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Recent Start date Enrollment

Interventional × Brain Neoplasms × defactinib × Clear all

Phase

Status

Sponsor Class

Study Type

Interventional 1

Sponsor

Cancer Type

Dermatologic 1 CNS 1

Conditions

Pancreatic Neoplasms 7 Ovarian Neoplasms 4 Mesothelioma, Malignant 4 Carcinoma, Non-Small-Cell Lung 3 Neoplasms 2 Mesothelioma 2 Lung Neoplasms 2 Glioblastoma 2 Uterine Cervical Neoplasms 1 Thyroid Neoplasms 1 Phase IB 1 Neoplasms, Mesothelial 1 Neoplasm Metastasis 1 Myelodysplastic Syndromes 1 Melanoma 1 Low-Grade Serous Ovarian Cancer 1 Low Grade Serous Ovarian Cancer 1 Leukemia, Myelomonocytic, Chronic 1 Leukemia, Myeloid, Acute 1 Carcinoma, Ovarian Epithelial 1 Carcinoma, Endometrioid 1 Brain Neoplasms 1 Advanced Colorectal Cancer 1 Adenoma 1 Adenocarcinoma of Lung 1

Interventions

Temozolomide 133 Radiosurgery 101 Radiotherapy 83 Bevacizumab 83 Magnetic Resonance Spectroscopy 56 Carboplatin 44 Etoposide 31 pembrolizumab 30 Irinotecan 28 Cyclophosphamide 28 Surgical Procedures, Operative 27 Nivolumab 27 Erlotinib Hydrochloride 26 Radiation 24 Carmustine 24 Lomustine 21 Filgrastim 21 Cisplatin 20 Trastuzumab 19 Ipilimumab 19 Aminolevulinic Acid 18 Vincristine 17 Capecitabine 17 Specimen Handling 16 Pemetrexed 16 Mental Status and Dementia Tests 16 Topotecan 15 Lapatinib 13 Imatinib Mesylate 13 Granulocyte Colony-Stimulating Factor 13

Date Range

30 days 90 days 1 year All

Options

Has results Has announcements

NCT06194929 2025-12-03

DETERMINE

University of Utah

Phase 1/2 Recruiting

CNSDermatologic

Brain Neoplasms, Melanoma

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