Clinical Trials

101 enrolled

Head and Neck Neoplasms, Lung Neoplasms, Pulmonary Disease, Chronic Obstructive

NCT04075305 2026-03-05

MOMENTUM

BreastCNSGastrointestinalGenitourinaryHead & NeckThoracic

8,000 enrolled

Urinary Bladder Neoplasms, Brain Neoplasms, Breast Neoplasms, Esophageal Neoplasms, Genital Neoplasms, Female, Head and Neck Neoplasms, Liver Neoplasms, Lung Neoplasms, Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Radiation Injuries, Rectal Neoplasms

NCT06091930 2026-03-04

A Study to Test Different Doses of BI 765049 Alone and in Combination With Ezabenlimab in Asian People With Advanced Cancer (Solid Tumours) Positive for B7-H6

97 enrolled

Gastrointestinal Neoplasms, Head and Neck Neoplasms, Liver Neoplasms, Lung Neoplasms, Pancreatic Neoplasms, Colorectal Neoplasms

NCT07020117 2026-03-04

A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors

BreastHead & NeckThoracic

150 enrolled

Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Triple Negative Breast Neoplasms

NCT07447050 2026-03-03

Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial

BreastGastrointestinalGynecologicHead & NeckSarcomaThoracic

24 enrolled

Breast Neoplasms, Head and Neck Neoplasms, Liver Neoplasms, Lung Neoplasms, Ovarian Neoplasms, Sarcoma, Stomach Neoplasms, Urogenital Neoplasms, Colorectal Neoplasms

NCT06910657 2026-03-02

IDOV-Immune for Advanced Solid Tumors

BreastDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

78 enrolled

Adrenal Gland Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Sarcoma, Stomach Neoplasms, Vaccinia, Colorectal Neoplasms

NCT07124000 2026-02-24

DP-04

DermatologicGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

100 enrolled

Adenocarcinoma, Anus Neoplasms, Urinary Bladder Neoplasms, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Liver Neoplasms, Melanoma, Mouth Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Salivary Gland Neoplasms, Sarcoma, Testicular Neoplasms, Thyroid Neoplasms, Urethral Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Endometrial Neoplasms, Gastrointestinal Stromal Tumors, Small Cell Lung Carcinoma

NCT04354064 2026-02-20

Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors

BreastDermatologicGastrointestinalGenitourinaryHead & NeckSarcomaThoracic

100 enrolled

Breast Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Melanoma, Prostatic Neoplasms, Sarcoma, Skin Neoplasms, Urogenital Neoplasms

NCT05647122 2026-02-20

EGRET

403 enrolled

Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Neoplasms, Colorectal Neoplasms

NCT04485013 2026-02-18

TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

240 enrolled

Adenocarcinoma of Lung, Squamous Cell Carcinoma of Head and Neck, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Triple Negative Breast Neoplasms

NCT07085091 2026-02-17

A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors

170 enrolled

Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Head and Neck Neoplasms, Neoplasm Metastasis, Colorectal Neoplasms

NCT04930432 2026-02-10

Study of MCLA-129, a Human Bispecific EGFR and cMet Antibody, in Patients With Advanced NSCLC and Other Solid Tumors

400 enrolled

Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Colorectal Neoplasms

NCT04916990 2026-02-05

Improving Care for Rural Patients With Solid Tumors

BreastGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

320 enrolled

Urinary Bladder Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Colonic Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Rectal Neoplasms, Thyroid Neoplasms

NCT06639191 2026-01-30

AKIR001

Phase EARLY_PHASE1 Recruiting

15 enrolled

EndocrineGynecologicHead & NeckThoracic

Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Vulvar Neoplasms, Thyroid Carcinoma, Anaplastic

NCT05995821 2026-01-29

Immunobiology Blood and Tissue Collection of Upper Aerodigestive Malignancies

1,250 enrolled

Gastrointestinal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms

NCT06172478 2026-01-28

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

740 enrolled

Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Melanoma, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Stomach Neoplasms, Endometrial Neoplasms

NCT07358806 2026-01-22

Study to Assess the Effect of OCT-598 in Patients With Advanced Solid Tumors

BreastGenitourinaryHead & NeckThoracic

51 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Prostatic Neoplasms

NCT07292168 2026-01-21

TAGNOT

BreastGenitourinaryHead & NeckThoracic

58 enrolled

Acrocephalosyndactylia, Breast Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Prostatic Neoplasms

NCT05366881 2026-01-20

CAMPERR

BreastCNSGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther hematologic neoplasmPlasma cellSarcomaThoracic

