Clinical Trials

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT04044937 2026-03-11

UC-GlioFET

143 enrolled

Brain Neoplasms, Glioblastoma

NCT06914479 2026-03-11

Virus-Based Gene Therapy (AdV-HSV1-TK and AdV-Flt3L) in Combination With Valacyclovir for the Treatment of Pediatric and Young Adult Patients With Resectable, Recurrent Primary Malignant Brain Tumors

11 enrolled

Brain Neoplasms

NCT06315296 2026-03-03

An Interactive Time-Restricted Diet Intervention (txt4fasting) for Reducing Neurocognitive Decline and Improving Survival in Patients With Brain Metastases From Breast or Lung Cancer

Phase NA Terminated

1 enrolled

BreastCNSThoracic

Brain Neoplasms, Breast Neoplasms, Lung Neoplasms

NCT06322602 2026-03-03

Ommaya Reservoir Placement at the Time of Biopsy for Longitudinal Biomarker Collection in Patients With Brain Tumors

20 enrolled

Brain Neoplasms

NCT03270059 2026-02-27

Gadolinium and Ferumoxytol MRI in Diagnosing Patients With Abnormalities in the Central Nervous System

Phase 2 Recruiting

150 enrolled

Brain Neoplasms, Cranial Nerve Diseases, Central Nervous System Neoplasms

NCT05376878 2026-02-23

An Investigational Scan (64Cu-DOTA-Trastuzumab PET/MRI) in Imaging Patients With HER2+ Breast Cancer With Brain Metastasis

Phase 4 Recruiting

Phase NA Not yet recruiting

BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT07278440 2026-02-13

An Exercise Intervention for Improving Mental and Physical Health in Patients With Primary Brain Tumors and Their Caregivers, ET-NEURO Trial

36 enrolled

Brain Neoplasms

NCT04047264 2026-02-12

Feasibility of Intraoperative Microdialysis During Neurosurgery for Central Nervous System Malignancies

100 enrolled

Brain Neoplasms, Glioblastoma, Glioma

NCT06132685 2026-02-10

Post-Operative Dosing of Dexamethasone in Patients With Brain Tumors After a Craniotomy, PODS Trial

Phase 2 Recruiting

200 enrolled

Phase 1 Active not recruiting

Brain Neoplasms, Meningioma

NCT04459273 2026-02-05

FAPI PET RDRC

26 enrolled

CNSDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckNETOther hematologic neoplasm

Adrenal Gland Neoplasms, Urinary Bladder Neoplasms, Brain Neoplasms, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Carcinoma, Hepatocellular, Neoplasms, Unknown Primary, Skin Neoplasms, Testicular Neoplasms, Thymus Neoplasms, Thyroid Neoplasms, Cholangiocarcinoma, Neuroendocrine Tumors, Hematologic Neoplasms

NCT06650163 2026-02-05

Zr-89 Crefmirlimab Berdoxam and Immuno-Positron Emission Tomography for the Imaging of Patients With Resectable Brain Tumors

20 enrolled

Brain Neoplasms, Glioma, Meningioma

NCT07339085 2026-01-15

Advanced Magnetic Resonance Imaging for the Identification of Recurrent Brain Tumors and Radiation Necrosis

42 enrolled

BreastCNSDermatologicGenitourinaryThoracic

Brain Neoplasms

NCT06500455 2026-01-14

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

Phase 3 Recruiting

269 enrolled

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Lung Neoplasms, Melanoma, Neoplasm Metastasis

NCT03830151 2026-01-13

Hyperpolarized Carbon C 13 Pyruvate in Diagnosing Glioma in Patients With Brain Tumors

13 enrolled

Brain Neoplasms

NCT06788886 2025-12-30

Breathing Practice for Brain and Mental Health in Cancer and Neurodegenerative Diseases

CNSEndocrineGenitourinaryNET

147 enrolled

Brain Neoplasms, Multiple Sclerosis, Prostatic Neoplasms, Neuroendocrine Tumors

NCT03750227 2025-12-24

Pre-Operative or Post-Operative Stereotactic Radiosurgery in Treating Patients With Operative Metastatic Brain Tumors

