Clinical Trials

BreastDermatologicGastrointestinalGenitourinaryHead & NeckSarcomaThoracic

100 enrolled

Breast Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Melanoma, Prostatic Neoplasms, Sarcoma, Skin Neoplasms, Urogenital Neoplasms

NCT06237881 2026-02-18

A Phase 1/2 Study of KSQ-001EX, Autologous Tumor Infiltrating Lymphocytes Engineered to Inactivate the SOCS1 Gene, in Patients With Select Advanced Solid Tumors

Phase 1/2 Active not recruiting

15 enrolled

Phase 2 Not yet recruiting

Head and Neck Neoplasms, Lung Neoplasms, Melanoma

NCT07405086 2026-02-12

Morning Versus Afternoon Administration of Immunotherapy for the Treatment of Advanced or Metastatic Solid Tumors, The Knight SHIFT Study

160 enrolled

DermatologicGastrointestinalGenitourinaryHead & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Hepatocellular, Lung Neoplasms, Melanoma, Neoplasm Metastasis

NCT05334069 2026-02-04

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

BreastDermatologicGastrointestinalGenitourinaryHead & NeckLymphoidMyeloidOther hematologic neoplasmSarcomaThoracic

2,000 enrolled

Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Esophageal Neoplasms, Lung Neoplasms, Melanoma, Prostatic Neoplasms, Sarcoma, Stomach Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Acute, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT03474497 2026-01-29

UCDCC#272: IL-2, Radiotherapy, and Pembrolizumab in Patients Refractory to Checkpoint Blockade

Phase 1/2 Active not recruiting

18 enrolled 13 charts

Phase 1 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Melanoma

NCT02432963 2026-01-28

Vaccine Therapy and Pembrolizumab in Treating Patients With Solid Tumors That Have Failed Prior Therapy

11 enrolled

BreastDermatologicGastrointestinalGenitourinaryHead & NeckSarcomaThoracic

Squamous Cell Carcinoma of Head and Neck, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Colonic Neoplasms, Carcinoma, Hepatocellular, Melanoma, Pancreatic Neoplasms, Rectal Neoplasms, Sarcoma, Triple Negative Breast Neoplasms

NCT02012699 2026-01-22

iCaRe2

BreastCNSDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckNETOther hematologic neoplasmOther solid neoplasmPlasma cellSarcomaThoracic

999,999 enrolled

Anus Neoplasms, Bile Duct Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Duodenal Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Hypopharyngeal Neoplasms, Kidney Neoplasms, Laryngeal Neoplasms, Leukemia, Lip Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Mesothelioma, Mouth Neoplasms, Multiple Myeloma, Nasopharyngeal Neoplasms, Neoplasms, Unknown Primary, Oropharyngeal Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Paranasal Sinus Neoplasms, Paraproteinemias, Penile Neoplasms, Peritoneal Neoplasms, Adenomatous Polyposis Coli, Prostatic Neoplasms, Rectal Neoplasms, Salivary Gland Neoplasms, Sarcoma, Skin Neoplasms, Stomach Neoplasms, Testicular Neoplasms, Thymus Neoplasms, Thyroid Neoplasms, Ureteral Neoplasms, Urethral Neoplasms, Vaginal Neoplasms, Central Nervous System Neoplasms, Thyroid Nodule, Endometrial Neoplasms, Neuroendocrine Tumors, Gastrointestinal Stromal Tumors

NCT02724488 2026-01-08

SPECIAL

Active not recruiting

14 enrolled

BreastDermatologicHead & Neck

Head and Neck Neoplasms, Melanoma

NCT07310758 2025-12-30

Contrast-enhanced Ultrasound for Sentinel Node Detection

Phase 2/3 Recruiting

91 enrolled

Breast Neoplasms, Head and Neck Neoplasms, Melanoma

NCT04157985 2025-12-11

Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors

Phase 3 Completed

161 enrolled

DermatologicGastrointestinalGenitourinaryGynecologicHead & Neck

Squamous Cell Carcinoma of Head and Neck, Anus Neoplasms, Urinary Bladder Neoplasms, Uterine Cervical Neoplasms, Carcinoma, Hepatocellular, Kidney Neoplasms, Melanoma, Stomach Neoplasms, Colorectal Neoplasms, Carcinoma, Merkel Cell, Cholangiocarcinoma

NCT06265285 2025-12-04

Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program

DermatologicGastrointestinalGenitourinaryHead & NeckThoracic

50 enrolled

Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Esophageal Neoplasms, Carcinoma, Hepatocellular, Melanoma, Colorectal Neoplasms

NCT05859074 2025-12-03

A Study of MQ710 With and Without Pembrolizumab in People With Solid Tumor Cancer

Phase 1 Recruiting

56 enrolled

DermatologicHead & NeckSarcoma

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Hemangiosarcoma, Melanoma, Neoplasm Metastasis, Neoplasms, Paget Disease, Extramammary, Sarcoma, Kaposi, Skin Neoplasms, Carcinoma, Merkel Cell, Adenocarcinoma, Sebaceous, Carcinoma, Skin Appendage

