Clinical Trials

Diffuse Intrinsic Pontine Glioma, Bone Neoplasms, Medulloblastoma, Neoplasms, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Rhabdoid Tumor

NCT03600649 2023-11-21

Clinical Trial of SP-2577 (Seclidemstat) in Patients With Relapsed or Refractory Ewing or Ewing-related Sarcomas

Phase 1 Unknown

50 enrolled

Histiocytoma, Angiomatoid Fibrous, Chondrosarcoma, Extraskeletal Myxoid, Fibroma, Myoepithelioma, Sarcoma, Sarcoma, Ewing, Liposarcoma, Myxoid, Sarcoma, Clear Cell, Desmoplastic Small Round Cell Tumor

NCT05266196 2023-08-01

A Rollover Protocol to Allow for Continued Access to the LSD1 Inhibitor Seclidemstat (SP-2577)

Phase 1/2 Unknown

10 enrolled

Histiocytoma, Angiomatoid Fibrous, Chondrosarcoma, Extraskeletal Myxoid, Myoepithelioma, Sarcoma, Ewing, Liposarcoma, Myxoid, Sarcoma, Clear Cell, Desmoplastic Small Round Cell Tumor

NCT04661852 2023-02-15

Cabozantinib With Topotecan-Cyclophosphamide

12 enrolled

Sarcoma, Ewing, Osteosarcoma

NCT00014443 2023-01-09

Topotecan and Thalidomide in Treating Patients With Recurrent or Refractory Malignant Glioma

Phase 2 Terminated

5 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT02357810 2022-06-07

Pazopanib Hydrochloride and Topotecan Hydrochloride in Treating Patients With Metastatic Soft Tissue and Bone Sarcomas

178 enrolled 16 charts

Liposarcoma, Sarcoma, Osteosarcoma

NCT01004874 2022-04-13

Avastin/Radiation (XRT)/Temozolomide (Temodar) Followed by Avastin/Temodar/Topotecan for Glioblastoma

80 enrolled 11 charts

Glioblastoma, Glioma, Gliosarcoma

NCT02390843 2020-04-03

AflacST1402

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

13 enrolled

Carcinoma, Renal Cell, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma, Sarcoma, Clear Cell, Rhabdoid Tumor

NCT01492673 2019-10-29

Cyclophosphamide, Topotecan, and Bevacizumab (CTB) in Patients With Relapsed/Refractory Ewing's Sarcoma and Neuroblastoma

9 enrolled 9 charts

Neuroblastoma, Sarcoma, Sarcoma, Ewing

NCT00610571 2013-10-25

Ph I Oral Topotecan and Temozolomide for Patients With Malignant Gliomas

62 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT00379457 2013-08-12

Combination Chemotherapy in Treating Young Patients With Nonmetastatic Rhabdomyosarcoma

Phase 3 Unknown

600 enrolled

Malignant mesenchymal tumor, Sarcoma

NCT00334867 2013-06-28

Combination Chemotherapy With or Without Topotecan in Treating Patients With Newly Diagnosed Localized Ewing's Sarcoma

Phase 3 Withdrawn

Sarcoma, Neuroectodermal Tumors, Primitive, Peripheral

NCT00003958 2013-06-17

Combination Chemotherapy in Treating Patients With Previously Untreated Rhabdomyosarcoma

Phase 3 Completed

702 enrolled

Malignant mesenchymal tumor, Rhabdomyosarcoma, Sarcoma

NCT00003156 2013-04-11

Topotecan in Treating Patients With Recurrent or Refractory Cancer of the Uterus

Phase 2 Terminated

NCT00842452 2013-04-05

Topotecan in Treating Patients With Gynecologic Cancer That Cannot Be Removed by Surgery

26 enrolled

GynecologicSarcoma

Carcinoma, Ovarian Epithelial, Uterine Cervical Neoplasms, Fallopian Tube Neoplasms, Ovarian Neoplasms, Sarcoma, Vaginal Neoplasms, Vulvar Neoplasms, Endometrial Neoplasms

NCT00005811 2013-02-21

Topotecan Hydrochloride in Treating Children With Meningeal Cancer That Has Not Responded to Previous Treatment

CNSLymphoidOther hematologic neoplasmSarcoma

77 enrolled

Burkitt Lymphoma, Medulloblastoma, Recurrence, Lymphoma, Large B-Cell, Diffuse, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Dendritic Cell Sarcoma, Interdigitating, Meningeal Carcinomatosis

NCT00003745 2013-02-05

Chemotherapy in Treating Children With Recurrent or Refractory Sarcomas

125 enrolled

Sarcoma, Osteosarcoma, Neuroectodermal Tumors, Primitive, Peripheral

NCT00002643 2013-02-01

Combination Chemotherapy in Treating Patients With Newly Diagnosed Metastatic Ewing's Sarcoma or Primitive Neuroectodermal Tumor

130 enrolled

Neutropenia, Sarcoma, Neuroectodermal Tumors, Primitive, Peripheral

NCT00541138 2011-09-21

Tamoxifen, Carboplatin, and Topotecan in Treating Patients With CNS Metastases or Recurrent Brain or Spinal Cord Tumors

50 enrolled

CNSLymphoidOther hematologic neoplasmSarcoma

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Neoplasm Metastasis, Oligodendroglioma, Central Nervous System Neoplasms, Glioma, Subependymal, Gliosarcoma

NCT00112619 2011-06-30

Topotecan in Treating Young Patients With Neoplastic Meningitis Due to Leukemia, Lymphoma, or Solid Tumors

Phase 1 Terminated

19 enrolled

Familial ependymoma, Astrocytoma, Burkitt Lymphoma, Leukemia, Lymphoma, Medulloblastoma, Neoplasms, Unknown Primary, Oligodendroglioma, Recurrence, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Rhabdoid Tumor, Optic Nerve Glioma, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myelomonocytic, Juvenile, Dendritic Cell Sarcoma, Interdigitating, Meningeal Carcinomatosis

NCT00130858 2009-04-02

a Multicenter Clinical Trial for the Treatment of Children and Adolescents With Soft Tissue Sarcoma Stage 4

90 enrolled

NCT00001335 2008-03-04

New Therapeutic Strategies for Patients With Ewing's Sarcoma Family of Tumors, High Risk Rhabdomyosarcoma, and Neuroblastoma

90 enrolled