Phase 3 Recruiting

140 enrolled

Brain Neoplasms

NCT05904704 2025-11-14

Oxygen-Enhanced MRI for Generating Hypoxia Maps in Patients With Intracranial Tumors

Phase NA Withdrawn

Brain Neoplasms

NCT00870129 2025-10-10

Magnetic Resonance (MR) Imaging to Determine High Risk Areas in Patients With Malignant Gliomas and to Design Potential Radiation Plans and to Examine Metabolite Changes in Gliomas and Other Solid Tumors

135 enrolled

Phase EARLY_PHASE1 Recruiting

Brain Neoplasms, Glioma

NCT06328686 2025-09-17

Arginine and Whole Brain Radiation Therapy for the Treatment of Patients With Brain Metastases

Brain Neoplasms, Neoplasm Metastasis

NCT05388877 2025-08-19

E6201 and Dabrafenib for the Treatment of Central Nervous System Metastases From BRAF V600 Mutated Metastatic Melanoma

Phase 1 Terminated

13 enrolled

CNSDermatologic

Brain Neoplasms, Melanoma

NCT07118176 2025-08-12

Determining the Biodistribution of an Imaging Tracer (68Ga-FAPi-46) in Patients With Solid Tumors or Hematologic Cancers

BreastCNSEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckNETSarcomaThoracic

30 enrolled

Adrenal Gland Neoplasms, Anus Neoplasms, Urinary Bladder Neoplasms, Brain Neoplasms, Breast Neoplasms, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Carcinoma, Hepatocellular, Lung Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Penile Neoplasms, Prostatic Neoplasms, Salivary Gland Neoplasms, Sarcoma, Stomach Neoplasms, Testicular Neoplasms, Thyroid Neoplasms, Uterine Neoplasms, Vaginal Neoplasms, Colorectal Neoplasms, Carcinoma, Medullary, Cholangiocarcinoma, Neuroendocrine Tumors, Solitary Fibrous Tumors

NCT04588246 2025-06-06

Comparing Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in Patients With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery

Phase 3 Terminated

19 enrolled 19 charts

BreastCNSDermatologicGastrointestinalGenitourinaryThoracic

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Gastrointestinal Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Small Cell Lung Carcinoma

NCT05840770 2025-05-26

Cemiplimab for the Treatment of Untreated Brain Metastases From PD-L1 >= 50% Non-Small Cell Lung Cancer

Phase 2 Withdrawn

Phase EARLY_PHASE1 Completed

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT02020720 2025-01-23

18F-DOPA-PET in Planning Surgery in Patients With Gliomas

72 enrolled

Phase EARLY_PHASE1 Recruiting

Brain Neoplasms, Glioma

NCT05996432 2024-09-23

Image-Based, In-Vivo Assessment of Tumor Hypoxia to Guide Hypoxia-Driven Adaptive Radiation Therapy

48 enrolled

CNSHead & Neck

Squamous Cell Carcinoma of Head and Neck, Brain Neoplasms

NCT03539731 2024-08-12

[18F]DASA-23 and PET Scan in Evaluating Pyruvate Kinase M2 Expression in Patients With Intracranial Tumors or Recurrent Glioblastoma and Healthy Volunteers

Phase 1 Terminated

27 enrolled

Phase NA Not yet recruiting

Brain Neoplasms, Glioblastoma

NCT06466031 2024-07-30

Application of MET-PET in Fusion With MRI in the Treatment of Glioblastoma Multiforme

189 enrolled

Phase EARLY_PHASE1 Completed

Brain Neoplasms, Glioblastoma

NCT04752267 2024-05-24

18F-FMAU PET/CT and MRI for the Detection of Brain Tumors in Patients With Brain Cancer or Brain Metastases

BreastCNSDermatologicGastrointestinalGenitourinaryThoracic

Brain Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Colonic Neoplasms, Glioma, Lung Neoplasms, Melanoma

NCT05054998 2024-05-01

Dual Time Point FDG PET/MRI Scan in Improving the Imaging Cancer Patients With Brain Metastases

