Clinical Trials

Carcinoma, Hepatocellular, Neoplasm Metastasis

NCT04233567 2026-02-24

Infigratinib for the Treatment of Advanced or Metastatic Solid Tumors in Patients With FGFR Gene Mutations

17 enrolled 12 charts

Neoplasm Metastasis, Cholangiocarcinoma

NCT03993353 2026-02-12

Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Cancer

GastrointestinalHead & Neck

7 enrolled 14 charts

Pyridoxine-dependent epilepsy, Parkinson Disease 4, Autosomal Dominant Lewy Body, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Esophageal Neoplasms, Head and Neck Neoplasms, Mouth Neoplasms, Neoplasm Metastasis, Neoplasms

NCT06229080 2026-02-12

SEGWAY

20 enrolled

Liver Neoplasms, Neoplasm Metastasis

NCT03775980 2026-02-11

CIEMAR

500 enrolled

Colonic Neoplasms, Neoplasm Metastasis

NCT05648240 2026-02-10

EARDIS

120 enrolled

Neoplasm Metastasis, Colorectal Neoplasms

NCT06379880 2026-02-04

FEGALA

BreastGastrointestinalGenitourinaryThoracic

411 enrolled

Breast Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Prostatic Neoplasms, Colorectal Neoplasms

NCT07386639 2026-02-04

GENDER-HCC-MET

19,019 enrolled

Carcinoma, Hepatocellular, Liver Neoplasms, Neoplasm Metastasis

NCT02639026 2025-11-25

Trial Of Hypofractionated Radiotherapy In Combination With MEDI4736 And Tremelimumab For Patients With Metastatic Melanoma And Lung, Breast And Pancreatic Cancers

BreastDermatologicGastrointestinalThoracic

53 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Neoplasm Metastasis, Pancreatic Neoplasms

NCT05472532 2025-11-20

INOVOLINE

BreastGastrointestinalGenitourinaryGynecologicThoracic

101 enrolled

Breast Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms, Stomach Neoplasms

NCT05052723 2025-11-19

Cabozantinib and Pembrolizumab in Metastatic Pancreas

21 enrolled 12 charts

Adenocarcinoma, Neoplasm Metastasis, Pancreatic Neoplasms

NCT01693835 2025-11-18

"Cancersensor": Circadian Rhythms

32 enrolled

Neoplasm Metastasis, Neoplasms, Colorectal Neoplasms

NCT04208958 2025-10-27

ConsortiumIO

DermatologicGastrointestinal

56 enrolled 11 charts

Melanoma, Neoplasm Metastasis, Stomach Neoplasms, Colorectal Neoplasms

NCT05091346 2025-10-24

A Study of E7386 in Combination With Pembrolizumab in Previously Treated Participants With Selected Solid Tumors

DermatologicGastrointestinal

89 enrolled 24 charts

Carcinoma, Hepatocellular, Melanoma, Neoplasm Metastasis, Colorectal Neoplasms

NCT02159989 2025-10-20

Sapanisertib and Ziv-Aflibercept in Treating Patients With Recurrent Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

GastrointestinalGynecologic

83 enrolled 21 charts

Fibrolamellar hepatocellular carcinoma, Adenoma, Islet Cell, Neoplasm Metastasis, Ovarian Neoplasms

NCT04263948 2025-10-03

MULTIDOM

58 enrolled

Motor Activity, Neoplasm Metastasis, Pancreatic Neoplasms, Patient Compliance

NCT06358001 2025-09-22

EchoTip AcuCore Post-Market Clinical Study

EndocrineGastrointestinalLymphoidNET

183 enrolled

Autoimmune Pancreatitis, Adenocarcinoma, Carcinoma, Hepatocellular, Lymphoma, Neoplasm Metastasis, Cholangiocarcinoma, Neuroendocrine Tumors, Pancreatitis, Chronic

NCT03711058 2025-09-16

Study of PI3Kinase Inhibition (Copanlisib) and Anti-PD-1 Antibody Nivolumab in Relapsed/Refractory Solid Tumors With Expansions in Mismatch-repair Proficient (MSS) Colorectal Cancer

48 enrolled 16 charts

Colonic Neoplasms, Neoplasm Metastasis, Spinocerebellar Degenerations

NCT03126110 2025-08-14

Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of INCAGN01876 Combined With Immune Therapies in Advanced or Metastatic Malignancies

