Clinical Trials Browser

Bronchial Neoplasms, Carcinoma, Carcinoma, Non-Small-Cell Lung, Lung Diseases, Lung Neoplasms, Neoplasms, Neoplasms by Site, Hereditary Sensory and Autonomic Neuropathies, Respiratory Tract Diseases, Respiratory Tract Neoplasms

NCT05815173 2025-12-30

Ladarixin With Sotorasib in Advanced NSCLC

Phase 1 Recruiting

40 enrolled

Thoracic

Advanced Non-small Cell Lung Cancer With KRAS G12C Mutation

NCT05313009 2025-12-16

Tarlox and Sotorasib in Patients With KRAS G12C Mutations

Phase 1/2 Terminated

5 enrolled 9 charts

Thoracic

Carcinoma, Non-Small-Cell Lung

NCT04625647 2025-12-05

Testing the Use of Targeted Treatment (AMG 510) for KRAS G12C Mutated Advanced Non-squamous Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)

Phase 2 Active not recruiting

116 enrolled

Thoracic

Adenocarcinoma of Lung, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT05118854 2025-10-20

A Phase II Study of Neoadjuvant Sotorasib in Combination With Cisplatin or Carboplatin and Pemetrexed for Surgically Resectable Stage IIA-IIIB Non-Squamous Non-Small Cell Lung Cancer With a KRAS p.G12C Mutation

Phase 2 Recruiting

27 enrolled

Thoracic

Lung Neoplasms

NCT04303780 2025-10-14

Study to Compare AMG 510 "Proposed INN Sotorasib" With Docetaxel in Non Small Cell Lung Cancer (NSCLC) (CodeBreak 200).

Phase 3 Active not recruiting

345 enrolled 11 charts

Thoracic

KRAS p, G12c Mutated /Advanced Metastatic NSCLC

NCT04892017 2025-10-10

A Phase 1/2 Study of Inlexisertib (DCC-3116) in Patients With RAS/MAPK Pathway Mutant Solid Tumors

Phase 1/2 Active not recruiting

144 enrolled

Thoracic

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

NCT06249282 2025-06-17

Carfilzomib in Combination With Sotorasib for the Treatment of Patients With KRAS G12C Mutated Advanced or Metastatic Non-small Cell Lung Cancer

Phase 1 Recruiting

15 enrolled

Thoracic

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT05631249 2025-05-08

CODEBREAK-IGR

Phase 2 Recruiting

40 enrolled

Thoracic

Carcinoma, Non-Small-Cell Lung

NCT05374538 2025-05-01

VIC-1911 Monotherapy in Combination With Sotorasib for the Treatment of KRAS G12C-Mutant Non-Small Cell Lung Cancer

Phase 1 Terminated

3 enrolled 13 charts

Thoracic

Carcinoma, Non-Small-Cell Lung

NCT04720976 2025-04-11

JAB-3312 Based Combination Therapy in Adult Patients With Advanced Solid Tumors

Phase 1/2 Completed

58 enrolled

Other solid neoplasmThoracic

Solid Tumor

NCT05398094 2025-04-10

MERIT-lung

Phase 2 Recruiting

19 enrolled

Thoracic

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT05480865 2024-12-12

Argonaut

Phase 1 Terminated

28 enrolled

Thoracic

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

NCT06068153 2024-11-20

AMBER

Phase 2 Withdrawn

Thoracic

Carcinoma, Non-Small-Cell Lung

NCT06314763 2024-04-30

ROSIE

Phase 4 Completed

21 enrolled

Classical hematologyThoracic

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Venous Thromboembolism

NCT05815186 2024-03-29

Ladarixin With Sotorasib in Advanced NSCLC - Phase II

Phase 2 Withdrawn

Thoracic

Advanced Non-small Cell Lung Cancer With KRAS G12C Mutation

NCT06127940 2023-11-13

K-SAB

Phase 1 Unknown

20 enrolled

Thoracic

Non-small Cell Lung Cancer Metastatic

NCT05311709 2023-11-09

SOLUCOM

Phase 2 Unknown

100 enrolled

Thoracic

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasms

NCT05180422 2023-10-18

A Phase I/II Study of AMG 510 in Combination With MVASI in Patients With Advanced, Unresectable or Metastatic KRAS G12C Mutant NSCLC With Asymptomatic Brain Metastasis

Phase 1/2 Withdrawn

Thoracic

Carcinoma, Non-Small-Cell Lung

NCT04959981 2023-07-25

HERKULES-2

Phase 1 Completed

24 enrolled

Thoracic

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Noonan Syndrome, Thoracic Neoplasms

NCT05400577 2023-07-17

Sotorasib in KRAS G12C Mutated, Resectable, Stage Ib-IIIA NSCLC

Phase 2 Withdrawn

Thoracic

Carcinoma, Non-Small-Cell Lung

NCT05451056 2022-07-11

breakthrough

Phase 2 Unknown

37 enrolled

Thoracic

Carcinoma, Non-Small-Cell Lung