Clinical Trials

392 enrolled

Head and Neck Neoplasms, Mouth Neoplasms, Tongue Neoplasms

NCT04540588 2025-12-02

Retreatment With Intratumoral Diffusing Alpha Radiation Emitters

DermatologicHead & NeckSarcoma

2 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Lip Neoplasms, Recurrence, Sarcoma, Kaposi, Skin Neoplasms, Soft Tissue Neoplasms, Tongue Neoplasms

NCT00765440 2025-09-30

Study of Nutrition Regimens in Treating Patients With Cancer of the Upper Aerodigestive Tract

Phase 3 Completed

311 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Infections, Tongue Neoplasms, Malnutrition

NCT00875849 2025-09-30

AACER

53 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Tongue Neoplasms

NCT00665392 2025-08-01

ECHO-07

42 enrolled 24 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Tongue Neoplasms

NCT02245100 2025-05-15

Circulating Tumor DNA in Predicting Outcomes in Patients With Stage IV Head and Neck Cancer or Stage III-IV Non-small Cell Lung Cancer

130 enrolled

Head & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Salivary Gland Neoplasms, Tongue Neoplasms

NCT01847326 2024-07-31

Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Carboplatin Followed By Chemoradiation in Treating Patients With Recurrent Head and Neck Cancer

48 enrolled

Squamous Cell Carcinoma of Head and Neck, Salivary Gland Neoplasms, Tongue Neoplasms

NCT04337853 2023-11-03

Radiotherapy of Tongue Cancer Using an Intraoral Stent

13 enrolled

Head and Neck Neoplasms, Tongue Neoplasms

NCT03602079 2023-08-03

Study of A166 in Patients With Relapsed/Refractory Cancers Expressing HER2 Antigen or Having Amplified HER2 Gene

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

49 enrolled

Bile Duct Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Colonic Neoplasms, Head and Neck Neoplasms, Laryngeal Neoplasms, Lip Neoplasms, Liver Neoplasms, Lung Neoplasms, Mouth Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Salivary Gland Neoplasms, Skin Neoplasms, Stomach Neoplasms, Tongue Neoplasms, Tonsillar Neoplasms, Urologic Neoplasms, Carcinoma, Mucoepidermoid, Cholangiocarcinoma, Rare Diseases

NCT04430842 2023-01-18

Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmSarcomaThoracic

15 enrolled

Sleepiness, Mesothelioma, Malignant, Anorexia, Astrocytoma, Urinary Bladder Neoplasms, Brain Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Esophageal Neoplasms, Glioblastoma, Head and Neck Neoplasms, Headache, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Sarcoma, Seizures, Speech Disorders, Stomach Neoplasms, Thymoma, Tongue Neoplasms, Urologic Neoplasms, Vomiting, Colorectal Neoplasms, Cholangiocarcinoma

NCT00530049 2021-12-21

Measuring Patient Satisfaction With Facial Appearance: Development and Validation of a New Patient-Reported Outcome Measure

1,745 enrolled

Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Salivary Gland Neoplasms, Tongue Neoplasms

NCT03239834 2021-08-12

Clinical Evaluation of the OncAlert RAPID in Subjects Presenting for Evaluation and/or Initial Biopsy; Impact on Decision-Making

893 enrolled

Gingival Neoplasms, Leukoplakia, Oral, Lip Neoplasms, Oropharyngeal Neoplasms, Palatal Neoplasms, Tongue Neoplasms, Oral Ulcer

NCT00293462 2021-07-30

GM-CSF Mouthwash for Preventing and Treating Mucositis in Patients Undergoing Radiation Therapy for Head and Neck Cancer

Phase 3 Completed

91 enrolled 16 charts

CNSHead & Neck

Head and Neck Neoplasms, Radiation Injuries, Stomatitis, Tongue Neoplasms, Esthesioneuroblastoma, Olfactory