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmThoracic

145 enrolled 47 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Carcinoma, Hepatocellular, Melanoma, Mesothelioma, Neoplasm Metastasis, Ovarian Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Carcinoma, Merkel Cell, Endometrial Neoplasms, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT00680901 2025-08-07

LOGiC - Lapatinib Optimization Study in ErbB2 (HER2) Positive Gastric Cancer: A Phase III Global, Blinded Study Designed to Evaluate Clinical Endpoints and Safety of Chemotherapy Plus Lapatinib

Phase 3 Completed

545 enrolled 24 charts

Esophageal Neoplasms, Neoplasm Metastasis, Neoplasms

NCT02903914 2025-08-05

Arginase Inhibitor INCB001158 as a Single Agent and in Combination With Immune Checkpoint Therapy in Patients With Advanced/Metastatic Solid Tumors

GastrointestinalGenitourinaryHead & NeckOther solid neoplasmThoracic

260 enrolled 52 charts

Parkinson Disease 4, Autosomal Dominant Lewy Body, Urinary Bladder Neoplasms, Carcinoma, Renal Cell, Head and Neck Neoplasms, Lung Neoplasms, Mesothelioma, Neoplasm Metastasis, Stomach Neoplasms, Colorectal Neoplasms

NCT04306900 2025-07-29

TTX-030 in Combination With Immunotherapy and/or Chemotherapy in Subjects With Advanced Cancers

GastrointestinalGenitourinaryThoracic

185 enrolled 28 charts

Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis, Neoplasms, Pancreatic Neoplasms, Colorectal Neoplasms

NCT03639935 2025-06-03

Rucaparib in Combination With Nivolumab in Patients With Advanced or Metastatic Biliary Tract Cancer Following Platinum Therapy

32 enrolled 14 charts

Biliary Tract Neoplasms, Neoplasm Metastasis

NCT03250273 2025-05-28

A Clinical Trial of Entinostat in Combination With Nivolumab for Patients With Previously Treated Unresectable or Metastatic Cholangiocarcinoma and Pancreatic Adenocarcinoma

44 enrolled 19 charts

Neoplasm Metastasis, Pancreatic Neoplasms, Cholangiocarcinoma

NCT06980792 2025-05-20

Surgical Approach for Adenocarcinoma of the Pancreas With Synchronous Liver Metastases

90 enrolled

Neoplasm Metastasis, Pancreatic Neoplasms

NCT02380443 2025-05-16

AlloStim® Immunotherapy Dosing Alone or in Combination With Cryoablation in Metastatic Colorectal Cancer

13 enrolled 8 charts

Neoplasm Metastasis, Colorectal Neoplasms

NCT01746979 2025-05-11

MAESTRO

Phase 3 Completed

693 enrolled 8 charts

Neoplasm Metastasis, Pancreatic Neoplasms

NCT05396300 2025-04-22

A Clinical Study of CEA-targeted CAR-T in the Treatment of CEA-positive Advanced Malignant Solid Tumors

43 enrolled

Esophageal Neoplasms, Neoplasm Metastasis, Pancreatic Neoplasms, Recurrence, Stomach Neoplasms, Colorectal Neoplasms

NCT02795988 2025-04-16

A Study of IMU-131(HER-Vaxx) and Chemotherapy Compared to Chemotherapy Only in Patients With HER2 Positive Advanced Gastric Cancer

64 enrolled 20 charts

Adenocarcinoma, Gastrointestinal Neoplasms, Neoplasm Metastasis

NCT00059930 2025-03-26

Adjuvant Hepatic Arterial Infusion and Combination Chemotherapy in Treating Patients With Resectable Hepatic Metastases From Colorectal Cancer

38 enrolled

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT05131815 2025-02-26

The BurnAlong Pilot Study for Adolescent and Young Adult Cancer Survivors

BreastCNSDermatologicGastrointestinalGenitourinaryHead & NeckLymphoidOther hematologic neoplasmPlasma cellSarcomaThoracic

8 enrolled

Bone Neoplasms, Brain Neoplasms, Breast Neoplasms, Gastrointestinal Neoplasms, Glioblastoma, Head and Neck Neoplasms, Hodgkin Disease, Leukemia, Lung Neoplasms, Lymphoma, Lymphoma, Non-Hodgkin, Motor Activity, Multiple Myeloma, Neoplasm Metastasis, Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Sarcoma, Skin Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms

NCT05087992 2025-02-19

A Study to Find the Best Dose of BI 905711 in Combination With Chemotherapy and to Test Whether This Dose Helps People With Advanced Gastrointestinal Cancers

