NCT06495125 2025-04-17Defactinib, Avutometinib and Nivolumab for the Treatment of Anti-PD1 Refractory LKB1-Mutant Advanced Non-Small Cell Lung CancerEmory UniversityPhase 2 Recruiting50 enrolled
NCT02004028 2024-02-20Window of Opportunity Study of VS-6063 (Defactinib) in Surgical Resectable Malignant Pleural Mesothelioma ParticipantsVerastem, Inc.Phase 2 Terminated35 enrolled 15 charts
NCT04201145 2020-11-17Pembrolizumab + Defactinib In Pleural MesotheliomaDana-Farber Cancer InstitutePhase 1 Withdrawn
NCT02758587 2018-03-19Study of FAK (Defactinib) and PD-1 (Pembrolizumab) Inhibition in Advanced Solid Malignancies (FAK-PD1)NHS Greater Glasgow and ClydePhase 1/2 Unknown59 enrolled
NCT01951690 2017-04-13Phase II Study of VS-6063 in Patients With KRAS Mutant Non-Small Cell Lung CancerVerastem, Inc.Phase 2 Completed55 enrolled
NCT02372227 2017-01-30A Phase 1 Dose Escalation Study of VS-5584 Administered in Combination With VS-6063, in Subjects With Relapsed Malignant MesotheliomaVerastem, Inc.Phase 1 Terminated21 enrolled