Clinical Trials

Brain Neoplasms, Glioblastoma, Glioma

NCT06914479 2026-03-11

Virus-Based Gene Therapy (AdV-HSV1-TK and AdV-Flt3L) in Combination With Valacyclovir for the Treatment of Pediatric and Young Adult Patients With Resectable, Recurrent Primary Malignant Brain Tumors

11 enrolled

Brain Neoplasms

NCT07063693 2026-03-10

ABY-029 Glioma Trial

33 enrolled

Brain Neoplasms

NCT02389309 2026-03-09

Dasatinib, Temsirolimus, and Cyclophosphamide in Treating Patients With Advanced, Recurrent, or Refractory Solid Tumors

14 enrolled

Brain Neoplasms

NCT02858869 2026-03-09

Pembrolizumab and Stereotactic Radiosurgery for Melanoma or Non-Small Cell Lung Cancer Brain Metastases

25 enrolled 14 charts

CNSDermatologicThoracic

Uveal Melanoma, Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma

NCT04573140 2026-03-09

PNOC020

28 enrolled

CNSLymphoid

Brain Neoplasms, Glioblastoma, Glioma, Lymphoma, Follicular

NCT05353530 2026-03-09

IMPACT

39 enrolled

Brain Neoplasms, Glioblastoma

NCT06254326 2026-03-09

ADAGiO

12 enrolled

Brain Neoplasms, Oligodendroglioma

NCT06389591 2026-03-09

RNA-Lipid Particle (RNA-LP) Vaccines for Recurrent Adult Glioblastoma (GBM)

24 enrolled

Brain Neoplasms, Glioblastoma

NCT02303678 2026-03-06

D2C7 for Adult Patients With Recurrent Malignant Glioma

81 enrolled

Phase 1 Not yet recruiting

Brain Neoplasms, Glioma

NCT07454668 2026-03-06

Trastuzumab Deruxtecan + Stereotactic Radiosurgery (SRS) in HER2+ Breast Cancer Brain Metastases

20 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms, Neoplasm Metastasis, Neoplasms

NCT04510051 2026-03-05

CAR T Cells After Lymphodepletion for the Treatment of IL13Rα2 Positive Recurrent or Refractory Brain Tumors in Children

Brain Neoplasms

NCT03152318 2026-03-04

rQNestin

62 enrolled

Astrocytoma, Brain Neoplasms, Disease, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Ganglioglioma

NCT05538130 2026-03-04

A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors

CNSDermatologicHead & NeckThoracic

124 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Glioma, Melanoma, Neoplasms, Thyroid Neoplasms

NCT03719768 2026-03-02

Avelumab With Radiotherapy in Patients With Leptomeningeal Disease

16 enrolled

Brain Neoplasms, Meningeal Neoplasms, Meningeal Carcinomatosis

NCT05413304 2026-02-27

Abemaciclib Neuropharmacokinetics of Diffuse Midline Glioma Using Intratumoral Microdialysis

1 enrolled

Brain Neoplasms, Glioma

NCT06104488 2026-02-25

A Study of Avutometinib for People With Solid Tumor Cancers

23 enrolled

Brain Neoplasms, Neoplasms, Neuroblastoma, Central Nervous System Neoplasms, Neurofibroma, Plexiform

NCT02669173 2026-02-23

Capecitabine + Bevacizumab in Patients With Recurrent Glioblastoma

12 enrolled

Brain Neoplasms, Glioblastoma, Recurrence

NCT03911388 2026-02-17

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

24 enrolled

CNSSarcoma

Choroid Plexus Carcinoma, Astrocytoma, Brain Diseases, Brain Neoplasms, Central Nervous System Diseases, Cerebellar Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Neoplasm Metastasis, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Glandular and Epithelial, Neoplasms, Nerve Tissue, Nervous System Diseases, Nervous System Neoplasms, Oligodendroglioma, Virus Diseases, Central Nervous System Neoplasms, Neuroectodermal Tumors, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Gliosarcoma, Rhabdoid Tumor

NCT04689048 2026-02-17

Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radiosurgery

20 enrolled

Brain Neoplasms

NCT02909777 2026-02-11

Trial of CUDC-907 in Children and Young Adults With Relapsed or Refractory Solid Tumors, CNS Tumors, or Lymphoma

26 enrolled

CNSLymphoid

Brain Neoplasms, Lymphoma, Neuroblastoma

NCT04459273 2026-02-05

FAPI PET RDRC

CNSDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckNETOther hematologic neoplasm

26 enrolled

Adrenal Gland Neoplasms, Urinary Bladder Neoplasms, Brain Neoplasms, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Carcinoma, Hepatocellular, Neoplasms, Unknown Primary, Skin Neoplasms, Testicular Neoplasms, Thymus Neoplasms, Thyroid Neoplasms, Cholangiocarcinoma, Neuroendocrine Tumors, Hematologic Neoplasms

