Clinical Trials

62 enrolled

Astrocytoma, Brain Neoplasms, Disease, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Ganglioglioma

NCT06665724 2026-02-27

Clinical Trial Evaluating Safety of 5-Aminolevulinic Acid (5-ALA) Combined With CV01 Delivery of Ultrasound for Sonodynamic Therapy (SDT) in Patients With Newly Diagnosed High-Grade Glioma (HGG) Prior to Resection and Standard Adjuvant Therapy (ALA SDT GLIOMA 401)

16 enrolled

Astrocytoma, Glioblastoma, Oligodendroglioma

NCT03911388 2026-02-17

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

Choroid Plexus Carcinoma, Astrocytoma, Brain Diseases, Brain Neoplasms, Central Nervous System Diseases, Cerebellar Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Neoplasm Metastasis, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Glandular and Epithelial, Neoplasms, Nerve Tissue, Nervous System Diseases, Nervous System Neoplasms, Oligodendroglioma, Virus Diseases, Central Nervous System Neoplasms, Neuroectodermal Tumors, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Gliosarcoma, Rhabdoid Tumor

NCT04197934 2026-02-12

WSD0922-FU for the Treatment of Glioblastoma, Anaplastic Astrocytoma, or Non-small Cell Lung Cancer With Central Nervous System Metastases

56 enrolled

CNSThoracic

Astrocytoma, Carcinoma, Non-Small-Cell Lung, Glioblastoma, Lung Neoplasms

NCT05236036 2026-01-14

Mycophenolate Mofetil in Combination With Standard of Care for the Treatment of Glioblastoma

60 enrolled

Astrocytoma, Glioblastoma

NCT07031765 2025-12-18

Peds CHAMP1ON

12 enrolled

Astrocytoma, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma

NCT05686798 2025-12-16

Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.

18 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma

NCT07089641 2025-11-24

ERAS801-SARG

10 enrolled

Astrocytoma

NCT02192359 2025-11-14

Carboxylesterase-Expressing Allogeneic Neural Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade Gliomas

18 enrolled 16 charts

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT07223034 2025-11-04

A Study of 177Lu-PSMA-617 in People With Gliomas

20 enrolled

Astrocytoma, Glioblastoma, Glioma

NCT05789394 2025-10-27

Allogenic Adipose-Derived Mesenchymal Stem Cells for the Treatment of Recurrent Glioblastoma or Recurrent Astrocytoma in Patients Undergoing Craniotomy

20 enrolled

Astrocytoma, Glioblastoma

NCT05341947 2025-10-22

Activated Autologous T Cells Against Glioma Cancer Stem Cell Antigens for Patients With Recurrent Glioblastoma

Phase 1 Withdrawn

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma

NCT02062827 2025-10-02

M032-HSV-1

29 enrolled 16 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Virus Diseases, Gliosarcoma

NCT06614855 2025-08-06

A Phase IB 2 Dose Trial of IRS-1 HSV C134 (IND 17296) Administered Intratumorally in Patients With Recurrent Malignant Glioma

12 enrolled

Astrocytoma, Glioblastoma, Gliosarcoma

NCT06815029 2025-06-26

Intracranial Genetically Modified Immune Cells (TGFβR2KO/IL13Rα2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant Astrocytoma

27 enrolled

Phase 1 Enrolling by invitation

Astrocytoma, Glioblastoma, Lymphoma, Follicular

NCT06896110 2025-06-26

Intrathecal Azacitidine and Nivolumab in Patients With Recurrent High-grade Glioma

34 enrolled

Astrocytoma, Glioblastoma

NCT05698524 2025-05-20

A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT02186509 2025-04-30

Alisertib and Fractionated Stereotactic Radiosurgery in Treating Patients With Recurrent High Grade Gliomas

17 enrolled 11 charts

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT00638898 2025-03-20

Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor

25 enrolled

CNSGenitourinarySarcoma

Familial ependymoma, Astrocytoma, Brain Neoplasms, Medulloblastoma, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Testicular Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Optic Nerve Glioma

NCT02722512 2025-02-18

Trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine

10 enrolled

Astrocytoma, Ependymoma, Glioblastoma

NCT02549833 2024-11-22

Neo-adjuvant Evaluation of Glioma Lysate Vaccines in WHO Grade II Glioma

28 enrolled

Astrocytoma, Glioma, Lymphoma, Follicular, Oligodendroglioma

NCT02924038 2024-06-14

A Study of Varlilumab and IMA950 Vaccine Plus Poly-ICLC in Patients With WHO Grade II Low-Grade Glioma (LGG)

14 enrolled 10 charts

Astrocytoma, Glioma, Lymphoma, Follicular, Oligodendroglioma

NCT03434262 2024-05-31

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

68 enrolled

Choroid Plexus Carcinoma, Microphthalmia, Isolated, with Coloboma 5, Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Lymphoma, Follicular, Medulloblastoma, Meningioma, Neoplasms, Neoplasms, Germ Cell and Embryonal, Oligodendroglioma, Pinealoma, Recurrence, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Rhabdoid Tumor, Pyloric Stenosis, Hypertrophic

NCT02457845 2024-01-19

HSV G207 Alone or With a Single Radiation Dose in Children With Progressive or Recurrent Supratentorial Brain Tumors

13 enrolled

Choroid Plexus Carcinoma, Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Neoplasms, Neoplasms, Germ Cell and Embryonal, Oligodendroglioma, Virus Diseases, Supratentorial Neoplasms, Neuroectodermal Tumors, Primitive, Gliosarcoma, Rhabdoid Tumor

