Clinical Trials Browser

Radiosurgery × Head & Neck × Clear all

NCT07156227 2026-03-18

Testing the Addition of an Anti-Cancer Drug, Camonsertib, to Radiation Therapy for Recurrent Head and Neck Squamous Cell Carcinoma

Phase 1 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT06211335 2026-03-12

Losartan, Pembrolizumab and Stereotactic Body Radiation Therapy for the Treatment of Patients With Locally Recurrent, Refractory or Oligometastatic Head and Neck Squamous Cell Carcinoma

Phase 1 Recruiting

Squamous Cell Carcinoma of Head and Neck

NCT06641791 2026-03-10

Palliative Steroeotactic Body Radiotherapy vs Palliative Standard Radiotherapy in Patients With Advanced Head and Neck Cancer

Phase 3 Recruiting

Head and Neck Neoplasms

NCT05674396 2026-02-19

3-5 FrAction Stereotactic Body Radiation Therapy for Palliation of Head and Neck Squamous Cell Carcinoma: the FAST Phase II Randomized Trial

Phase 2 Recruiting

Squamous Cell Carcinoma of Head and Neck

NCT03164460 2026-02-13

Stereotactic Body Radiation Therapy or Intensity Modulated Radiation/Proton Therapy in Treating Patients With Recurrent Head and Neck Cancer

Phase 2 Suspended

Recurrent Head and Neck Carcinoma

NCT04862455 2026-01-23

NBTXR3, Radiation Therapy, and Pembrolizumab for the Treatment of Recurrent or Metastatic Head and Neck Squamous Cell Cancer

Phase 2 Terminated

Squamous Cell Carcinoma of Head and Neck

NCT02713269 2025-10-30

Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord

Phase 2 Active not recruiting

DermatologicGastrointestinalGenitourinaryHead & NeckSarcoma

Carcinoma, Renal Cell, Gastrointestinal Neoplasms, Melanoma, Neoplasms, Unknown Primary, Sarcoma, Spinal Cord Compression, Thyroid Neoplasms

NCT04693377 2025-10-27

Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial

Phase NA Recruiting

DermatologicGastrointestinalGenitourinaryHead & NeckSarcoma

Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Melanoma, Neoplasm Metastasis, Prostatic Neoplasms, Sarcoma, Thyroid Neoplasms, Colorectal Neoplasms

NCT03070366 2025-09-02

OMET

Phase 2 Active not recruiting

Squamous Cell Carcinoma of Head and Neck

NCT02474368 2025-07-10

Study Evaluating a Stereotactic Boost/Treatment for Recurrent or Metastatic Cancer of the Head and Neck

Phase 1 Active not recruiting

Head and Neck Neoplasms

NCT03635164 2025-06-27

Radiotherapy With Durvalumab Prior to Surgical Resection for HPV Negative Squamous Cell Carcinoma

Phase 1 Completed

Squamous Cell Carcinoma of Head and Neck

NCT04576091 2024-12-13

Testing the Addition of an Anti-cancer Drug, BAY 1895344, With Radiation Therapy to the Usual Pembrolizumab Treatment for Recurrent Head and Neck Cancer

Phase 1 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms, Salivary Gland Neoplasms

NCT03539198 2024-11-14

Study of Proton SBRT and Immunotherapy for Recurrent/Progressive Locoregional or Metastatic Head and Neck Cancer

Head and Neck Neoplasms

NCT04220775 2024-11-07

Bintrafusp Alfa and Stereotactic Body Radiation Therapy for the Treatment of Recurrent or Second Primary Head and Neck Squamous Cell Cancer

Phase 1/2 Terminated

3 enrolled 8 charts

Squamous Cell Carcinoma of Head and Neck

NCT03892720 2024-08-27

Stereotactic Body Radiation Therapy Using HyperArc in Treating Patients With Recurrent Head and Neck Cancer

Phase NA Completed

Recurrent Head and Neck Carcinoma

NCT04498767 2024-08-26

OligoRARE

Phase NA Recruiting

DermatologicGastrointestinalGenitourinaryHead & NeckSarcoma

Urinary Bladder Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Melanoma, Pancreatic Neoplasms, Sarcoma, Skin Neoplasms, Stomach Neoplasms