NCT00833261 2020-08-21

Nab-Paclitaxel, Cetuximab, Cisplatin, and Radiation Therapy in Treating Patients With Recurrent Head and Neck Cancer

37 enrolled 6 charts

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Tongue Neoplasms, Carcinoma, Verrucous

NCT00851877 2020-08-21

Nab-Paclitaxel, Cisplatin, and Cetuximab With Concurrent Radiation Therapy for Locally Advanced Head and Neck Cancer

37 enrolled 9 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Tongue Neoplasms

NCT01175980 2020-08-03

Vorinostat in Treating Patients With Locally Advanced, Recurrent, or Metastatic Adenoid Cystic Carcinoma

30 enrolled 16 charts

Salivary Gland Neoplasms, Tongue Neoplasms

NCT01469429 2020-02-20

Phase 1b Food Based Modulation of Biomarkers in Human Tissues at High-Risk for Oral Cancer.

70 enrolled

Squamous Cell Carcinoma of Head and Neck, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Paranasal Sinus Neoplasms, Salivary Gland Neoplasms, Tongue Neoplasms

NCT01504932 2020-02-20

Freeze-Dried Black Raspberries in Preventing Oral Cancer Recurrence in High At-Risk Appalachian Patients Oral Cancer Survivors

42 enrolled

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms, Tongue Neoplasms

NCT01816841 2020-01-30

Direct Visual Fluorescence in Finding Oral Cancer in High-Risk Patients and Patients Undergoing Routine Dental Care

68 enrolled

Lymphoid Interstitial Pneumonia, Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms, Tongue Neoplasms

NCT00656513 2019-11-19

Acupuncture-Like Transcutaneous Electrical Nerve Stimulation (ALTENS) or Pilocarpine in Treating Early Dry Mouth in Patients Undergoing Radiation Therapy for Head and Neck Cancer

Phase 2/3 Completed

196 enrolled 13 charts

Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Salivary Gland Neoplasms, Tongue Neoplasms, Xerostomia

NCT04126226 2019-10-15

Quality of Life in Patients Treated for Tongue and/or Jaw Neoplasia Before and After Speech Therapy

30 enrolled

Communication Disorders, Deglutition Disorders, Jaw Neoplasms, Mouth Neoplasms, Speech Intelligibility, Tongue Neoplasms

NCT01806675 2019-10-03

18F-FPPRGD2 PET/CT or PET/MRI in Predicting Early Response in Patients With Cancer Receiving Anti-Angiogenesis Therapy

BreastCNSGastrointestinalGenitourinaryHead & NeckSarcomaThoracic

25 enrolled 14 charts

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Colonic Neoplasms, Glioblastoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Salivary Gland Neoplasms, Tongue Neoplasms, Esthesioneuroblastoma, Olfactory, Gliosarcoma, Breast Neoplasms, Male

NCT02123511 2019-04-30

Acetylcysteine Rinse in Reducing Saliva Thickness and Mucositis in Patients With Head and Neck Cancer Undergoing Radiation Therapy

34 enrolled 16 charts

Head & NeckOther

Squamous Cell Carcinoma of Head and Neck, Salivary Gland Neoplasms, Tongue Neoplasms, Mucositis

NCT00984074 2019-04-24

MRI Mapping in Planning Radiation Therapy to the Base of Skull and Brain in Patients With Nonmetastatic Head and Neck Cancer

3 enrolled

CNSHead & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Salivary Gland Neoplasms, Tongue Neoplasms, Esthesioneuroblastoma, Olfactory

NCT02035527 2018-05-24

Sorafenib Tosylate, Cisplatin, and Docetaxel in Treating Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck

3 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Salivary Gland Neoplasms, Tongue Neoplasms

NCT01316757 2018-02-26

Carboplatin, Paclitaxel, Cetuximab, and Erlotinib Hydrochloride in Treating Patients With Metastatic or Recurrent Head and Neck Squamous Cell Cancer

24 enrolled

Squamous Cell Carcinoma of Head and Neck, Salivary Gland Neoplasms, Tongue Neoplasms

NCT01195922 2017-12-06

Rapamycin Therapy in Head and Neck Squamous Cell Carcinoma

37 enrolled 6 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Mouth Neoplasms, Tongue Neoplasms

NCT00423930 2017-08-18

Cisplatin, Bevacizumab, and Intensity-Modulated Radiation Therapy in Treating Patients With Stage III or Stage IV Head and Neck Cancer

44 enrolled 9 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Tongue Neoplasms

NCT01015963 2017-07-13

Studying DNA in Tissue Samples From Caucasian and African-American Cancer Patients Who Received Docetaxel on Clinical Trial CLB-9871

BreastCNSGenitourinaryHead & NeckThoracic

69 enrolled

Squamous Cell Carcinoma of Head and Neck, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Lung Neoplasms, Salivary Gland Neoplasms, Tongue Neoplasms, Esthesioneuroblastoma, Olfactory, Small Cell Lung Carcinoma

NCT01256385 2017-03-27

MAESTRO HN

86 enrolled 11 charts

Lymphoid Interstitial Pneumonia, Squamous Cell Carcinoma of Head and Neck, Salivary Gland Neoplasms, Tongue Neoplasms

NCT02007200 2016-10-24

Soy Isoflavones in Preventing Head and Neck Cancer Recurrence in Patients With Stage I-IV Head and Neck Cancer Undergoing Surgery

55 enrolled 8 charts

GastrointestinalGenitourinaryGynecologicHead & NeckOther hematologic neoplasmThoracic

Lymphoid Interstitial Pneumonia, Squamous Cell Carcinoma of Head and Neck, Tongue Neoplasms

NCT00365508 2016-03-29

Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking

Phase 4 Completed

642 enrolled 8 charts

Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Hypopharyngeal Neoplasms, Kidney Neoplasms, Laryngeal Neoplasms, Leukemia, Liver Neoplasms, Lung Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Tobacco Use Disorder, Tongue Neoplasms, Leukemia, Myeloid, Acute, Small Cell Lung Carcinoma

NCT00397384 2015-09-30

Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer

CNSGastrointestinalHead & NeckSarcomaThoracic

43 enrolled

Squamous Cell Carcinoma of Head and Neck, Anus Neoplasms, Appendiceal Neoplasms, Bile Duct Neoplasms, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Carcinoma, Hepatocellular, Pancreatic Neoplasms, Rectal Neoplasms, Salivary Gland Neoplasms, Stomach Neoplasms, Tongue Neoplasms, Esthesioneuroblastoma, Olfactory, Gastrointestinal Stromal Tumors

NCT00458978 2015-05-05

Cediranib Maleate in Treating Patients With Recurrent or Newly Diagnosed Metastatic Head and Neck Cancer

6 enrolled

Lymphoid Interstitial Pneumonia, Squamous Cell Carcinoma of Head and Neck, Salivary Gland Neoplasms, Tongue Neoplasms

NCT00114283 2015-04-15

Lapatinib Ditosylate in Treating Patients With Metastatic or Recurrent Head and Neck Cancer

30 enrolled

Squamous Cell Carcinoma of Head and Neck, Salivary Gland Neoplasms, Tongue Neoplasms

NCT01334177 2015-03-05

TLR8 Agonist VTX-2337 and Cetuximab in Treating Patients With Locally Advanced, Recurrent, or Metastatic Squamous Cell Cancer of Head and Neck

13 enrolled

Squamous Cell Carcinoma of Head and Neck, Salivary Gland Neoplasms, Tongue Neoplasms

NCT00330382 2014-12-19

Bowman-Birk Inhibitor Concentrate in Preventing Cancer in Patients With Oral Leukoplakia

