Clinical Trials

60 enrolled

Urinary Bladder Neoplasms

NCT03866382 2026-03-18

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

314 enrolled

Urachal adenocarcinoma, Urinary Bladder Neoplasms, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Penile Neoplasms, Prostatic Neoplasms, Urethral Neoplasms, Urogenital Neoplasms

NCT04071236 2026-03-18

Radiation Medication (Radium-223 Dichloride) Versus Radium-223 Dichloride Plus Radiation Enhancing Medication (M3814) Versus Radium-223 Dichloride Plus M3814 Plus Avelumab (a Type of Immunotherapy) for Advanced Prostate Cancer Not Responsive to Hormonal Therapy

90 enrolled

Lymphatic Metastasis, Prostatic Neoplasms

NCT04314401 2026-03-18

National Cancer Institute "Cancer Moonshot Biobank"

BreastDermatologicGastrointestinalGenitourinaryGynecologicOther hematologic neoplasmPlasma cellThoracic

1,600 enrolled

Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Fallopian Tube Neoplasms, Lung Neoplasms, Melanoma, Multiple Myeloma, Ovarian Neoplasms, Prostatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Leukemia, Myeloid, Acute, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT04628767 2026-03-18

Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer

Phase 2/3 Recruiting

249 enrolled

Renal Pelvis and Ureter Urothelial Carcinoma

NCT04981509 2026-03-18

Testing of Bevacizumab, Erlotinib, and Atezolizumab in Combination for Advanced-Stage Kidney Cancer

65 enrolled

Hereditary leiomyomatosis and renal cell cancer, Papillary renal cell carcinoma, sporadic, Carcinoma, Renal Cell

NCT05691465 2026-03-18

Testing the Safety and Effectiveness of Radiation-based Treatment (Lutetium Lu 177 Dotatate) for Metastatic Prostate Cancer That Has Neuroendocrine Cells

30 enrolled

Prostatic Neoplasms

NCT05987241 2026-03-18

Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study

Phase 2/3 Recruiting

992 enrolled

Muscle Invasive Bladder Urothelial Carcinoma

NCT06022822 2026-03-18

Placebo-Controlled Trial of Urolithin A Supplementation in Men With Prostate Cancer Undergoing Radical Prostatectomy, URO-PRO Trial

90 enrolled

Prostate Adenocarcinoma

NCT06439836 2026-03-18

Pembrolizumab Plus CA-4948 for the Treatment of Patients With Progressive Metastatic Urothelial Cancer Despite Prior Immunotherapy

Phase 1 Recruiting

27 enrolled

Carcinoma, Transitional Cell

NCT06524544 2026-03-18

A Study Comparing the Combination of Pembrolizumab and Sacituzumab Govitecan Versus Standard of Care in the Treatment of Advanced Urothelial Cancer

Phase 3 Recruiting

320 enrolled

Carcinoma, Transitional Cell

NCT06770582 2026-03-18

Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC Trial

160 enrolled

BreastGastrointestinalGenitourinaryGynecologicThoracic

Urinary Bladder Neoplasms

NCT06995898 2026-03-18

The Vanguard Study: Testing a New Way to Screen for Cancer

Phase NA Recruiting

24,000 enrolled

Urinary Bladder Neoplasms, Breast Neoplasms, Esophageal Neoplasms, Carcinoma, Hepatocellular, Lung Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms

NCT07061964 2026-03-18

Combining Immunotherapy and Radiation Therapy to Help Patients Avoid Bladder Removal After Treatment Shrinks Muscle Invasive Bladder Cancer, BRIGHT Trial

111 enrolled

Urinary Bladder Neoplasms

NCT06161532 2026-03-17

Sacituzumab Govitecan With or Without Atezolizumab Immunotherapy in Rare Genitourinary Tumors (SMART) Such as High Grade Neuroendocrine Carcinomas, Adenocarcinoma, and Squamous Cell Bladder/Urinary Tract Cancer, Renal Medullary Carcinoma and Penile C...

60 enrolled

Carcinoma, Transitional Cell

NCT00001238 2026-03-16

Von Hippel-Lindau (VHL): Clinical Manifestations, Diagnosis, Management and Molecular Bases of Inherited Renal and Other Urologic Malignant Disorders

5,000 enrolled

EndocrineGenitourinary

Hereditary leiomyomatosis and renal cell cancer, Carcinoma, Renal Cell, Kidney Neoplasms, Pheochromocytoma

NCT06096870 2026-03-16

Enzalutamide and PDS01ADC in PET Positive Recurrent Prostate Cancer (pprPC) Without Testosterone Lowering Therapy

65 enrolled

Prostatic Neoplasms

NCT05616650 2026-03-13

Focal Therapy With Stereotactic Body Radiation Therapy (SBRT) for Patients With a Single Prostate Tumor

42 enrolled

Prostatic Neoplasms

NCT05361798 2026-03-12

T-Cell Clonality After Stereotactic Body Radiation Therapy Alone and in Combination With the Immunocytokine M9241 in Localized High- and Intermediate-Risk Prostate Cancer Treated With Androgen Deprivation Therapy

65 enrolled

Prostatic Neoplasms

NCT00001823 2026-03-11

Evaluation for NCI Surgery Branch Clinical Research Protocols

DermatologicGastrointestinalGenitourinaryThoracic

7,000 enrolled

Urinary Bladder Neoplasms, Lung Neoplasms, Melanoma, Neoplasms, Colorectal Neoplasms

NCT01109394 2026-03-11

Comprehensive Omics Analysis of Pediatric and Adult Solid Tumors and Establishment of a Repository for Related Biological Studies