NCT02168270 2023-11-24

Temozolomide and Ascorbic Acid in Treating Patients With Recurrent High-Grade Glioma

4 enrolled 6 charts

Astrocytoma, Glioblastoma, Oligodendroglioma, Gliosarcoma

NCT04757662 2023-06-13

Tadalafil to Overcome Immunosuppression During Chemoradiotherapy for IDH-wildtype Grade III-IV Astrocytoma

18 enrolled

Astrocytoma, Glioblastoma

NCT02238496 2023-05-25

Perifosine and Torisel (Temsirolimus) for Recurrent/Progressive Malignant Gliomas

10 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma

NCT02444546 2023-04-24

Wild-Type Reovirus in Combination With Sargramostim in Treating Younger Patients With High-Grade Relapsed or Refractory Brain Tumors

6 enrolled

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Brain Neoplasms, Glioma, Medulloblastoma, Oligodendroglioma, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT03696355 2023-01-18

Study of GDC-0084 in Pediatric Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma or Diffuse Midline Gliomas

27 enrolled

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms

NCT03355794 2023-01-13

A Study of Ribociclib and Everolimus Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG)

19 enrolled

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Glioblastoma, Glioma

NCT01808820 2022-07-20

Dendritic Cell (DC) Vaccine for Malignant Glioma and Glioblastoma

20 enrolled

Astrocytoma, Glioblastoma, Glioma

NCT02644291 2022-06-23

Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors

16 enrolled

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Glioblastoma, Glioma, Medulloblastoma, Oligodendroglioma, Brain Stem Neoplasms

NCT02423525 2022-03-10

Safety Study of Afatinib for Brain Cancer

Astrocytoma, Brain Neoplasms, Glioblastoma, Meningioma, Oligodendroglioma, Meningeal Carcinomatosis

NCT02010606 2021-11-22

Phase I Study of a Dendritic Cell Vaccine for Patients With Either Newly Diagnosed or Recurrent Glioblastoma

39 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Neoplasms

NCT02015819 2021-10-20

Genetically Modified Neural Stem Cells, Flucytosine, and Leucovorin for Treating Patients With Recurrent High-Grade Gliomas

16 enrolled 16 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Oligodendroglioma, Gliosarcoma

NCT00068510 2020-08-03

Vaccine Therapy in Treating Patients With Malignant Glioma

28 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00509431 2020-07-31

Erlotinib and Sirolimus in Treating Patients With Recurrent Malignant Glioma

19 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00498979 2020-07-24

Sodium Stibogluconate and IFNa-2b Followed By CDDP, VLB and DTIC Treating Pts.With Advanced Melanoma or Other Cancers

22 enrolled

CNSDermatologicSarcoma

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Melanoma, Oligodendroglioma, Glioma, Subependymal, Gliosarcoma

NCT01331135 2020-05-29

Aflac ST0901

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

18 enrolled

Astrocytoma, Carcinoma, Renal Cell, Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Recurrence, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma, Sarcoma, Clear Cell, Rhabdoid Tumor

NCT02529072 2020-03-26

AVERT

6 enrolled 11 charts

Astrocytoma, Glioblastoma, Glioma

NCT00007813 2020-02-17

Peripheral Stem Cell Transplantation Plus Chemotherapy in Treating Patients With Malignant Solid Tumors

CNSGastrointestinalGenitourinaryGynecologicSarcoma

21 enrolled

Familial ependymoma, Ovarian Germ Cell Cancer, Testicular Germ Cell Tumor, Astrocytoma, Liver Neoplasms, Medulloblastoma, Neuroblastoma, Oligodendroglioma, Ovarian Neoplasms, Sarcoma, Teratoma, Testicular Neoplasms, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Hepatoblastoma, Neuroectodermal Tumors, Primitive, Peripheral, Rhabdoid Tumor, Optic Nerve Glioma

NCT00390299 2020-01-02

Viral Therapy in Treating Patients With Recurrent Glioblastoma Multiforme

23 enrolled 15 charts

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma

NCT01392209 2019-11-22

Hypofractionated Stereotactic Radiotherapy With Bevacizumab in the Treatment of Recurrent Malignant Glioma

15 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma

NCT01654497 2019-11-14

Dexanabinol in Patients With Brain Cancer

26 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Meningioma, Neoplasm Metastasis, Neoplasms, Oligodendroglioma

NCT01480050 2019-05-22

Mibefradil Dihydrochloride and Temozolomide in Treating Patients With Recurrent Glioma

28 enrolled

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms

NCT00002824 2019-03-13

Gene Therapy in Treating Patients With Primary Brain Tumors

Astrocytoma, Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT01682746 2019-02-25

Photodynamic Therapy (PDT) for Recurrent Pediatric Brain Tumors

5 enrolled

CNSEndocrineSarcoma

Astrocytoma, Brain Neoplasms, Chordoma, Craniopharyngioma, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Neoplasms, Germ Cell and Embryonal, Oligodendroglioma, Pituitary Neoplasms, Germinoma, Neuroectodermal Tumors, Primitive, Glioma, Subependymal, Optic Nerve Glioma

NCT00671801 2018-11-13

Irinotecan Plus Lenalidomide in Adult Patients With Recurrent Glioblastoma Multiforme: Phase I

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT01967758 2018-08-17

Phase I Study of Safety and Immunogenicity of ADU-623

11 enrolled