325 enrolled 15 charts

Leukoplakia, Oral, Mouth Neoplasms, Oropharyngeal Neoplasms, Tongue Neoplasms

NCT00507767 2014-10-01

Dasatinib in Treating Patients With Recurrent or Metastatic Head and Neck Cancer

15 enrolled 8 charts

Squamous Cell Carcinoma of Head and Neck, Salivary Gland Neoplasms, Tongue Neoplasms

NCT00049283 2014-06-06

Erlotinib, Docetaxel, and Radiation Therapy in Treating Patients With Locally Advanced Head and Neck Cancer

30 enrolled

Squamous Cell Carcinoma of Head and Neck, Tongue Neoplasms

NCT00103259 2014-05-23

Bortezomib With or Without Irinotecan in Treating Patients With Locally Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck

71 enrolled 8 charts

Squamous Cell Carcinoma of Head and Neck, Tongue Neoplasms

NCT00513435 2014-04-30

Saracatinib in Treating Patients With Recurrent or Metastatic Head and Neck Cancer

9 enrolled 8 charts

Squamous Cell Carcinoma of Head and Neck, Tongue Neoplasms

NCT00101335 2013-07-11

Celecoxib in Preventing Head and Neck Cancer in Patients With Oral Leukoplakia

Head & NeckOther neoplasm

Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Leukoplakia, Oral, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Precancerous Conditions, Tongue Neoplasms

NCT00021138 2013-05-15

Computer-Assisted Scheduling of Nicotine Inhaler Use in Participants Who Plan to Stop Smoking

GastrointestinalHead & NeckThoracic

Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Lung Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Tongue Neoplasms, Small Cell Lung Carcinoma

NCT00033618 2013-02-27

Ixabepilone in Treating Patients With Metastatic or Recurrent Squamous Cell Cancer of the Head and Neck

144 enrolled

Squamous Cell Carcinoma of Head and Neck, Salivary Gland Neoplasms, Tongue Neoplasms

NCT00064103 2013-01-23

Gene Therapy in Preventing Cancer in Patients With Premalignant Carcinoma of the Oral Cavity or Pharynx

51 enrolled

Mouth Neoplasms, Oropharyngeal Neoplasms, Tongue Neoplasms

NCT00828516 2013-01-17

AMWELL-SL

56 enrolled 6 charts

BreastCNSHead & Neck

Squamous Cell Carcinoma of Head and Neck, Breast Neoplasms, Head and Neck Neoplasms, Lymphedema, Salivary Gland Neoplasms, Tongue Neoplasms, Esthesioneuroblastoma, Olfactory, Breast Neoplasms, Male

NCT00068497 2013-01-14

Gefitinib in Treating Patients With Metastatic or Unresectable Head and Neck Cancer or Non-Small Cell Lung Cancer

CNSEndocrineHead & NeckThoracic

40 enrolled

Squamous Cell Carcinoma of Head and Neck, Thyroid Cancer, Papillary, Carcinoma, Non-Small-Cell Lung, Parathyroid Neoplasms, Salivary Gland Neoplasms, Thyroid Neoplasms, Tongue Neoplasms, Adenocarcinoma, Follicular, Carcinoma, Medullary, Esthesioneuroblastoma, Olfactory, Thyroid Carcinoma, Anaplastic

NCT00062348 2012-01-20

Boronophenylalanine-Fructose Complex (BPA-F) and/or Sodium Borocaptate (BSH) Followed By Surgery in Treating Patients With Thyroid Cancer, Head and Neck Cancer, or Liver Metastases

EndocrineGastrointestinalHead & Neck

27 enrolled

Squamous Cell Carcinoma of Head and Neck, Thyroid Cancer, Papillary, Colonic Neoplasms, Head and Neck Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Salivary Gland Neoplasms, Thyroid Neoplasms, Tongue Neoplasms, Colorectal Neoplasms, Adenocarcinoma, Follicular, Carcinoma, Medullary, Thyroid Carcinoma, Anaplastic

NCT00050388 2008-06-24

Phase II Trial of Allovectin-7® for Head and Neck Cancer

Phase 3 Completed