Clinical Trials Browser

Laryngeal Diseases

NCT04590963 2026-03-13

INTERLINK-1

Phase 3 Active not recruiting

370 enrolled 21 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Laryngeal Diseases

NCT05199584 2026-03-05

A Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function Mutations

Phase 2 Completed

20 enrolled

CNSDermatologicEndocrineHead & NeckOther solid neoplasmSarcomaThoracic

Uveal Melanoma, Glioma, Adenoma, Islet Cell, Laryngeal Diseases, Medulloblastoma, Melanoma, Mesothelioma, Neuroblastoma, Pituitary Diseases, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Osteosarcoma

NCT06525220 2026-02-23

A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)

Phase 3 Recruiting

500 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Laryngeal Diseases

NCT03656133 2026-02-20

Use of a Proliferation Saturation Index to Determine Personalized Radiotherapy for HPV + Oropharyngeal Cancers

Phase NA Completed

55 enrolled 10 charts

Head & Neck

Laryngeal Diseases, Oropharyngeal Neoplasms

NCT05386550 2026-02-19

Phase III Xevinapant (Debio 1143) and Radiotherapy in Resected LA SCCHN, High Risk, Cisplatin-ineligible Participants (XRAY VISION)

Phase 3 Terminated

166 enrolled 15 charts

Head & Neck

Head and Neck Neoplasms, Laryngeal Diseases

NCT07419464 2026-02-19

5-Fluorouracil Response and Optimization STudy (The FROST Trial)

Phase 2 Not yet recruiting

46 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Laryngeal Diseases

NCT04368702 2026-02-09

CONFIRM

Phase NA Recruiting

70 enrolled

BreastGastrointestinalGenitourinaryHead & NeckLymphoid

Breast Carcinoma In Situ, Urinary Bladder Neoplasms, Laryngeal Diseases, Laryngeal Neoplasms, Lymphoma, Stomach Neoplasms, Lymphoma, Mantle-Cell

NCT00576134 2025-12-22

The Objective is to Respond to Patients' Needs in the Field of Larynx Replacement

Phase 1 Completed

10 enrolled

Head & Neck

Deglutition Disorders, Laryngeal Diseases, Laryngeal Neoplasms

NCT07287865 2025-12-17

TL&TPL

Active not recruiting

400 enrolled

Head & Neck

Laryngeal Diseases

NCT03556228 2025-12-11

VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

Phase 1/2 Recruiting

242 enrolled

GastrointestinalHead & NeckOther solid neoplasmThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Adenoid Cystic, Esophageal Neoplasms, Head and Neck Neoplasms, Laryngeal Diseases, Lung Neoplasms, Mesothelioma, Neoplasm Metastasis, Pancreatic Neoplasms, Salivary Gland Neoplasms, Tracheal Diseases, Small Cell Lung Carcinoma

NCT06080503 2025-11-26

G-FORCE

Phase NA Recruiting

67 enrolled

Head & Neck

Laryngeal Diseases, Laryngeal Neoplasms

NCT06303180 2025-11-14

NIDCD Otolaryngology Clinical Protocol Biospecimen Bank

Recruiting

1,000 enrolled

Head & Neck

Head and Neck Neoplasms, Hearing Disorders, Laryngeal Diseases, Speech, Hearing Loss

NCT02586207 2025-10-07

Pembrolizumab in Combination With CRT for LA-SCCHN

Phase 1 Completed

59 enrolled 9 charts

Head & Neck

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Diseases, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT06819228 2025-10-03

Window Trial of Fluorescently Labeled Panitumumab (Panitumumab-IRDye800) in Head and Neck Cancer

Phase EARLY_PHASE1 Recruiting

18 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Diseases, Mouth Neoplasms, Tongue Neoplasms

NCT06915454 2025-10-03

High-Resolution PET-CT Imaging for Surgical Margin Visualization

Phase NA Recruiting

50 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Diseases, Mouth Neoplasms, Neoplasms, Tongue Neoplasms

NCT01644786 2025-10-02

The Head and Neck Tumor Biobank

Completed

419 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Laryngeal Diseases

NCT06056310 2025-09-29

Phase 1b Safety Study of Xevinapant, Weekly Cisplatin, and RT in Participants With Unresected LA SCCHN (HyperlynX)

