Clinical Trials

Colorectal Neoplasms

NCT05286814 2026-02-24

PDS01ADC in Combination With Hepatic Artery Infusion Pump (HAIP) and Systemic Therapy for Subjects With Metastatic Colorectal Cancer, Intrahepatic Cholangiocarcinoma, or Metastatic Adrenocortical Carcinoma

EndocrineGastrointestinal

70 enrolled

Cirrhosis, Familial, with Pulmonary Hypertension, Adrenal Cortex Neoplasms, Adrenal Gland Neoplasms, Bile Duct Neoplasms, Colorectal Neoplasms, Adrenocortical Carcinoma, Cholangiocarcinoma

NCT01815359 2026-02-05

ICARuS

292 enrolled

Appendiceal Neoplasms, Colorectal Neoplasms

NCT06313203 2026-02-02

TOMCAT

39 enrolled

Cholangiocarcinoma

NCT04891289 2025-11-24

Gemcitabine and Oxaliplatin Chemotherapy With or Without a Floxuridine and Dexamethasone Pump in People With Cholangiocarcinoma That Cannot Be Removed With Surgery

164 enrolled

Cholangiocarcinoma

NCT00492999 2025-08-17

Hepatic Arterial Infusion With Floxuridine and Dexamethasone Combined With Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver

64 enrolled

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT03856658 2025-06-17

Hepatic Artery Infusional Floxuridine to Treat Pancreatic Cancer Liver Metastases

14 enrolled

Pancreatic Neoplasms, Carcinoma, Pancreatic Ductal

NCT00059930 2025-03-26

Adjuvant Hepatic Arterial Infusion and Combination Chemotherapy in Treating Patients With Resectable Hepatic Metastases From Colorectal Cancer

38 enrolled

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT06888063 2025-03-21

PUMP IV

40 enrolled

Cirrhosis, Familial, with Pulmonary Hypertension, Cholangiocarcinoma

NCT01862315 2025-03-19

Hepatic Arterial Infusion (HAI) With Floxuridine (FUDR) and Dexamethasone (Dex) Combined With Systemic Gemcitabine and Oxaliplatin in Patients With Unresectable Intrahepatic Cholangiocarcinoma (ICC)

55 enrolled

Cholangiocarcinoma

NCT06857773 2025-03-04

PUMP-IT RCT

Phase 3 Recruiting

306 enrolled

Colorectal Neoplasms

NCT00410956 2024-12-10

Floxuridine and Dexamethasone as a Hepatic Arterial Infusion and Bevacizumab in Treating Patients With Primary Liver Cancer That Cannot be Removed by Surgery

22 enrolled 12 charts

Carcinoma, Hepatocellular, Liver Neoplasms

NCT04898504 2024-11-07

EXCALIBUR1+2

45 enrolled

Colorectal Neoplasms

NCT00019760 2023-10-31

Isolated Hepatic Perfusion With Melphalan Followed By Chemotherapy in Treating Patients With Unresectable Colorectal Cancer That is Metastatic to the Liver

Colonic Neoplasms, Gastrointestinal Neoplasms, Carcinoma, Hepatocellular, Neoplasm Metastasis, Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Genetic Diseases, Inborn

NCT00587067 2023-04-04

A Phase II Study of Continuous Hepatic Arterial Infusion With Floxuridine (FUDR) and Dexamethasone (DEX) in Patients With Unresectable Primary Hepatic Malignancy

34 enrolled 12 charts

Liver Neoplasms, Neoplasms

NCT03678428 2023-02-16

FUDR/Oxaliplatin HAI Plus Irinotecan vs. FOLFOXIRI Chemotherapy in Treating Initially Unresectable CRCLM

Phase 3 Terminated

92 enrolled

Colorectal Neoplasms

NCT03493061 2023-02-15

A Study of Systemic Chemotherapy With CPT-11 Plus HAI (FUDR+L-OHP) in Patients With Initially Unresectable CRCLM

60 enrolled

Colonic Neoplasms

NCT01525069 2022-08-10

Hepatic Arterial Infusion in Treating Patients With Locally Advanced, Non-Metastatic Cholangiocarcinoma

Phase 1 Terminated

27 enrolled

Liver Neoplasms, Cholangiocarcinoma

NCT00695201 2021-07-01

Hepatic Arterial Infusion With Floxuridine and Dexamethasone in Combination With Intravenous Oxaliplatin Plus Irinotecan in Patients With Unresectable Hepatic Metastases From Colorectal Cancer

52 enrolled

Colonic Neoplasms, Rectal Neoplasms

NCT04668976 2020-12-21

A Study of the Use of the Medtronic Pump and Codman Catheter to Give Chemotherapy to Patients With Colorectal Carcinoma or Cholangiocarcinoma

Phase 2 Unknown

100 enrolled

Colorectal Neoplasms, Cholangiocarcinoma

NCT04552093 2020-09-17

PUMP-IT

Phase 2/3 Unknown

31 enrolled

Colorectal Neoplasms

NCT01938729 2020-09-11

Hepatic Arterial Infusion With Floxuridine and Dexamethasone in Combination With Gemcitabine as Adjuvant Treatment After Resection of Intrahepatic Cholangiocarcinoma

8 enrolled

Cholangiocarcinoma

NCT03069950 2019-05-21

Study of Chemotherapy With or Without Hepatic Arterial Infusion for Patients With Unresectable Metastatic Colorectal Cancer to the Liver

Phase 2 Withdrawn

Colorectal Adenocarcinoma Metastatic to the Liver

NCT00645710 2019-03-28

Hepatic Arterial Infusion of Floxuridine, Gemcitabine Hydrochloride, and Radiolabeled Monoclonal Antibody Therapy in Treating Liver Metastases in Patients With Metastatic Colorectal Cancer Previously Treated With Surgery

Phase 1/2 Completed

16 enrolled 12 charts

Colonic Neoplasms, Rectal Neoplasms

NCT00004142 2018-10-26

Radiofrequency Ablation Followed By Hepatic Artery Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver

40 enrolled

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT00848783 2018-01-08

Irinotecan/Cisplatin, Potentially Curative Surgery With or Without Floxuridine, Followed by Capecitabine for Stomach and Gastro-esophageal Junction (GEJ) Cancers

Phase 2 Terminated

8 enrolled 9 charts

Esophageal Neoplasms, Stomach Neoplasms

NCT00449163 2017-05-11

Combination Chemotherapy and Bevacizumab in Treating Patients With Stage IV Colorectal Cancer

Phase 2 Terminated

25 enrolled 10 charts

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00002842 2017-04-11

Liver Resection and Floxuridine Plus Fluorouracil and Leucovorin in Treating Patients With Liver Metastases From Colorectal Cancer

49 enrolled 5 charts

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT00448682 2017-02-07

Combination Chemotherapy as First-Line Therapy in Treating Patients With Stage IV Gastric Cancer That Cannot Be Removed By Surgery

Phase 2 Terminated

25 enrolled 3 charts

Stomach Neoplasms

NCT00448760 2017-02-07

Combination Chemotherapy in Treating Patients With Previously Untreated Stage II or Stage III Esophageal Cancer That Can Be Removed By Surgery

29 enrolled 12 charts

Adenocarcinoma Of Esophagus, Esophageal Neoplasms

NCT00002716 2016-07-13

Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal Cancer

Phase 3 Completed

135 enrolled

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT00063960 2016-07-06

Hepatic Arterial Infusion With Floxuridine and Systemic Irinotecan After Surgery in Treating Patients With Hepatic (Liver) Metastases From Colorectal Cancer

94 enrolled

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT00858338 2016-03-11

Adjuvant Intraperitoneal Floxuridine Added to Chemoradiation for Fully Resected Advanced Stomach Cancer

28 enrolled

Stomach Neoplasms

NCT02529774 2015-08-20

Alternating Systemic and Hepatic Artery Infusion Therapy As Adjuvant Treatment After Resection of Liver Metastases From Colorectal Cancer

