Clinical Trials

64 enrolled

Phase 2/3 Not yet recruiting

Biliary Tract Neoplasms, Carcinoma, Hepatocellular

NCT07437287 2026-02-27

CROCOBIL

160 enrolled

Biliary Tract Neoplasms

NCT04907643 2026-02-20

Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes

EndocrineGastrointestinalNET

360 enrolled

Cancer Pain, Anus Neoplasms, Appendiceal Neoplasms, Bile Duct Neoplasms, Biliary Tract Neoplasms, Carcinoid Tumor, Colonic Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Gastrointestinal Neoplasms, Liver Neoplasms, Neoplasm Metastasis, Pancreatic Neoplasms, Rectal Neoplasms, Recurrence, Stomach Neoplasms, Neuroendocrine Tumors, Visceral Pain

NCT07146646 2026-02-19

Trifluridine/Tipiracil + Oxaliplatin in Participants With Advanced or Metastatic Biliary Tract Cancer

27 enrolled

Biliary Tract Neoplasms, Gallbladder Neoplasms, Cholangiocarcinoma

NCT03785873 2026-02-13

Phase Ib/II Trial of Nal-Irinotecan and Nivolumab as Second-Line Treatment in Patients With Advanced Biliary Tract Cancer

Phase 1/2 Completed

34 enrolled 13 charts

Phase 1 Not yet recruiting

Biliary Tract Neoplasms

NCT07107750 2026-02-04

Emavusertib (CA-4948) in Combination With Cisplatin, Gemcitabine, and Durvalumab in Patients With Untreated Advanced or Metastatic Biliary Tract Cancer

48 enrolled

Phase 2 Active not recruiting

Biliary Tract Neoplasms

NCT04005339 2026-01-26

NAPOLI-2: Fluorouracil, Leucovorin, and Nanoliposomal Irinotecan in Biliary Cancer

48 enrolled

Phase 2 Active not recruiting

Biliary Tract Neoplasms, Gastrointestinal Neoplasms

NCT05170438 2026-01-20

LenPac

51 enrolled

Biliary Tract Neoplasms

NCT06548412 2026-01-20

CTX-009 With Gemcitabine, Cisplatin, and Durvalumab as First-line Therapy in Patients With Unresectable or Metastatic Biliary Tract Cancers

Phase 1/2 Recruiting

50 enrolled

Biliary Tract Neoplasms

NCT07235007 2026-01-13

BRAVE

120 enrolled

Biliary Tract Neoplasms, Cholangiocarcinoma

NCT04203160 2025-12-31

Gemcitabine and Cisplatin With or Without CPI-613 as First Line Therapy for Patients With Advanced Unresectable Biliary Tract Cancer (BilT-04)

Phase 1/2 Terminated

75 enrolled 17 charts

Biliary Tract Neoplasms, Gallbladder Neoplasms, Cholangiocarcinoma

NCT06065371 2025-12-19

Sacituzumab Govitecan in Combination With Capecitabine for Advanced Gastrointestinal Cancers After Progression on Standard Therapy

Phase 1 Recruiting

20 enrolled

Phase 1 Active not recruiting

Biliary Tract Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms

NCT05220046 2025-12-17

Palliadelic Treatment to Reduce Psychological Distress in Persons With Advanced Gastrointestinal Cancers

24 enrolled

Biliary Tract Neoplasms, Gastrointestinal Neoplasms, Pancreatic Neoplasms

NCT07282262 2025-12-15

An Exploratory Study on the Use of Ivosidenib for the Precise Treatment of Advanced Biliary Tract Malignancies With IDH1 Mutations in the Later Line of Therapy.

300 enrolled

Biliary Tract Neoplasms

NCT06546969 2025-12-10

Chemoimmunotherapy Combined With Hyperthermia and Spatially-Fractionated Radiotherapy in Advanced Biliary Tract Cancer

Phase 1 Recruiting

15 enrolled

Phase 1/2 Not yet recruiting

Biliary Tract Neoplasms, Cholangiocarcinoma

NCT07269158 2025-12-08

A Phase IIb Randomized Clinical Trial of Immune Checkpoint Inhibitor-based Maintenance Therapy in Patients With Advanced Biliary Tract Cancer

