Neck

45 enrolled

Digestive System Diseases, Digestive System Neoplasms, Esophageal Diseases, Esophageal Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Stomach Diseases, Stomach Neoplasms

NCT03559543 2024-02-07

Evaluation of Ocoxin®-Viusid® in Metastatic Colorectal Adenocarcinoma

40 enrolled

Colonic Diseases, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Rectal Diseases, Colorectal Neoplasms

NCT05200325 2023-12-04

Clinical Utility Evidence for TissueCypher®

Phase NA Completed

280 enrolled

Barrett Esophagus, Digestive System Diseases

NCT02753127 2023-11-15

CanStem303C

1,253 enrolled 18 charts

Colonic Diseases, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Glandular and Epithelial, Rectal Diseases, Colorectal Neoplasms

NCT02993731 2023-11-15

CanStem111P

1,134 enrolled 18 charts

Adenocarcinoma, Digestive System Diseases, Digestive System Neoplasms, Endocrine System Diseases, Endocrine Gland Neoplasms, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Glandular and Epithelial, Pancreatic Diseases, Pancreatic Neoplasms, Carcinoma, Pancreatic Ductal

NCT05494060 2023-11-07

EXPLORING

Phase 2 Recruiting

80 enrolled

Phase 2 Active not recruiting

Carcinoma, Digestive System Diseases, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Stomach Neoplasms

NCT05602935 2023-09-28

Efficacy and Safety of SOX Regimen Combined With Camrelizumab as Neoadjuvant Treatment in Locally Advanced Gastric Cancer: a Phase II, Single-arm Study

29 enrolled

Digestive System Diseases, Digestive System Neoplasms, Neoplasms, Neoplasms by Site, Stomach Diseases, Stomach Neoplasms

NCT01964430 2023-06-28

apact

866 enrolled 21 charts

Adenocarcinoma, Digestive System Diseases, Digestive System Neoplasms, Endocrine System Diseases, Endocrine Gland Neoplasms, Neoplasms, Neoplasms by Site, Pancreatic Diseases, Pancreatic Neoplasms

NCT05051358 2023-05-26

TEUS Registry

Unknown

5,000 enrolled

Bile Duct Diseases, Digestive System Diseases, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Pancreatic Diseases, Digestive System Fistula

NCT03717298 2023-03-28

Evaluation of Ocoxin-Viusid® in Advanced Pancreatic Adenocarcinoma

30 enrolled

EndocrineGastrointestinalNET

Digestive System Diseases, Digestive System Neoplasms, Endocrine System Diseases, Endocrine Gland Neoplasms, Pancreatic Diseases, Pancreatic Neoplasms

NCT04949282 2022-12-23

SEPTRALU

Recruiting

5,000 enrolled

Gastro-enteropancreatic neuroendocrine tumor, Digestive System Diseases, Digestive System Neoplasms, Endocrine System Diseases, Endocrine Gland Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Pancreatic Diseases, Pancreatic Neoplasms, Stomach Neoplasms, Neuroectodermal Tumors, Neuroendocrine Tumors

NCT05252078 2022-12-16

ALTER-E005

Phase 2 Recruiting

30 enrolled

DermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

Esophageal Squamous Cell Carcinoma, Carcinoma, Squamous Cell, Digestive System Diseases, Digestive System Neoplasms, Esophageal Diseases, Esophageal Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Squamous Cell

NCT03634982 2022-09-01

Dose Escalation of RMC-4630 Monotherapy in Relapsed/Refractory Solid Tumors

Phase 1 Unknown

133 enrolled

Urinary Bladder Neoplasms, Bronchial Neoplasms, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Uterine Cervical Neoplasms, Digestive System Diseases, Digestive System Neoplasms, Esophageal Diseases, Esophageal Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Lung Diseases, Lung Neoplasms, Melanoma, Neoplasms, Neoplasms by Site, Neoplasms, Glandular and Epithelial, Noonan Syndrome, Ovarian Neoplasms, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Skin Neoplasms, Thoracic Neoplasms, Uterine Neoplasms, Neoplasms, Squamous Cell

NCT04080843 2022-07-13

ALTER-C-002

30 enrolled

Colonic Diseases, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Neoplasms, Neoplasms by Site, Rectal Diseases, Colorectal Neoplasms

NCT05322486 2022-04-11

Palliative Primary Tumor Resection in Minimally Symptomatic Patients With Colorectal Cancer and Synchronous Unresectable Metastases

Unknown

200 enrolled

Colonic Diseases, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Neoplasm Metastasis, Neoplasms, Neoplasms by Site, Rectal Diseases, Colorectal Neoplasms, Neoplasms, Second Primary

NCT02292173 2021-06-10

Trametinib in Combination With Sorafenib in Patients With Advanced Hepatocellular Cancer

17 enrolled

Digestive System Diseases, Liver Diseases, Liver Neoplasms

NCT01966289 2021-03-30

SGI-110 in Combination With an Allogeneic Colon Cancer Cell Vaccine (GVAX) and Cyclophosphamide (CY) in Metastatic Colorectal Cancer (mCRC)

18 enrolled

Colonic Diseases, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Neoplasms, Neoplasms by Site, Rectal Diseases, Colorectal Neoplasms

NCT03723447 2021-02-17

TINGLE

Phase 4 Completed

102 enrolled 9 charts

Crohn Disease, Digestive System Diseases, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Neuralgia, Pain, Pain, Postoperative, Colorectal Neoplasms, Inflammatory Bowel Diseases

NCT02981524 2021-02-10

Study of GVAX (With CY) and Pembrolizumab in MMR-p Advanced Colorectal Cancer

17 enrolled 12 charts

Colonic Diseases, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Neoplasms, Neoplasms by Site, Rectal Diseases, Colorectal Neoplasms

NCT04287335 2020-12-08

CLEAR-C

4,758 enrolled