Phase 4 Completed

12 enrolled

Brain Neoplasms, Neoplasm Metastasis

NCT05977803 2024-04-09

ACROP

60 enrolled

Brain Neoplasms, Lung Neoplasms, Neoplasm Metastasis

NCT06137651 2024-04-01

Trotabresib in Combination With Vinorelbine and Radiation Therapy for the Treatment of HER2+ Breast Cancer With Central Nervous System or Leptomeningeal Metastasis

Phase 1 Withdrawn

BreastCNS

Brain Neoplasms, Breast Neoplasms, Meningeal Carcinomatosis

NCT06257498 2024-02-14

Heads-Up

9 enrolled

Brain Neoplasms

NCT02073968 2024-01-25

PAINT

35 enrolled 13 charts

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT03680144 2024-01-11

Utility of Perfusion MRI to Detect Radiation Necrosis in Patients With Brain Metastases

8 enrolled

Brain Neoplasms

NCT04132843 2022-11-21

Novel MRI Techniques for the Characterization and Treatment Assessment of High Grade Brain Lesions

6 enrolled

CNSLymphoid

Brain Neoplasms, Lymphoma

NCT00597246 2020-12-17

Imaging Brain Tumors With FACBC and Methionine

30 enrolled 7 charts

Brain Neoplasms, Central Nervous System Neoplasms

NCT01674582 2020-09-03

Treatment Effects Inclusive Cognitive Impact and Possibilities to Individually Adjusted Treatment in Patients With Intracranial Tumors With Clinical, Neuropsychological and Imaging Parameters

150 enrolled

Brain Neoplasms, Glioma

NCT01228448 2020-08-18

In-Room PET in Proton Radiation Therapy

59 enrolled

CNSHead & Neck

Brain Neoplasms, Head and Neck Neoplasms, Skull Base Neoplasms

NCT02167204 2020-01-13

18F-FLT PET/CT in Measuring Cell Proliferation in Patients With Brain Tumors

9 enrolled 9 charts

Brain Neoplasms

NCT02120287 2019-05-07

Border Zone Stereotactic Radiosurgery With Bevacizumab in Patients With Glioblastoma Multiforme

16 enrolled 20 charts

Brain Neoplasms, Glioblastoma

NCT00276770 2019-02-27

Positron Emission Tomography Using Fluorothymidine F 18 in Finding Recurrent Disease in Patients With Gliomas

12 enrolled

CNSSarcoma

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT02796729 2019-01-28

CEST- Glucose Enhanced MRI for Metastatic Brain Tumours

Phase 2 Terminated

3 enrolled

Brain Neoplasms, Neoplasm Metastasis

NCT01342757 2018-01-29

Magnetic Resonance Spectroscopy Imaging in Predicting Response to Vorinostat and Temozolomide in Patients With Recurrent or Progressive Glioblastoma

12 enrolled 8 charts

Phase EARLY_PHASE1 Completed

Brain Neoplasms, Depression, Glioblastoma

NCT02452216 2017-08-31

Using Ferumoxytol-Enhanced MRI to Measure Inflammation in Patients With Brain Tumors or Other Conditions of the CNS

Ischemic Stroke, Hemorrhagic Stroke, Brain Injuries, Brain Neoplasms, Central Nervous System Infections, Neurodegenerative Diseases, Central Nervous System Vascular Malformations

NCT02194452 2017-04-28

Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors

Phase NA Withdrawn

CNSSarcoma

Familial ependymoma, Astrocytoma, Brain Neoplasms, Craniopharyngioma, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Neuroma, Acoustic, Oligodendroglioma, Pinealoma, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Glioma, Subependymal, Gliosarcoma, Optic Nerve Glioma

NCT02241668 2016-02-26

Fluoro-L-Thymidine Positron Emission Tomography (FLT PET) vs. Adv. Magnetic Resonance (MR) Techniques in Recurrent Glioma

Phase NA Withdrawn

CNSGastrointestinalHead & NeckLymphoidThoracic

Brain Neoplasms

NCT00123760 2016-02-25

Study of 18F-Fluorodeoxyglucose (FluGlucoScan) in Patients With Cancer or Suspected Cancer

Phase 2/3 Completed

10,838 enrolled

Brain Neoplasms, Lung Neoplasms, Lymphoma, Thyroid Neoplasms, Colorectal Neoplasms

NCT00492089 2014-05-09

Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer