Clinical Trials

Phase 2 Active not recruiting

Liposarcoma

NCT04044768 2026-02-06

Spearhead 1 Study in Subjects With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma

52 enrolled 15 charts 1 FDA

Phase 3 Active not recruiting

Sarcoma, Sarcoma, Synovial, Liposarcoma, Myxoid

NCT03673501 2026-02-05

INTRIGUE

453 enrolled 20 charts

Gastrointestinal Stromal Tumors

NCT04544995 2026-01-21

Dose Escalation and Cohort Expansion Study of Niraparib and Dostarlimab in Paediatric Participants With Solid Tumors (SCOOP)

Phase 1/2 Active not recruiting

47 enrolled 43 charts

CNSSarcoma

Neoplasms, Neuroblastoma, Osteosarcoma

NCT03899792 2026-01-06

LIBRETTO-121

36 enrolled 13 charts 2 FDA

BreastCNSEndocrineGastrointestinalHead & NeckSarcomaThoracic

Thyroid Cancer, Papillary, Breast Neoplasms, Bronchial Neoplasms, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Endocrine System Diseases, Endocrine Gland Neoplasms, Head and Neck Neoplasms, Lung Diseases, Lung Neoplasms, Neoplasms, Neoplasms by Site, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Sarcoma, Thoracic Neoplasms, Thyroid Diseases, Thyroid Neoplasms, Central Nervous System Neoplasms, Myofibromatosis, Carcinoma, Medullary

NCT04145349 2025-12-08

CAMPFIRE: A Study of Ramucirumab (LY3009806) in Children and Young Adults With Desmoplastic Small Round Cell Tumor

Phase 1/2 Active not recruiting

30 enrolled 16 charts

Sarcoma, Desmoplastic Small Round Cell Tumor

NCT03725605 2025-12-05

LTX-315 and Adoptive T-cell Therapy in Advanced Soft Tissue Sarcoma (ATLAS-IT-04)

6 enrolled 17 charts

NCT02625389 2025-10-10

A Study to Evaluate How Safe and Effective is the Mixture of Lipiodol® Ultra Fluid and Glue When Used for Embolization Procedures

Phase 4 Completed

132 enrolled 9 charts

Arteriovenous Malformations, Hemangioendothelioma, Hemangiosarcoma

NCT06376682 2025-09-22

EPIBONE

Phase NA Completed

34 enrolled 11 charts

Bone Neoplasms, Fractures, Bone

NCT02784795 2025-08-21

A Study of LY3039478 in Participants With Advanced or Metastatic Solid Tumors

BreastGastrointestinalSarcoma

94 enrolled 28 charts

Breast Neoplasms, Colonic Neoplasms, Sarcoma, Cholangiocarcinoma

NCT03395080 2025-08-01

P204

111 enrolled 22 charts

GynecologicSarcoma

Carcinosarcoma, Ovarian Neoplasms, Uterine Neoplasms, Endometrial Neoplasms

NCT02451943 2025-07-15

ANNOUNCE

Phase 3 Completed

509 enrolled 23 charts

Leiomyosarcoma, Liposarcoma, Sarcoma, Histiocytoma, Malignant Fibrous

NCT06115681 2025-07-10

Real-world Study of Dedifferentiated Liposarcoma Patients in China

Completed

1,390 enrolled 14 charts

Liposarcoma

NCT02601950 2025-06-22

A Study of Tazemetostat in Adult Participants With Soft Tissue Sarcoma

267 enrolled 25 charts 2 FDA

Sarcoma, Sarcoma, Synovial

NCT05269355 2025-06-13

SUNRISELMS

Phase 2/3 Terminated

359 enrolled 15 charts

Leiomyosarcoma

NCT05580588 2025-06-13

Open-Label Study of the CDK4/6 Inhibitor SPH4336 in Subjects With Locally Advanced or Metastatic Liposarcomas

Phase 2 Terminated

14 enrolled 8 charts

Liposarcoma

NCT00742963 2025-05-13

Dose-Escalation Study of TH-302 in Combination With Doxorubicin to Treat Patients With Advanced Soft Tissue Sarcoma

107 enrolled 7 charts

NCT04579757 2025-05-08

Surufatinib in Combination With Tislelizumab in Subjects With Advanced Solid Tumors

