Clinical Trials

Leukemia, Lymphocytic, Chronic, B-Cell

NCT02242942 2025-11-06

Comparison of the Treatments of Obinutuzumab + Venetoclax Versus Obinutuzumab + Chlorambucil in Patients With Chronic Lymphocytic Leukemia

445 enrolled 22 charts 1 FDA

Phase 3 Active not recruiting

Leukemia, Lymphocytic, Chronic, B-Cell

NCT02475681 2025-08-27

ElevateTN

535 enrolled 19 charts 1 FDA

Leukemia, Lymphocytic, Chronic, B-Cell

NCT02612311 2024-12-13

UNITY-CLL

Phase 3 Terminated

603 enrolled 17 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT04578613 2023-06-05

ICP-022 Versus Chlorambucil Combined With Rituximab in the Treatment of Untreated CLL/SLL

218 enrolled

Leukemia, Lymphocytic, Chronic, B-Cell

NCT00558961 2023-03-27

GL-CLB-001

Phase 1/2 Terminated

13 enrolled

Leukemia, Leukemia, Lymphocytic, Chronic, B-Cell

NCT02336048 2021-04-08

A Study Evaluating the Safety of Tocilizumab in Addition to Standard of Care Premedication Given Before Obinutuzumab + Chlorambucil in Participants With Untreated B-Cell Chronic Lymphocytic Leukemia (B-CLL) and Comorbidities

Phase 1 Terminated

38 enrolled

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01088048 2021-03-18

Study to Investigate Idelalisib in Combination With Chemotherapeutic Agents, Immunomodulatory Agents and Anti-CD20 Monoclonal Antibody (mAb) in Participants With Relapsed or Refractory Indolent B-cell Non-Hodgkin's Lymphoma, Mantle Cell Lymphoma or Chronic Lymphocytic Leukemia

Phase 1 Completed

241 enrolled 31 charts

Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Mantle-Cell

NCT01905943 2019-10-28

A Safety and Efficacy Study of Obinutuzumab Alone or in Combination With Chemotherapy in Participants With Chronic Lymphocytic Leukemia

979 enrolled 16 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT02100852 2019-10-02

TGR-1202, a PI3K Delta Inhibitor, in Combination With Obinutuzumab and Chlorambucil in Patients With Chronic Lymphocytic Leukemia (CLL)

Phase 1 Completed

19 enrolled

Leukemia, Lymphocytic, Chronic, B-Cell

NCT00910910 2019-07-09

ORIGIN

450 enrolled 25 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT00748189 2019-06-25

COMPLEMENT 1

Phase 3 Terminated

447 enrolled 32 charts

Neoplasms, Leukemia, B-Cell, Leukemia, Lymphocytic, Chronic, B-Cell

NCT00262795 2019-05-23

Fludarabine or Chlorambucil as First-Line Therapy in Treating Older Patients With Previously Untreated Chronic Lymphocytic Leukemia

206 enrolled

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01283386 2019-03-14

A Study to Compare Mabthera (Rituximab), Fludarabine and Cyclophosphamide to Mabthera and Chlorambucil in Participants With Chronic Lymphocytic Leukemia and Unfavorable Somatic Status

Phase 4 Terminated

26 enrolled 13 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01403246 2019-02-12

Chlorambucil + Lenalidomide and Lenalidomide Maintenance in Untreated Elderly With Chronic Lymphocytic Leukemia (CLL)

Phase 1/2 Terminated

9 enrolled 5 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01980875 2018-11-19

Efficacy and Safety of Idelalisib in Combination With Obinutuzumab Compared to Chlorambucil in Combination With Obinutuzumab for Previously Untreated Chronic Lymphocytic Leukemia

Phase 3 Terminated

57 enrolled 12 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01010061 2018-09-14

CLL11: A Study of Obinutuzumab (RO5072759 [GA101]) With Chlorambucil in Patients With Previously Untreated Chronic Lymphocytic Leukemia (Stage 1a)

787 enrolled 20 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01998880 2018-09-14

CLL11: A Study of Rituximab With Chlorambucil or Chlorambucil Alone in Patients With Previously Untreated Chronic Lymphocytic Leukemia (Stage 1b)

787 enrolled 19 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT02053610 2018-09-14

CLL11: A Study of Obinutuzumab (RO5072759 [GA101]) With Chlorambucil in Patients With Previously Untreated Chronic Lymphocytic Leukemia (Stage 2)

787 enrolled 19 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01722487 2017-11-30

Open-label Phase 3 BTK Inhibitor Ibrutinib vs Chlorambucil Patients 65 Years or Older With Treatment-naive CLL or SLL

269 enrolled 14 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT00738374 2017-08-15

A Study of MabThera (Rituximab) Plus Chlorambucil in Patients With Previously Untreated Chronic Lymphocytic Leukemia.

97 enrolled 27 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01868893 2017-04-17

An Expanded Access, Open-Label Study of Obinutuzumab (GA101) Plus Chlorambucil in Patients With Previously Untreated Chronic Lymphocytic Leukemia

20 enrolled 8 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01563055 2015-08-10

A Phase I/II, Open-label Study of Ofatumumab Added to Chlorambucil in Previously Untreated Japanese Patients With Chronic Lymphocytic Leukemia

10 enrolled 52 charts

Leukemia, B-Cell

NCT01056510 2015-06-25

A Study of MabThera Added to Bendamustine or Chlorambucil in Patients With Chronic Lymphocytic Leukemia (MaBLe)

Phase 4 Completed

357 enrolled 25 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01808326 2015-06-22

A Phase II, Open Label, Single Arm, Multicenter Study of Chlorambucil in Japanese Previously Untreated Patients With Chronic Lymphocytic Leukemia

Other hematologic neoplasm

5 enrolled 23 charts

Leukemia

NCT00004218 2013-12-18

Chemotherapy in Treating Patients With Newly Diagnosed Chronic Lymphocytic Leukemia

Leukemia, Leukemia, Lymphocytic, Chronic, B-Cell

NCT01109264 2013-08-23

Bendamustine Hydrochloride Injection for Initial Treatment of Chronic Lymphocytic Leukemia

147 enrolled

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01678430 2012-10-15

RIAltO

670 enrolled

Leukemia, B-Cell

NCT01657955 2012-08-06

CLL

96 enrolled

Leukemia, Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell

NCT00151736 2012-06-11

Safety and Efficacy of SDX-101 (R-Etodolac) in Combination With Chlorambucil, and That of Chlorambucil Alone, in Patients With Chronic Lymphocytic Leukemia (CLL)

Phase 2 Terminated

88 enrolled

Leukemia, Leukemia, Lymphocytic, Chronic, B-Cell

NCT00017108 2008-07-24

Chlorambucil in Treating Patients With Advanced Chronic Lymphocytic Leukemia