Clinical Trials

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Carcinomatosis

NCT06296745 2026-01-30

Intrathecal Pemetrexed for Leptomeningeal Metastasis From Lung Adenocarcinoma That Progressed After Osimertinib.

36 enrolled

Phase NA Not yet recruiting

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT07348965 2026-01-16

Pulsatile High-dose Furmonertinib in EGFR-mutant NSCLC With Leptomeningeal Metastasis

42 enrolled

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT06500481 2026-01-14

Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial

Phase 3 Recruiting

115 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Carcinomatosis

NCT07304739 2025-12-26

Furmonertinib Combined With Intrathecal Chemotherapy and Stereotactic Radiotherapy (SRT) for EGFR-Mutated NSCLC Patients With Brain Parenchymal and Leptomeningeal Metastases

30 enrolled

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT06518057 2025-12-11

Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer

22 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Carcinomatosis

NCT06910761 2025-12-08

Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer

35 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Carcinomatosis

NCT05746325 2025-10-27

Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast or Lung Cancer

Phase NA Recruiting

5 enrolled

Breast Neoplasms, Lung Neoplasms, Meningeal Carcinomatosis

NCT07005791 2025-06-05

AI-Based Ultrasound Prediction Model for Intracranial Pressure and Prognosis in Lung Cancer Patients With Leptomeningeal Metastasis: A Dual-Center Study

Not yet recruiting

142 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Carcinomatosis

NCT06718972 2025-04-27

CLM-tree datab

Recruiting

1,000 enrolled

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT06728865 2024-12-11

Better Brain

70 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT06399926 2024-05-06

Efficacy and Safety of Intraventricule Pemetrexed Disodium Administered Via Ommaya Reservoir

Recruiting

64 enrolled

Phase 4 Not yet recruiting

Lung Neoplasms, Meningeal Carcinomatosis

NCT06282874 2024-02-28

Lorlatinib in Patients With ALK-Positive NSCLC With Brain or Leptomeningeal Metastases

50 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT05810350 2023-04-13

Aumolertinib Combined Intrathecal Chemotherapy for Leptomeningeal Metastasis From EGFR-Mutated NSCLC and Prognostic Value of Dynamic Changes in cfDNA Profiles

40 enrolled

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT04944069 2021-06-29

ATTRACT

Phase NA Unknown

69 enrolled

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT04833205 2021-04-20

Clinical Efficacy and Safety of EGFR-TKI Combined With Nimotuzumab in the Treatment of Leptomeningeal Metastases From Lung Cancer

30 enrolled

Lung Neoplasms, Meningeal Carcinomatosis

NCT04425681 2020-06-11

OWBLM

20 enrolled

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT04148898 2019-11-04

OWONBNSCLCLM

80 enrolled

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT02607605 2017-10-26

ctDNA

Unknown

10 enrolled

Lung Neoplasms, Meningeal Carcinomatosis

NCT02803619 2016-06-17

A Multi-center Prospective Observational Biomarker Study on EGFRm+ Non-small Cell Lung Cancer Patients With Leptomeningeal Metastasis

Unknown

60 enrolled

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT00830245 2011-07-26

A Study to Assess the Efficacy of Erlotinib for Leptomeningeal Carcinomatosis in EGFR Mutation Positive Non-small Cell Lung Cancer

Phase 2 Terminated

20 enrolled