Phase 1 Terminated

18 enrolled 9 charts

Head & Neck

Head and Neck Neoplasms, Laryngeal Diseases

NCT03429036 2025-08-14

Biospecimen Procurement for Head and Neck Disorders

Recruiting

1,000 enrolled

Head & Neck

Head and Neck Neoplasms, Hearing Disorders, Laryngeal Diseases, Pharyngeal Neoplasms

NCT06078527 2025-07-23

Assessment of Laryngopharyngeal Sensation: Cancer Survivor Cohort

Phase NA Not yet recruiting

40 enrolled

Head & Neck

Globus Sensation, Laryngeal Diseases, Vocal Cord Paralysis, Dysphonia

NCT03529422 2025-07-20

Durvalumab With Radiotherapy for Adjuvant Treatment of Intermediate Risk SCCHN

Phase 2 Active not recruiting

18 enrolled 10 charts

Head & Neck

Lymphoid Interstitial Pneumonia, Laryngeal Diseases, Mouth Neoplasms

NCT03854032 2025-06-06

Nivolumab and BMS986205 in Treating Patients With Stage II-IV Squamous Cell Cancer of the Head and Neck

Phase 2 Active not recruiting

45 enrolled

Head & Neck

Lymphoid Interstitial Pneumonia, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Laryngeal Diseases

NCT03109873 2025-04-30

Metformin Hydrochloride in Affecting Cytokines and Exosomes in Patients With Head and Neck Cancer

Phase EARLY_PHASE1 Completed

9 enrolled 6 charts

Head & Neck

Lymphoid Interstitial Pneumonia, Laryngeal Diseases

NCT03162731 2025-04-29

Nivolumab, Ipilimumab, and Radiation Therapy in Treating Patients With Stage III-IVB Head and Neck Cancer

Phase EARLY_PHASE1 Completed

24 enrolled

Head & Neck

Lymphoid Interstitial Pneumonia, Laryngeal Diseases

NCT02128906 2025-03-26

Radiotherapy With Cisplatin vs. Docetaxel-cetuximab in HNSCC: ERCC1 Biomarker Enrichment and Interaction Design

Phase 2 Recruiting

120 enrolled

Head & Neck

Carcinoma, Squamous Cell, Laryngeal Diseases

Clinical Trials

DEREDIA

INTERLINK-1

A Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function Mutations

A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)

Use of a Proliferation Saturation Index to Determine Personalized Radiotherapy for HPV + Oropharyngeal Cancers

Phase III Xevinapant (Debio 1143) and Radiotherapy in Resected LA SCCHN, High Risk, Cisplatin-ineligible Participants (XRAY VISION)

5-Fluorouracil Response and Optimization STudy (The FROST Trial)

CONFIRM

The Objective is to Respond to Patients' Needs in the Field of Larynx Replacement

TL&TPL

VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

G-FORCE

NIDCD Otolaryngology Clinical Protocol Biospecimen Bank

Pembrolizumab in Combination With CRT for LA-SCCHN

Window Trial of Fluorescently Labeled Panitumumab (Panitumumab-IRDye800) in Head and Neck Cancer

High-Resolution PET-CT Imaging for Surgical Margin Visualization

The Head and Neck Tumor Biobank

Phase 1b Safety Study of Xevinapant, Weekly Cisplatin, and RT in Participants With Unresected LA SCCHN (HyperlynX)

Biospecimen Procurement for Head and Neck Disorders

Assessment of Laryngopharyngeal Sensation: Cancer Survivor Cohort

Durvalumab With Radiotherapy for Adjuvant Treatment of Intermediate Risk SCCHN

Nivolumab and BMS986205 in Treating Patients With Stage II-IV Squamous Cell Cancer of the Head and Neck

Metformin Hydrochloride in Affecting Cytokines and Exosomes in Patients With Head and Neck Cancer

Nivolumab, Ipilimumab, and Radiation Therapy in Treating Patients With Stage III-IVB Head and Neck Cancer

Radiotherapy With Cisplatin vs. Docetaxel-cetuximab in HNSCC: ERCC1 Biomarker Enrichment and Interaction Design