Clinical Trials

Head and Neck Neoplasms

NCT06305962 2026-02-19

177Lu-anti-PD-L1 sdAb in Metastatic Solid Tumors

BreastDermatologicGynecologicHead & NeckThoracic

30 enrolled

Turcot syndrome, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Melanoma, Endometrial Neoplasms, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT06639191 2026-01-30

AKIR001

EndocrineGynecologicHead & NeckThoracic

Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Vulvar Neoplasms, Thyroid Carcinoma, Anaplastic

NCT05553782 2026-01-26

Drug Screening Using Novel IMD in Salivary and Head and Neck Cancers

30 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Salivary Gland Neoplasms

NCT06579248 2026-01-14

Intraoral Hypothermia Device for Preserving Taste During Radiation

Head and Neck Neoplasms, Taste Disorders

NCT05245682 2026-01-08

Tolinapant and Radiation for Cisplatin-Ineligible, Previously Untreated, Locally Advanced Head and Neck Cancer

Head & NeckOther solid neoplasm

10 enrolled 8 charts

Head and Neck Carcinoma of Unknown Primary

NCT06645808 2025-12-29

VARTUTRACE

BreastCNSGastrointestinalGenitourinaryHead & NeckSarcomaThoracic

32 enrolled

Squamous Cell Carcinoma of Head and Neck, Urinary Bladder Neoplasms, Breast Neoplasms, Chondrosarcoma, Colonic Neoplasms, Esophageal Neoplasms, Glioblastoma, Lung Neoplasms, Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Sarcoma, Osteosarcoma, Stomach Neoplasms

NCT05183048 2025-12-26

Comparison of 89Zr Panitumumab and (18)F-Fluorodeoxyglucose to Identify Head and Neck Squamous Cell Carcinoma

14 enrolled

Phase EARLY_PHASE1 Withdrawn

Squamous Cell Carcinoma of Head and Neck

NCT05845307 2025-12-08

Randomized Pre-surgical Window-of-Opportunity Trial of TTI-101 in Patients With Stage II-IV Resectable HPV-negative Squamous Cell Carcinoma of the Head and Neck

Squamous Cell Carcinoma of Head and Neck

NCT01098955 2025-11-10

Smoking Cessation Treatment for Head & Neck Cancer Patients

51 enrolled

Head and Neck Neoplasms, Neoplasms, Smoking Cessation

NCT07218068 2025-11-03

IPDP

13 enrolled

Dental Caries, Head and Neck Neoplasms, Stomatognathic Diseases, Osteoradionecrosis

NCT02790853 2025-10-14

Multimodal Imaging for Surveillance in Patients With Oral Potentially Malignant Disorders

63 enrolled

Mouth Diseases, Mouth Neoplasms

NCT02467738 2025-09-19

Surgical Resection and Intraoperative Cesium-131 Brachytherapy for Head and Neck Cancer

30 enrolled

Recurrent Head and Neck Carcinoma

NCT05403125 2025-09-17

SDF Application in Oral Cancer Patients to Prevent Dental Caries

56 enrolled

Dental Caries, Pharyngeal Neoplasms, Xerostomia

NCT07168785 2025-09-11

[18F]-AraG PET Imaging in LA HNSCC

5 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT05816785 2025-09-03

Pilot Study of Imatinib Cetuximab Combo for H & N Cancer

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT06273852 2025-08-11

A Study of the Intratumoral Microdose Administration of PBA-0405 in Patients With Solid Tumors

8 enrolled

BreastHead & Neck

Squamous Cell Carcinoma of Head and Neck, Triple Negative Breast Neoplasms

NCT06700070 2025-08-11

A Phase 0 Multicenter Study of the Pharmacodynamic Effects of Intratumoral Microdose Administration of PBA-0111 in Patients With Solid Tumors

BreastHead & Neck

Squamous Cell Carcinoma of Head and Neck, Triple Negative Breast Neoplasms

NCT07026981 2025-08-08

[Ga-68]MTP220 PET for Biodistribution and Efficacy in Pancreatic Cancer and Head and Neck Cancers

GastrointestinalHead & Neck

Head and Neck Neoplasms, Pancreatic Neoplasms

NCT03215095 2025-07-17

RAI Plus Immunotherapy for Recurrent/Metastatic Thyroid Cancers

11 enrolled 6 charts

Thyroid Neoplasms

NCT06308913 2025-07-15

Pembrolizumab, INCB081776, and Radiation Therapy for Head and Neck Squamous Cell Carcinoma

Phase EARLY_PHASE1 Withdrawn

Squamous Cell Carcinoma of Head and Neck, Neoplasm Metastasis

NCT06086925 2025-07-11

A Window of Opportunity Study of Black Raspberry for Patients With HNSCC

Squamous Cell Carcinoma of Head and Neck

NCT03085056 2025-07-03

Trametinib in Combination With Paclitaxel in the Treatment of Anaplastic Thyroid Cancer

13 enrolled

EndocrineHead & Neck

Thyroid Carcinoma, Anaplastic

NCT07028918 2025-06-19

NCLDR

35 enrolled

Acidemia, isovaleric, Squamous Cell Carcinoma of Head and Neck

NCT02083692 2025-05-15

Pilot Study of Metformin in Head and Neck Squamous Cell Cancer and Its Effects on Stromal-epithelial Metabolic Uncoupling