NCT04830267 2024-03-28

The Efficacy of Camrelizumab Plus Stereotactic Body Radiotherapy in R/M NPC

Phase 2 Recruiting

Nasopharyngeal Carcinoma

NCT02703493 2024-03-12

Image-Guided Stereotactic Radiosurgery (SRS) Boost for HPV-Oropharyngeal Cancer

Phase NA Completed

Oropharyngeal Neoplasms

NCT05259319 2023-10-17

IMMUNOs-SBRT

Phase 1 Unknown

GenitourinaryHead & NeckThoracic

Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Head and Neck Neoplasms, Neoplasms

NCT04834349 2023-09-13

Re-irradiation With NBTXR3 in Combination With Pembrolizumab for the Treatment of Inoperable Locoregional Recurrent Head and Neck Squamous Cell Cancer

Phase 2 Withdrawn

Squamous Cell Carcinoma of Head and Neck

NCT03522584 2023-06-12

Durvalumab, Tremelimumab and Hypofractionated Radiation Therapy in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Phase 1/2 Terminated

6 enrolled 8 charts

Squamous Cell Carcinoma of Head and Neck

NCT02158234 2023-01-19

Stereotactic Body Radiotherapy and Concurrent Cisplatin for Re-Irradiation of Unresectable, Recurrent Squamous Cell Carcinomas of Head and Neck

Phase 1 Completed

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Diseases

NCT03122496 2022-06-08

Immunotherapy and Stereotactic Body Radiotherapy (SBRT) for Metastatic Anaplastic Thyroid Cancer

Phase 1 Completed

EndocrineHead & Neck

Thyroid Carcinoma, Anaplastic

NCT02684253 2022-03-10

Screening Trial of Nivolumab With Image Guided, Stereotactic Body Radiotherapy (SBRT) Versus Nivolumab Alone in Patients With Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC)

Phase 2 Completed

65 enrolled 10 charts

Squamous Cell Carcinoma of Head and Neck

NCT01104922 2022-02-14

Re-irradiation With Fractionated Stereotactic Radiosurgery Plus Cetuximab in Patients With Recurrent Squamous Cell Carcinoma of the Head and Neck

Phase 2 Completed

48 enrolled 15 charts

Squamous Cell Carcinoma of Head and Neck

NCT02516969 2022-01-14

Surgery With or Without Adjuvant Stereotactic Body Radiotherapy

Phase NA Completed

7 enrolled 8 charts

Head and Neck Neoplasms

NCT03402737 2021-02-18

SBRT + Immunomodulating Systemic Therapy for Inoperable, Recurrent H&N

Phase NA Terminated

Head and Neck Neoplasms

NCT04435938 2020-12-02

SHINE

Phase 2 Unknown

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Neoplasms, Squamous Cell

NCT04399785 2020-05-22

Phase II Study for Combination of Camrelizumab and SBRT in the First-line Treatment for R/M HNSCC

Phase 2 Unknown

Squamous Cell Carcinoma of Head and Neck

NCT01344356 2020-04-10

Stereotactic Body Radiotherapy for Head and Neck Tumors

Phase 4 Completed

19 enrolled 10 charts

Squamous Cell Carcinoma of Head and Neck, Nasopharyngeal Carcinoma, Head and Neck Neoplasms, Salivary Gland Neoplasms

NCT02110992 2019-11-25

Safety Study of SBRT and Docetaxel for Locally Recurrent or Second Primary Squamous Cell Carcinoma of the Head and Neck

Phase 1 Terminated

Head and Neck Neoplasms

NCT02388932 2019-01-24

Stereotactic Body Radiation Therapy in Treating Patients With High Risk Locally Advanced Head and Neck Cancer

Phase NA Terminated

3 enrolled 7 charts

Squamous Cell Carcinoma of Head and Neck

NCT00851253 2018-01-17

Stereotactic Radiosurgery in Treating Patients With Locally Advanced or Recurrent Head and Neck Cancer

Phase NA Completed

12 enrolled 10 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Salivary Gland Neoplasms

NCT01586182 2015-09-04

Stereotactic Boost for Oropharyngeal Squamous Cell Carcinoma

Phase 1/2 Withdrawn

Squamous Cell Carcinoma of Head and Neck

NCT00738868 2011-05-13

Cetuximab and Stereotactic Radiation Therapy in Treating Patients With Recurrent Head and Neck Cancer That Cannot Be Removed By Surgery

Phase 2 Completed

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Salivary Gland Neoplasms