Clinical Trials Browser

Interventional × Metformin × Head & Neck × Clear all

NCT02581137 2026-03-18

Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion

Phase 2 Active not recruiting

26 enrolled 10 charts

Erythroplasia, Hyperplasia, Leukoplakia, Oral, Mouth Neoplasms

NCT07387900 2026-02-06

Evaluation of the Chemo-preventive Effect of Combined Topical and Systemic Metformin on Oral Leukoplakia

Phase 2 Recruiting

Leukoplakia, Oral

NCT04414540 2025-12-19

Combining Pembrolizumab and Metformin in Metastatic Head and Neck Cancer Patients

Phase 2 Active not recruiting

Squamous Cell Carcinoma of Head and Neck

NCT03109847 2025-12-11

Metformin to Mitigate Sequelae of Radioactive Iodine Treatment for Thyroid Cancers

Phase 2 Terminated

13 enrolled 8 charts

Thyroid Diseases

NCT05237960 2025-09-29

Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or Erythroplakia

Phase 2 Active not recruiting

Erythroplasia, Leukoplakia, Oral

NCT02083692 2025-05-15

Pilot Study of Metformin in Head and Neck Squamous Cell Cancer and Its Effects on Stromal-epithelial Metabolic Uncoupling

Phase EARLY_PHASE1 Completed

Head and Neck Squamous Cell Cancer

NCT03618654 2025-05-15

Durvalumab With or Without Metformin in Treating Participants With Head and Neck Squamous Cell Carcinoma

Phase EARLY_PHASE1 Completed

Squamous Cell Carcinoma of Head and Neck

NCT05536037 2025-05-15

Metformin for the Prevention of Oral Cancer in Patients With Oral Premalignant Lesions

Phase 1 Terminated

Erythroplasia, Leukoplakia, Mouth Neoplasms

NCT03109873 2025-04-30

Metformin Hydrochloride in Affecting Cytokines and Exosomes in Patients With Head and Neck Cancer

Phase EARLY_PHASE1 Completed

9 enrolled 6 charts

Lymphoid Interstitial Pneumonia, Laryngeal Diseases

NCT04114136 2025-02-10

Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies

Phase 2 Recruiting

DermatologicGastrointestinalHead & Neck

Adenocarcinoma Of Esophagus, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Hepatocellular, Melanoma

NCT02949700 2023-06-29

Phase I/II Study OF Metformin in Combination With Cisplatin and Radiation in Head and Neck Squamous Cell Carcinoma

Phase 1/2 Completed

26 enrolled 14 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT05468554 2022-10-19

METHYR

Phase 3 Not yet recruiting

Thyroid Neoplasms

NCT03510390 2021-11-18

HEAD-MET

Phase NA Completed

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT04298684 2020-09-11

METNODTHYR

Phase 4 Unknown

Diabetes Mellitus, Type 2, Insulin Resistance, Thyroid Nodule

NCT02325401 2020-06-11

Dose-finding Study of Metformin With Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma

Phase 1 Completed

20 enrolled 11 charts

Head and Neck Neoplasms

NCT03183752 2019-04-19

Insulin Resistance and Metformin Use on Volume of Benign Thyroid Nodules

Phase NA Completed

Insulin Resistance, Thyroid Diseases, Thyroid Nodule

NCT03684707 2018-09-26

Cancer Chemoprevention by Metformin Hydrochloride Compared to Placebo in Oral Potentially Malignant Lesions

Phase 4 Unknown

Mouth Neoplasms

NCT03685409 2018-09-26

Cancer Chemoprevention by Metformin Hydrochloride in Oral Potentially Malignant Lesions

Phase 3 Unknown

Mouth Neoplasms

NCT02402348 2017-02-08

Pilot Study of Metformin in HNSCC to Investigate the Effects of MF, Tumor Genotype and MF-genotype Interactions, on Tumor Metabolism and Anoikis

Phase EARLY_PHASE1 Terminated

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT01341886 2011-04-26

Effect of Metformin on Decrement in Levothyroxin Dose Required for Thyroid Stimulating Hormone (TSH) Suppression in Patients With Differentiated Thyroid Cancer

Phase NA Completed

Thyroid Neoplasms