CNSGenitourinaryOther solid neoplasmSarcoma

6,035 enrolled

Kidney Neoplasms, Neoplasms, Neuroblastoma, Retinoblastoma, Sarcoma

NCT00026884 2026-03-10

Collection of Serum and Tissue Samples From Patients With Biopsy-Proved or Suspected Malignant Disease

5,950 enrolled

Urinary Bladder Neoplasms, Kidney Neoplasms, Neoplasms, Neoplastic Syndromes, Hereditary

NCT01834001 2026-03-09

Imaging Studies to Check the Local Response of Prostate Cancer to Radiation Therapy

300 enrolled

Prostatic Neoplasms

NCT05665361 2026-03-09

Palbociclib and Sasanlimab for the Treatment of Advanced Clear Cell Renal Cell Carcinoma (ccRCC) or Papillary Renal Cell Carcinoma (pRCC)

100 enrolled

Carcinoma, Renal Cell, Kidney Neoplasms

NCT00033137 2026-03-06

Genetic Analysis of Birt Hogg-Dube Syndrome and Characterization of Predisposition to Kidney Cancer

950 enrolled

Kidney Neoplasms, Neoplasms, Pneumothorax

NCT01441089 2026-03-06

Collection of Blood From Patients With Cancer, Other Tumors, or Tumor Predisposition Syndromes for Genetic Analysis

BreastGenitourinaryGynecologicLymphoidThoracic

1,100 enrolled

Breast Neoplasms, Lung Neoplasms, Lymphoma, Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms

NCT00451022 2026-02-23

Follow-Up Study of Subjects Previously Enrolled in Poxviral Vector Gene Transfer Studies

BreastGastrointestinalGenitourinaryThoracic

750 enrolled

Breast Neoplasms, Colonic Neoplasms, Liver Neoplasms, Lung Neoplasms, Prostatic Neoplasms

NCT02379429 2026-02-17

Care of the Urothelial Cancer Patient and Prospective Procurement of Urothelial Cancer Tissue

500 enrolled

Urinary Bladder Neoplasms, Urologic Neoplasms

NCT04706663 2026-02-17

Precision-Based Genomics in Prostate Cancer

2,000 enrolled

Prostatic Neoplasms, Genetic Predisposition to Disease

NCT05155033 2026-02-17

Phase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal Cell Carcinoma

DermatologicGenitourinary

78 enrolled

Carcinoma, Renal Cell, Melanoma

NCT02594202 2026-02-05

Care of the Prostate Cancer Patient and Prospective Procurement of Prostate Cancer Tissue

3,000 enrolled

Prostatic Neoplasms, Carcinogenesis

NCT04923178 2026-01-26

A Multi-Center Natural History of Urothelial Cancer and Rare Genitourinary Tract Malignancies

1,100 enrolled

Urachal adenocarcinoma, Urinary Bladder Neoplasms, Carcinoma, Renal Cell, Penile Neoplasms, Urogenital Neoplasms

NCT03354416 2026-01-21

Profiling of Radiological Factors in Treatment and Outcomes in Prostate Cancer

10,000 enrolled

Prostatic Hyperplasia, Prostatic Neoplasms

NCT02830724 2026-01-16

Administering Peripheral Blood Lymphocytes Transduced With a CD70-Binding Chimeric Antigen Receptor to People With CD70 Expressing Cancers

BreastDermatologicGastrointestinalGenitourinaryGynecologic

124 enrolled

Breast Neoplasms, Carcinoma, Renal Cell, Melanoma, Ovarian Neoplasms, Pancreatic Neoplasms

NCT04633252 2026-01-16

M9241 in Combination With Docetaxel in Adults With Metastatic Castration Sensitive and Castration Resistant Prostate Cancer

86 enrolled

Prostatic Neoplasms

NCT03805919 2026-01-08

Men at High Genetic Risk for Prostate Cancer

GastrointestinalGenitourinary

500 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Prostatic Neoplasms

NCT06161506 2025-12-23

Surface Electrical Stimulation for Urinary Incontinence in Men Treated for Prostate Cancer

41 enrolled

Prostatic Hyperplasia, Prostatic Neoplasms, Urinary Incontinence, Urinary Incontinence, Stress, Urinary Incontinence, Urge

NCT04808427 2025-11-26

Pilot Study to Investigate Magnetic Resonance (MR) Image Guided Focal Therapy in Prostate Cancer

Phase NA Recruiting

21 enrolled

CNSEndocrineGenitourinaryHead & Neck

Prostatic Neoplasms

NCT06479811 2025-11-25

[212Pb]VMT-Alpha-NET in Metastatic or Inoperable Somatostatin-Receptor Positive Gastrointestinal Neuroendocrine Tumors, Pheochromocytoma/Paragangliomas, Small Cell Lung, Renal Cell, and Head and Neck Cancers

Phase 1 Recruiting

120 enrolled

Head and Neck Neoplasms, Kidney Neoplasms, Paraganglioma, Pheochromocytoma

NCT04235764 2025-11-17

En-bloc Transurethral Resection of Bladder Tumor (En-bloc TURBT) Specimens Using a Redesigned Surgical Resectoscope Device

25 enrolled

Urinary Bladder Neoplasms

NCT06503146 2025-11-12

18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection

CNSEndocrineGastrointestinalGenitourinaryGynecologicOther solid neoplasmSarcomaThoracic

320 enrolled

Urinary Bladder Neoplasms, Carcinoma, Hepatocellular, Mesothelioma, Ovarian Neoplasms, Paraganglioma, Pheochromocytoma, Sarcoma, Stomach Neoplasms, Cholangiocarcinoma, Small Cell Lung Carcinoma

NCT05155046 2025-08-01

18F-DCFPyL Imaging as a Method to Assess Treatment Response to Stereotactic Body Radiation Therapy

130 enrolled