NCT06650163 2026-02-05

Zr-89 Crefmirlimab Berdoxam and Immuno-Positron Emission Tomography for the Imaging of Patients With Resectable Brain Tumors

20 enrolled

Phase 1 Not yet recruiting

Brain Neoplasms, Glioma, Meningioma

NCT07390539 2026-02-05

B7-H3.CD28Z.CART in CNS Neoplasms

70 enrolled

Brain Neoplasms, Ependymoma, Medulloblastoma, Meningeal Neoplasms, Pinealoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT06253871 2026-02-03

A Phase 1/1b Study of IAM1363 in HER2 Cancers

BreastCNSGastrointestinalThoracic

243 enrolled

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Neoplasms, Stomach Neoplasms

NCT03324360 2026-01-29

Role of Hyperpolarized 13C-Pyruvate MR Spectroscopy in Patients With Intracranial Metastasis Treated With (SRS)

276 enrolled

Brain Neoplasms

NCT05762419 2026-01-28

FUS Etoposide for DMG

10 enrolled

Diffuse Intrinsic Pontine Glioma, Brain Diseases, Brain Neoplasms, Glioma, Nervous System Neoplasms, Central Nervous System Neoplasms

NCT07087002 2026-01-27

GPC2-CAR T Cell Therapy for Relapsed or Refractory Medulloblastoma in Children and Young Adults

Brain Neoplasms, Medulloblastoma, Pinealoma, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT03262636 2026-01-23

TumorGlow(TM)

363 enrolled

Brain Neoplasms

NCT06193174 2026-01-22

Re-Administration of C134 in Patients With Recurrent GBM (C134-HSV-1)

Phase 1 Terminated

1 enrolled

Brain Neoplasms, Glioma, Recurrence

NCT06458712 2026-01-16

Study to Assess Safety, Tolerability and Activity of DSB2455 in Participants With Advanced Malignancies

90 enrolled

Kenny-Caffey syndrome, Type 1, Brain Neoplasms

NCT03830151 2026-01-13

Hyperpolarized Carbon C 13 Pyruvate in Diagnosing Glioma in Patients With Brain Tumors

13 enrolled

Brain Neoplasms

NCT05106296 2026-01-09

Chemo-immunotherapy Using Ibrutinib Plus Indoximod for Patients With Pediatric Brain Cancer

37 enrolled

Phase 1 Not yet recruiting

Brain Neoplasms, Ependymoma, Glioblastoma, Medulloblastoma, Neuroectodermal Tumors, Primitive

NCT07331064 2026-01-09

GABRIEL

15 enrolled

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Glioma, Recurrence, Rhabdoid Tumor

NCT03465618 2026-01-07

A First in Human Study Using 89Zr-cRGDY Ultrasmall Silica Particle Tracers for Malignant Brain Tumors

17 enrolled

CNSEndocrine

Brain Neoplasms, Pituitary Neoplasms

NCT02709226 2025-12-31

Dose Escalation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma

17 enrolled

CNSSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT05553522 2025-12-31

Tucatinib, Trastuzumab, and Capecitabine With SRS for Brain Metastases From HER-2 Positive Breast Cancer

Phase 1 Terminated

1 enrolled

Brain Neoplasms

NCT03423628 2025-12-22

A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer

180 enrolled

Brain Neoplasms, Glioblastoma, Inhibition, Psychological, Meningeal Neoplasms, Hereditary Sensory and Autonomic Neuropathies

NCT03638167 2025-12-17

EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors

11 enrolled

Choroid Plexus Carcinoma, Brain Neoplasms, Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Pinealoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT05686798 2025-12-16

Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma

NCT04185038 2025-12-15

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

90 enrolled

Choroid Plexus Carcinoma, Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Pinealoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT03807765 2025-12-04

Stereotactic Radiation and Nivolumab in the Management of Metastatic Breast Cancer Brain Metastases

14 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT04250545 2025-11-25

Testing of the Anti Cancer Drugs CB-839 HCl (Telaglenastat) and MLN0128 (Sapanisertib) in Advanced Stage Non-small Cell Lung Cancer

22 enrolled

CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Neoplasms

NCT05293197 2025-11-20

SONOKID

24 enrolled

Brain Neoplasms, Glioma, Neoplasms, Germ Cell and Embryonal

NCT05768880 2025-11-20

Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors

72 enrolled

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Recurrence, Central Nervous System Neoplasms

NCT06132945 2025-11-14

A Study of Cabozantinib and Nivolumab With Radiation Therapy for People With Renal Cell Carcinoma That Has Spread to the Brain

2 enrolled

CNSGenitourinary

Brain Neoplasms, Carcinoma, Renal Cell

NCT07139990 2025-11-10

PRISM

45 enrolled

Brain Neoplasms

NCT02993146 2025-10-29

Ropidoxuridine and Whole Brain Radiation Therapy in Treating Patients With Brain Metastases