Clinical Trials

Adenomatous Polyposis Coli

NCT03512756 2024-11-06

A Randomized Phase 2/3 Multi-Center Study of SM-88 in Participants With Metastatic Pancreatic Cancer

Phase 2/3 Terminated

130 enrolled 13 charts

Neoplasm Metastasis, Neoplasms, Pancreatic Neoplasms

NCT03095703 2024-10-24

Sirolimus and Familial Adenomatous Polyposis (FAP)

4 enrolled 10 charts

BreastClassical hematologyGastrointestinalGenitourinaryLymphoidMyeloidOther hematologic neoplasmPlasma cell

Adenomatous Polyposis Coli

NCT03878524 2024-03-04

Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial

Phase 1 Terminated

2 enrolled

Anemia, Blast Crisis, Breast Neoplasms, Hodgkin Disease, Lymphoma, Non-Hodgkin, Multiple Myeloma, Myelodysplastic Syndromes, Myeloproliferative Disorders, Neoplasm Metastasis, Pancreatic Neoplasms, Prostatic Neoplasms, Thrombocytosis, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Accelerated Phase, Leukemia, Myeloid, Chronic-Phase, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Myelodysplastic-Myeloproliferative Diseases, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative, Primary Myelofibrosis

NCT02048384 2021-04-12

A Study of Metformin With or Without Rapamycin as Maintenance Therapy After Induction Chemotherapy in Subjects With Pancreatic Cancer

22 enrolled

Adenocarcinoma, Neoplasm Metastasis, Pancreatic Neoplasms

NCT01331135 2020-05-29

Aflac ST0901

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

18 enrolled

Astrocytoma, Carcinoma, Renal Cell, Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Recurrence, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma, Sarcoma, Clear Cell, Rhabdoid Tumor

NCT02145559 2019-04-22

A Pharmacodynamic Study of Sirolimus and Metformin in Patients With Advanced Solid Tumors

BreastGastrointestinalGenitourinaryLymphoidThoracic

24 enrolled

Breast Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Lymphoma

NCT01537107 2019-04-08

Sirolimus and Vismodegib in Treating Patients With Solid Tumors or Pancreatic Cancer That is Metastatic or Cannot Be Removed By Surgery

31 enrolled

Pancreatic Neoplasms

NCT00409994 2019-03-18

Safety Study of Rapamycin Administered Before and During Radiotherapy to Treat Rectum Cancer

Phase 1/2 Completed

44 enrolled

Rectal Neoplasms, Colorectal Neoplasms

NCT01010126 2019-01-25

Temsirolimus and Bevacizumab in Treating Patients With Advanced Endometrial, Ovarian, Liver, Carcinoid, or Islet Cell Cancer

GastrointestinalGynecologic

252 enrolled 20 charts

Fallopian Tube Neoplasms, Carcinoma, Hepatocellular, Ovarian Neoplasms, Somatostatinoma

NCT00276744 2018-10-24

Individualized Drug Treatment for Treating Patients With Pancreatic Cancer

Phase 2 Terminated

249 enrolled 4 charts

Pancreatic Neoplasms

NCT03662412 2018-09-07

Study of Sirolimus in Patients With Advanced Pancreatic Cancer

Phase 1/2 Unknown

36 enrolled

Pancreatic Neoplasms

NCT01390818 2017-03-07

Trial of MEK Inhibitor and PI3K/mTOR Inhibitor in Subjects With Locally Advanced or Metastatic Solid Tumors

BreastDermatologicGastrointestinalThoracic

146 enrolled 42 charts

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Neoplasm Metastasis, Colorectal Neoplasms

NCT01374750 2016-06-01

Sirolimus

45 enrolled

Carcinoma, Hepatocellular

NCT02724332 2016-03-31

Adjuvant Anti-Recurrence Treatment With Rapamycin on Early-stage HCC

300 enrolled

Carcinoma, Hepatocellular

NCT00355862 2014-07-30

Immunosuppression in Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma

Phase 3 Completed

525 enrolled

Carcinoma, Hepatocellular

NCT00375245 2014-01-17

Rapamycin With Grapefruit Juice for Advanced Malignancies

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther solid neoplasmThoracic

41 enrolled

Urinary Bladder Neoplasms, Breast Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Lymphoma, Melanoma, Mesothelioma, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Stomach Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms

NCT00328770 2013-06-24

De Novo Sirolimus-based Immunosuppression After Liver Transplantation for Hepatocellular Carcinoma

Phase 2/3 Completed

70 enrolled 9 charts

Carcinoma, Hepatocellular

NCT00467194 2013-06-17

Sirolimus and Bevacizumab in Treating Patients With Liver Cancer That Cannot Be Removed by Surgery

27 enrolled

Carcinoma, Hepatocellular, Liver Neoplasms

NCT00087074 2013-06-04

CCI-779 in Treating Patients With Soft Tissue Sarcoma or Gastrointestinal Stromal Tumor

55 enrolled

GastrointestinalSarcoma

Sarcoma, Gastrointestinal Stromal Tumors

NCT00075647 2013-01-17

CCI-779 in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer

40 enrolled

Pancreatic Neoplasms

NCT00554125 2007-11-06

Sirolimus-Based Immunosuppression Therapy in OLT for Patients With HCC Exceeding Milan Criteria

Phase 3 Unknown

220 enrolled