Clinical Trials Browser

Phase 3 × Rectal Neoplasms × Gastrointestinal × Clear all

NCT00102011 2026-03-09

00-046

Phase 3 Completed

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT04215731 2026-03-03

FOBEAR

Phase 3 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT04928807 2026-02-27

Short-Course Radiotherapy Followed by Neoadjuvant Chemotherapy and Camrelizumab in Locally Advanced Rectal Cancer (UNION)

Phase 3 Active not recruiting

Gastrointestinal

Rectal Neoplasms

NCT06123156 2026-02-18

RECTIL

Phase 3 Not yet recruiting

Gastrointestinal

Rectal Neoplasms

NCT07113275 2026-02-12

A Clinical Trial Comparing Long-Course Versus Short-Course Radiotherapy Followed by Immunotherapy Combined With Total Neoadjuvant Therapy (TNT) to Long-Course Radiotherapy Followed by TNT in High-Risk Locally Advanced Rectal Cancer

Phase 3 Not yet recruiting

Gastrointestinal

Rectal Neoplasms

NCT04495088 2026-02-02

Preoperative FOLFOX Versus Postoperative Risk-adapted Chemotherapy in Patients With Locally Advanced Rectal Cancer

Phase 3 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT07372300 2026-01-28

mEHT

Phase 3 Recruiting

Gastrointestinal

Hyperthermia, Rectal Neoplasms

NCT03875781 2026-01-15

NORAD01

Phase 3 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06205485 2026-01-13

NEO-RT

Phase 3 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT04095299 2026-01-08

WW3

Phase 3 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT02314182 2025-12-19

GRECCAR8

Phase 3 Completed

Gastrointestinal

Rectal Neoplasms

NCT02505750 2025-09-29

OPERA

Phase 3 Active not recruiting

Gastrointestinal

Rectal Neoplasms

NCT07188025 2025-09-23

REACT

Phase 3 Not yet recruiting

Gastrointestinal

Rectal Neoplasms

NCT01999634 2025-09-22

MTM-COLON-II

Phase 3 Completed

Gastrointestinal

Rectal Neoplasms, Anastomotic Leak

NCT01727388 2025-09-19

RIFIONA

Phase 3 Completed

Gastrointestinal

Colonic Neoplasms, Diverticulitis, Gastrointestinal Hemorrhage, Hernia, Rectal Neoplasms, Colorectal Neoplasms

NCT04534075 2025-09-08

FIDURA

Phase 3 Completed

GastrointestinalGenitourinaryGynecologic

Anus Neoplasms, Urinary Bladder Neoplasms, Uterine Cervical Neoplasms, Colonic Neoplasms, Flatulence, Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms, Rectal Neoplasms

NCT07132463 2025-08-20

Neoadjuvant Chemoradiotherapy Followed by Chemotherapy With or Without Tislelizumab for Resectable Ultra-low Rectal Cancer: The RELIEVE-02 Study

Phase 3 Not yet recruiting

Gastrointestinal

Rectal Neoplasms

NCT04607421 2025-08-14

A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal Cancer

Phase 3 Active not recruiting

831 enrolled 2 FDA

Gastrointestinal

Colonic Diseases, Colonic Neoplasms, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Neoplasms, Rectal Diseases, Rectal Neoplasms, Colorectal Neoplasms

NCT07070622 2025-07-17

OPLAR

Phase 3 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT04922853 2025-07-11

COPEC

Phase 3 Active not recruiting

Gastrointestinal

Rectal Neoplasms

NCT06936774 2025-07-03

iRECOVER

Phase 3 Not yet recruiting

Gastrointestinal

Low Anterior Resection Syndrome, Rectal Neoplasms

NCT06507371 2025-06-26

mRCAT-III

Phase 3 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06850090 2025-06-25

Neoadjuvant Radiotherapy for Rectal Adenocarcinoma With Capecitabine Versus TAS-102 (Neo-REACT): A Multi-center, Randomized, Phase III Trial