13 enrolled 17 charts

Gastrointestinal Neoplasms, Neoplasm Metastasis

NCT04666688 2025-02-12

LYT-200 Alone and in Combination With Chemotherapy or Tislelizumab in Patients With Locally Advanced or Metastatic Solid Tumors

GastrointestinalGenitourinaryHead & Neck

44 enrolled

Bile Duct Neoplasms, Carcinoma, Transitional Cell, Colonic Neoplasms, Head and Neck Neoplasms, Neoplasm Metastasis, Pancreatic Neoplasms, Colorectal Neoplasms

NCT05462314 2025-01-28

Intestinal Microbiome, Oral Microbiome, and Whole Blood Transcriptome Analyses in Gastrointestinal Malignancies

24 enrolled

Biliary Tract Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Liver Neoplasms, Neoplasm Metastasis, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT03730558 2025-01-22

ZETA

120 enrolled

Colonic Neoplasms, Neoplasm Metastasis

NCT03824366 2025-01-10

MAP-RT

20 enrolled 8 charts

Hemoptysis, Gastrointestinal Hemorrhage, Mediastinal Diseases, Neoplasm Metastasis, Neoplasms, Superior Vena Cava Syndrome

NCT05007613 2025-01-01

Second-line Cabozantinib and Atezolizumab in Patients With Recurrent or Metastatic Esophageal Squamous Cell Carcinoma

24 enrolled

Carcinoma, Squamous Cell, Esophageal Neoplasms, Neoplasm Metastasis

NCT04534218 2024-12-20

REPROGRAM-01

49 enrolled

Colonic Neoplasms, Neoplasm Metastasis

NCT04672434 2024-12-09

Sym024 Monotherapy and in Combination With Sym021 in Patients With Advanced Solid Tumor Malignancies

GastrointestinalGynecologicHead & NeckOther solid neoplasmThoracic

48 enrolled

Squamous Cell Carcinoma of Head and Neck, Uterine Cervical Neoplasms, Esophageal Neoplasms, Mesothelioma, Neoplasm Metastasis, Stomach Neoplasms, Colorectal Neoplasms, Cholangiocarcinoma

NCT04319757 2024-12-05

ACE1702 in Subjects With Advanced or Metastatic HER2-expressing Solid Tumors

BreastGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

12 enrolled

Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms

NCT04842968 2024-12-02

MB

200 enrolled

Lymphatic Metastasis, Neoplasm Metastasis, Neoplasms, Colorectal Neoplasms

NCT03436563 2024-11-27

M7824 in Patients With Metastatic Colorectal Cancer or With Advanced Solid Tumors With Microsatellite Instability

4 enrolled 7 charts

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms, Microsatellite Instability

NCT02143401 2024-11-22

Navitoclax and Sorafenib Tosylate in Treating Patients With Relapsed or Refractory Solid Tumors

29 enrolled

Fibrosis, Hepatitis B, Hepatitis C, Carcinoma, Hepatocellular, Neoplasm Metastasis, Neoplasms

NCT00514007 2024-11-20

Study of Continuous OSI-906 Dosing

BreastGastrointestinalGenitourinaryGynecologicThoracic

95 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Kidney Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Colorectal Neoplasms

NCT05712889 2024-11-15

Phase 1 Dose Escalation Study for VIP236 in Patients With Advanced Cancer

BreastGastrointestinalGynecologicThoracic

29 enrolled

Biliary Tract Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Stomach Neoplasms, Endometrial Neoplasms, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT04313868 2024-11-06

GEN2

61 enrolled

Carcinoma, Hepatocellular, Liver Neoplasms, Neoplasm Metastasis

NCT03430843 2024-10-26

A Study of Tislelizumab (BGB-A317) Versus Chemotherapy as Second Line Treatment in Participants With Advanced Esophageal Squamous Cell Carcinoma

Phase 3 Completed

512 enrolled 27 charts

Esophageal Squamous Cell Carcinoma, Neoplasm Metastasis

NCT03087591 2024-10-10

APN401 in Treating Patients With Recurrent or Metastatic Pancreatic Cancer, Colorectal Cancer, or Other Solid Tumors That Cannot Be Removed by Surgery

11 enrolled 26 charts

CNSGastrointestinal

Brain Neoplasms, Neoplasm Metastasis, Pancreatic Neoplasms, Colorectal Neoplasms

NCT03475004 2024-09-19

Study of Pembrolizumab, Binimetinib, and Bevacizumab in Patients With Refractory Colorectal Cancer

53 enrolled 14 charts