50 enrolled

Head and Neck Squamous Cell Cancer

NCT03618654 2025-05-15

Durvalumab With or Without Metformin in Treating Participants With Head and Neck Squamous Cell Carcinoma

38 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT05278260 2025-05-14

Hydrogen-rich Water and Treatment of Mucositis Caused by Radiation Therapy in Head and Neck Cancer Patients

Head and Neck Neoplasms, Stomatitis

NCT03109873 2025-04-30

Metformin Hydrochloride in Affecting Cytokines and Exosomes in Patients With Head and Neck Cancer

9 enrolled 6 charts

Lymphoid Interstitial Pneumonia, Laryngeal Diseases

NCT03162731 2025-04-29

Nivolumab, Ipilimumab, and Radiation Therapy in Treating Patients With Stage III-IVB Head and Neck Cancer

Lymphoid Interstitial Pneumonia, Laryngeal Diseases

NCT06898437 2025-04-15

Study of 177Lu-LNC1004 Injection in FAP-positive Radioiodine-refractory Differentiated Thyroid Cancer

20 enrolled

Phase EARLY_PHASE1 Terminated

Thyroid Neoplasms

NCT05322135 2025-04-09

A Pilot Study of Glutamine PET Imaging of Head and Neck Squamous Cell Carcinoma

3 enrolled

Phase EARLY_PHASE1 Terminated

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT02827838 2025-03-17

Durvalumab Before Surgery in Treating Patients With Oral Cavity or Oropharynx Cancer

17 enrolled 12 charts

Squamous Cell Carcinoma of Head and Neck, Papillomavirus Infections

NCT06806189 2025-02-03

Lipiodal Injection Technique for Free Flap Sparing Adjuvant RT Planning in HNC

Head and Neck Neoplasms

NCT04883645 2025-01-28

Neoadjuvant Imiquimod Immunotherapy for Oral Cancer

16 enrolled 10 charts

Squamous Cell Carcinoma of Head and Neck

NCT03459729 2025-01-16

Pharmacokinetic (PK) Analysis of Antitumor B in Patients With Oral Cancer

6 enrolled 14 charts

Squamous Cell Carcinoma of Head and Neck

NCT04188951 2024-12-04

HFHS-1801-A Pilot Study of Immunotherapy As Consolidation Therapy for Patients with Recurrent Head and Neck Cancer

Head and Neck Neoplasms

NCT05587543 2024-11-12

Clinical Study on the EBV CAR-T /TCR-T Cells in the Treatment of Nasopharyngeal Carcinoma

Nasopharyngeal Carcinoma

NCT05996432 2024-09-23

Image-Based, In-Vivo Assessment of Tumor Hypoxia to Guide Hypoxia-Driven Adaptive Radiation Therapy

Phase EARLY_PHASE1 Enrolling by invitation

48 enrolled

CNSHead & Neck

Squamous Cell Carcinoma of Head and Neck, Brain Neoplasms

NCT04085913 2024-07-29

Exparel Injection Effect on Postoperative Opioid Usage

100 enrolled

Parathyroid Neoplasms, Thyroid Diseases

NCT06370026 2024-05-02

KSD-101 Therapy for Standard Treatment Failed EBV-associated NPC: an Exploratory Clinical Trial

Nasopharyngeal Carcinoma

NCT04541108 2024-04-18

Phase 0 Master Protocol for CIVO Intratumoral Microdosing of Anti-Cancer Therapies

DermatologicHead & NeckLymphoidSarcoma

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Lymphoma, Melanoma, Sarcoma

NCT03868020 2024-03-28

Fluciclovine F18 PET/CT in Identifying the Origin of Head and Neck Squamous Cell Carcinoma in Patients With Metastatic Cervical Nodal Disease

16 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT06097793 2024-03-12

KSD-101 Therapy for EBV-associated Nasopharyngeal Carcinoma: an Exploratory Clinical Trial

Nasopharyngeal Carcinoma

NCT06062602 2023-10-06

PBI-MST-01(NCT04541108) Substudy TAK-02: Intratumoral Microdosing of TAK-676 in HNSCC

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT03575598 2023-07-27

SNOW

Phase EARLY_PHASE1 Unknown

Squamous Cell Carcinoma of Head and Neck

NCT05886075 2023-06-02

A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Relapsed/Refractory Advanced Solid Tumors

BreastGastrointestinalGynecologicHead & NeckSarcomaThoracic

Breast Neoplasms, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Liver Neoplasms, Lung Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Sarcoma, Stomach Neoplasms, Colorectal Neoplasms, Small Cell Lung Carcinoma

NCT03282461 2023-05-18

A Microdose Evaluation Study of ABY-029 in Head and Neck Oncology Surgery

Phase EARLY_PHASE1 Unknown

Head and Neck Neoplasms

NCT05831930 2023-04-26

The Effect of Nitozumab in the Treatment of Head and Neck Squamous Cell Carcinoma

62 enrolled

Phase EARLY_PHASE1 Terminated

Squamous Cell Carcinoma of Head and Neck

NCT02582008 2023-03-22

Bupropion Hydrochloride or Patient's Choice for Smoking Cessation in Patients With Squamous Cell Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy

9 enrolled