Clinical Trials

60 enrolled

Phase 2 Active not recruiting

Recurrence, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT03849651 2026-03-04

TCRαβ-depleted Progenitor Cell Graft With Additional Memory T-cell DLI, Plus Selected Use of Blinatumomab, in Naive T-cell Depleted Haploidentical Donor Hematopoietc Cell Transplantation for Hematologic Malignancies

69 enrolled 17 charts

Hodgkin Disease, Lymphoma, Non-Hodgkin, Myelodysplastic Syndromes, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Acute, Leukemia, Large Granular Lymphocytic, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myelomonocytic, Juvenile

NCT06326463 2026-01-23

CAR T-cell Therapy Directed to CD70 for Pediatric Patients With Hematological Malignancies

18 enrolled

Lymphoma, Leukemia, Myeloid, Acute, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT07052370 2025-12-31

TCRαβ-depleted Progenitor Cell Graft With Early Memory T-cell DLI, Plus Selected Use of Blinatumomab, in naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies

30 enrolled

Hematologic Neoplasms

NCT04881240 2025-12-23

Study of CD19-directed Allogeneic Memory T-cell Therapy for Relapsed/Refractory CD19+ Leukemia

60 enrolled

Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT05115630 2025-12-19

Off-the-shelf NK Cells + SCT for Myeloid Malignancies

MyeloidOther hematologic neoplasm

24 enrolled 9 charts

Myelodysplastic Syndromes, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Acute

NCT06847269 2025-10-27

CAR T CELL Therapy for Pediatric, Adolescent and Young Adult Patients With CD19-Positive Leukemia

Phase 2 Recruiting

25 enrolled

Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT04318678 2025-10-23

CD123-Directed T-Cell Therapy for Acute Myelogenous Leukemia (CATCHAML)

108 enrolled

Blastic Plasmacytoid Dendritic Cell Neoplasm, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

NCT04678401 2025-10-20

IS-free Treg HaploHCT

MyeloidOther hematologic neoplasm

30 enrolled

Graft vs Host Disease, Myelodysplastic Syndromes, Leukemia, Myeloid, Acute

NCT05579769 2025-10-02

Pediatric Study of GVHD Ppx w/o Calcineurin Inhibitors After Day60 Post First Allo HSCT for Hematological Malignancies.

Phase 2 Terminated

3 enrolled 10 charts

Phase 2 Active not recruiting

Hematologic Neoplasms

NCT02790515 2025-08-12

Provision of TCRγδ T Cells and Memory T Cells Plus Selected Use of Blinatumomab in Naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies Relapsed or Refractory Despite Prior Transplantation

170 enrolled

LymphoidMyeloidOther hematologic neoplasmSarcoma

Lymphoma, Non-Hodgkin, Myelodysplastic Syndromes, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Acute, Sarcoma, Myeloid, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myelomonocytic, Juvenile

NCT05032183 2025-08-11

Tagraxofusp and Low-Intensity Chemotherapy for the Treatment of CD123 Positive Relapsed or Refractory Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

Phase 1/2 Terminated

4 enrolled 8 charts

Burkitt Lymphoma, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

NCT04752163 2025-05-23

DS-1594b With or Without Azacitidine, Venetoclax, or Mini-HCVD for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia

Phase 1/2 Terminated

17 enrolled 15 charts

Myelodysplastic Syndromes, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT02880293 2024-12-06

Haploidentical (Half-matched) Related Donor Stem Cell Transplantation Using Killer Immunoglobulin-like Receptors in Addition to Normal Selection Factors to Determine the Best Donor

Phase NA Completed

44 enrolled 8 charts

Phase 2 Active not recruiting

Hematologic Neoplasms

NCT03821610 2024-05-16

ALL-RIC

242 enrolled

Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT03056339 2024-03-25

Umbilical & Cord Blood (CB) Derived CAR-Engineered NK Cells for B Lymphoid Malignancies

Phase 1/2 Completed

49 enrolled 12 charts

Lymphoma, Non-Hodgkin, Recurrence, Leukemia, Lymphocytic, Chronic, B-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT01807611 2022-10-31

Haploidentical Donor Hematopoietic Progenitor Cell and NK Cell Transplantation for Hematologic Malignancy

82 enrolled 18 charts

Leukemia, Lymphoma

NCT01319981 2022-09-27

Hyper-CVAD With Liposomal Vincristine in Acute Lymphoblastic Leukemia

31 enrolled 9 charts

Leukemia, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00671658 2020-12-03

