Clinical Trials

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms, Oropharyngeal Neoplasms, Xerostomia

NCT05106608 2026-01-05

LAXER

Phase NA Recruiting

Head and Neck Neoplasms, Neoplasms, Xerostomia

NCT00540774 2025-12-18

Optical Sensor for Photodynamic Detection of Oral Pathology

Phase NA Suspended

2,500 enrolled

Phase 2 Not yet recruiting

Gingivitis, Mouth Diseases, Mouth Neoplasms, Periodontitis, Stomatitis, Xerostomia

NCT07290946 2025-12-18

MESRIX-more

100 enrolled

Phase 3 Active not recruiting

Head and Neck Neoplasms, Sjogren's Syndrome, Xerostomia

NCT01266044 2025-10-27

Controlled Trial Of Acupuncture To Prevent Radiation-Induced Xerostomia

435 enrolled

Phase 1 Active not recruiting

Head and Neck Neoplasms, Oropharyngeal Neoplasms, Xerostomia

NCT02446249 2025-09-25

Safety of a Single Administration of AAV2hAQP1, an Adeno-Associated Viral Vector Encoding Human Aquaporin-1 to One Parotid Salivary Gland in People With Irradiation-Induced Parotid Salivary Hypofunction

17 enrolled

Phase EARLY_PHASE1 Completed

Head and Neck Neoplasms, Xerostomia

NCT05403125 2025-09-17

SDF Application in Oral Cancer Patients to Prevent Dental Caries

56 enrolled

Dental Caries, Pharyngeal Neoplasms, Xerostomia

NCT04805528 2025-09-11

Study of Non-invasive Acupuncture-like Transcutaneous Electrical Nerve Stimulation (Altens) to Help Alleviate Xerostomia After Radiation Therapy for Cancers of the Head and Neck

Phase NA Recruiting

75 enrolled

Head and Neck Neoplasms, Xerostomia

NCT06276946 2025-09-05

Sparing Parotid Ducts Via MRI Sialography for Reduced Patient Reported Xerostomia

Phase NA Withdrawn

Head and Neck Neoplasms, Oropharyngeal Neoplasms, Xerostomia

NCT03552965 2025-09-02

Margin-Based Vs. Robust Photon Radiotherapy Planning in IMRT of HN-SQCC

23 enrolled 21 charts

Squamous Cell Carcinoma of Head and Neck, Xerostomia

NCT06465628 2025-05-28

Acupressure on Xerostomia in Head and Neck Cancer Patients

Phase NA Recruiting

126 enrolled

Head and Neck Neoplasms, Xerostomia

NCT06122636 2025-04-03

HNC

62 enrolled

Dental Plaque, Head and Neck Neoplasms, Periodontal Diseases, Stomatitis, Xerostomia, Dysbiosis

NCT04608773 2024-02-01

Blinded Dry Mouth Spray Crossover Study

129 enrolled 12 charts

Head and Neck Neoplasms, Xerostomia

NCT04717765 2023-11-29

Photobiomodulation in Oral Lesions Resulting From Anti-neoplastic Prevention

Head and Neck Neoplasms, Mouth Neoplasms, Osteoradionecrosis, Stomatitis, Xerostomia, Bisphosphonate-Associated Osteonecrosis of the Jaw

NCT05614843 2023-10-10

Photobiomodulation Therapy in Patients With Head and Neck Cancer Post-Radiotherapy

32 enrolled

Head and Neck Neoplasms, Neoplasms, Xerostomia

NCT02990468 2023-03-15

BMX-HN

Phase 1/2 Completed

29 enrolled 14 charts

Head and Neck Neoplasms, Xerostomia, Mucositis

NCT05242991 2023-03-09

Effectiveness of Photobiomodulation Protocols in Radiation-induced Oral Side Effects in H&N Cancer Patients