Phase 2/3 Unknown

432 enrolled

Resected Liver Metastases From Colorectal Cancer

NCT02402972 2015-03-31

A Multi-center Randomized Controlled Trial of Intraportal Chemotherapy Combined With Adjuvant Chemotherapy (mFOLFOX6) for Stage II and III Colon Cancer

Phase 3 Unknown

700 enrolled

Neoplasm Metastasis, Colorectal Neoplasms

NCT00183911 2014-05-22

Study of 5-Fluorouracil and Leucovorin and Intra-abdominal Floxuridine Chemoradiation in Patients With Fully Resected Locally Advanced Gastric Adenocarcinoma

25 enrolled

Stomach Neoplasms

NCT00408551 2013-12-19

Chemotherapy and Internal Radiation in Treating Patients With Colorectal Cancer That Has Spread to the Liver

Phase 2 Unknown

20 enrolled

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT00026234 2013-07-16

Hepatic Arterial Infusion Plus Chemotherapy in Treating Patients With Colorectal Cancer Metastatic to the Liver

75 enrolled

Colonic Neoplasms, Rectal Neoplasms

NCT00002783 2013-07-03

Combination Chemotherapy Before and After Surgery in Treating Patients With Stomach Cancer

50 enrolled

Stomach Neoplasms

NCT00003753 2013-06-24

Floxuridine, Dexamethasone, and Irinotecan After Surgery in Treating Patients With Liver Metastases From Colorectal Cancer

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT00006038 2013-06-19

Combination Chemotherapy Followed by Surgery and Intraperitoneal Chemotherapy in Treating Patients With Locally Advanced Stomach Cancer

Adenocarcinoma Of Esophagus, Esophageal Neoplasms, Stomach Neoplasms

NCT00268463 2013-05-15

Oxaliplatin and Capecitabine With or Without an Hepatic Arterial Infusion With Floxuridine in Treating Patients Who Are Undergoing Surgery and/or Ablation for Liver Metastases Due to Colorectal Cancer

Phase 3 Terminated

22 enrolled 3 charts

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT00008294 2013-01-18

Combination Chemotherapy in Treating Patients With Unresectable Liver Metastases From Colorectal Cancer

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT00020501 2012-03-08

Chemotherapy With or Without Isolated Hepatic Perfusion With Melphalan in Treating Patients With Colorectal Cancer That Has Spread to the Liver

Phase 3 Completed

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT00005860 2011-04-26

Oxaliplatin With Or Without Floxuridine and Leucovorin in Treating Patients With Metastatic Cancer of the Peritoneum

CNSEndocrineGastrointestinalGynecologicSarcoma

Appendiceal Neoplasms, Bile Duct Neoplasms, Colonic Neoplasms, Vipoma, Fallopian Tube Neoplasms, Gallbladder Neoplasms, Glucagonoma, Carcinoma, Hepatocellular, Insulinoma, Neoplasms, Neoplasms, Unknown Primary, Neuroblastoma, Pancreatic Neoplasms, Pheochromocytoma, Pseudomyxoma Peritonei, Somatostatinoma, Stomach Neoplasms, Gastrinoma, Carcinoma, Islet Cell, Gastrointestinal Stromal Tumors

NCT00005049 2011-04-06

Combination Chemotherapy in Treating Patients With Stage III Ovarian Epithelial Cancer or Gastrointestinal Cancer

GastrointestinalGynecologicSarcoma

45 enrolled

Carcinoma, Ovarian Epithelial, Colonic Neoplasms, Ovarian Neoplasms, Rectal Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Gastrointestinal Stromal Tumors

NCT00643877 2009-03-25

PHRAC

Phase 3 Unknown

600 enrolled

Neoplasm Metastasis, Colorectal Neoplasms

NCT00001576 2008-03-04

A Phase I Study of Isolated Hepatic Perfusion With Escalating Dose Melphalan Followed by Postoperative Hepatic Arterial Floxuridine and Leucovorin for Metastatic Unresectable Colorectal Cancers of the Liver

28 enrolled