EndocrineGastrointestinalHead & NeckNETSarcomaThoracic

87 enrolled 29 charts

Neoplasm Metastasis, Sarcoma, Stomach Neoplasms, Colorectal Neoplasms, Neuroendocrine Tumors, Small Cell Lung Carcinoma, Thyroid Carcinoma, Anaplastic

NCT04383210 2025-04-03

Study of Seribantumab in Adult Patients With NRG1 Gene Fusion Positive Advanced Solid Tumors

Phase 2 Terminated

54 enrolled 11 charts

BreastGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

Fibromatosis, Gingival, 2, Bile Duct Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Sarcoma, Uterine Neoplasms, Colorectal Neoplasms, Cholangiocarcinoma

NCT03157167 2025-03-05

An Evaluation of Tc 99m Tilmanocept by Intravenous (IV) and Subcutaneous (SC) Injection in Kaposi Sarcoma (KS)

15 enrolled 12 charts

Sarcoma, Kaposi, HIV Infections

NCT03058289 2025-02-27

IT-01

BreastGastrointestinalHead & NeckLymphoidSarcomaThoracic

111 enrolled 21 charts

Diabetes Mellitus, Insulin-Dependent, 12, Bile Duct Neoplasms, Breast Neoplasms, Carcinoma, Carcinoma, Squamous Cell, Colonic Neoplasms, Head and Neck Neoplasms, Liver Neoplasms, Lung Neoplasms, Lymphoma, Neoplasms, Pancreatic Neoplasms, Sarcoma

NCT04537715 2025-02-19

Effects of Itraconazole and Rifampin on the Blood Tazemetostat Levels

LymphoidOther hematologic neoplasmOther solid neoplasmSarcomaThoracic

42 enrolled 39 charts

Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Mesothelioma, Sarcoma, Sarcoma, Synovial, Lymphoma, Large B-Cell, Diffuse, Rhabdoid Tumor, Hematologic Neoplasms

NCT02401815 2025-02-14

CGT9486 (Formerly Known as PLX9486) as a Single Agent and in Combination With PLX3397 (Pexidartinib) or Sunitinib in Participants With Advanced Solid Tumors

51 enrolled 32 charts

Gastrointestinal Stromal Tumors

NCT02657005 2025-02-12

TK216 in Patients With Relapsed or Refractory Ewing Sarcoma

85 enrolled 18 charts

Sarcoma, Ewing

NCT04633122 2025-02-10

A Study to Assess DCC-2618 and Sunitinib in Patients With Advanced GIST After Treatment With Imatinib

108 enrolled 11 charts

Gastrointestinal Stromal Tumors

NCT03150862 2025-02-04

A Study Assessing Pamiparib With Radiation and/or Temozolomide (TMZ) in Participants With Newly Diagnosed or Recurrent Glioblastoma

142 enrolled 21 charts 1 FDA

116 enrolled 31 charts

CNSSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Nervous System Diseases, Central Nervous System Neoplasms, Neuroectodermal Tumors, Gliosarcoma

NCT03785964 2025-01-31

DeFi

Phase 3 Completed

Desmoid Tumors

NCT04979442 2025-01-14

MANTRA

Phase 3 Terminated

175 enrolled 16 charts

Liposarcoma, Sarcoma

NCT05100628 2025-01-06

A Study of NOX66 Plus Doxorubicin in Anthracycline-naïve, Adult Patients With Soft Tissue Sarcoma

9 enrolled 10 charts

NCT04996004 2024-12-11

TTI-621-03

Phase 2 Terminated

76 enrolled 53 charts

Hemangiosarcoma, Leiomyosarcoma, Liposarcoma, Sarcoma, Dermatofibrosarcoma

NCT05236257 2024-12-10

EPI VITRAKVI

Completed

93 enrolled 14 charts

Locally Advanced or Metastatic Infantile Fibrosarcoma Harboring an NTRK Gene Fusion

NCT04526509 2024-11-26

Master Protocol to Assess Safety and Dose of First Time in Human Next Generation Engineered T Cells in NY-ESO-1 and/or LAGE-1a Positive Advanced Solid Tumors

12 enrolled 12 charts

Neoplasms, Liposarcoma, Myxoid

NCT04825574 2024-11-26

Study for Patients Previously Treated in Avapritinib Clinical Trials

Phase 4 Completed

2 enrolled 4 charts

Gastrointestinal Stromal Tumors

NCT03474640 2024-11-22

Safety, Tolerability and Pharmacokinetics of an Anti-PD-1 Monoclonal Antibody in Subjects With Advanced Malignancies