132 enrolled

Head and Neck Neoplasms, Taste Disorders, Trismus, Xerostomia, Mucositis

NCT00595933 2022-09-07

Comparing Over-the-counter Dry Mouth Remedies After Radiation

Phase 1 Completed

28 enrolled

Head and Neck Neoplasms, Xerostomia

NCT02292368 2022-09-01

Neurological Effects of Acupuncture to Prevent Radiation-induced Xerostomia

30 enrolled

Head and Neck Neoplasms, Nasopharyngeal Neoplasms, Xerostomia

NCT04880148 2021-12-09

HONEY

200 enrolled

Head and Neck Neoplasms, Radiation Injuries, Stomatitis, Xerostomia

NCT02941276 2021-11-03

LEONIDAS-2

84 enrolled

Head and Neck Neoplasms, Xerostomia

NCT01874587 2021-07-27

ARTIX

Phase 3 Completed

132 enrolled

Oropharyngeal Neoplasms, Xerostomia

NCT00430378 2021-06-10

Acupuncture for Prevention of Radiation-Induced Xerostomia

100 enrolled

Nasopharyngeal Neoplasms, Xerostomia

NCT04007081 2021-03-24

Salivary Gland Autotransplantation for Treatment of XRT Induced Xerostomia

12 enrolled

Head and Neck Neoplasms, Xerostomia

NCT03874572 2021-01-29

MESRIX-SAFETY

Phase 1 Unknown

10 enrolled

Oropharyngeal Neoplasms, Salivary Gland Diseases, Xerostomia

NCT04700475 2021-01-08

Effect of Low Level Laser Therapy on Prevention of Radiotherapy Induced Xerostomia in Cancer Patients.

Head and Neck Neoplasms, Xerostomia

NCT00862550 2020-12-30

Xerostomia Pilot Fudan: Acupuncture for Prevention of Radiation-Induced Xerostomia

23 enrolled

Nasopharyngeal Carcinoma, Head and Neck Neoplasms, Xerostomia

NCT03151889 2020-08-12

TENS_HIR

67 enrolled

Head and Neck Neoplasms, Xerostomia

NCT04491435 2020-07-29

Saliva Substitute Mouthwash in NPC Survivors With Xerostomia: A Randomized Controlled Trial

94 enrolled

Phase EARLY_PHASE1 Terminated

Nasopharyngeal Neoplasms, Xerostomia

NCT03578432 2019-12-02

Everolimus in Restoring Salivary Gland Function in Participants With Locally Advanced Head and Neck Cancer Treated With Radiation Therapy

2 enrolled

Head and Neck Neoplasms, Mouth Neoplasms, Xerostomia

NCT00656513 2019-11-19

Acupuncture-Like Transcutaneous Electrical Nerve Stimulation (ALTENS) or Pilocarpine in Treating Early Dry Mouth in Patients Undergoing Radiation Therapy for Head and Neck Cancer

Phase 2/3 Completed

196 enrolled 13 charts

Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Salivary Gland Neoplasms, Tongue Neoplasms, Xerostomia

NCT03302676 2019-03-14

The Use of Chewing Gum for Xerostomia and Hyposalivation After Radiotherapy for Oral and Oropharyngeal Tumors

109 enrolled

Head and Neck Neoplasms, Xerostomia

NCT03035825 2019-02-08

Efficacy of Oral Moisturizing Jelly on Oral Health and Nutrition in Post-radiotherapy Head and Neck Cancer Patients

73 enrolled

Head and Neck Neoplasms, Xerostomia

NCT00068237 2019-02-05

Salivary Gland Surgery Before Radiation Therapy in Preventing Radiation-Caused Xerostomia in Patients With Head and Neck Cancer

49 enrolled 13 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Radiation Injuries, Xerostomia

NCT00372320 2018-09-11

Effect of AdhAQP1 on Salivary Flow in Patients Treated With Radiation for Head and Neck Cancer