NCT05768178 2025-11-24

DETERMINE

Phase 2/3 Recruiting

30 enrolled

CNSDermatologicEndocrineGastrointestinalGynecologicHead & NeckMyeloidOther hematologic neoplasmPlasma cellThoracic

Thyroid Cancer, Papillary, Carcinoma, Non-Small-Cell Lung, Glioma, Laryngeal Neoplasms, Melanoma, Multiple Myeloma, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Ovarian Neoplasms, Colorectal Neoplasms, Hematologic Neoplasms, Erdheim-Chester Disease, Thyroid Carcinoma, Anaplastic

NCT07106827 2025-11-24

A Study of GV20-0251 in Advanced or Refractory Solid Tumors

Phase 1 Recruiting

10 enrolled

DermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Hepatocellular, Melanoma, Testicular Neoplasms, Endometrial Neoplasms, Cholangiocarcinoma

NCT06897735 2025-11-18

EDDIS-a1

Phase 1 Not yet recruiting

24 enrolled

Phase 1/2 Active not recruiting

Lung Neoplasms, Melanoma, Mouth Neoplasms

NCT04074967 2025-11-06

Study of ARRY-614 Plus Either Nivolumab or Nivolumab+Ipilimumab

70 enrolled

Phase 2 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Melanoma

NCT02713269 2025-10-30

Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord

60 enrolled

DermatologicGastrointestinalGenitourinaryHead & NeckSarcoma

Carcinoma, Renal Cell, Gastrointestinal Neoplasms, Melanoma, Neoplasms, Unknown Primary, Sarcoma, Spinal Cord Compression, Thyroid Neoplasms

NCT04693377 2025-10-27

Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial

Phase NA Recruiting

40 enrolled

DermatologicGastrointestinalGenitourinaryHead & NeckSarcoma

Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Melanoma, Neoplasm Metastasis, Prostatic Neoplasms, Sarcoma, Thyroid Neoplasms, Colorectal Neoplasms

NCT06171945 2025-10-27

AYAConnect

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOtherOther hematologic neoplasmSarcoma

63 enrolled

Psychological Well-Being, Urinary Bladder Neoplasms, Bone Neoplasms, Brain Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Colonic Neoplasms, Head and Neck Neoplasms, Hodgkin Disease, Kidney Neoplasms, Leukemia, Liver Neoplasms, Lymphoma, Non-Hodgkin, Melanoma, Motor Activity, Mouth Neoplasms, Neoplasms, Obesity, Pancreatic Neoplasms, Pharyngeal Neoplasms, Rectal Neoplasms, Sarcoma, Testicular Neoplasms, Thyroid Neoplasms, Weight Loss, Endometrial Neoplasms, Overweight

NCT05039801 2025-10-14

IACS-6274 With or Without Bevacizumab and Paclitaxel for the Treatment of Advanced Solid Tumors

Phase 1 Recruiting

54 enrolled

DermatologicGynecologicHead & NeckSarcoma

Squamous Cell Carcinoma of Head and Neck, Chondrosarcoma, Melanoma, Ovarian Neoplasms, Endometrial Neoplasms

NCT05053230 2025-10-09

IMPROVE

Phase NA Recruiting

480 enrolled

DermatologicGynecologicHead & NeckThoracic

Genital Neoplasms, Female, Head and Neck Neoplasms, Melanoma, Ovarian Neoplasms, Thoracic Neoplasms

NCT03948724 2025-08-17

EDHITO

DermatologicGenitourinaryHead & Neck

411 enrolled

Carcinoma, Renal Cell, Head and Neck Neoplasms, Melanoma

NCT06384417 2025-08-08

Using an End-of-life Conversation Game to Engage Patients With Cancer in Advance Care Planning: Phase 2

Phase NA Active not recruiting

32 enrolled

BreastDermatologicGastrointestinalHead & NeckThoracic

Breast Neoplasms, Head and Neck Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Urogenital Neoplasms, Colorectal Neoplasms

NCT05714553 2025-07-18

NUC-3373 in Combination With Other Agents in Patients With Advanced Solid Tumours

Phase 1/2 Terminated

19 enrolled

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmThoracic

Squamous Cell Carcinoma of Head and Neck, Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Esophageal Neoplasms, Melanoma, Neoplasm Metastasis, Neoplasms, Stomach Neoplasms, Endometrial Neoplasms, Triple Negative Breast Neoplasms

NCT07072143 2025-07-18

PARTNER

CNSDermatologicGastrointestinalHead & NeckOther solid neoplasmSarcomaThoracic

6,250 enrolled

Pleuropulmonary blastoma, Nasopharyngeal Carcinoma, Adrenal Cortex Neoplasms, Melanoma, Mesothelioma, Pancreatic Neoplasms, Thymus Neoplasms, Thyroid Neoplasms, Esthesioneuroblastoma, Olfactory, Gastrointestinal Stromal Tumors

NCT03336606 2025-07-10

Study of MEDI0562 Prior to Surgical Resection in Head and Neck Squamous Cell Carcinoma (HNSCC) or Melanoma

Phase 1 Active not recruiting

35 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Melanoma, Neoplasms, Squamous Cell

