Clinical Trials Browser

Phase 1/2 × INDUSTRY × Astrocytoma × Clear all

Astrocytoma, Breast Neoplasms, Fallopian Tube Neoplasms, Glioma, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms

NCT06047379 2026-03-02

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

Phase 1/2 Recruiting

134 enrolled

CNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Astrocytoma, Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Squamous Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Glioblastoma, Melanoma, Stomach Neoplasms, Colorectal Neoplasms, Carcinoma, Merkel Cell, Central Nervous System Neoplasms, Small Cell Lung Carcinoma

NCT05765812 2026-02-27

A Study of Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma

Phase 1/2 Recruiting

116 enrolled

CNSLymphoid

Astrocytoma, Glioblastoma, Lymphoma, Follicular

NCT03330197 2025-08-12

A Study of Ad-RTS-hIL-12 + Veledimex in Pediatric Subjects With Brain Tumors Including DIPG

Phase 1/2 Terminated

6 enrolled 14 charts

CNS

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Glioblastoma, Glioma

NCT02655601 2025-06-08

BMX-HGG

Phase 1/2 Completed

177 enrolled 34 charts

CNS

Astrocytoma, Glioblastoma, Glioma

NCT05737212 2025-02-21

Studying the Safety, Efficacy, and Pharmacokinetic Characteristics of BNCT in Patients With Recurrent High-grade Gliomas

Phase 1/2 Terminated

7 enrolled

CNS

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma

NCT03150862 2025-02-04

A Study Assessing Pamiparib With Radiation and/or Temozolomide (TMZ) in Participants With Newly Diagnosed or Recurrent Glioblastoma

Phase 1/2 Completed

116 enrolled 31 charts

CNSSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Nervous System Diseases, Central Nervous System Neoplasms, Neuroectodermal Tumors, Gliosarcoma

NCT03234595 2024-09-19

A Phase I/IIa Study of Cerebraca Wafer Plus Adjuvant Temozolomide (TMZ) in Patients With Recurrent High Grade Glioma

Phase 1/2 Completed

22 enrolled

CNS

Astrocytoma, Glioblastoma, Glioma

NCT01081223 2023-06-01

Phase I/II Study To Test The Safety and Efficacy of TVI-Brain-1 As A Treatment For Recurrent Grade IV Glioma

Phase 1/2 Completed

12 enrolled 11 charts

CNS

Astrocytoma, Brain Diseases, Brain Neoplasms, Central Nervous System Diseases, Glioblastoma, Glioma, Neoplasms, Nervous System Diseases, Nervous System Neoplasms, Central Nervous System Neoplasms

NCT03649464 2022-10-07

Investigation of Oral OKN-007 in Recurrent High-grade Glioma Participants

Phase 1/2 Withdrawn

CNS

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma

NCT00024570 2014-11-14

Interstitial Infusion of IL13-PE38QQR Cytotoxin in Recurrent Malignant Glioma

Phase 1/2 Completed

60 enrolled

CNS

Astrocytoma, Glioblastoma, Glioma, Recurrence

NCT00041587 2011-06-06

Pre-operative IL13-PE38QQR in Patients With Recurrent or Progressive Malignant Glioma

Phase 1/2 Completed

80 enrolled

CNS

Astrocytoma, Glioblastoma, Glioma, Neoplasms

NCT00683761 2009-07-17

A Study of 131I-TM601 in Adults With Recurrent Malignant Glioma

Phase 1/2 Unknown

64 enrolled

CNS

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma

NCT00115440 2009-01-28

BNCT to Treat Glioma That Has Progressed Following Radiotherapy

Phase 1/2 Completed

22 enrolled

CNS

Astrocytoma, Glioblastoma

NCT00028158 2005-06-24

Safety and Effectiveness Study of G207, a Tumor-Killing Virus, in Patients With Recurrent Brain Cancer

Phase 1/2 Completed

65 enrolled

CNS

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma

Clinical Trials

CERTIS1

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

A Study of Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma

A Study of Ad-RTS-hIL-12 + Veledimex in Pediatric Subjects With Brain Tumors Including DIPG

BMX-HGG

Studying the Safety, Efficacy, and Pharmacokinetic Characteristics of BNCT in Patients With Recurrent High-grade Gliomas

A Study Assessing Pamiparib With Radiation and/or Temozolomide (TMZ) in Participants With Newly Diagnosed or Recurrent Glioblastoma

A Phase I/IIa Study of Cerebraca Wafer Plus Adjuvant Temozolomide (TMZ) in Patients With Recurrent High Grade Glioma

Phase I/II Study To Test The Safety and Efficacy of TVI-Brain-1 As A Treatment For Recurrent Grade IV Glioma

Investigation of Oral OKN-007 in Recurrent High-grade Glioma Participants

Interstitial Infusion of IL13-PE38QQR Cytotoxin in Recurrent Malignant Glioma

Pre-operative IL13-PE38QQR in Patients With Recurrent or Progressive Malignant Glioma

A Study of 131I-TM601 in Adults With Recurrent Malignant Glioma

BNCT to Treat Glioma That Has Progressed Following Radiotherapy

Safety and Effectiveness Study of G207, a Tumor-Killing Virus, in Patients With Recurrent Brain Cancer