Clinical Trials Browser

Interventional × Chemoradiotherapy × Head & Neck × Clear all

NCT06984861 2026-03-09

A Study of Reduced Radiation Therapy With Chemotherapy in People With HPV-Positive Throat Cancer

Phase 2 Recruiting

Oropharyngeal Neoplasms

NCT07209189 2026-03-09

(NeoScorch HN)

Phase 2 Recruiting

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms, Papillomavirus Infections

NCT06059261 2026-02-18

Envafolimab Combined With Chemoradiotherapy and Recombinant Human Endostatin for LA-NPC.

Phase 2 Recruiting

Nasopharyngeal Carcinoma

NCT07407205 2026-02-17

Tumor Mutational Burden, Liquid Biopsy, Angiogenic Factors and DCE-MRI Perfusion in HPV-Negative Oropharyngeal Cancer

Phase NA Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Oropharyngeal Neoplasms

NCT07402538 2026-02-11

Surgery With or Without Neoadjuvant Treatment of SBRT Plus Chemoimmunotherapy in Resectable Locally Advanced Oral and HPV-unrelated Oropharyngeal Squamous Cell Carcinoma

Phase 3 Not yet recruiting

Mouth Neoplasms, Oropharyngeal Neoplasms

NCT05894083 2026-02-02

A Phase II Study for p16+ Oropharyngeal Cancer PerSonalized De-escalation Treatment at University of MIchigan (CuSToMIze)

Phase 2 Recruiting

Squamous Cell Carcinoma of Head and Neck, Oropharyngeal Neoplasms

NCT07369882 2026-01-27

Comparison of Efficacy Between De-escalated Surgery and Standard Surgery After Neoadjuvant Immunotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma

Phase NA Recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07248956 2025-12-23

Neoadjuvant Chemotherapy Combined With Finotonlimab in the Treatment of Locally Advanced Hypopharyngeal Carcinoma

Phase 2 Recruiting

Hypopharyngeal Neoplasms

NCT01154920 2025-12-17

Paclitaxel, Carboplatin and Cetuximab (PCC) With Cetuximab, Docetaxel, Cisplatin and Fluorouracil (C-TPF) in Previously Untreated Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma

Phase 2 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT04004871 2025-12-11

Induction Chemotherapy With Nab-paclitaxel, Cisplatin and Fluorouracil for Locoregionally Advanced Nasopharyngeal Carcinoma

Phase 2 Completed

Nasopharyngeal Carcinoma, Nasopharyngeal Neoplasms

NCT05307939 2025-11-05

A Study on Using Cell-Free Tumor DNA (ctDNA) Testing to Decide When to StartRoutine Treatment in People With Human Papilloma Virus (HPV)- Associated Oropharynx Cancer (OPC)

Phase 2 Recruiting

Oropharyngeal Neoplasms

NCT06445114 2025-11-04

Using CircuLating Tumor DNA to Risk Adapt Post-Operative Therapy for HPV-associated Oropharyngeal Cancer

Phase 2 Recruiting

Carcinoma, Oropharyngeal Neoplasms

NCT01720563 2025-06-04

A Phase II Trial of PG2 in Patients With Advanced Pharyngeal or Laryngeal Squamous Cell Carcinoma Under Concurrent Chemoradiotherapy

Phase 2 Terminated

Squamous Cell Carcinoma of Head and Neck

NCT03107182 2025-05-06

OPTIMA-II

Phase 2 Completed

72 enrolled 14 charts

Squamous Cell Carcinoma of Head and Neck

NCT03838263 2025-03-04

IMMUNEBOOST

Phase 2 Completed

Oropharyngeal Neoplasms

NCT06455410 2024-06-25

GP Plus Adebrelimab Versus GP Neoadjuvant Chemotherapy for Nasopharyngeal Carcinoma

Phase 2 Recruiting

Nasopharyngeal Carcinoma

NCT06151743 2024-04-30

Neoadjuvant PD-1 Inhibitor Combined With Cetuximab and Platinum in Resectable Locally Advanced Hypopharyngeal Carcinoma

Phase 2 Recruiting

Locally Advanced Hypopharyngeal Carcinoma

NCT04393506 2023-11-22

Inductive Camrelizumab and Apatinib for Patients With Locally Advanced and Resectable Oral Squamous Cell Carcinoma