160 enrolled

Biliary Tract Neoplasms, Gallbladder Neoplasms, Cholangiocarcinoma

NCT07267078 2025-12-05

Tuvonralimab and Iparomlimab Based Regimens for the Neoadjuvant Treatment of Biliary Tract Cancer

45 enrolled

Biliary Tract Neoplasms

NCT06001658 2025-12-03

Perioperative Gemcitabine, Cisplatin, and Pembrolizumab in Potentially Resectable Biliary Tract Cancers

27 enrolled

GastrointestinalGenitourinaryHead & Neck

Biliary Tract Neoplasms, Carcinoma

NCT04779151 2025-12-01

NIRADO

Phase 2 Terminated

51 enrolled

Biliary Tract Neoplasms, Carcinoma, Renal Cell, Head and Neck Neoplasms

NCT06529718 2025-11-17

SEVILLA

72 enrolled

Biliary Tract Neoplasms, Cholangiocarcinoma

NCT03044587 2025-10-01

NIFE

Phase 2 Completed

93 enrolled

Bile Duct Neoplasms, Biliary Tract Neoplasms, Cholangiocarcinoma

NCT06731998 2025-09-18

LapTAP

48 enrolled

Agnosia, Biliary Tract Neoplasms, Gastrointestinal Neoplasms, Liver Neoplasms, Neoplasms, Colorectal Neoplasms

NCT05429203 2025-09-15

Comparison of Duodenoscope With Single-use Distal Cover and the Conventional Reusable Duodenoscope

Phase NA Completed

319 enrolled 21 charts

Phase NA Not yet recruiting

Biliary Tract Neoplasms, Gallbladder Diseases, Pancreatic Diseases, Pancreatic Neoplasms, Choledocholithiasis

NCT07169916 2025-09-12

YJ-BTC

210 enrolled

Biliary Tract Neoplasms

NCT07159204 2025-09-08

PILOT-BTC

100 enrolled

Biliary Tract Neoplasms

NCT07159217 2025-09-08

Disitamab Vedotin Plus Lenvatinib and PD-1 Inhibitors for Treating HER2-positive Advanced Biliary Tract Cancer

65 enrolled

Biliary Tract Neoplasms

NCT07160283 2025-09-08

The Efficacy and Safety of Trilaciclib in Bone Marrow Protection Before Chemotherapy for Advanced Bile Duct Cancer and Pancreatic Cancer

96 enrolled

Biliary Tract Neoplasms, Pancreatic Neoplasms

NCT07156058 2025-09-04

MiniPDX-based Postoperative Adjuvant Therapy for Biliary Tract Cancer

204 enrolled

BreastGastrointestinalSarcomaThoracic

Biliary Tract Neoplasms

NCT06084689 2025-09-02

EMPIRE

Phase 2 Withdrawn

Tertiary Lymphoid Structures, Biliary Tract Neoplasms, Carcinoma, Non-Small-Cell Lung, Sarcoma, Colorectal Neoplasms, Triple Negative Breast Neoplasms

NCT06178445 2025-08-19

TRAP-BTC

24 enrolled

Biliary Tract Neoplasms, Gallbladder Neoplasms, Cholangiocarcinoma

NCT07129018 2025-08-19

Trastuzumab Rezetecan Combined With Pertuzumab and Iparomlimab and Tuvonralimab for Biliary Tract Cancer

63 enrolled

Biliary Tract Neoplasms

NCT04057365 2025-08-13

Study of the Combination of DKN-01 and Nivolumab in Previously Treated Patients With Advanced Biliary Tract Cancer (BTC)

Phase 2 Terminated

15 enrolled 8 charts

Biliary Tract Neoplasms

NCT07109167 2025-08-07

The Safety and Efficacy of Benmelstobart Injection in Patients With Advanced Biliary Tract Malignant Tumors

30 enrolled

Biliary Tract Neoplasms

NCT06375967 2025-07-29

CARPEGIEM

128 enrolled

Biliary Tract Neoplasms

NCT06653192 2025-07-29

EUS-guided Choledochoduodenostomy vs ERCP as First Line in Malignant Distal Obstruction (CARPEDIEM Trial)