GastrointestinalHead & NeckSarcoma

184 enrolled 20 charts

Nasopharyngeal Carcinoma, Chondrosarcoma, Esophageal Neoplasms, Carcinoma, Hepatocellular, Sarcoma, Stomach Neoplasms

NCT05943990 2024-11-13

Study of GSK3845097 in Previously Treated Participants With Advanced Synovial Sarcoma and Myxoid/Round Cell Liposarcoma

5 enrolled 16 charts

Neoplasms, Liposarcoma, Myxoid

NCT06048705 2024-11-13

Study of GSK3901961 In Previously Treated Advanced (Metastatic OR Unresectable) Synovial Sarcoma/ Myxoid/Round Cell Liposarcoma, and Previously Treated Metastatic Non-Small Cell Lung Cancer

7 enrolled 19 charts

SarcomaThoracic

Carcinoma, Non-Small-Cell Lung, Neoplasms, Liposarcoma, Myxoid

NCT03126591 2024-10-23

A Study of Olaratumab (LY3012207) Plus Pembrolizumab in Participants With Advanced or Metastatic Soft Tissue Sarcoma

41 enrolled 19 charts

NCT02601937 2024-10-03

EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Sarcoma

109 enrolled 25 charts

Sarcoma, Synovial, Rhabdoid Tumor

NCT00819169 2024-08-20

QUILT-3.026: AMG 655 in Combination With AMG 479 in Advanced, Refractory Solid Tumors

GastrointestinalGynecologicSarcomaThoracic

89 enrolled 20 charts

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis, Ovarian Neoplasms, Pancreatic Neoplasms, Sarcoma, Colorectal Neoplasms

NCT01863745 2024-08-19

Nilotinib Roll-over Protocol for Patients in Novartis-sponsored Nilotinib Study and Benefiting From Nilotinib Treatment

15 enrolled 7 charts

Neoplasms, Gastrointestinal Stromal Tumors

NCT04154189 2024-07-22

A Study to Compare the Efficacy and Safety of Ifosfamide and Etoposide With or Without Lenvatinib in Children, Adolescents and Young Adults With Relapsed and Refractory Osteosarcoma

81 enrolled 22 charts

Recurrence, Osteosarcoma

NCT02509598 2024-06-28

A Study of Lymphoseek® as a Lymphoid Tissue Targeting Agent in Pediatric Patients With Melanoma, Rhabdomyosarcoma, or Other Solid Tumors Who Are Undergoing Lymph Node Mapping

24 enrolled 18 charts

DermatologicSarcoma

Melanoma, Rhabdomyosarcoma

NCT02049905 2024-06-13

Phase 3 Study to Treat Patients With Soft Tissue Sarcomas

Phase 3 Completed

433 enrolled 10 charts

Neoplasm Metastasis, Sarcoma

NCT02029430 2024-06-11

A Study to Investigate ALDOXORUBICIN in HIV-infected Subjects With Kaposi's Sarcoma

15 enrolled 9 charts

Acquired Immunodeficiency Syndrome, HIV Seropositivity, Neoplasms, Sarcoma, Sarcoma, Kaposi

NCT05093322 2024-06-07

A Study of Surufatinib in Combination With Gemcitabine in Pediatric, Adolescent, and Young Adult Patients With Recurrent or Refractory Solid Tumors

13 enrolled 17 charts

LymphoidSarcoma

Lymphoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma

NCT05160168 2024-06-05

A Study of THE-630 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)

32 enrolled 20 charts

Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Neoplasms, Neoplasms by Histologic Type, Neoplasms, Connective Tissue, Neoplasms, Connective and Soft Tissue, Gastrointestinal Stromal Tumors

NCT01514188 2024-05-29

Preliminary Efficacy and Safety of INNO-206 Compared to Doxorubicin in Advanced Soft Tissue Sarcoma

126 enrolled 13 charts

Neoplasm Metastasis, Sarcoma

NCT02235701 2024-05-29

Study to Investigate the Safety and Activity of Aldoxorubicin Plus Ifosfamide/Mesna in Subjects With Metastatic Soft Tissue Sarcoma

70 enrolled 10 charts