Phase 1 Completed

Mouth Neoplasms

NCT04473716 2023-11-22

Neoadjuvant Toripalimab and Paclitaxel/Cisplatin on Pathological Response in Oral Squamous Cell Carcinoma Patients

Phase 1 Completed

Mouth Neoplasms

NCT05993858 2023-08-15

PC-1

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT05980715 2023-08-08

HNC-SYSU-003

Phase 3 Recruiting

Squamous Cell Carcinoma of Head and Neck

NCT02207439 2023-07-25

Phase II Trial of Nelfinavir With Concurrent Chemoradiotherapy in Squamous Cell Carcinoma of the Head and Neck

Phase 2 Completed

18 enrolled 9 charts

Squamous Cell Carcinoma of Head and Neck

NCT04522050 2023-07-12

Gemcitabine-based Induction Chemotherapy Combined With Concurrent Chemoradiotherapy in Locally Advanced Nasopharyngeal Carcinoma

Phase 1 Unknown

Nasopharyngeal Carcinoma

NCT02952586 2021-09-22

Study To Compare Avelumab In Combination With Standard of Care Chemoradiotherapy (SoC CRT) Versus SoC CRT for Definitive Treatment In Patients With Locally Advanced Squamous Cell Carcinoma Of The Head And Neck (JAVELIN HEAD AND NECK 100)

Phase 3 Terminated

697 enrolled 26 charts

Squamous Cell Carcinoma of Head and Neck

NCT04296747 2020-03-05

Toripalimab in Combination With Chemotherapy as Induced Chemotherapy for Localized Hypopharyngeal Cancer

Phase 2 Unknown

Squamous Cell Carcinoma of Head and Neck, Hypopharyngeal Neoplasms

NCT03427359 2018-02-09

Induction Cisplatin and Capecitabine Followed by Concurrent Chemoradiotherapy for Nasopharyngeal Carcinoma

Phase 2 Completed

Nasopharyngeal Carcinoma

NCT03424291 2018-02-06

A Retrospective Clinical Study of Apatinib in Combination With Radiotherapy / Chemotherapy Second-line and Above in the Treatment of Recurrent / Metastatic Head and Neck Squamous Cell Carcinoma

Phase 2 Unknown

Squamous Cell Carcinoma of Head and Neck

NCT03045484 2017-11-29

Comparison of Oxycodone to Control Moderate or Severe Oral Mucositis Pain Induced by Chemoradiotherapy

Phase NA Unknown

Nasopharyngeal Carcinoma

NCT03058432 2017-02-23

Concurrent Chemotherapy for Elderly Patients With Locoregionally Advanced Nasopharyngeal Carcinoma

Phase 2 Unknown

Nasopharyngeal Carcinoma

NCT01074021 2015-10-30

Nimotuzumab in Combination With Chemoradiation for Nasopharyngeal Cancer

Phase 3 Unknown

Nasopharyngeal Neoplasms

NCT00424255 2014-07-18

Study Of Adjuvant Lapatinib In High-Risk Head And Neck Cancer Subjects After Surgery

Phase 3 Completed

688 enrolled 19 charts

Head and Neck Neoplasms

NCT00705627 2014-05-28

A Multicenter Trial Comparing Multi-course Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma

Phase 3 Unknown

Nasopharyngeal Carcinoma

NCT00959387 2014-03-26

Induction Chemotherapy for Advanced Head and Neck Cancer

Phase 2 Completed

Head and Neck Neoplasms

NCT01245959 2014-02-13

Induction Chemotherapy in Patients With Locoregionally Advanced Nasopharyngeal Carcinoma

Phase 3 Unknown

Nasopharyngeal Carcinoma

NCT00128817 2013-01-23

Concurrent Chemoradiation Versus Surgery With Adjuvant Therapy in Advanced Laryngopharyngeal Cancers

Phase 3 Terminated

Laryngeal Diseases, Laryngeal Neoplasms, Neoplasms

NCT00140556 2013-01-18

Angiogenic and EGFR Blockade With Curative Chemoradiation for Advanced Head and Neck Cancer

Phase EARLY_PHASE1 Completed

28 enrolled 8 charts

Head and Neck Neoplasms, Pharyngeal Neoplasms, Tonsillar Neoplasms