NCT03991741 2025-07-03

Adoptive Cell Transfer of Autologous Tumor Infiltrating Lymphocytes and High-Dose Interleukin 2 in Select Solid Tumors

Phase 1 Terminated

3 enrolled 9 charts

Phase 2 Active not recruiting

Head and Neck Neoplasms, Melanoma, Neoplasm Metastasis

NCT05286294 2025-07-03

MITRIC

20 enrolled

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Melanoma

NCT05078047 2025-06-05

MOIO

Phase 3 Recruiting

646 enrolled

Esophageal Squamous Cell Carcinoma, Carcinoma, Basal Cell, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Melanoma, Carcinoma, Merkel Cell, Endometrial Neoplasms, Triple Negative Breast Neoplasms

NCT02331134 2025-05-31

Tissue and Hematopoietic/Mesenchymal Stem Cell for Humanized Xenograft Studies in Melanoma and Squamous Head and Neck Cancer

9 enrolled 9 charts

Head and Neck Neoplasms, Melanoma

NCT02318771 2025-05-15

Radiation Therapy and MK-3475 for Patients With Recurrent/Metastatic Head and Neck Cancer, Renal Cell Cancer, Melanoma, and Lung Cancer

Phase 1 Completed

41 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Renal Cell, Lung Neoplasms, Melanoma

NCT00405405 2025-05-06

Phase I of Biologics and Chemoradiation Therapy for Advanced Head and Neck Cancer

Phase 1 Completed

13 enrolled

Head and Neck Neoplasms, Melanoma, Parotid Neoplasms, Thyroid Neoplasms

NCT05621837 2025-05-02

Serpentine

BreastDermatologicGenitourinaryHead & Neck

1,000 enrolled

Squamous Cell Carcinoma of Head and Neck, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Melanoma, Carcinoma, Small Cell

NCT05483400 2025-03-30

TIRACAN

97 enrolled

Head and Neck Neoplasms, Melanoma

NCT05913388 2025-03-11

GB1211 and Pembrolizumab Versus Pembrolizumab and Placebo in Patients With Metastatic Melanoma and Head and Neck Squamous Cell Carcinoma

92 enrolled

Phase 1 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Melanoma

NCT03236935 2025-03-10

Phase Ib of L-NMMA and Pembrolizumab

12 enrolled

BreastCNSDermatologicGastrointestinalHead & NeckOther hematologic neoplasmThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Melanoma, DNA Repair-Deficiency Disorders

NCT06168825 2025-02-27

MOM

Completed

40 enrolled

Brain Neoplasms, Breast Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Melanoma, Neoplasms, Urogenital Neoplasms, Colorectal Neoplasms, Central Nervous System Neoplasms, Hematologic Neoplasms

NCT05231655 2025-02-24

EVIDENT

CNSDermatologicGenitourinaryHead & NeckSarcoma

600 enrolled

Urinary Bladder Neoplasms, Glioblastoma, Head and Neck Neoplasms, Kidney Neoplasms, Melanoma, Sarcoma

NCT03412058 2025-02-20

CHECK'UP

Phase NA Active not recruiting

670 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Melanoma

NCT04114136 2025-02-10

Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies

DermatologicGastrointestinalHead & Neck

72 enrolled

Adenocarcinoma Of Esophagus, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Hepatocellular, Melanoma

NCT05403177 2025-02-03

MOHCCN-O

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther hematologic neoplasmThoracic

500 enrolled

Breast Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Leukemia, Lung Neoplasms, Lymphoma, Melanoma, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Colorectal Neoplasms

NCT02906943 2024-12-04

OCTANE

BreastDermatologicGastrointestinalHead & NeckThoracic

10,000 enrolled

Breast Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Melanoma, Neoplasms, Unknown Primary, Urogenital Neoplasms, Colorectal Neoplasms

NCT06666634 2024-10-30

NANOSCAN

Phase NA Recruiting

29 enrolled

DermatologicGenitourinaryHead & Neck

Melanoma, Mouth Neoplasms, Penile Neoplasms

NCT05878964 2024-10-04

SkinHealth

BreastDermatologicGastrointestinalGenitourinaryHead & NeckThoracic

420 enrolled

Urinary Bladder Neoplasms, Breast Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Lung Neoplasms, Melanoma, Skin Neoplasms, Stomach Neoplasms

NCT04604158 2024-05-21

Evaluating the Effect of a Mobile Audio Companion (Elly) to Reduce Anxiety in Cancer Patients

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther hematologic neoplasmPlasma cellSarcomaThoracic

38 enrolled

Anxiety Disorders, Urinary Bladder Neoplasms, Breast Neoplasms, Glioblastoma, Head and Neck Neoplasms, Kidney Neoplasms, Leukemia, Lung Neoplasms, Lymphoma, Melanoma, Multiple Myeloma, Neoplasm Metastasis, Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Sarcoma, Social Isolation, Uterine Neoplasms, Colorectal Neoplasms

NCT03590054 2024-03-22

Abexinostat in Combination With Pembrolizumab in Patients With Advanced Solid Tumor Malignancies

Phase 1 Completed

35 enrolled