Phase 3 Not yet recruiting

Gastrointestinal

Rectal Neoplasms

NCT01804790 2025-06-12

Néofirinox

Phase 3 Completed

Gastrointestinal

Neoplasms, Rectal Neoplasms

NCT05482516 2025-05-22

MRD-GI

Phase 3 Recruiting

Gastrointestinal

Colonic Neoplasms, Carcinoma, Hepatocellular, Rectal Neoplasms

NCT06968221 2025-05-15

Bovine Reinforcement in Stomach, Colorectal and Lung Operation

Phase 3 Recruiting

GastrointestinalThoracic

Lung Neoplasms, Rectal Neoplasms

NCT05646511 2025-04-03

ENSEMBLE

Phase 3 Recruiting

Gastrointestinal

Digestive System Neoplasms, Gastrointestinal Neoplasms, Intestinal Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT04316013 2025-03-14

Volatile Anaesthesia and Perioperative Outcomes Related to Cancer: the VAPOR-C Trial

Phase 3 Terminated

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Rectal Neoplasms

NCT06832917 2025-03-11

NeoCaCRT-III

Phase 3 Not yet recruiting

Gastrointestinal

Rectal Neoplasms

NCT04793958 2025-02-11

KRYSTAL-10

Phase 3 Active not recruiting

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT04246684 2024-09-19

Short RT Versus RCT,Followed by Chemo.and Organ Preservation for Interm and High-risk Rectal Cancer Patients

Phase 3 Active not recruiting

Gastrointestinal

Rectal Neoplasms

NCT00297791 2024-08-21

COLORII

Phase 3 Completed

Gastrointestinal

Rectal Neoplasms

NCT02514278 2024-08-14

GRECCAR12

Phase 3 Completed

Gastrointestinal

Rectal Neoplasms

NCT03879109 2024-08-14

GRECCAR15

Phase 3 Active not recruiting

Gastrointestinal

Rectal Neoplasms

NCT05939687 2024-08-07

ProMeLAR

Phase 3 Recruiting

Gastrointestinal

Incisional Hernia, Neoplasms, Rectal Neoplasms

NCT06450574 2024-06-10

TAUTEM-T1

Phase 3 Not yet recruiting

Gastrointestinal

Rectal Neoplasms

NCT00565708 2024-02-02

ASCOLT

Phase 3 Unknown

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT06229041 2024-01-29

Total Neoadjuvant Treatment ±Immunotherapy for High Risk Locally Advanced Rectal Cancer (TNTi)

Phase 3 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06097416 2023-10-25

Neoadjuvant Chemoradiotherapy Versus Total Neoadjuvant Therapy in the Treatment of T3 Rectal Cancer

Phase 3 Not yet recruiting

Gastrointestinal

Rectal Neoplasms

NCT02551237 2023-10-13

NACRE

Phase 3 Completed

Gastrointestinal

Rectal Neoplasms

NCT05081687 2023-10-11

BRAZIL-TNT

Phase 3 Unknown

Gastrointestinal

Rectal Neoplasms, Colorectal Neoplasms

NCT02031939 2023-08-25

Randomized Controlled Study on Optimize Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer

Phase 3 Unknown

Gastrointestinal

Rectal Neoplasms

NCT05984485 2023-08-09

TaLaR-02

Phase 3 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT00079066 2023-08-04

Cetuximab + Best Supportive Care Compared With Best Supportive Care Alone in Metastatic Epidermal Growth Factor Receptor-Positive Colorectal Cancer

Phase 3 Completed

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00303628 2023-07-06

Postoperative Chemotherapy With or Without Bevacizumab for Patients With Stage II or III Rectal Cancer

Phase 3 Terminated

355 enrolled 11 charts

Gastrointestinal

Rectal Neoplasms

NCT00003057 2023-06-18

Octreotide Compared With Loperamide Hydrochloride for Chemotherapy-Related Diarrhea in Patients With Colorectal Cancer

Phase 3 Completed

Gastrointestinal

Colonic Neoplasms, Diarrhea, Rectal Neoplasms, Colorectal Neoplasms

NCT02288195 2023-05-12

CONVERT: Neoadjuvant Chemotherapy Alone Versus Preoperative Chemoradiation for Locally Advanced Rectal Cancer Patients

Phase 3 Unknown

Gastrointestinal

Rectal Neoplasms

NCT05752136 2023-05-08

Preoperative Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Rectal Adenocarcinoma

Phase 3 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT04087421 2023-05-03

Comparison of Transanal Irrigation and Glycerol Suppositories in Treatment of Low Anterior Resection Syndrome

Phase 3 Recruiting

Gastrointestinal

Low Anterior Resection Syndrome, Rectal Neoplasms

NCT01558921 2023-01-13

RAPIDO

Phase 3 Active not recruiting

Gastrointestinal

Rectal Neoplasms