7,000 enrolled

Urinary Bladder Neoplasms, Brain Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Leukemia, Lung Neoplasms, Lymphoma, Multiple Myeloma, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Sarcoma, Stomach Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms

NCT06710756 2026-01-16

Lead-212 PSV359 Therapy for Patients With Solid Tumors

GastrointestinalGynecologicHead & NeckOther solid neoplasmSarcomaThoracic

112 enrolled

Esophageal Neoplasms, Head and Neck Neoplasms, Mesothelioma, Ovarian Neoplasms, Sarcoma, Stomach Neoplasms, Colorectal Neoplasms

NCT07327489 2026-01-08

ELEPHAS-05

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

2,000 enrolled

Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Kidney Neoplasms, Liver Neoplasms, Melanoma, Neoplasms, Skin Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Triple Negative Breast Neoplasms

NCT05520099 2025-12-26

ELEPHAS-02

DermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

416 enrolled

Squamous Cell Carcinoma of Head and Neck, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Neoplasms, Skin Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms

NCT07192068 2025-12-19

AcSé HER2

GastrointestinalHead & NeckSarcomaThoracic

105 enrolled

Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Sarcoma, Colorectal Neoplasms

NCT03556228 2025-12-11

VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

GastrointestinalHead & NeckOther solid neoplasmThoracic

242 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Adenoid Cystic, Esophageal Neoplasms, Head and Neck Neoplasms, Laryngeal Diseases, Lung Neoplasms, Mesothelioma, Neoplasm Metastasis, Pancreatic Neoplasms, Salivary Gland Neoplasms, Tracheal Diseases, Small Cell Lung Carcinoma

NCT07090499 2025-12-09

A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors

GastrointestinalGenitourinaryHead & NeckThoracic

310 enrolled

Adenocarcinoma Of Esophagus, Adenocarcinoma of Lung, Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Transitional Cell, Esophageal Neoplasms, Head and Neck Neoplasms, Pancreatic Neoplasms

NCT05053230 2025-10-09

IMPROVE

DermatologicGynecologicHead & NeckThoracic

480 enrolled

Genital Neoplasms, Female, Head and Neck Neoplasms, Melanoma, Ovarian Neoplasms, Thoracic Neoplasms

NCT05194982 2025-09-26

A Study of BL-B01D1 in Patients With Locally Advanced or Metastatic Solid Tumor

570 enrolled

Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Neoplasm Metastasis, Small Cell Lung Carcinoma

NCT05941507 2025-09-24

A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors

BreastCNSGastrointestinalGynecologicHead & NeckThoracic

300 enrolled

Squamous Cell Carcinoma of Head and Neck, Anus Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Glioblastoma, Head and Neck Neoplasms, Lung Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Salivary Gland Neoplasms, Stomach Neoplasms, Endometrial Neoplasms

NCT00900419 2025-09-22

Biomarkers in Patients With Respiratory Tract Dysplasia or Lung Cancer, Head and Neck Cancer, or Aerodigestive Tract Cancer and in Normal Volunteers

GastrointestinalHead & NeckOther neoplasmThoracic

700 enrolled

Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Lung Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Precancerous Conditions, Salivary Gland Neoplasms, Tongue Neoplasms, Small Cell Lung Carcinoma

NCT04273061 2025-09-22

CAPTIV-8

BreastDermatologicGastrointestinalHead & NeckSarcomaThoracic

200 enrolled

Breast Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Neoplasms, Unknown Primary, Sarcoma, Skin Neoplasms, Urogenital Neoplasms

NCT06904365 2025-09-22

OvAR-Y

BreastGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

10 enrolled

Anus Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Colonic Neoplasms, Head and Neck Neoplasms, Liver Neoplasms, Lung Neoplasms, Rectal Neoplasms, Sarcoma, Stomach Neoplasms, Uterine Neoplasms

NCT03958240 2025-09-15

DECIDE

GastrointestinalGynecologicHead & NeckThoracic

1,100 enrolled

Anus Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Ovarian Neoplasms

NCT05076760 2025-08-29

MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid Tumors

BreastDermatologicGastrointestinalHead & NeckThoracic

40 enrolled

Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Melanoma, Neoplasm Metastasis, Pancreatic Neoplasms, Carcinoma, Merkel Cell, Triple Negative Breast Neoplasms

NCT05318027 2025-08-01

ChatBot and Activity Monitoring in Patients Undergoing Chemoradiotherapy

70 enrolled

Gastrointestinal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms

NCT06691776 2025-08-01

FASCINATE

GenitourinaryGynecologicHead & NeckThoracic

100 enrolled

Urinary Bladder Neoplasms, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Prostatic Neoplasms