120 enrolled

Biliary Tract Neoplasms, Pancreatic Neoplasms

NCT07062263 2025-07-14

TAB-2

Phase 3 Recruiting

220 enrolled

Biliary Tract Neoplasms

NCT05451043 2025-06-26

Durvalumab and Tremelimumab in Combination With Propranolol and Chemotherapy for Treatment of Advanced Hepatopancreabiliary Tumors (BLOCKED)

62 enrolled

Biliary Tract Neoplasms, Liver Neoplasms, Pancreatic Neoplasms, Cholangiocarcinoma

NCT07030140 2025-06-22

Phase II Study of Neoadjuvant Tislelizumab Plus Radiotherapy and GP Chemotherapy for Borderline/Unresectable Hilar Cholangiocarcinoma

38 enrolled

Bile Duct Neoplasms, Biliary Tract Neoplasms, Cholangiocarcinoma, Klatskin Tumor

NCT07025174 2025-06-17

SAIB

60 enrolled

Bile Duct Neoplasms, Biliary Tract Neoplasms, Gallbladder Neoplasms, Cholangiocarcinoma

NCT07003815 2025-06-04

Envafolimab With Chemotherapy and Simvastatin in Advanced Biliary Tract Cancer

62 enrolled

Biliary Tract Neoplasms

NCT03639935 2025-06-03

Rucaparib in Combination With Nivolumab in Patients With Advanced or Metastatic Biliary Tract Cancer Following Platinum Therapy

Phase 2 Completed

32 enrolled 14 charts

Phase 2 Active not recruiting

Biliary Tract Neoplasms, Neoplasm Metastasis

NCT06638931 2025-05-28

ANTARES

28 enrolled

BreastCNSEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckNETOther solid neoplasmSarcomaThoracic

Urachal adenocarcinoma, Urachal cancer, Fibrolamellar hepatocellular carcinoma, Secretory breast carcinoma, Carcinoma, Ovarian Epithelial, Adrenal Gland Neoplasms, Anus Neoplasms, Biliary Tract Neoplasms, Carcinosarcoma, Carcinoma, Adenoid Cystic, Fallopian Tube Neoplasms, Fibrosarcoma, Gallbladder Neoplasms, Granulosa Cell Tumor, Hemangiosarcoma, Leiomyosarcoma, Mesothelioma, Neuroblastoma, Parathyroid Neoplasms, Penile Neoplasms, Sarcoma, Sarcoma, Kaposi, Osteosarcoma, Thyroid Neoplasms, Trophoblastic Neoplasms, Urethral Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Hepatoblastoma, Endodermal Sinus Tumor, Neuroectodermal Tumors, Primitive, Cholangiocarcinoma, Sertoli-Leydig Cell Tumor, Neurofibrosarcoma, Hemangioblastoma, Neuroendocrine Tumors

NCT06993025 2025-05-28

Ivonescimab in Combination With Liposomal Irinotecan and 5-FU/LV in Potentially Resectable Biliary Tract Malignancies

30 enrolled

Biliary Tract Neoplasms

NCT06960733 2025-05-07

Comparison Between Winged Versus Traditional Plastic Stents for Biliary Drainage

Phase NA Completed

21 enrolled

Biliary Tract Neoplasms, Cholecystolithiasis

NCT00359320 2025-05-02

A Randomized Trial of Two Surgical Techniques for Pancreaticojejunostomy in Patients Undergoing Pancreaticoduodenectomy

Phase NA Terminated

54 enrolled

Biliary Tract Neoplasms, Duodenal Neoplasms, Pancreatic Neoplasms, Pancreatitis, Chronic

NCT05239169 2025-05-01

Immunotherapy With Durva and Treme With or Without Capecitabine in Adjuvant Treatment for Biliary Tract Cancer

Phase 2 Completed

40 enrolled

Biliary Tract Neoplasms, Gallbladder Neoplasms, Cholangiocarcinoma, Klatskin Tumor

NCT05615818 2025-04-23

SAFIR-ABC10

Phase 3 Recruiting

800 enrolled

Phase EARLY_PHASE1 Recruiting

Biliary Tract Neoplasms

NCT06937567 2025-04-22

CDH17 CAR-T Therapy in Advanced Malignant Solid Tumors

18 enrolled

Biliary Tract Neoplasms, Neoplasm Metastasis, Stomach Neoplasms, Colorectal Neoplasms

NCT06214572 2025-04-11

RUGB

Phase 2/3 Recruiting

249 enrolled