Phase 1 Completed

17 enrolled

Adenoviridae Infections, Head and Neck Neoplasms, Xerostomia

NCT00352118 2017-12-28

Combination Chemotherapy and Radiation Therapy in Treating Patients With Locally Advanced Head and Neck Cancer

Phase 2 Terminated

4 enrolled 4 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Xerostomia, Mucositis

NCT01762514 2017-07-13

A Phase II Clinical Trial on Comparison of Effectiveness and Safeness of Different Amifostine Regimens

Phase 2 Unknown

360 enrolled

Nasopharyngeal Carcinoma, Bone Marrow Diseases, Nasopharyngeal Neoplasms, Salivary Gland Diseases, Xerostomia, Mucositis

NCT00503776 2017-06-20

Chemo/XRT +/- Amifostine to Assess Outcomes Related to Xerostomia, Mucositis, & Dysphagia

Phase 2 Terminated

41 enrolled 12 charts

Squamous Cell Carcinoma of Head and Neck, Deglutition Disorders, Head and Neck Neoplasms, Radiation Injuries, Salivary Gland Neoplasms, Xerostomia, Mucositis

NCT00095927 2017-01-04

Randomized Amifostine For SCCHN

58 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Radiation Injuries, Xerostomia, Mucositis

NCT00101582 2016-09-27

Palifermin for the Reduction of Oral Mucositis in Patients With Locally Advanced Head and Neck Cancer

Phase 3 Completed

188 enrolled 19 charts

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Diseases, Stomatitis, Xerostomia, Oral Ulcer, Mucositis

NCT02854358 2016-08-03

Efficacy of Traditional Persian Medicine Preparation Versus Artificial Saliva for Radiation Induced Xerostomia

Head and Neck Neoplasms, Xerostomia

NCT00623129 2016-04-19

Electroacupuncture in Treating Chronic Dry Mouth Caused By Radiation Therapy in Patients With Head and Neck Cancer

Phase NA Terminated

30 enrolled

Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Radiation Injuries, Salivary Gland Neoplasms, Xerostomia

NCT00168116 2016-02-24

Xerostomia in Head and Neck Cancer Patients Receiving Radiation as the Primary Treatment Versus Patients Who Will Not Have Such a Procedure

42 enrolled

Head and Neck Neoplasms, Xerostomia

NCT01682031 2014-08-22

Selenomethionine in Reducing Mucositis in Patients With Locally Advanced Head and Neck Cancer Who Are Receiving Cisplatin and Radiation Therapy

Phase 2 Terminated

18 enrolled 8 charts

Squamous Cell Carcinoma of Head and Neck, Radiation Injuries, Xerostomia, Mucositis

NCT01885065 2013-06-24

Efficacy of Novel Edible Gel-based Artificial Saliva in Cancer Patients

25 enrolled

GastrointestinalHead & NeckOther

Head and Neck Neoplasms, Neoplasms, Xerostomia

NCT00928161 2012-09-07

Reflux Disease in Head and Neck Cancer Patients Undergoing Radiation Therapy

Phase NA Withdrawn

Gastroesophageal Reflux, Head and Neck Neoplasms, Heartburn, Oropharyngeal Neoplasms, Xerostomia, Mucositis

NCT00168181 2011-04-18

Trial Comparing Oral Pilocarpine (Salagen) Versus Submandibular Salivary Gland Transfer Protocol, For the Prevention of Radiation (XRT) Induced Xerostomia in Head and Neck Cancer Patients

Phase 3 Completed

220 enrolled

Head and Neck Neoplasms, Neoplasms, Xerostomia

NCT00408759 2006-12-07

Hypnosis for Treating Xerostomia Following Radiotherapy in Head & Neck Cancer Patients

Phase 2 Unknown

10 enrolled

Head and Neck Neoplasms, Xerostomia

NCT00138827 2005-12-15

Mouth Care Regimes During Radiotherapy

Phase 4 Completed

50 enrolled