NCT03093116 2025-07-10

TRIDENT-1

EndocrineGastrointestinalHead & NeckNETSarcomaThoracic

500 enrolled 2 FDA

Adenocarcinoma, Bronchial Neoplasms, Carcinoma, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Colonic Diseases, Colonic Neoplasms, Digestive System Neoplasms, Endocrine System Diseases, Endocrine Gland Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Lung Diseases, Lung Neoplasms, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Sarcoma, Thoracic Neoplasms, Thyroid Diseases, Thyroid Neoplasms, Neuroectodermal Tumors, Carcinoma, Neuroendocrine, Neuroendocrine Tumors

NCT05592626 2025-07-09

START-001

DermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

365 enrolled

Abdominal Neoplasms, Biliary Tract Neoplasms, Urinary Bladder Neoplasms, Carcinoma, Carcinoma, Basal Cell, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Genital Neoplasms, Female, Head and Neck Neoplasms, Lung Neoplasms, Melanoma, Nasopharyngeal Neoplasms, Neoplasms, Neoplasms by Site, Stomach Neoplasms, Urogenital Neoplasms, Vulvar Diseases, Vulvar Neoplasms, Colorectal Neoplasms, Carcinoma, Merkel Cell, Endometrial Neoplasms, Epstein-Barr Virus Infections, Papillomavirus Infections, Microsatellite Instability, Small Cell Lung Carcinoma

NCT00568490 2025-07-02

Identification of Secreted Markers for Tumor Hypoxia in Patients With Head and Neck or Lung Cancers

200 enrolled

Head and Neck Neoplasms, Lip Neoplasms, Lung Neoplasms

NCT06580002 2025-06-26

Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial

BreastGastrointestinalGynecologicHead & NeckSarcomaThoracic

51 enrolled

Breast Neoplasms, Head and Neck Neoplasms, Liver Neoplasms, Lung Neoplasms, Ovarian Neoplasms, Sarcoma, Stomach Neoplasms, Urogenital Neoplasms, Colorectal Neoplasms

NCT06239194 2025-06-22

Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

BreastGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

115 enrolled

Biliary Tract Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Liver Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms, Thyroid Neoplasms, Endometrial Neoplasms

NCT05944237 2025-06-08

HTL0039732 in Participants With Advanced Solid Tumours

EndocrineGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmSarcomaThoracic

150 enrolled

Mesothelioma, Malignant, Urinary Bladder Neoplasms, Uterine Cervical Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Lung Neoplasms, Neoplasms, Pancreatic Neoplasms, Pheochromocytoma, Sarcoma, Stomach Neoplasms, Colorectal Neoplasms, Prostatic Neoplasms, Castration-Resistant

NCT05144698 2025-05-14

RAPA-201 Therapy of Solid Tumors

DermatologicGastrointestinalHead & NeckThoracic

37 enrolled

Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Melanoma

NCT06673329 2025-05-14

Brodalumab in the Treatment of Immune-Related Adverse Events

BreastCNSDermatologicGastrointestinalGenitourinaryHead & NeckThoracic

11 enrolled

Brain Neoplasms, Breast Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Mouth Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Skin Neoplasms, Stomach Neoplasms, Testicular Neoplasms, Thyroid Neoplasms

NCT06438705 2025-03-11

99mTc Labeled FAP Targeted Molecular Probe in Early Diagnosis of Tumors

20 enrolled

Head and Neck Neoplasms, Lung Neoplasms, Pancreatic Neoplasms

NCT05403177 2025-02-03

MOHCCN-O

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther hematologic neoplasmThoracic

500 enrolled

Breast Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Leukemia, Lung Neoplasms, Lymphoma, Melanoma, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Colorectal Neoplasms

NCT03117946 2024-12-27

i-RTCT

220 enrolled

Head and Neck Neoplasms, Lung Neoplasms

NCT05349227 2024-12-11

COACH

BreastGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

625 enrolled

Breast Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Motor Activity, Neoplasm Metastasis, Ovarian Neoplasms, Prostatic Neoplasms, Stomach Neoplasms, Endometrial Neoplasms

NCT02906943 2024-12-04

OCTANE

BreastDermatologicGastrointestinalHead & NeckThoracic

10,000 enrolled

Breast Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Melanoma, Neoplasms, Unknown Primary, Urogenital Neoplasms, Colorectal Neoplasms

NCT05878964 2024-10-04

SkinHealth