Clinical Trials Browser

Interventional × Weight Loss × Gastrointestinal × Clear all

NCT06989437 2026-02-06

A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue

Phase 2/3 Recruiting

Gastrointestinal

Anorexia, Cachexia, Fatigue, Neoplasm Metastasis, Neoplasms, Pancreatic Neoplasms, Weight Loss

NCT06937177 2025-12-12

Safely Optimizing Body Weight With TCMCB07 in Patients With Newly Diagnosed Metastatic Colorectal Cancer Undergoing Chemotherapy

Phase 2 Recruiting

Gastrointestinal

Cachexia, Colorectal Neoplasms, Weight Loss

NCT04844970 2025-11-17

Anamorelin Study for Advanced Pancreatic Cancer

Phase 2 Terminated

4 enrolled 12 charts

Gastrointestinal

Anorexia, Cachexia, Pancreatic Neoplasms, Weight Loss

NCT06171945 2025-10-27

AYAConnect

Phase NA Completed

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOtherOther hematologic neoplasmSarcoma

Psychological Well-Being, Urinary Bladder Neoplasms, Bone Neoplasms, Brain Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Colonic Neoplasms, Head and Neck Neoplasms, Hodgkin Disease, Kidney Neoplasms, Leukemia, Liver Neoplasms, Lymphoma, Non-Hodgkin, Melanoma, Motor Activity, Mouth Neoplasms, Neoplasms, Obesity, Pancreatic Neoplasms, Pharyngeal Neoplasms, Rectal Neoplasms, Sarcoma, Testicular Neoplasms, Thyroid Neoplasms, Weight Loss, Endometrial Neoplasms, Overweight

NCT04780477 2025-07-20

Fiber-rich Foods to Treat Obesity and Prevent Colon Cancer

Phase NA Active not recruiting

GastrointestinalOther

Colonic Neoplasms, Obesity, Weight Loss

NCT05114798 2025-07-09

Time-restricted Eating Versus Daily Continuous Calorie Restriction on Body Weight and Colorectal Cancer Risk Markers

Phase NA Recruiting

GastrointestinalOther

Intermittent Fasting, Obesity, Colorectal Neoplasms, Weight Loss

NCT05546476 2025-05-31

PROACC-1

Phase 2 Completed

187 enrolled 24 charts

GastrointestinalThoracic

Anorexia, Cachexia, Carcinoma, Non-Small-Cell Lung, Fatigue, Neoplasms, Pancreatic Neoplasms, Colorectal Neoplasms, Weight Loss

NCT04871204 2024-10-31

OTIS

Phase 2 Completed

Gastrointestinal

Esophageal Neoplasms, Stomach Neoplasms, Weight Loss

NCT04803305 2024-01-12

Study to Compare the Effects of Repeated Doses of an Investigational New Drug and a Placebo on Appetite in Advanced Cancer and Anorexia

Phase 1 Completed

18 enrolled 14 charts

BreastGastrointestinalGenitourinaryGynecologicThoracic

Anorexia, Breast Neoplasms, Cachexia, Carcinoma, Non-Small-Cell Lung, Fatigue, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Colorectal Neoplasms, Weight Loss

NCT00846313 2023-12-29

ColErn

Phase NA Withdrawn

Gastrointestinal

Colorectal Neoplasms, Weight Loss

NCT04299048 2023-12-14

Study to Assess the Safety and Tolerability of Repeated Doses of an Investigational New Drug in Patients With Cancer and Cachexia.

Phase 1 Completed

11 enrolled 13 charts

GastrointestinalThoracic

Anorexia, Cachexia, Carcinoma, Non-Small-Cell Lung, Fatigue, Muscular Atrophy, Pancreatic Neoplasms, Colorectal Neoplasms, Weight Loss

NCT02381249 2023-11-27

The Effect of Satiety Gut Hormone Modulation on Appetitive Drive After Upper Gastrointestinal Surgery

Phase NA Completed

Gastrointestinal

Duodenal Neoplasms, Esophageal Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Weight Loss, Malnutrition

NCT02385617 2023-11-27

Food Intake and Gut Hormones in Patients Who Have Undergone Upper Gastrointestinal Surgery for Cancer

Phase NA Completed

Gastrointestinal

Endocrine System Diseases, Esophageal Neoplasms, Stomach Neoplasms, Weight Loss, Malnutrition

NCT04131426 2023-08-15

Evaluating the Combined Intervention of Nutritional Supplementation (Remune) and Exercise in Patients With Cancer Cachexia

Phase 1 Completed

GastrointestinalThoracic

Cachexia, Gastrointestinal Neoplasms, Lung Neoplasms, Motor Activity, Neoplasms, Weight Loss

NCT02385630 2021-08-18

Longitudinal Assessment of Gut Hormone Secretion Following Upper Gastrointestinal Surgery for Cancer

Phase NA Completed

Gastrointestinal

Esophageal Neoplasms, Feeding Behavior, Stomach Neoplasms, Weight Loss, Malnutrition

NCT04802486 2021-03-17

The Effects of a 12 Week Home-based Exercise Intervention on Physical Performance in Patients With Cancers of the Gastrointestinal Tract With Pre- Cachexia or Cachexia

Phase NA Completed

Gastrointestinal

Cachexia, Gastrointestinal Neoplasms, Motor Activity, Weight Loss

NCT03207724 2020-12-30

OnFX

Phase 1 Completed

Gastrointestinal

Adenocarcinoma, Cachexia, Disease, Pancreatic Neoplasms, Weight Loss

NCT02269631 2019-01-25

Legume Diet Satiety Pilot Study

Phase NA Completed

12 enrolled 8 charts

GastrointestinalOther

Obesity, Colorectal Neoplasms, Weight Loss

NCT02541461 2018-08-13

Body Composition After Laparoscopic Gastrectomy for Gastric Cancer

Phase NA Completed

Gastrointestinal

Stomach Neoplasms, Weight Loss

NCT02100189 2017-05-11

Esophageal Cytology With FISH in Detecting Esophageal Cancer

Phase NA Completed

50 enrolled 9 charts

Gastrointestinal

Adenocarcinoma Of Esophagus, Esophageal Squamous Cell Carcinoma, Deglutition Disorders, Esophagitis, Gastroesophageal Reflux, Weight Loss

NCT00637728 2016-06-23

Treatment of Cancer-anorexia Using Megestrol Acetate Concentrated Suspension in Lung or Pancreatic Cancer Patients

Phase 3 Terminated

5 enrolled 8 charts

GastrointestinalThoracic

Anorexia, Body Weight, Cachexia, Lung Neoplasms, Pancreatic Neoplasms, Weight Loss

NCT02670265 2016-02-01

NUPAN

Phase NA Completed

Gastrointestinal

Biliary Tract Neoplasms, Hyperphagia, Pancreatic Neoplasms, Weight Loss, Malnutrition

NCT00513357 2012-12-11

Melatonin Versus Placebo and the Effect on Appetite in Advanced Cancer Patients

Phase 3 Completed

82 enrolled 7 charts

GastrointestinalThoracic

Anorexia, Cachexia, Gastrointestinal Neoplasms, Lung Neoplasms, Weight Loss

NCT00196885 2008-06-20

Effect of an Antioxidant on Cancer-Cachectic Patients Undergoing Exercise Training

Phase 2 Completed

GastrointestinalLymphoid

Carcinoma, Bronchogenic, Gastrointestinal Neoplasms, Hodgkin Disease, Lymphoma, Non-Hodgkin, Muscular Atrophy, Weight Loss