Modified Hyper-CVAD (Cyclophosphamide, Vincristine, Adriamycin, and Dexamethasone) Program for Acute Lymphoblastic Leukemia

220 enrolled 6 charts

Leukemia, Lymphoma, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT01010217 2020-03-25

Mismatched Transplantation Using High-dose Post-transplant Cyclophosphamide

Classical hematologyLymphoidMyeloidOther hematologic neoplasmPlasma cell

176 enrolled 18 charts

Anemia, Aplastic, Hematologic Diseases, Hodgkin Disease, Leukemia, Lymphoma, Non-Hodgkin, Multiple Myeloma, Myelodysplastic Syndromes, Myeloproliferative Disorders, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Acute, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00057005 2020-01-18

ADVL

Phase 1 Completed

6 enrolled

Leukemia

NCT02167958 2019-10-15

Nonmyeloablative Hematopoietic Cell Transplantation (HCT) for Patients With Hematologic Malignancies Using Related, HLA-Haploidentical Donors: A Pilot Trial of Peripheral Blood Stem Cells (PBSC) as the Donor Source

Phase 1 Completed

28 enrolled

Leukemia, Lymphoma, Primary Myelofibrosis

NCT00067002 2019-05-01

Randomized Double Cord Blood Transplant Study

110 enrolled 12 charts

Lymphoma, Non-Hodgkin, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Acute, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00968253 2019-02-27

RAD001 Study in Treatment of Relapsed or Refractory Acute Lymphocytic Leukemia

Phase 1/2 Completed

24 enrolled 9 charts

Leukemia, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00002865 2018-08-10

High-Intensity, Brief-Duration Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphocytic Leukemia

25 enrolled

Leukemia, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT02199041 2018-02-07

Combined T Cell Depleted Haploidentical Peripheral Blood Stem Cell and Unrelated Umbilical Cord Blood Transplantation in Patients With Hematologic Malignancies Using a Total Lymphoid Irradiation Based Preparative Regimen

Phase 2 Terminated

24 enrolled 17 charts

Hematologic Neoplasms

NCT01181271 2017-03-09

Tandem Auto-Allo Transplant for Lymphoma

42 enrolled 18 charts

Hodgkin Disease, Lymphoma, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, T-Cell, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Mantle-Cell

NCT00429416 2016-11-29

Research Study to Determine if an Experimental Agent, LLME Can Decrease the Incidence and Severity of Graft-Versus-Host-Disease (GVHD) Following Blood (Hematopoietic) Stem Cell Transplantation

Phase 1/2 Completed

14 enrolled 11 charts

Phase EARLY_PHASE1 Completed

Graft vs Host Disease, Hematologic Neoplasms

NCT01331590 2016-09-20

Disrupting the Bone Marrow Microenvironment With G-CSF in Acute Lymphoblastic Leukemia

13 enrolled

Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00002494 2016-07-04

Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia

134 enrolled

Burkitt Lymphoma, Leukemia, Lymphoma

NCT00578461 2016-04-22

REGKINE

Phase NA Terminated

26 enrolled 7 charts

Hodgkin Disease, Leukemia, Lymphoma, Lymphoma, Non-Hodgkin, Myeloproliferative Disorders, Neoplasms

NCT00578539 2016-04-22

REGALE

Phase NA Terminated

24 enrolled 7 charts

Hodgkin Disease, Leukemia, Lymphoma, Non-Hodgkin, Myeloproliferative Disorders

NCT00038610 2015-09-18

Study of Hyper-CVAD Plus Imatinib Mesylate for Philadelphia-Positive Acute Lymphocytic Leukemia

54 enrolled 7 charts

Leukemia

NCT00941928 2014-05-22

Haploidentical Natural Killer (NK) Cells With Epratuzumab for Relapsed Acute Lymphoblastic Leukemia (ALL)

Phase 2 Terminated

2 enrolled 3 charts

Leukemia, Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00002961 2013-10-16

Chemotherapy With or Without Total-Body Irradiation Prior to Bone Marrow Transplantation in Treating Children With Acute Lymphoblastic Leukemia

Phase 3 Terminated

43 enrolled

Leukemia, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00006373 2013-06-04

Combination Chemotherapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Non-Hodgkin's Lymphoma or Hodgkin's Lymphoma

27 enrolled