Clinical Trials

12 trials
RecentStart dateEnrollment
Completed × Head and Neck Neoplasms × Other solid neoplasm × Clear all
NCT02903914 2025-08-05

Arginase Inhibitor INCB001158 as a Single Agent and in Combination With Immune Checkpoint Therapy in Patients With Advanced/Metastatic Solid Tumors

Incyte Corporation

Phase 1 Completed
260 enrolled 52 charts
GastrointestinalGenitourinaryHead & NeckOther solid neoplasmThoracic

Parkinson Disease 4, Autosomal Dominant Lewy Body, Urinary Bladder Neoplasms, Carcinoma, Renal Cell, Head and Neck Neoplasms, Lung Neoplasms, Mesothelioma, Neoplasm Metastasis, Stomach Neoplasms, Colorectal Neoplasms

NCT04430842 2023-01-18

Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S

Quadriga Biosciences, Inc.

Phase 1 Completed
15 enrolled
BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmSarcomaThoracic

Sleepiness, Mesothelioma, Malignant, Anorexia, Astrocytoma, Urinary Bladder Neoplasms, Brain Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Esophageal Neoplasms, Glioblastoma, Head and Neck Neoplasms, Headache, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Sarcoma, Seizures, Speech Disorders, Stomach Neoplasms, Thymoma, Tongue Neoplasms, Urologic Neoplasms, Vomiting, Colorectal Neoplasms, Cholangiocarcinoma

NCT03517488 2022-12-01

DUET-2

Xencor, Inc.

Phase 1 Completed
150 enrolled
BreastDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmThoracic

Squamous Cell Carcinoma of Head and Neck, Nasopharyngeal Carcinoma, Anus Neoplasms, Bile Duct Neoplasms, Breast Neoplasms, Carcinoma, Basal Cell, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Fallopian Tube Neoplasms, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Liver Neoplasms, Melanoma, Mesothelioma, Nasopharyngeal Neoplasms, Ovarian Neoplasms, Penile Neoplasms, Prostatic Neoplasms, Salivary Gland Neoplasms, Stomach Neoplasms, Thymoma, Thymus Neoplasms, Vulvar Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Carcinoma, Neuroendocrine, Cholangiocarcinoma, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT01135849 2015-11-17

B-Receptor Signaling in Cardiomyopathy

Stanford University

Completed
99 enrolled
BreastCNSClassical hematologyDermatologicEndocrineGastrointestinalGenitourinaryHead & NeckLymphoidMyeloidNETOther hematologic neoplasmOther solid neoplasmPlasma cellSarcomaThoracic

Amyloidosis, Anemia, Anus Neoplasms, Bone Neoplasms, Brain Neoplasms, Breast Neoplasms, Carcinoma, Carcinoma, Renal Cell, Colonic Neoplasms, Endocrine Gland Neoplasms, Esophageal Neoplasms, Eye Neoplasms, Gallbladder Neoplasms, Head and Neck Neoplasms, Hodgkin Disease, Leukemia, Lung Neoplasms, Lymphoma, Non-Hodgkin, Mesothelioma, Multiple Myeloma, Myelodysplastic Syndromes, Myeloproliferative Disorders, Neurologic Manifestations, Pancreatic Neoplasms, Prostatic Neoplasms, Sarcoma, Skin Neoplasms, Stomach Neoplasms, Testicular Neoplasms, Thymus Neoplasms, Thyroid Neoplasms, Neuroendocrine Tumors, Gastrointestinal Stromal Tumors

NCT00413075 2015-07-08

Study of Oral PXD101 in Patients With Advanced Solid Tumors or Lymphoma

Valerio Therapeutics

Phase 1 Completed
121 enrolled
BreastGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther solid neoplasmSarcomaThoracic

Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Chondrosarcoma, Esophageal Neoplasms, Fibrosarcoma, Head and Neck Neoplasms, Hemangiosarcoma, Hodgkin Disease, Kidney Neoplasms, Leiomyosarcoma, Liposarcoma, Lung Neoplasms, Lymphoma, Mesothelioma, Otorhinolaryngologic Neoplasms, Ovarian Neoplasms, Parathyroid Neoplasms, Prostatic Neoplasms, Sarcoma, Osteosarcoma, Thyroid Neoplasms, Colorectal Neoplasms, Lymphoma, B-Cell, Lymphoma, T-Cell, Adenosarcoma, Mixed Tumor, Mesodermal, Mesothelioma, Cystic, Carcinoma, Small Cell

NCT00413322 2015-07-08

Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors

Valerio Therapeutics

Phase 1 Completed
35 enrolled
BreastGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmSarcomaThoracic

Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Carcinosarcoma, Chondrosarcoma, Solitary Pulmonary Nodule, Phyllodes Tumor, Esophageal Neoplasms, Facial Neoplasms, Fibrosarcoma, Head and Neck Neoplasms, Hemangiosarcoma, Kidney Neoplasms, Leiomyosarcoma, Liposarcoma, Lung Neoplasms, Lymphangiosarcoma, Mesothelioma, Mouth Neoplasms, Myosarcoma, Myxosarcoma, Neoplasms, Otorhinolaryngologic Neoplasms, Ovarian Neoplasms, Pancoast Syndrome, Parathyroid Neoplasms, Sarcoma, Osteosarcoma, Thyroid Neoplasms, Tracheal Neoplasms, Colorectal Neoplasms, Adenosarcoma, Mixed Tumor, Mesodermal, Mesothelioma, Cystic, Carcinoma, Small Cell, Pulmonary Sclerosing Hemangioma, Histiocytoma, Malignant Fibrous

NCT00006981 2015-04-30

Immunotoxin Therapy in Treating Patients With Advanced Cancer

National Cancer Institute (NCI)

Phase 1 Completed
GastrointestinalGynecologicHead & NeckOther solid neoplasmThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Ovarian Epithelial, Mesothelioma, Malignant, Brenner Tumor, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Fallopian Tube Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Salivary Gland Neoplasms

NCT00066651 2015-04-30

Immunotoxin Therapy in Treating Patients With Advanced Solid Tumors

National Cancer Institute (NCI)

Phase 1 Completed
GastrointestinalGynecologicHead & NeckOther solid neoplasmThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Ovarian Epithelial, Mesothelioma, Malignant, Brenner Tumor, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Fallopian Tube Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Salivary Gland Neoplasms

NCT00375245 2014-01-17

Rapamycin With Grapefruit Juice for Advanced Malignancies

University of Chicago

Phase 1 Completed
41 enrolled
BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther solid neoplasmThoracic

Urinary Bladder Neoplasms, Breast Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Lymphoma, Melanoma, Mesothelioma, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Stomach Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms